Manitoba Neuroscience Network

2015/2016 Seminar & Visiting Speaker Series

Friday, December 4th, 2015 | 12:00 Noon

Christoph J.W. Pröschel https://www.urmc.rochester.edu/labs/proschel-lab/

Associate Professor of Genetics

University of Rochester Medical Center,

Department for Biomedical Genetics,

Stem Cell and Regenerative Medicine Institute

Pathways of Human Disease Program

TOPIC: Glial cell therapy: the opportunity for restoring function by restoring tissue homeostasis.

Location: Theatre C, Bannatyne Campus

Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy

(Nat Med. 2005 Mar;11(3):277-83.).

The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases

(Parkinsons Disease, Multiple sclerosis).

We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells.

(PLoS One. 2011 Mar 2;6(3)).

For more information, contact the MNN Office at

(T) 235.3939 or email: mnn@sbrc.ca

Kelly Jorundson

Administrative Manager

Division of Neurodegenerative Disorders

St. Boniface Hospital Research

& Department of Pharmacology & Therapeutics

College of Medicine, Faculty of Health Sciences

University of Manitoba

Room R4046 - 351 Taché Avenue

Winnipeg, MB R2H 2A6 CANADA

Tel: 204.235.3939 | Fax: 204.237.4092

Email: kjorund@sbrc.ca OR Kelly.Jorundson@umanitoba.ca

Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology