CENTRE ON AGING PRESENTS: 2011-2012 Research Seminar Series

Ben Albensi, PhD, Associate Professor

Department of Pharmacology and Therapeutics

Tuesday, April 10, 2012

Room 405 Brodie Centre

12:00 p.m. to 1:00 p.m.

TOPIC: The Involvement of NF-kB Signaling in Memory Impairment in Alzheimer's Disease

Memory impairments are central to a variety of neurological conditions, but the most familiar condition where memory is impaired is in Alzheimer's

disease. Treating Alzheimer's disease pathology and the cognitive deficits that are seen in this condition remain problematic. Part of the challenge of course

is that if we do not understand the fine details of how memory works on a basic biological or neurochemical level, then we are not able to effectively treat

memory impairments. However, over the last several years research associated with the biological basis of memory has made great strides. We now believe that

Alzheimer's disease is a disease of short term memory where the conversion of short term to long term memory becomes impaired. Recent developments also

suggest that transcription is essential for the consolidation of long term memory. In addition, transcriptional signaling pathways such as NF-kB play not only a

role in cancer and inflammatory responses, but also in long term memory and in Alzheimer's disease. The focus of this talk will be to discuss NF-kB signaling

in memory and in Alzheimer's disease. In particular, new data from our lab show several novel links in the NF-kB pathway that suggest distinct roles for NF-kB's

gene targets in differentially affecting memory and Alzheimer's disease pathology.

All are welcome to attend. For more information, call 474.8754

For presentation updates, visit www.umanitoba.ca/centres/aging/

The Centre on Aging's Research Seminar Series is supported by the Office of the Vice-President (Research and International)

Seminar co-sponsor: Department of Pharmacology and Therapeutics

Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba

Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund@sbrc.ca OR kjorund@yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharamcology