January 2013 - Neuro-All - University of Manitoba Mailing Lists

Dr. Derek van der Kooy's visit
by Winnipeg Chapter Society for Neuroscience 30 Jan '13

30 Jan '13

Dear All, As you may know, The Manitoba Neuroscience Network will be hosting Dr. Derek van der Kooy on Feb 22, 2013. He is currently a Professor at the Department of Medical Genetics. Dr. van der Kooy is one of the pioneers of the field of adult stem cells. His publications in the field of Neural stem cells, Retinal stem cells and pancreatic stem cells are published in top journals such as Cell, Science, Nature, Neuron,Development and J Neuroscience are highly cited. Dr. van der Kooy is also a great speaker and I will hope that you will try to attend his lecture on Feb 22, at noon, Room 626 in Regenerative Medicine. I am trying to schedule his short day visit on Feb 22nd and therefore I am asking those interested in meeting him to contact me at eftekhar(a)cc.umanitoba.ca. We may have to arrange for group meetings if individual meetings are not possible. The meetings will be planned in a meting room in Regen Med for the sake of time. Thank you for your time, Regards --

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Upcoming neuroscience-related talks....
by Winnipeg Chapter Society for Neuroscience 28 Jan '13

28 Jan '13

Edge of Science and Medicine Seminar Series | Dr. Paul Fernyhough Monday, February 04, 2013 12:00 - 1:00 PM Theatre B - Basic Medical Sciences Dr. Paul Fernyhough Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Director, Division of Neurodegenerative Disorders -St. Boniface Research Centre TOPIC: Drug discovery for neurological disease ------------------------------------------------------------- Manitoba Neuroscience Network Seminar Series | Dr. Derek van der Kooy Friday, February 22nd, 2013 | 12:00 noon Location: Regenerative Medicine Lecture Theatre (626 BMSB) Dr. Derek van der Kooy Professor, Department of Molecular Genetics University of Toronto Topic: Where Brains Come From For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds ------------------------------------------------------------- Edge of Science and Medicine Seminar Series | Dr. Detlev Boison Monday, February 25, 2013 Theatre B Basic Medical Sciences 12:00 - 1:00 PM Dr. Detlev Boison Interim Dow Chair of Neurology & Director of Neurobiology Research Director of Basic and Translational Research, Legacy Research Institute Adjunct Professor - Oregon Health & Science University, Portland, OR TOPIC: Therapeutic Epilepsy Research: Focus on Adenosine. ------------------------------------------------------------- Manitoba Neuroscience Network Seminar | Dr. X.-M. Li Date: Friday, March 22, 2013 Time: 9:00 am - 10:00 am Location: PZ236/238 PsychHealth Centre, Bannatyne Campus Dr. Xin-Min Li Professor, Department of Psychiatry University of Manitoba Topic: Depression: from clinical guidelines to neurobiology. ------------------------------------------------------------- Message from the Winnipeg Chapter of the Society for Neuroscience Please reserve MONDAY JUNE 10, 2013 for the 4th annual meeting of the Manitoba Neuroscience Network. The theme for 2013 will be "Neurodegeneration" and the meeting will be held jointly with the Manitoba-Ontario endMS Regional Research and Training Centre. The format will be similar to previous meetings, featuring: * Visiting expert speakers * Speakers showcasing local research * Networking opportunities * Poster session with trainee awards The official meeting and website announcement will follow early in 2013, with a MAY abstract deadline. Please plan on attending and thank you for making these meetings successful. Chris Anderson, Conference Chair Gilbert Kirouac, Program Committee Chair Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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MNN Seminar - Feb 22 @ 12noon | Dr. Derek van der Kooy
by Winnipeg Chapter Society for Neuroscience 25 Jan '13

