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Friday, May 20th, 2016 12:00 Noon | Theatre C, Bannatyne Campus

S p e a k e r

Dr. Derek Bowie

Professor - Department of Pharmacology & Therapeutics, McGill University

Director - GEPRO M

Topic: Ionotropic glutamate receptors and Fragile-X syndrome

Abstract: The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states. The talk will focus on recent work on NMDA-type iGluRs and how it relates to deficits in Fragile-X syndrome.

Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group, GEPRO M, and has been a Professor at McGill University since 2002. He is the recipient of the Canada Research Chair award in Receptor Pharmacology and serves on the editorial boards of the Journal of Physiology, Current Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University of London after completing his undergraduate degree at Strathclyde University in Scotland. He then carried out postdoctoral training in France (Université Louis Pasteur), Switzerland (University of Zurich) and the USA (National Institutes of Health) before holding a faculty position at Emory University in Atlanta. The Bowie lab focuses on the structure-function properties of ionotropic glutamate receptors, GABA-A receptors and sodium channels as well as examining their role in neuronal circuit behaviour.

http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html

Kelly Jorundson Manitoba Neuroscience Network R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6

Tel: 204.235.3939 Fax: 204.237.4092

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