S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D AT E
Friday, November 24th, 2017
9:00am
L O C AT I O N
PX236/238 Psychealth Building
S P E A K E R
Assistant Professor
Department of Human Anatomy & Cell Science, University of Manitoba
Topic: Cerebellar development in health and disease: Early mossy fiber afferent and cerebellar circuit formation
BIO: Dr. Marzban received his Bachelor of Science (B.Sc.) degree in Physiotherapy from Iran University of Medical Sciences, followed by a Master of Science degree (M.Sc.) in Human Anatomy from Mashhad University of Medical Sciences, Iran. He then obtained a Philosophy of Doctoral (PhD) in Anatomical Science from the Department of Human Anatomy, Tehran University of Medical Sciences, Tehran, Iran. Dr. Marzban was recruited as an Assistant Professor at the Medical School in Tehran University of Medical Sciences. He joined Dr. R. Hawkes’ laboratory as a Visiting Scientist and subsequently was recruited as an Assistant Professor (research) at the Department of Cell Biology and Anatomy, University of Calgary. Soon after, Dr. Marzban joined the University of Manitoba as an Assistant Professor in the Department of Human Anatomy and Cell Science.
Dr. Marzban research interests focus on understanding the cellular and molecular mechanisms of the developing cerebellum, specifically the etiology of neurodevelopmental disorders and neurodegenerative disease using mouse models (E.g. ACP2 and SNCA mutant lines).
Abstract; Cerebellar defects result in significant intellectual and motor function impairment that influences both the patients and their families. My research goal is to understand the cellular and molecular processes of normal and abnormal cerebellar development and how these processes are disrupted in cerebellar defects. I anticipate this fundamental research will provide solid knowledge to elucidate cerebellar disorders, prevent birth-defects and develop therapeutics that will improve the lives of affected individuals.
My ongoing research program is focused on early cerebellar circuit formation; early connectivity between cerebellar nuclei neurons and afferent pioneer axon, which is affected in nax (Acp2 -/-) mutant mice as model. In my presentation I will discuss the early pioneer axons to reach the cerebellum arise from the trigeminal system (not vestibular system) and target cerebellar nuclei neurons (not Purkinje cell), initiating the formation of the early cerebellar circuit. It will address a critical knowledge gap by providing essential developmental information that the trigeminal system develops in close proximity to the cerebellum and probably mechanisms that are affected in some cerebellar disorders.
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: kjorund@sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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