Neuro-All June 2011

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--CANCELLED-- Research Lecture: Dr. Sean Mulligan Friday, Jun 17, 2011

by Winnipeg Chapter Society for Neuroscience

Dr. Sean Mulligan's lecture scheduled for Friday June 17th has been CANCELLED. Kelly Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Taché Avenue Winnipeg, MB R2H 2A6 CANADA Tel: 204.235.3939 7Fax: 204.237.4092 Email: wcsn(a)sbrc.ca Website: www.sfn-manitoba.ca

12 years, 10 months

DND Visiting Speaker (Note change in time/location)

by Winnipeg Chapter Society for Neuroscience

(Judy/Sharon, can you circulate to Physiology staff?) DND Visiting Speaker - Dr. Sean Mulligan http://www.sbrc.ca/content/view/926/593/ DATE: Friday, June 17th, 2011 TIME: 1:00 pm LOCATION: Room 431 Basic Medical Sciences Bldg. (Physiology Conference Room) Dr. Sean Mulligan <http://www.medicine.usask.ca/physiology/people/faculty-members/sean-mulliga…> Assistant Professor, Department of Physiology University of Saskatchewan TOPIC: Functional optical imaging in free nerve endings: a pain in the dura. Biosketch: Dr. Sean Mulligan Assistant Professor, Department of Physiology Neural Systems & Plasticity Research Group, College of Medicine, University of Saskatchewan Postdoctoral Fellow (Psychiatry) Faculty of Medicine, University of British Columbia Ph.D. (Neuroscience) Faculty of Medicine, University of Calgary M.Sc. (Biology/Neurobiology) Simon Fraser University B.Sc. (Kinesiology/Anatomy & Physiology) Simon Fraser University Teaching Interests Neuroscience Cellular and Systems Level Physiology Research Interests Pain sensitivity within the skull is restricted to the intracranial meninges, the system of membranes that envelops the brain. Afferent thinly myelinated A��-fibres and unmyelinated C-fibres that originate from the trigeminal ganglion densely innervate the meninges, in particular the cranial dura mater. It is widely recognized that activation or sensitization of these dural nociceptive afferents is responsible for the genesis of migraine headaches. However, any details of the pathophysiological mechanisms involved are largely speculative and remain to be discovered. Identification of the underlying mechanisms of activation of dural nociceptors may have important implications for understanding and mitigating the pathogenesis of migraine headaches. We have developed a novel en bloc dural-skull preparation that allows us for the first time to apply optical imaging techniques to directly study with high resolution the free nerve endings and terminals of the nociceptive fibres that terminate in the dura mater. The objective of our research is to gain insight into the neurophysiology of peripheral pain activation to better understand the pathophysiological processes that occur during migraine headache. It is our hope that this will lead to new peripheral drug targets and offer additional therapeutic treatments for this devastating illness. Laboratory Techniques We are primarily an optical imaging laboratory that uses both two-photon laser scanning imaging as well as widefield epifluorescence microscopy. Microscopes are configured for both microfluorometric and transmitted light imaging using photomultiplier tube or high sensitivity EMCCD camera based detection. We combine optical imaging of calcium signaling selectively within individual terminals with electrophysiological stimulation, pharmacological manipulations, and UV and two-photon photolysis of caged compounds. Selected Publications Papers in refereed journals: Zampronio, A. R., Kuzmiski, J. B., Florence, C.M., Mulligan, S. J. and Pittman, Q. J. Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleus. Journal of Neuroscience (in press) Hines, D.J., Hines, R.M., Mulligan, S.J., and Macvicar, B.A. Microglia processes block the spread of damage in the brain and require functional chloride channels. Glia. 2009 Nov 15;57(15):1610-8. Umeshappa C.S., Huang, H., Xie, Y., Wei, Y., Mulligan, S.J., Deng, Y., and Xiang, J. CD4+ Th-APC with acquired peptide/MHC class I and II complexes stimulate type 1 helper CD4+ and central memory CD8+ T cell responses. Journal of Immunology Vol 182 pp 193-206 (2009). Pittman, Q. P and Mulligan, S.J. Dendritic Vasopressin Release: Reducing the Flow Makes Blood Vessels Grow. Endocrinology Vol 149(9) pp 4276-4278 (2008). Kisilevsky, A.E., Mulligan, S.J., Christophe, A., Iftinca, M.C., Varela, D., Tai, C., Chen, L., Hameed, S., Hamid, J., MacVicar, B.A. and Zamponi, G.W. D1 and D2 dopamine receptors interact directly with N-type calcium channels and differentially regulate channel activity. Neuron Vol 58 pp 557-570 (2008). Gordon, G.R., Mulligan, S. J. and MacVicar, B.A. Astrocyte control of the cerebrovasculature. Glia Vol 55 pp 1214-1221 (Cover Image) (2007). Mulligan, S.J. and MacVicar, B. A. VRACs CARVe a path for novel mechanisms of communication in the CNS. Science STKE Vol 2006/357 pe42 (2006). Mulligan, S.J. and MacVicar, B. A. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature Vol 431/7005 pp 195-199 (2004). Mulligan, S.J., Davison, I. and Delaney, K.R. Mitral cell presynaptic Ca2+ influx and synaptic transmission in frog amygdala. Neuroscience Vol 104/1 pp 137-151 (2001). Book Chapters: Florence, C.M. and Mulligan, S.J. Two-Photon Laser Scanning Microscopy: Imaging Astrocyte Calcium Signalling in the Brain Slice Preparation. In Neuromethods series, edited by Walz, W. and Doucette, R., Humana Press (2009). Gordon G.R.J., MacVicar, B.A., and Mulligan, S.J. Glia Control of Blood Flow. In The New Encyclopedia of Neuroscience, edited by Squire, L.R., Oxford:Academic Press (2009). Mulligan, S.J. and MacVicar, B. A. Two-Photon Fluorescence Microscopy: Basic Principles, Advantages and Risks. In Modern Research and Educational Topics in Microscopy, edited by A. M��ndez-Vilas, J. D��az, Formatex (2007). MacVicar, B. A. and Mulligan, S.J. Intrinsic Optical Signal Imaging in Brain slices. In Imaging in Neuroscience and Development: A Laboratory Manual, edited by Yuste, R. and Konnerth, A., Cold Spring Harbor Laboratory Press. (2005). Mulligan, S.J. and MacVicar, B. A. Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators. In Voltage-Gated Calcium Channels, edited by Zamponi, G.W., Landes Bioscience (2005). Kelly Jorundson Administrative Manager - Division of Neurodegenerative Disorders St. Boniface Hospital Research Centre & Pharmacology & Therap., University of Manitoba R4046 �C 351 Tach�� Avenue Winnipeg, MB R2H 2A6 CANADA 'Tel: 204.235.3939 7Fax: 204.237.4092 *Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> ; OR kjorund(a)yahoo.ca <mailto:kjorund@yahoo.ca>