25 Jan '13

Manitoba Neuroscience Network Seminar Series Friday, February 22nd, 2013 | 12:00 noon Dr. Derek van der Kooy Professor Department of Molecular Genetics University of Toronto Topic: Where Brains Come From Location: Regenerative Medicine Lecture Theatre (626 BMSB) Derek van der Kooy served as Professor in the Department of Anatomy and Cell Biology at the University of Toronto from 1991 until 2002, when he became a Professor in the Department of Molecular Genetics. Derek received a M.Sc. in Psychology at the University of British Columbia, and a Ph.D in Anatomy, first at Erasmus University in the Netherlands, and finishing in the Department of Anatomy at the University of Toronto. Dr. van der Kooy gained postdoctoral research experience at Cambridge University in England and at the Salk Institute in California. The van der Kooy lab works on various stem cell biology and developmental biology research projects; specifically, stem cells in organisms from Drosophila to humans. We produced the first report of stem cells in the adult mammalian eye, published in 2000 in Science. We also have isolated a rare stem cell from the adult mouse and human pancreas that can show extensive proliferation under defined condi-tions in vitro. Of interest to the lab is the lineage of neural stem cells from pluripotent embryonic stem cells, with relevance to the origin of the earliest neural stem cell in the developing embryo. ABSTRACT: One of the few neurobiological facts not anticipated by Cajal is the existence of neural stem cells in the embryonic and adult mammalian brain that can produce new neurons in the adult brain (new neurons first shown by Altman). The earliest mammalian neural stem cells differentiate from pluripotent embryonic stem cells. These primitive neural stem cells emerge in response to LIF and have a wider non-neural phenotypic potential than later neural stem cells. By embryonic day 8.5 in mouse, true FGF2 dependent neural stem cells emerge and by embryonic day 14 they have given rise to copies of themselves and to EGF dependent neural stem cells. The separate FGF2 and EGF dependent neural stem cells increase greatly in numbers later in neurogenesis, but by E14 appear identical to adult neural stem cells. The adult mammalian neural stem cells are mostly quiescent, dividing asymmetrically only once every few weeks. Mouse embryonic stem (ES) cells cultured in low cell density, completely defined media adopt a neural identity. Using a clonal colony-forming assay, we identify the novel primitive neural stem cell stage as a component of neural lineage specification (this cell is similar to the one we isolate from the early embryo), which is negatively regulated by TGFb-related signaling. These results are consistent with a default mechanism for neural fate specification. Primitive neural stem cells are formed directly from single ES cells in a LIF-dependent manner, express multiple neural precursor markers and give rise to neurons and glia. Moreover, in vivo mouse chimera experiments reveal that these primitive ES-derived neural stem cells have a broad range of neural and non-neural lineage potential. These results support a model whereby definitive neural stem cell formation is preceded by a primitive neural stem cell stage during neural lineage commitment. Most recently, we have found that the LIF-dependent, primitive neural stem cells persist in adult organisms and can repopulate a depleted definitive neural stem cell pool in the adult. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca <mailto:mnn@sbrc.ca> Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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2013 WCSN Membership Dues
by Winnipeg Chapter Society for Neuroscience 25 Jan '13

25 Jan '13

You are receiving this message either because you are a Winnipeg Chapter Society for Neuroscience (WCSN) member due for 2013 renewal or because you are a person we think may benefit from membership in your local Chapter of the international Society for Neuroscience. The WCSN organizes and promotes events in Manitoba designed to fuel excellence in Neuroscience research, education and outreach. We are the driving force behind the Manitoba Neuroscience Network annual meetings, seminar series and visiting speaker program. We also organize Brain Awareness Week activities and contribute to the development of local neuroscientists by awarding prizes for excellence at the Manitoba Science Schools Symposium. Please support initiatives such as these and help us build a strong and vibrant neuroscience community in Manitoba by clicking on this link www.sfn-manitoba.ca/application <http://www.sfn-manitoba.ca/application> to pay your dues by credit card, University of Manitoba FOAP, or cheque. A receipt will be issued by e-mail. 2013 MEMBERSHIP FEE SCHEDULE Students $ 15 Postdocs, Residents, Associates, Technicians $ 30 Faculty, Professionals $ 60 *All-inclusive Lab rate $ 100 *PI and names and affiliations of each individual lab member must be provided. If you have any questions about our vision, please contact the Chapter president at canderson(a)sbrc.ca <mailto:canderson@sbrc.ca> . Sincerely, Chris Anderson, PhD President - Winnipeg Chapter Society for Neuroscience Associate Professor, University of Manitoba Winnipeg Chapter Society for Neuroscience General Office: R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: wcsn(a)sbrc.ca <mailto:wcsn@sbrc.ca> <mailto:wcsn@sbrc.ca <mailto:wcsn@sbrc.ca> > Website: www.sfn-manitoba.ca <http://www.sfn-manitoba.ca>

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Manitoba Neuroscience Network Seminar - Tomorrow 9am - Dr. Tamra Werbowetski-Ogilvie
by Winnipeg Chapter Society for Neuroscience 24 Jan '13

