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S E M I N A R & V I S I T I N G S P E A K E R S E R I E S

D AT E

Friday, February 9th, 2018

12:00 NOON

L O C AT I O N

071 Apotex Bldg.

S P E A K E R

Dr. Katalin Toth https://cervo.ulaval.ca/en/katalin-toth CERVO Brain Research Centre

Université Laval

Professor, Department of Psychiatry and Neuroscience

T O P I C Information coding and calcium dynamics in hippocampal mossy fibre terminals

Abstract:

Neurons encode and transmit information in the frequency and temporal precision of action potentials (APs) they discharge Presynaptic terminals are key elements involved in the translation of electrical signals to neurotransmitter release. The differential spatial assembly of a myriad of voltage-gated channels, calcium buffers and calcium sensors confers specific properties to presynaptic terminals.The dynamic modulation of neurotransmitter release is thought to support the neuronal code used to transfer information. We use electrophysiological measurements in acute hippocampal slices with rapid presynaptic two-photon calcium imaging and experimentally-constrained modelling to study the mechanism by which mossy finer terminals in the hippocampus translate granule cell firing to postsynaptic signals. Our aim is to elucidate how a mossy fiber boutons integrate incoming bursts of action potentials to propagate information to CA3 pyramidal neurones.

Bio:

Katalin Tóth earned her PhD in 1995 from the Eötvös Loránd University in Budapest, Hungary, under the supervision of Tamás F. Freund, after completing an undergraduate degree in Biology. She then spent the next 2 years as postdoctoral fellow in the laboratory of Richard Miles at the Pasteur Institute in Paris, France, and studied the properties of synaptic interactions between connected pairs of neurons. She moved to the National Institutes of Health in the USA where she worked with Chris J. McBain on the plastic properties of hippocampal networks. She established her laboratory in 2000 at Laval University where she is currently a Professor in the Department of Psychiatry and Neuroscience. Her research is focused on presynaptic release mechanisms and information processing at hippocampal mossy fibres.

/sent on behalf of

Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour@umanitoba.ca

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network

Email: mailto:kjorund@sbrc.ca kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092

St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA

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