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Mark your calendars everyone!
The Spinal Cord Research Centre invites you to the
Will to Win International Research Symposium: In honor of Dr. Larry
Jordan
May 13 & 14, 2013
Two days of stimulating research presentations by 35 world renown
international and national neuroscience researchers. Details to follow.
Speakers:
Patrick Whelan
David Bennett
Monica Gorassini
Richard Stein
Arthur Prochazka
Keir Pearson
Vivian Mushahwar
Karim Fouad
Serge Rossignol
Trevor Drew
Rejean Dubuc
Jean-Pierre Gossard
Brian Noga
Shawn Hochman
Marie-Claude Perreault
David Magnuson
Ron Harris-Warrick
Robert Skinner
Robert Burke
Charles J Heckman
Paul Stein
Lorne Mendell
Doug Stuart
Marc Binder
Reggie Edgerton
Martyn Goulding
Jorge Quevedo
Pablo Rudomin
Urszula Slawinska
Elzbieta Jankowska
Ole Kiehn
Hans Hultborn
Sten Grillner
Alain Frigon
Gregoire Courtine
Contact:
Sharon McCartney
Spinal Cord Research Centre
University of Manitoba
204-789-3770
sharon(a)scrc.umanitoba.ca
Organizers:
Brian Schmidt, Dave McCrea, Rob Brownstone (Dalhousie University), John
Steeves (UBC)
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
From: The Winnipeg Chapter of the Society for Neuroscience
Please reserve MONDAY JUNE 10, 2013 for the 4th annual meeting of the Manitoba Neuroscience Network.
The theme for 2013 will be "Neurodegeneration" and the meeting will be held jointly with the Manitoba-Ontario endMS Regional Research and Training Centre.
The format will be similar to previous meetings, featuring:
· Visiting expert speakers
· Speakers showcasing local research
· Networking opportunities
· Poster session with trainee awards
The official meeting and website announcement will follow early in 2013, with a MAY abstract deadline.
Please plan on attending and thank you for making these meetings successful.
Chris Anderson, Conference Chair
Gilbert Kirouac, Program Committee Chair
Manitoba Neuroscience Network Seminar | Dr. Jiming Kong
http://www.sbrc.ca/2012/11/mnn-seminar-series-dr-jiming-kong/
Date: Friday, November 30, 2012
Time: 9:00 - 10:00am
Location: PZ236/238 PsychHealth, Bannatyne Campus
Dr. Jiming Kong
Professor - Department of Human Anatomy & Cell Science
University of Manitoba
Topic: Neuronal death in neurodegenerative diseases: the BNIP3 pathway
Dr. Jiming Kong earned his Bachelor of Medicine in 1983 from Luzhou
Medical College and PhD degree in 1994 from the First Military Medical
University in China. After a short visiting scholarship in Baylor
College of Medicine, he did three postdoctoral fellowships in University
of Massachusetts and University of Manitoba. He joined the Department of
Human Anatomy and Cell Science, University of Manitoba as an Assistant
Professor in 2002. He was promoted to Associate Professor in 2006 and
Professor in 2011. Dr. Kong's research program is directed to the
understanding of molecular regulation of neuronal cell death in
neurodegenerative diseases. Using in vivo and in vitro models of stroke,
amyotrophic lateral sclerosis, Alzheim-er's disease, schizophrenia and
depression, his group examines posttranslational oxidative modification
of SOD1 as a factor of age-related onset of neurodegenerative diseases,
investi-gates the role of mitochondrial death-inducing proteins in
regulating mitophagy and delayed neuronal death in stroke, and tests a
demyelinating hypothesis of schizophrenia. Dr. Kong is a recipient of
the prestigious Heart and Stroke Foundation of Canada New Investigator
award (2004-2009) and a principal investigator of the Canadian Stroke
Network (since 2007), which is one of the Centers of Excellence of
Canada. His research program is continuously support-ed by international
and national grant agencies such as the Muscular Dystrophy Association
(USA), National Natural Science Foundation of China, Canadian Institutes
of Health Research, Canadian Stroke Network, Canada Foundation for
Innovation, and Heart and Stroke Foun-dation of Canada. He has about 70
publications. In recent 5 years, he has 36 peer-reviewed publications
and 3 book chapters.