24 Jan '13

Manitoba Neuroscience Network Seminar Series: Friday, January 25th, 2013 | 9:00 am Dr. Tamra Werbowetski-Ogilvie Canada Research Chair in Neuro-oncology & Human Stem CellsAssistant Professor, Regenerative Medicine ProgramDepartment of Biochemistry & Medical Genetics and Physiology University of Manitoba Topic: Deconstructing medulloblastoma heterogeneity: targeting a spectrum of phenotypes. Location: PX236/238 PsychHealth Bldg. SHORT BIOSKETCH * Assistant Professor | Regenerative Medicine Program, Department of Biochemistry & Medical Genetics & Physiology, University of Manitoba * Honours Bachelor of Science in Biology, University of Western Ontario, London, ON * PhD Neuroscience (Department of Neurology and Neurosurgery) Montreal Neurological Institute, McGill University, Montreal, QC. Positions and Employment: - August 2005-October 2010 PDF, McMaster Stem Cell and Cancer Research Institute, McMaster Univ. - November 2010-present Assistant Professor, Regenerative Medicine Program, Department of Biochemistry & Medical Genetics And Physiology, University of Manitoba, Winnipeg, Manitoba, Canada Selected Peer Reviewed Publications (Selected from 18 peer-reviewed publications) 1. Werbowetski T, Bjerkvig R, Del Maestro R. 2004. Evidence for a secreted chemorepellent that directs glioma cell invasion. Journal of Neurobiology 60(1): 71-88. 2. Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N, Angers-Loustau A, Agar NY, Wu J, Bjerkvig R, Antel J, Faury D, Rao Y, Del Maestro RF. 2006. Inhibition of medulloblastoma cell invasion by Slit. Oncogene 25(37) 5103-5112. 3. Werbowetski-Ogilvie TE*, Agar NY*, Waldkircher de Oliveira RM, Faury D, Antel JP, Jabado N, Del Maestro RF. 2006. Isolation of a natural inhibitor of human malignant glial cell invasion: inter alpha trypsin inhibitor heavy chain 2. *These authors contributed equally to this work. Cancer Research 66(3) 1464-1472. 4. Cerdan C, Bendall SC, Wang L, Stewart M, Werbowetski T, Bhatia M. 2006. Complement targeting of nonhuman sialic acid does not mediate cell death of human ESCs. Nature Medicine 12(10) 1113-1114. 5. Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bossé M, Lajoie G, Bhatia M. 2007. IGF and FGF cooperatively establish the regulatory stem niche of pluripotent human cells. Nature. 448:1015-1021. 6. Werbowetski-Ogilvie TE, Bossé M, Stewart M, Schnerch A, Ramos-Mejia R, Rouleau A, Wynder T, Smith MJ, Dingwall S, Carter T, Williams C, Harris C, Dolling J, Wynder C, Boreham D. Bhatia M. 2009. Characterization of human embryonic stem cells with features of neoplastic progression. Nature Biotechnology. 27:91-97 7. Ji JF*, Werbowetski-Ogilvie TE*, Zhong B, Hong SH, Bhatia M. 2009. Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells. * These authors contributed equally to this work. PLoS ONE. 4:11 8. Werbowetski-Ogilvie TE, Schnerch A, Rampalli S, Lee JB, Levadoux-Martin M, Mills CE, Bhatia M. 2011. Evidence for the transmission of neoplastic properties from transformed to normal human stem cells. Oncogene. 30(46): 4632-44 9. Werbowetski-Ogilvie TE*, Coudière Morrison L, Fiebig-Comyn A, Bhatia M*. 2012. In vivo generation of neural tumors from neoplastic pluripotent stem cells models early human pediatric brain tumor formation. Stem Cells. 30(3): 392-404. * Denotes co-corresponding authorship. 10. Coudière Morrison *, McClelland R *, Aiken C, Bridges M, Wang X, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE. 2012. Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes. Under Review, Neoplasia. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds An initiative of: Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Edge of Science and Medicine Seminar - Paul Fernyhough
by Winnipeg Chapter Society for Neuroscience 24 Jan '13

24 Jan '13

Everyone is invited.... Edge of Science and Medicine Seminar Series Monday, February 04, 2013 12:00 - 1:00 PM Theatre B - Basic Medical Sciences Dr. Paul Fernyhough Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Director, Division of Neurodegenerative Disorders -St. Boniface Research Centre TOPIC: Drug discovery for neurological disease Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Edge of Science seminar | Feb 4 12:00 noon
by Winnipeg Chapter Society for Neuroscience 16 Jan '13

