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DND Visiting Speaker - Dr. Sean Mulligan

DATE:  Friday, September 23, 2011 TIME:  12:00 pm LOCATION:  Room 431 Basic Medical Sciences Bldg. (Physiology Conference Room)

Dr. Sean Mulligan Assistant Professor, Department of Physiology University of Saskatchewan

TOPIC:    Functional optical imaging in free nerve endings:  a pain in the dura.

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PUBLIC LECTURE: NEUROSCIENCE RESEARCH PROGRAM CANDIDATE

Dr. Véronique André

TOPIC: "Striatal Circuitry and Dopamine Modulation in Huntington's Disease"

Thursday, September 29, 2011 9:00 A.M. - 10:00 A.M. Location: Theatre C, Basic Medical Sciences Bldg.

Dr. Véronique André, Associate Research Physiologist - Intellectual and Developmental Disabilities Research Center - UCLA Neuropsychiatric Institute

For more information, contact Dr. Kevin Coombs Neuroscience Research Program, Faculty of Medicine at (204)789-3375 or kcoombs@cc.umanitoba.ca

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Everyone welcome!

Friday September 30th, 2011 3:00 pm - 4:00 pm in P412 Duff Roblin Building

Department of Psychology Colloquium

"A cholinergic explanation of dense amnesia?"

Mark G. Baxter Associate Professor Department of Neuroscience, Mount Sinai School of Medicine

Abstract: Episodic memory depends on a network of interconnected brain structures. Damage to either the fornix or mammillary bodies causes amnesia in both humans and nonhuman primates. We have found that the severity of amnesia after damage to either of these structures is modulated by prior loss of cholinergic projections to the inferotemporal cortex, the cortical region through which visual information reaches these structures. Macaque monkeys with cholinergic depletion of inferotemporal cortex had unimpaired episodic memory performance. However, these monkeys were substantially more impaired following additional lesions of either the fornix or the mammillary bodies than were monkeys with intact temporal cortical cholinergic input. Reversing the order of the lesions resulted in less severe amnesia, indicating that the presence of cholinergic projections to temporal cortex at the time of fornix or mammillary body damage facilitates recovery. These findings show that humans with loss of cortical cholinergic function, for example in Alzheimer's disease, may be less able to adapt to the impairments caused by neuronal damage within cortical and subcortical structures important for memory. Consequently, drugs that increase cortical cholinergic neurotransmission may slow disease progress by augmenting this adaptive process. Sponsors: Department of Psychology & Arts Endowment Fund

Wine & Cheese to follow talk in the Psychology Lounge.

Contact: Tammy L. Ivanco, PhD. Associate Professor, Department of Psychology P415 Duff Roblin Building, 190 Dysart Road University of Manitoba Winnipeg, MB, R3T-2N2 204-474-7375

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Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 24.237.4092 Website: sfn-manitoba.ca