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Presented in co-operation with University of Manitoba
Clinical Neuroscience Rounds
An initiative of:
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Kelly Jorundson
Administrative Manager
Division of Neurodegenerative Disorders
St. Boniface Hospital Research
Department of Pharmacology & Therapeutics
University of Manitoba
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sbrc.ca/dnd OR
www.umanitoba.ca/medicine/units/pharmacology
Manitoba Neuroscience Network Seminar | Dr. Jiming Kong
Date: Friday, November 30, 2012
Time: 9:00 - 10:00am
Location: PZ236/238 PsychHealth, Bannatyne Campus
Dr. Jiming Kong
Professor - Department of Human Anatomy & Cell Science
University of Manitoba
Topic: Neuronal death in neurodegenerative diseases: the BNIP3 pathway
Dr. Jiming Kong earned his Bachelor of Medicine in 1983 from Luzhou
Medical College and PhD degree in 1994 from the First Military Medical
University in China. After a short visiting scholarship in Baylor
College of Medicine, he did three postdoctoral fellowships in University
of Massachusetts and University of Manitoba. He joined the Department of
Human Anatomy and Cell Science, University of Manitoba as an Assistant
Professor in 2002. He was promoted to Associate Professor in 2006 and
Professor in 2011. Dr. Kong's research program is directed to the
understanding of molecular regulation of neuronal cell death in
neurodegenerative diseases. Using in vivo and in vitro models of stroke,
amyotrophic lateral sclerosis, Alzheim-er's disease, schizophrenia and
depression, his group examines posttranslational oxidative modification
of SOD1 as a factor of age-related onset of neurodegenerative diseases,
investi-gates the role of mitochondrial death-inducing proteins in
regulating mitophagy and delayed neuronal death in stroke, and tests a
demyelinating hypothesis of schizophrenia. Dr. Kong is a recipient of
the prestigious Heart and Stroke Foundation of Canada New Investigator
award (2004-2009) and a principal investigator of the Canadian Stroke
Network (since 2007), which is one of the Centers of Excellence of
Canada. His research program is continuously support-ed by international
and national grant agencies such as the Muscular Dystrophy Association
(USA), National Natural Science Foundation of China, Canadian Institutes
of Health Research, Canadian Stroke Network, Canada Foundation for
Innovation, and Heart and Stroke Foun-dation of Canada. He has about 70
publications. In recent 5 years, he has 36 peer-reviewed publications
and 3 book chapters.
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Presented in co-operation with University of Manitoba
Clinical Neuroscience Rounds
An initiative of:
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
View online:
http://www.sbrc.ca/2012/11/pharmacology-invited-speaker-lecture-dr-long-
jun-wu/
Invited Speaker Lecture - Dr. Long-Jun Wu
DATE: Friday, Nov 16, 2012
TIME: 12:00 noon
LOCATION: A229 Chown Bldg., Bannatyne Campus **
**Video-linked to R1002 SBHR Bldg. (St. Boniface Campus)
<http://www.sbrc.ca/wp-content/uploads/2012/11/web_Long-Jun-photo.jpg>
Long-Jun Wu, PhD
Assistant Professor
Department of Cell Biology and Neuroscience
Rutgers University
New Brunswick, NJ
TOPIC: Microglia-neuron communication in normal and diseased brain
The long-term goal of my lab is to understand microglia-neuron
communication in the brain. Microglia are the principal immune-response
cells in the central nervous system. Resting microglia constantly survey
the microenvironment in the normal brain. Upon brain dysfunction,
microglia are activated and exert detrimental or beneficial effects on
the surrounding neurons. Microglia have remarkably fast and dynamic
activities in both the normal and pathological brain. An exciting
possibility is that they are communicating with neurons through ion
channel mechanisms. In neuronal circuits, microglia are assumed to be
crucial to synaptic pruning and plasticity, yet no direct evidence has
been identified. Microglia are strongly activated in pathological
conditions such as pain, stroke and neurodegeneration, however, the
molecular mechanisms for microglial activation and function in brain
diseases are still controversial.
Overall, we are interested in three interrelated topics on
microglia-neuron communication: (1) The ion channel mechanism of
microglia-neuron communication; (2) Microglia in synaptic function; and
(3) Microglia's contribution to neuropathic pain. We have been exploring
microglia chemotaxis (Wu et al., Glia, 2007, Fig.1), microglia in
synaptic plasticity (Wu and Zhuo, J Neurophysiol, 2008), as well as an
unique microglial voltage-gated proton channel, Hv1, in the brain (Wu et
al., Nat Neurosci, 2012). Taking Hv1 proton channel as an entry point,
our initial project will study direct communication from microglia to
neurons through microglial Hv1. We will then explore how microglia
function in neuronal circuits under normal and pain conditions. The
results from our studies would advance the understanding of microglia
function in the brain and provide therapeutic targets for neuropathic
pain treatment.
SELECTED PUBLICATIONS
Research Articles
1. Wu LJ*, Wu G*, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR,
Feener EP, Clapham DE. 2012. The voltage-gated proton channel Hv1
enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4):
565-573.
2. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE.
2012. The channel kinase, TRPM7, is required for early embryonic
development. Proceedings of the National Academy of Science, USA,
109(5): E225-233.
