Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, December 11th, 2015 | 3:00 p.m.
Yu Tian Wang <http://www.neuroscience.ubc.ca/people/Wang>
Professor, Department of Medicine, Division of Neurology
Chair in Stroke Research
University of British Columbia
TOPIC: Peptide-based research tools and therapeutics in the
post-genome era
Location: Theatre C, Bannatyne Campus
Research Focus: I have a long-standing research interest in
understanding the molecular mechanisms responsible for regulating the
function and intracellular trafficking of neurotransmitter receptors
critical for brain functions such as learning, memory and cognition, and
investigating the manner by which these mechanisms may be altered in
central nervous disease processes. My goal is to be able to treat
central nervous disorders such as stroke, drug addiction, and
schizophrenia by designing new therapeutics that specifically target
these receptors and their pathways. With particular relevance to this
project, we have made a significant impact on stroke research. We
discovered that NMDA receptor NR2A and NR2B subunits have respective
roles in promoting cell survival and cell death (J. Neurosci. 27:2846,
2007). We have characterized the molecular steps downstream of the NR2B
death pathway, and also developed several specific inhibitors to disrupt
this pathway and demonstrated their therapeutic potentials in reducing
brain damage following stroke (Science 298:846, 2002; JBC 279:41267,
2004; Nature Med. 15:1399, 2009; J. Neurosci. 33:7997, 2013). To
translate these basic scientific discoveries into potential therapeutics
for brain dysfunctions, I founded, along with five other
scientists/clinicians, the NoNO Inc. in Toronto that has recently
completed a successful phase 2 clinical trial, demonstrating for the
first time a clinically effective neuroprotectant NA-1 (Tat-NR2B9c) in
reducing ischemic brain damage (Lancet Neurol 11:942, 2012). Our
research expertise spans functionally characterizing synaptic
plasticity, biochemically mapping protein-protein interaction sites, and
designing specific peptides for use in models of CNS disorders.
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Manitoba Neuroscience Network 2015/2016 Seminar/Visiting Speaker Series
Friday, November 27th, 2015 | 9:00 am
SAEID GHAVAMI <http://umanitoba.ca/faculties/health_sciences/medicine/units/anatomy/8827.h…>
Assistant Professor - Department of Human Anatomy & Cell Science,
College of Medicine, Faculty of Health Sciences
University of Manitoba
TOPIC: “Targeting Mevalonate Cascade: A New Advancement in Glioblastoma Therapeutic Approach?”
Location: PX236/238 PsychHealth Bldg.
In past 10 years, my research has been focused on developing new therapeutic approaches in lung cancer, cardiopulmonary diseases, and infection disease based on modification of apoptosis, autophagy, and unfolded protein response (UPR) pathway. My long-term research plan will be built based on the following major topics: Role of Autophagy and UPR in Regulation of Transforming Growth Factor beta 1 (TGF-1)-induced Epithelial Mesenchymal Transition (EMT) in Lung Cancer Model: In the first step autophagy and UPR will be modulated in breast cancer cell lines (chemical inhibitors and targeting ATG genes and UPR related genes with shRNA) and TGF-1-induced EMT will be investigated. The cross talk between EMT related transcription factors and UPR related transcription factors would be also investigated. In the second phase, lung cancer animal model will be used and UPR/Autophagy pathway would be specifically targeted using nanoparticle packed autophagy/UPR inhibitors and EMT/metastasis will be investigated in presence of different inhibitors. Our long-term goal in this project will be decreasing metastasis in lung cancer using novel strategies by targeting autophagy/UPR pathways. Targeting Mevalonate Cascade as New Approach for Breast Cancer Therapeutic Strategies: Mevalonate cascade is an essential pathway in many living organisms, which is responsible for cholesterol biosynthesis while also, provides prenyl functional groups for protein prenylation. Both cholesterol and prenylated proteins are recently identified as important targets in many cancers. My group will investigate the functions of mevaloante cascade in different breast cancer. We will focus on application of different statins (HMGCoA inhibitors), geranylgeranyl transferase, and farensyl transferase inhibitors as new tools to target breast cancer. Our research will be focused on the effects of these inhibitors on apoptosis/autophagy/UPR in breast cancer model. We will use both in vitro and in vivo model for our investigation.