16 Jan '13

everyone is invited! Edge of Science and Medicine Seminar Series Monday, February 04, 2013 12:00 - 1:00 PM Theatre B - Basic Medical Sciences Dr. Paul Fernyhough <http://www.sbrc.ca/dnd/faculty/dr-paul-fernyhough/> Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Director, Division of Neurodegenerative Disorders -St. Boniface Research Centre TOPIC: Drug discovery for neurological disease For more information contact: Karen Donald 204.789.3553 Karen.Donald(a)med.umanitoba.ca Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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REMINDER: MNN Seminar - Friday Jan 18 | Dr. Samuel David 12Noon
by Winnipeg Chapter Society for Neuroscience 15 Jan '13

15 Jan '13

Reminder: Manitoba Neuroscience Network Seminar Series Friday, January 18th, 2013 | 12:00 noon Dr. Samuel David Professor - Department of Neurology & Neurosur-gery, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre Topic: Targeting inflammation in spinal cord injury Location: Theatre B, Bannatyne Campus Short Biosketch: Dr. Sam David is a Professor in the Department of Neurology and Neurosurgery, at the Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center in Montreal. He obtained his PhD degree in 1979 from the University of Manitoba, and did postdoctoral work at McGill University and University College London, UK. His research focuses on molecular mechanisms of inflammation after spinal cord and peripheral nerve injury, CNS autoimmune disease, and the molecular control of iron homeostasis in the CNS and its dysregulation in CNS pathologies. He has published in top tier journals such as Science, PNAS, Neuron, Nature Immunology, Nature Reviews Neuroscience, Brain, and Journal of Neuroscience. He is Director of the CIHR Training Program in Neuroinflammation, which includes 16 laboratories at three Montreal area Universities. He is the current President of the Canadian Association of Neuroscience, member of the Medical Advisory Committee of the MS Society of Canada, member of the Scientific Advisory Board of Wings for Life Spinal Cord Research Foundation, and other organizations. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Student Luncheon with MNN Speaker Dr. Samuel David Jan 18 @ 1pm | 431 BMSB
by Winnipeg Chapter Society for Neuroscience 09 Jan '13

09 Jan '13

Please circulate notice to your students..... Attention Graduate Students: Graduate Student Luncheon with MNN Speaker: Dr. Samuel David What: Lunch with Dr. Samuel David and students When: Friday, January 18, 1:00 pm Where: Physiology Library Room 431, BMSB, Bannatyne Campus On January 18th the Winnipeg Chapter for Neuroscience and the Manitoba Neuroscience Network will be hosting Dr. Samuel David, President of the Canadian Association for Neuroscience. For more information follow the link: http://www.sfn-manitoba.ca/news/?id+20120912wcsn5.txt Following the 12:00 pm seminar, graduate students will have the opportunity to meet Dr. David in an informal lunch. Please circulate this e-mail; all students are welcome. Also, please confirm your attendance by January 13, to the address esteli(a)scrc.umanitoba.ca and indicate whether your have any dietary restrictions. Thank you, sent on behalf of/ Esteli Vasquez PhD Student Spinal Cord Research Centre Department of Physiology, University of Manitoba 745 Bannatyne Avenue Winnipeg, Manitoba R3E 0J9 Phone: (204) 789-3274, Fax: (204) 789-3930 E-Mail: esteli(a)scrc.umanitoba.ca

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MNN Seminar - Friday Jan 18 | Dr. Samuel David 12Noon
by Winnipeg Chapter Society for Neuroscience 08 Jan '13

08 Jan '13

everyone is invited!! Manitoba Neuroscience Network Seminar Series Friday, January 18th, 2013 | 12:00 noon Dr. Samuel David Professor - Department of Neurology & Neurosur-gery, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre Topic: Targeting inflammation in spinal cord injury Location: Theatre B, Bannatyne Campus Short Biosketch: Dr. Sam David is a Professor in the Department of Neurology and Neurosurgery, at the Centre for Research in Neuroscience, The Research Institute of the McGill University Health Center in Montreal. He obtained his PhD degree in 1979 from the University of Manitoba, and did postdoctoral work at McGill University and University College London, UK. His research focuses on molecular mechanisms of inflammation after spinal cord and peripheral nerve injury, CNS autoimmune disease, and the molecular control of iron homeostasis in the CNS and its dysregulation in CNS pathologies. He has published in top tier journals such as Science, PNAS, Neuron, Nature Immunology, Nature Reviews Neuroscience, Brain, and Journal of Neuroscience. He is Director of the CIHR Training Program in Neuroinflammation, which includes 16 laboratories at three Montreal area Universities. He is the current President of the Canadian Association of Neuroscience, member of the Medical Advisory Committee of the MS Society of Canada, member of the Scientific Advisory Board of Wings for Life Spinal Cord Research Foundation, and other organizations. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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