3. Wang H*, Xu H*, Wu LJ*, Kim SS*, Chen T, Koga K, Descalzi G,
Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. 2011. Identification of
an adenylyl cyclase inhibitor for treating neuropathic and inflammatory
pain. Science Translational Medicine, 3 (65): 65ra3
4. Slusky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X,
Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. 2010. Enhancement of
learning and memory by elevating brain magnesium. Neuron, 65 (2):
165-177.
5. Wu LJ, Mellstrom B, Wang H, Ren M, Domingo S, Kim SS, Li XY,
Chen T, Naranjo JR, Zhuo M. 2010. DREAM (Downstream Regulatory Element
Antagonist Modulator) contributes to synaptic depression and contextual
fear memory. Molecular Brain, 3 (1): 3.
6. Wu LJ, Li X, Chen T, Ren M, Zhuo M. 2009. Characterization of
intracortical synaptic connections in the mouse anterior cingulate
cortex using dual patch clamp recording. Molecular Brain, 2 (1): 32.
7. Wu LJ, Steenland HK, Kim SS, Isiegas C, Ted A, Kaang BK, Zhuo M.
2008. Enhancement of presynaptic glutamate release and persistent
inflammatory pain by increasing neuronal cAMP in the anterior cingulate
cortex. Molecular Pain, 4 (1): 40.
8. Wang H*, Wu LJ*, Kim SS*, Lee FJ, Gong B, Toyoda H, Ren M, Xu H,
Liu F, Zhao MG, Zhuo M. 2008. FMRP acts as a key messenger for dopamine
modulation in the forebrain. Neuron, 59 (4): 634-647.
9. Xu H*, Wu LJ*, Wang H*, Zhang X, Vadakkan KI, Kim SS, Steenland
HW, Zhuo M. 2008. Presynaptic and postsynaptic amplifications of
neuropathic pain in the anterior cingulate cortex. Journal of
Neuroscience, 28 (29): 7445-7453.
10. Hines RM*, Wu LJ*, Hines DJ, Steenland H, Mansour S, Dahlhaus R,
Singaraja RR, Cao X, Sammler E, Hormuzdi SG, Zhuo M, El-Husseini A.
2008. Synaptic imbalance, stereotypies and impaired social interactions
in mice with altered neuroligin 2 expression. Journal of Neuroscience,
28 (24): 6055-6067.
11. Wang H, Wu LJ, Zhang F, Zhuo M. 2008. Roles of
calcium-stimulated adenylyl cyclase and calmodulin-dependent protein
kinase IV in the regulation of FMRP by Group I metabotropic glutamate
receptors. Journal of Neuroscience, 28 (17): 4385-4397.
12. Zhang F, Vadakkan K, Kim SS, Wu LJ, Shang Y, Zhuo M. 2008.
Selective activation of microglia in spinal cord but not higher cortical
regions following nerve injury in adult mouse. Molecular Pain, 4 (1):
15.
13. Wu LJ*, Zhang XH*, Fukushima H, Zhang F, Wang H, Toyoda H, Li
BM, Kida S, Zhuo M. 2008. Genetic enhancement of trace fear memory and
cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent
protein kinase IV. European Journal of Neuroscience, 27 (8): 1923-1932.
14. Wu LJ, Zhuo M. 2008. Resting microglial motility is independent
of synaptic plasticity in mammalian brain. Journal of Neurophysiology,
99 (4): 2026-2032.
15. Wu LJ*, Ren M*, Wang H*, Kim SS, Cao X, Zhuo M. 2008. Neurabin
contributes to hippocampal long-term potentiation and contextual fear
memory. PLoS ONE, 3 (1): e1407.
16. Duan B*, Wu LJ*, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL.
2007. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal
horn neurons contributes to inflammatory pain hypersensitivity. Journal
of Neuroscience, 27 (41): 11139-11148.
17. Wu LJ, Vadakkan KI, Zhuo M. 2007. ATP-induced chemotaxis of
microglial processes requires P2Y receptor-activated initiation of
outward potassium currents. Glia, 55 (8): 810-821.
18. Wu LJ, Xu H, Ren M, Cao X, Zhuo M. 2007. Pharmacological
isolation of postsynaptic currents mediated by NR2A- and NR2B-containing
NMDA receptors in the anterior cingulate cortex. Molecular Pain, 3 (1):
11.
19. Wu LJ, Xu H, Ren M, Zhuo M. 2007. Genetic and Pharmacological
studies of GluR5 modulation of inhibitory synaptic transmission in the
anterior cingulate cortex of adult mice. Developmental Neurobiology, 67
(2): 146-157.