Modulation of Influenza Virus Replication by Targeting Apoptosis/Autophagy/UPR: Influenza viruses are common pathogens of the upper respiratory tract and a substantial disease burden worldwide. It has been reported that seasonal epidemics influence about
15% of the world’s population and could cause a significant morbidity and mortality. In the recent years immunization strategies have been developed against influenza viruses infection and is considered as of one the most effective way to protect against the
infection, but the vaccine’s effectiveness is mainly depends on the match with the prevalent viral strain(s) in a given year. There are also reports of increasing numbers of drug resistant flu strains further highlights a need to identify new anti-influenza strategies. I
have recently initiated a preliminary investigation about the role of cell death pathway in influenza virus replication (H1N1). Now I want to continue this line of research and investigate the possibility of the suppressing influenza virus replication by modulation
apoptosis/autophagy, or autophagy/ER-stress cross talk and hopefully could provide a new therapeutic strategy for influenza virus infections.
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, December 4th, 2015 | 12:00 Noon
Christoph J.W. Pröschel <https://www.urmc.rochester.edu/labs/proschel-lab/>
Associate Professor of Genetics
University of Rochester Medical Center,
Department for Biomedical Genetics,
Stem Cell and Regenerative Medicine Institute
Pathways of Human Disease Program
TOPIC: Glial cell therapy: the opportunity for restoring function by restoring tissue homeostasis.
Location: Theatre C, Bannatyne Campus
Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy
(Nat Med. 2005 Mar;11(3):277-83.).
The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases
(Parkinsons Disease, Multiple sclerosis).
We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells.
(PLoS One. 2011 Mar 2;6(3)).
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Kelly Jorundson
Administrative Manager
Division of Neurodegenerative Disorders
St. Boniface Hospital Research
& Department of Pharmacology & Therapeutics
College of Medicine, Faculty of Health Sciences
University of Manitoba
Room R4046 - 351 Taché Avenue
Winnipeg, MB R2H 2A6 CANADA
Tel: 204.235.3939 | Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR Kelly.Jorundson(a)umanitoba.ca
Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology
Manitoba Neuroscience Network 2015/2016 Seminar/Visiting Speaker Series***
Friday, November 27th, 2015| 9:00 am
SAEID GHAVAMI <http://umanitoba.ca/faculties/health_sciences/medicine/units/anatomy/8827.h…>
Assistant Professor - Department of Human
Anatomy & Cell Science, College of Medicine,
Faculty of Health Sciences
University of Manitoba
TOPIC: “Targeting Mevalonate Cascade: A New Advancement in Glioblastoma Therapeutic Approach?”
Location: PX236/238 PsychHealth Bldg.
In past 10 years, my research has been focused on developing new therapeutic approaches in lung cancer, cardiopulmonary diseases, and infection disease based on modification of apoptosis, autophagy, and unfolded protein response (UPR) pathway. My long-term research plan will be built based on the following major topics: Role of Autophagy and UPR in Regulation of Transforming Growth Factor beta 1 (TGF-1)-induced Epithelial Mesenchymal Transition (EMT) in Lung Cancer Model: In the first step autophagy and UPR will be modulated in breast cancer cell lines (chemical inhibitors and targeting ATG genes and UPR related genes with shRNA) and TGF-1-induced EMT will be investigated. The cross talk between EMT related transcription factors and UPR related transcription factors would be also investigated. In the second phase, lung cancer animal model will be used and UPR/Autophagy pathway would be specifically targeted using nanoparticle packed autophagy/UPR inhibitors and EMT/metastasis will be investigated in presence of different inhibitors. Our long-term goal in this project will be decreasing metastasis in lung cancer using novel strategies by targeting autophagy/UPR pathways. Targeting Mevalonate Cascade as New Approach for Breast Cancer Therapeutic Strategies: Mevalonate cascade is an essential pathway in many living organisms, which is responsible for cholesterol biosynthesis while also, provides prenyl functional groups for protein prenylation. Both cholesterol and prenylated proteins are recently identified as important targets in many cancers. My group will investigate the functions of mevaloante cascade in different breast cancer. We will focus on application of different statins (HMGCoA inhibitors), geranylgeranyl transferase, and farensyl transferase inhibitors as new tools to target breast cancer. Our research will be focused on the effects of these inhibitors on apoptosis/autophagy/UPR in breast cancer model. We will use both in vitro and in vivo model for our investigation.
Modulation of Influenza Virus Replication by Targeting Apoptosis/Autophagy/UPR: Influenza viruses are common pathogens of the upper respiratory tract and a substantial disease burden worldwide. It has been reported that seasonal epidemics influence about
15% of the world’s population and could cause a significant morbidity and mortality. In the recent years immunization strategies have been developed against influenza viruses infection and is considered as of one the most effective way to protect against the
infection, but the vaccine’s effectiveness is mainly depends on the match with the prevalent viral strain(s) in a given year. There are also reports of increasing numbers of drug resistant flu strains further highlights a need to identify new anti-influenza strategies. I
have recently initiated a preliminary investigation about the role of cell death pathway in influenza virus replication (H1N1). Now I want to continue this line of research and investigate the possibility of the suppressing influenza virus replication by modulation
apoptosis/autophagy, or autophagy/ER-stress cross talk and hopefully could provide a new therapeutic strategy for influenza virus infections.
