Neuro-All March 2019

neuro-all@lists.umanitoba.ca

2 participants
10 discussions

Reminder: MNN Seminar Series: Dr. Spencer Gibson | Fri., Mar 29 @ 9am

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, March 29, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Spencer Gibson, PhD Professor, Department of Immunology & Biochemistry and Medical Genetics Director, Manitoba Institute of Cell Biology Senior Scientist, Research Institute in Oncology and Hematology Director, Translational Research University of Manitoba T O P I C Understanding the regulation of cell death in glioblastoma. Context Matters? O B J E C T I V E S · Context (location, microenvironment, and time) matters in cell death · Understand different forms of cell death · Role this plays in glioblastoma treatment. A B S T R A C T Cells undergo different forms of cell death depending on the context. In cancer including glioblastoma (GBM), the context depends upon location, microenvironment and time. This will determine whether a cancer cell dies or survives. The context is dynamic and changes over time leading to drug resistance in cancer. The location of cell death regulatory gene changes their function, we found that a BH3 only Bcl-2 family member BNIP3 switch from pro-cell death to pro-survival depending on subcellular localization. The microenvironment also changes where hypoxic regions develop and drive GBM drug resistance and growth factor signaling that changes cell survival. Finally time changes cell death responses where different types of cell death could occur at different times. We found that ferroptosis (iron dependent cell death)is induced at early times during hypoxia but switches to autophagy (self-eating) during late times. Thus, understanding this balance between cell death and survival will allow more rationale therapeutic strategies to be develop and hopefully prevent drug resistance in GBM. B I O S K E T C H: Dr. Gibson graduate the University of Toronto where he gained his Ph.D. in the Department of Laboratory Medicine and Pathobiology. During his Ph.D. studies, he traveled to M.D. Anderson Cancer Center in Houston, Texas as a pre-doctoral fellow where he completed his Ph.D. studies. Dr. Gibson was a post-doctoral fellow at the National Jewish Medical and Research Center in Denver, Colorado. Dr. Spencer B. Gibson is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba and is a Senior Investigator at the Research Institute of Oncology and Hematology (formally the Manitoba Institute of Cell Biology, MICB) since 1999. In 2008, the Manitoba Health Research Council awarded Dr. Gibson a Manitoba Research Chair to support his research efforts. At the Research Insitute, Dr. Gibson is Director of Translational Research where he contributed to the creation of the expansion of the Manitoba Tumor Bank and initiated new translational research projects. He is also appointed as Director, MICB from 2012-2014, to provide leadership for cancer research with the province of Manitoba and is currently Section Head, Cell Biology for the Research Institute at CancerCare Manitoba. Dr. Gibson has 130 peer-reviewed publication with an h-index of 49. The focus of his research is to define the signal transduction pathways leading to cell death or survival in cancer including leukemia. This will elucidate targets that could tip balance in favour of cell death and will be the foundation to establish clinical trials using molecular targeted therapies to increase effectiveness of chemotherapy in cancer. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years

MNN Seminar Series: Dr. Spencer Gibson | Fri., Mar 29 @ 9am

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, March 29, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Spencer Gibson, PhD Professor, Department of Immunology & Biochemistry and Medical Genetics Director, Manitoba Institute of Cell Biology Senior Scientist, Research Institute in Oncology and Hematology Director, Translational Research University of Manitoba T O P I C Understanding the regulation of cell death in glioblastoma. Context Matters? O B J E C T I V E S · Context (location, microenvironment, and time) matters in cell death · Understand different forms of cell death · Role this plays in glioblastoma treatment. A B S T R A C T Cells undergo different forms of cell death depending on the context. In cancer including glioblastoma (GBM), the context depends upon location, microenvironment and time. This will determine whether a cancer cell dies or survives. The context is dynamic and changes over time leading to drug resistance in cancer. The location of cell death regulatory gene changes their function, we found that a BH3 only Bcl-2 family member BNIP3 switch from pro-cell death to pro-survival depending on subcellular localization. The microenvironment also changes where hypoxic regions develop and drive GBM drug resistance and growth factor signaling that changes cell survival. Finally time changes cell death responses where different types of cell death could occur at different times. We found that ferroptosis (iron dependent cell death)is induced at early times during hypoxia but switches to autophagy (self-eating) during late times. Thus, understanding this balance between cell death and survival will allow more rationale therapeutic strategies to be develop and hopefully prevent drug resistance in GBM. B I O S K E T C H: Dr. Gibson graduate the University of Toronto where he gained his Ph.D. in the Department of Laboratory Medicine and Pathobiology. During his Ph.D. studies, he traveled to M.D. Anderson Cancer Center in Houston, Texas as a pre-doctoral fellow where he completed his Ph.D. studies. Dr. Gibson was a post-doctoral fellow at the National Jewish Medical and Research Center in Denver, Colorado. Dr. Spencer B. Gibson is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba and is a Senior Investigator at the Research Institute of Oncology and Hematology (formally the Manitoba Institute of Cell Biology, MICB) since 1999. In 2008, the Manitoba Health Research Council awarded Dr. Gibson a Manitoba Research Chair to support his research efforts. At the Research Insitute, Dr. Gibson is Director of Translational Research where he contributed to the creation of the expansion of the Manitoba Tumor Bank and initiated new translational research projects. He is also appointed as Director, MICB from 2012-2014, to provide leadership for cancer research with the province of Manitoba and is currently Section Head, Cell Biology for the Research Institute at CancerCare Manitoba. Dr. Gibson has 130 peer-reviewed publication with an h-index of 49. The focus of his research is to define the signal transduction pathways leading to cell death or survival in cancer including leukemia. This will elucidate targets that could tip balance in favour of cell death and will be the foundation to establish clinical trials using molecular targeted therapies to increase effectiveness of chemotherapy in cancer. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years