20. Wu LJ*, Ko S*, Toyoda H*, Zhao MG*, Xu H, Vadakkan KI, Ren M,
Knifed E, Shum F, Quan J, Zhang XH, Zhuo M. 2007. Increased anxiety-like
behavior and enhanced synaptic efficacy in the amygdala of GluR5
knockout mice. PLoS ONE, 2 (1): e167.
21. Zhao MG*, Ko S*, Wu LJ*, Toyoda H*, Xu H, Quan J, Jia Y, Li JG,
Ren M, Xu Z, Zhuo M. 2006. Enhanced presynaptic neurotransmitter release
in the anterior cingulate cortex of the mice with chronic pain. Journal
of Neuroscience, 26 (35): 8923-8930.
22. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko S, Jia Y, Shum F,
Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP,
Kaang BK, Zhuo M. 2005. Upregulation of forebrain NMDA NR2B receptors
contributes to behavioral sensitization after inflammation. Journal of
Neuroscience, 25 (48): 11107-11116.
23. Zhao MG*, Toyoda H*, Lee YS*, Wu LJ*, Ko S*, Zhang XH*, Jia Y,
Shum F, Xu H, Li BM, Kaang BK, Zhuo M. 2005. Roles of NMDA NR2B subtype
receptor in prefrontal long-term potentiation and contextual fear
memory. Neuron, 47 (6): 859-872.
24. Wu LJ, Zhao MG, Toyoda H, Ko S, Zhuo M. 2005. Kainate
receptor-mediated synaptic transmission in the adult anterior cingulate
cortex. Journal of Neurophysiology, 94 (3): 1805-1813.
25. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu
TL. 2004. Characterizations of acid-sensing ion channels in dorsal horn
neurons of rat spinal cord. Journal of Biological Chemistry, 279 (42):
43716-43724.
26. Wu LJ, Li Y, Xu TL. 2002. Co-release and interaction of two
inhibitory co-transmitters in rat sacral dorsal commissural neurons.
NeuroReport, 13 (7): 977-981.
27. Wu LJ, Lu Y, Xu TL. 2001. A novel mechanical dissociation
technique for studying acutely isolated maturing Drosophila central
neurons. Journal of Neuroscience Methods, 108 (2): 199-206.
Reviews
1. Wu LJ, Sweet TB, Clapham DE. 2010. Current progress in the
mammalian TRP ion channel family. Pharmacological Reviews, 62 (3):
381-404.
2. Wu LJ, Zhuo M. 2009. Targeting the NMDA receptor subunit NR2B
for the treatment of neuropathic pain. Neurotherapeutics, 6 (4):
693-702.
3. Wu LJ, Wang YT, Zhuo M. 2009. Hook-up of GluA2, GRIP and
liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the
hippocampus. Molecular Brain, 2 (1): 17.
4. Wu LJ, Kim SS, Zhuo M. 2008. Molecular targets of anxiety: from
membrane to nucleus. Neurochemical Research, 33 (10): 1925-1932.
5. Wu LJ, Ko S, Zhuo M. 2007. Kainate receptor and pain: from
dorsal root ganglion to the anterior cingulate cortex. Current
Pharmaceutical Design, 13 (15): 1597-1605.
6. Wu LJ, Zhuo M. 2006. Supraspinal electrophysiological models for
studying chronic pain. Drug Discovery Today: Disease Models, 3 (4):
405-411.
7. Wu LJ, Xu H, Ko S, Yoshimura M, Zhuo M. 2005. Feed-forward
inhibition: a novel cellular mechanism for the analgesic effect of
substance P. Molecular Pain, 1 (1): 34
For more information:
Ben Albensi
Seminar Coordinator &
Associate Professor, Pharmacology & Therapeutics
T: 204.235.3942
E: balbensi(a)sbrc.ca
Kelly Jorundson
Administrative Manager
Division of Neurodegenerative Disorders
St. Boniface Hospital Research
Department of Pharmacology & Therapeutics
University of Manitoba
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sbrc.ca/dnd OR
www.umanitoba.ca/medicine/units/pharmacology
Hi everyone,
This is a reminder that tomorrow (November 9th) we have SCRC Journal
Club session. This Friday Erika Couto, MSc student from Dr. Larry Jordan
lab is presenting her data about:
"Counting serotoninergic neurons in the parapydamidal region after
unrestrained locomotion"
Come and learn about our Stereo Investigator microscopy/software system
sitting in Room 418!!
Esteli
Esteli Vasquez
PhD Student
Spinal Cord Research Centre
Department of Physiology, University of Manitoba
745 Bannatyne Avenue
Winnipeg, Manitoba R3E 0J9
Phone: (204) 789-3274, Fax: (204) 789-3930
E-Mail: esteli(a)scrc.umanitoba.ca
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca