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M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E:
Thursday December 13, 2018
12:00 Noon
L O C A T I O N:
Theatre B Bannatyne Campus
**followed by a trainee lunch in 431 BMSB
S P E A K E R
Dr. Shawn Hochman Professor and Interim Chair Emory University School of Medicine
Atlanta, GA
T O P I C: Paravertebral sympathetic thoracic chain ganglia: recruitment principles and plasticity after spinal cord injury
O b j e c t I v e s: Paravertebral chain sympathetic postganglionic neurons (SPNs) represent the final neural control element regulating vasomotor tone and can be thought of as a distribution system for sympathetic activity that must span the body vasculature. Alterations in sympathetic chain activity are implicated in various autonomic disorders. The thoracic SPNs (tSPNs) control vasomotor function in upper extremities and trunk (this includes vascular supply to integumentary, cardiorespiratory and digestive systems). tSPNs remain a barely-studied area of vertebrate autonomic neuroscience.
1. Use whole-cell patch clamp recordings in an adult mouse ex vivo preparation to uncover the operational principles governing tSPN recruitment. 2. Obtain a reliable cellular and synaptic data set for realistic computational simulation. The relative simplicity of the organization makes discovery of principles through modeling more assured than in more complex systems. 3. To determine whether changes in tSPNs contribute to autonomic dysfunction after spinal cord injury.
B I O S K E T C H:
Shawn Hochman is Professor and Interim Chair of Physiology at Emory University School of Medicine. His research embraces broad aspects of neuromodulation-based control of sensorimotor and autonomic integration. Current research focuses on emergent dysfunction in mouse models of spinal cord injury. Efforts include; (i) continuous non-invasive capture of changes in physio-behavioral variables in the vivarium home-cage, and (ii) the role of the peripheral NS in driving emergent sensory and autonomic dysfunction
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui@umanitoba.ca
Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network
Email: kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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