Graduate student positions available at UofManitoba

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Benjamin W. Lindsey, PhD I have two graduate student positions open for Fall 2019 in my lab in the Department of Human Anatomy & Cell Science. Please post/circulate the attached. Thank you kindly, Ben Benjamin W. Lindsey, PhD Laboratory of Neural Stem Cell Plasticity & Regeneration Department of Human Anatomy and Cell Science Benjamin.Lindsey(a)umanitoba.ca Office Phone: 204-789-3781 Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 1 month

MNN 9th Scientific Meeting - Save the Date!

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 JUNE 7th, 2019 Manitoba Neuroscience Network 9th SCIENTIFIC MEETING UNIVERSITY OF WINNIPEG Convocation Hall & Leatherdale Hall PROGRAM THEMES · Genetics of neurodevelopment · Emotional/cognitive neuroscience · Neuro-oncology · Historical perspectives on neuropathology · Focus on ALS R STRATION OPENS PROGRAM HIGHLIGHTS · Refreshment & exercise breaks · Taco bar lunch · Poster session · Exhibitor tables · Breakout sessions · WAG networking mixer & neuroscience art silent auction KEYNOTE SPEAKERS Dr. Daniel Goldowitz University of British Columbia Dr. Janice Robertson University of Toronto *REGISTRATION OPENS APRIL 1 , 2019 www.manitobaneuroscience.ca CHAIRS Dr. Domenico Di Curzio University of Winnipeg Dr. Renée Douville University of Winnipeg For more information: mnn2019(a)manitobaneuroscience.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 1 month

CAN elections

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tabrez Siddiqui Could you please forward to all Neuroscience faculty. From: "Alyson Fournier, Dr." <alyson.fournier(a)mcgill.ca> Subject: CAN elections Dear Tabrez, CAN has recently opened its call for nominations for the Spring election. Openings are available for vice president, secretary and 2 board members. It is important for CAN to have great cross-Canada representation and diversity on the executive so please bring this to the attention of any faculty at your institute who may be interested. Thanks for your time, Sincerely, Alyson Secretary - CAN https://can-acn.org/call-for-nominations-spring-2019-elections Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 1 month

****CANCELLED**** MNN Speaker | Alyson Fournier Mar 20th

by Kelly Jorundson

-----CANCELLED----- [cid:image001.jpg@01D158FE.B69B8D00] S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

5 years, 1 month

John P. Zubek Memorial Lecture Series | Matthew Hill

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tammy Ivanco Department of Psychology Colloquium JOHN P. ZUBEK MEMORIAL LECTURE Friday, March 15, 2019, 3:00 p.m., P412 Duff Roblin Refreshments served at 2:30 p.m., P408 Duff Roblin Wine & Cheese to follow talk Dr. Matthew Hill, PhD Department of Psychiatry, University of Calgary; Hotchkiss Brain Institute; The Mathison Centre for Mental Health research & Education Endocannabinoids: Multi-modal regulators of the stress response For more information: Dr. T.L. Ivanco, Associate Professor Department Of Psychology University of Manitoba 204-474-7375 Tammy.ivanco(a)umanitoba.ca Kelly Jorundson Administrative Manager, Division of Neurodegenerative Disorders St. Boniface Hospital Research & Department of Pharmacology & Therapeutics University of Manitoba Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca or <mailto:Kelly.jorundson@umanitoba.ca> kjorundson(a)sbgh.mb.ca Tel: 204.235.3939 Fax: 204.237.4092 cid:image001.jpg@01D2883E.86D93F20

5 years, 1 month

Reminder....MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm

by Kelly Jorundson

[cid:image001.jpg@01D158FE.B69B8D00] M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

5 years, 1 month

MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 1 month

Dementia Journal Club - March 13 10 AM at Ft Garry EITC - please post and/or distribute

by Kelly Jorundson

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Ben Albensi Come to our journal club on March 13th. Info below. Paper can be found at our Dementia Research website: http://dementiamanitoba.wixsite.com/m.../dementia-journal-club<http://dementiamanitoba.wixsite.com/mysite/dementia-journal-club?fbclid=IwA…> [cid:image003.jpg@01D4D4D1.722F1A90] Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

5 years, 1 month

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Neuro-All March 2019