12 years, 10 months

Physiology/SCRC Candidate Lectures, Dr. Eftekharpour, June 20 & 21, 2011

by Winnipeg Chapter Society for Neuroscience

The Department of Physiology/SCRC Candidate Lectures Speaker: Dr. Eftekhar Eftekharpour Senior Research Associate Spinal Cord Research Centre Department of Physiology University of Manitoba Winnipeg, Manitoba Research Lecture Monday, June 20 "Neuroprotective Approaches for the Treatment of Spinal Cord Injury" Monday, June 20, 2011 at 11:00AM Theatre B, 2nd Floor, Basic Medical Sciences Bldg 745 Bannatyne Avenue Everyone welcome Teaching Lecture Tuesday, June 21 "Glial Component of the CNS Neural Network" Tuesday, June 21, 2011 at 10:00AM Biochemistry Conference Room 341, BMSB 745 Bannatyne Avenue Everyone welcome Students encouraged to attend Posters attached. For more information contact: Dr. David McCrea Director: Spinal Cord Research Centre Phone: 789-3770 E-mail: dave(a)scrc.umanitoba.ca Spinal Cord Research Centre University of Manitoba Department of Physiology 745 Bannatyne Avenue Winnipeg, Manitoba Canada R3E 0J9 Tel: (204)789-3770 Fax: (204)789-3930 dave(a)scrc.umanitoba.ca

12 years, 10 months

DND Visiting Speaker - Dr. Sean Mulligan

by Winnipeg Chapter Society for Neuroscience

View online: http://www.sbrc.ca/content/view/926/593/ Division of Neurodegenerative Disorders Visiting Speaker - Dr. Sean Mulligan <http://www.medicine.usask.ca/physiology/people/faculty-members/sean-mulliga…> DATE: Friday, June 17th, 011 TIME: 12:00 Noon LOCATION: Theatre A Biosketch: Dr. Sean Mulligan Assistant Professor, Department of Physiology Neural Systems & Plasticity Research Group, College of Medicine, University of Saskatchewan Postdoctoral Fellow (Psychiatry) Faculty of Medicine, University of British Columbia Ph.D. (Neuroscience) Faculty of Medicine, University of Calgary M.Sc. (Biology/Neurobiology) Simon Fraser University B.Sc. (Kinesiology/Anatomy & Physiology) Simon Fraser University Teaching Interests Neuroscience Cellular and Systems Level Physiology Research Interests Pain sensitivity within the skull is restricted to the intracranial meninges, the system of membranes that envelops the brain. Afferent thinly myelinated A��-fibres and unmyelinated C-fibres that originate from the trigeminal ganglion densely innervate the meninges, in particular the cranial dura mater. It is widely recognized that activation or sensitization of these dural nociceptive afferents is responsible for the genesis of migraine headaches. However, any details of the pathophysiological mechanisms involved are largely speculative and remain to be discovered. Identification of the underlying mechanisms of activation of dural nociceptors may have important implications for understanding and mitigating the pathogenesis of migraine headaches. We have developed a novel en bloc dural-skull preparation that allows us for the first time to apply optical imaging techniques to directly study with high resolution the free nerve endings and terminals of the nociceptive fibres that terminate in the dura mater. The objective of our research is to gain insight into the neurophysiology of peripheral pain activation to better understand the pathophysiological processes that occur during migraine headache. It is our hope that this will lead to new peripheral drug targets and offer additional therapeutic treatments for this devastating illness. Laboratory Techniques We are primarily an optical imaging laboratory that uses both two-photon laser scanning imaging as well as widefield epifluorescence microscopy. Microscopes are configured for both microfluorometric and transmitted light imaging using photomultiplier tube or high sensitivity EMCCD camera based detection. We combine optical imaging of calcium signaling selectively within individual terminals with electrophysiological stimulation, pharmacological manipulations, and UV and two-photon photolysis of caged compounds. Selected Publications Papers in refereed journals: Zampronio, A. R., Kuzmiski, J. B., Florence, C.M., Mulligan, S. J. and Pittman, Q. J. Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleus. Journal of Neuroscience (in press) Hines, D.J., Hines, R.M., Mulligan, S.J., and Macvicar, B.A. Microglia processes block the spread of damage in the brain and require functional chloride channels. Glia. 2009 Nov 15;57(15):1610-8. Umeshappa C.S., Huang, H., Xie, Y., Wei, Y., Mulligan, S.J., Deng, Y., and Xiang, J. CD4+ Th-APC with acquired peptide/MHC class I and II complexes stimulate type 1 helper CD4+ and central memory CD8+ T cell responses. Journal of Immunology Vol 182 pp 193-206 (2009). Pittman, Q. P and Mulligan, S.J. Dendritic Vasopressin Release: Reducing the Flow Makes Blood Vessels Grow. Endocrinology Vol 149(9) pp 4276-4278 (2008). Kisilevsky, A.E., Mulligan, S.J., Christophe, A., Iftinca, M.C., Varela, D., Tai, C., Chen, L., Hameed, S., Hamid, J., MacVicar, B.A. and Zamponi, G.W. D1 and D2 dopamine receptors interact directly with N-type calcium channels and differentially regulate channel activity. Neuron Vol 58 pp 557-570 (2008). Gordon, G.R., Mulligan, S. J. and MacVicar, B.A. Astrocyte control of the cerebrovasculature. Glia Vol 55 pp 1214-1221 (Cover Image) (2007). Mulligan, S.J. and MacVicar, B. A. VRACs CARVe a path for novel mechanisms of communication in the CNS. Science STKE Vol 2006/357 pe42 (2006). Mulligan, S.J. and MacVicar, B. A. Calcium transients in astrocyte endfeet cause cerebrovascular constrictions. Nature Vol 431/7005 pp 195-199 (2004). Mulligan, S.J., Davison, I. and Delaney, K.R. Mitral cell presynaptic Ca2+ influx and synaptic transmission in frog amygdala. Neuroscience Vol 104/1 pp 137-151 (2001). Book Chapters: Florence, C.M. and Mulligan, S.J. Two-Photon Laser Scanning Microscopy: Imaging Astrocyte Calcium Signalling in the Brain Slice Preparation. In Neuromethods series, edited by Walz, W. and Doucette, R., Humana Press (2009). Gordon G.R.J., MacVicar, B.A., and Mulligan, S.J. Glia Control of Blood Flow. In The New Encyclopedia of Neuroscience, edited by Squire, L.R., Oxford:Academic Press (2009). Mulligan, S.J. and MacVicar, B. A. Two-Photon Fluorescence Microscopy: Basic Principles, Advantages and Risks. In Modern Research and Educational Topics in Microscopy, edited by A. M��ndez-Vilas, J. D��az, Formatex (2007). MacVicar, B. A. and Mulligan, S.J. Intrinsic Optical Signal Imaging in Brain slices. In Imaging in Neuroscience and Development: A Laboratory Manual, edited by Yuste, R. and Konnerth, A., Cold Spring Harbor Laboratory Press. (2005). Mulligan, S.J. and MacVicar, B. A. Monitoring Intracellular Ca2+ in Brain Slices with Fluorescent Indicators. In Voltage-Gated Calcium Channels, edited by Zamponi, G.W., Landes Bioscience (2005). Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 �C 351 Tach�� Avenue Winnipeg, MB R2H 2A6 CANADA Tel: 204.235.3939 7Fax: 204.237.4092 Email: wcsn(a)sbrc.ca Website: www.sfn-manitoba.ca

12 years, 10 months

Reminder: Research Lecture - Dr. Michael Kawaja

by Winnipeg Chapter Society for Neuroscience

Date: Friday, June 3, 2011 Time: 12:00 PM - 1:00 PM Location: Theatre C Dr. Michael Kawaja Professor, Department of Anatomy and Cell Biology Queen's University at Kingston Topic: Nerve Growth Factor - The driving force behind sympathetic sprouting. Biosketch: Dr. Kawaja did his undergraduate studies in biology at Acadia University and completed his doctoral degree in Anatomy at the University of Western Ontario in 1989. He then went on to have two MRC-funded post-doctoral positions, the first with Dr. Fred Gage at the University of California San Diego, and the second with Dr. John Roder at the Samuel Lunenfeld Institute at the Mount Sinai Hospital in Toronto. In 1993 Dr. Kawaja commenced his MRC-funded scholarship position as an Assistant Professor in the Department of Anatomy and Cell Biology at Queen's University. Over the last 17 years he has risen through the ranks of Associate and Full Professor at Queen's. Dr. Kawaja has held numerous operating grants from CIHR (MRC), Heart and Stroke Foundation, Ontario Neurotrauma Foundation, and Ontario Mental Ontario Ministry for Research and Innovation. He has served as a panel member of CIHR Scholarships and continues to serve as a panel member for CIHR Neuroscience "B". He has also served on a number of peer review panels including those for Alzheimer Society of Canada, Heart and Stroke Foundation of Canada, Multiple Sclerosis Society of Canada, Ontario Mental Health Foundation, and Ontario Ministry of Research and Innovation Early Researcher Awards. health Foundation. His research focuses on gaining a greater understanding of the reparative mechanisms in the mammalian central and peripheral nervous systems, as a consequence of injury and disease.

12 years, 10 months

Public Lecture for Neuroscience Research Program Candidate - June 10, 2011...

by Winnipeg Chapter Society for Neuroscience

Everyone is invited to attend… Neuroscience Research Program Candidate: Dr. Paul Cumming Public Lecture: “Investigation of Biogenic Amine Pharmacology with PET” DATE: Friday, June 10, 2011 TIME: 9:00 AM LOCATION: Apotex Centre Basement Lecture Theatre 071 Paul Cumming, Ph.D., Neurological Science ‐ Department of Nuclear Medicine ‐ Ludwig‐Maximilians Universität München, Germany Everyone is welcome to attend. For more information: Dr. Xin-Min Li Neuroscience Research Program, Faculty of Medicine T: (204) 977-5633 or xinmin_li(a)umanitoba.ca

12 years, 10 months

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Neuro-All June 2011