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Dear all,
Just a note that Dr. Proschel's lecture on Friday, Nov 20th has been
cancelled.
Regards,
Kelly
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Everyone is invited!
UNIVERSITY OF MANITOBA PRESENTS...
CAFE SCIENTIFIQUE 2015-2016
ALZHEIMER'S DISEASE - CAN YOU AVOID IT?
DATE/TIME: November 16, 2015 - 7 p.m.
PLACE: McNally Robinson Booksellers, 1120 Grant Avenue, Winnipeg
There are approx. 19,000 Manitobans over the age of 65 who have
Alzheimer's disease or another form of dementia: this is expected to
grow to over 34,000 by 2038. What is the latest research on Alzheimer's
disease telling us about the disease? Can it be avoided? If so, how?
Join our expert panel for an informative discussion.
Moderator:
Wendy Schettler
CEO, Alzheimer's Society of Manitoba
Panelists:
Dr. Benedict Albensi
Associate Professor, Pharmacology & Therapeutics, College of Medicine,
Faculty of Health Sciences, University of Manitoba and Manitoba Dementia
Research Chair; Principal Investigator, Division of Neurodegenerative
Disorders, St-Boniface Hospital Research; Everett Endowment Fund Chair
Dr. Colleen Millikin
Geriatric Clinical Psychologist, Deer Lodge Centre; Director, Early
Cognitive Change Clinic for Older Adults, St. Boniface Hospital;
Clinical Health Psychology Program, Winnipeg Regional Health Authority;
Assistant Professor, Clinical Health Psychology, College of Medicine,
Faculty of Health Sciences, University of Manitoba
Dr. Zahra Moussavi
Canada Research Chair in Biomedical Engineering, Professor, Electrical &
Computer Engineering, Faculty of Engineering; Professor, Psychiatry,
College of Medicine, Faculty of Health Sciences; Director, Biomedical
Engineering Program, University of Manitoba; Research Affiliate,
Riverview Health Centre and Centre on Aging.
VIEW ONLINE:
http://umanitoba.ca/research/cafescientifique/avoiding_alzheimers.html
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Hello everyone,
First, I am pleased to tell you that we have officially named our program with the Manitoba Craft Council, "Neurocraft". The name was chosen to reflect the partnership between our chapter and MCC, and will be used for all future grant applications and exhibitions. I am also pleased to tell you that we are now ready to start the next phase of our collaboration. I recently met with Tammy Sutherland, MCC director, and Seema Goel, our curator, to review the latest round of applications from the artists. We have chosen five incredibly talented artists, and once again, many of them have a deep personal connection to neuroscience. Here is a link to the Dropbox folder that contains their applications:
https://www.dropbox.com/sh/b52qffqb3irhbej/AAAWFY7Vnyi0v4X-v88DuLEWa?dl=0
We would like to match each of these artists with a researcher, so if you are interested in working with one of them, please contact me. For those of you that have already done so, I already have matches in mind for you, but please tell me if there is a particular person whose work resonates with you.
I hope you enjoy looking at these beautiful pieces, and as always, please feel free to contact me with any questions.
Best wishes, Sari
Sari S. Hannila, PhD
Assistant Professor, Department of Human Anatomy and Cell Science
Associate Member, Spinal Cord Research Centre
College of Medicine, Faculty of Health Sciences
University of Manitoba
[UM-logo-col-horz-Health-Sciences-right]
Department of Human Anatomy and Cell Science
Room 130, Basic Medical Sciences Building
745 Bannatyne Avenue
Winnipeg, Manitoba R3E 0J9
Tel: (204) 789-3483
Fax: (204) 789-3920
Sari.Hannila(a)umanitoba.ca<mailto:Sari.Hannila@med.umanitoba.ca>
Hello all,
Friday, Nov 20th 2015 - MNN Invited Speaker Dr. Chris Proschel
We have invited Dr. Chris Proschel (see below). He works on stem cells
and applications for neurodegenerative diseases. I was wondering if you
would be wanting to meet him. His research in the area on neural cell
biology. Please see the link.
https://www.urmc.rochester.edu/labs/proschel-lab/
Please kindly contact me if you would like to meet.
Regards
Eftekhar.eftekharpour(a)umanitoba.ca
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Some of you with demanding computational needs might be interested in the following Compute Canada workshop at the U of M:
Dear colleague,
WestGrid is bringing a full-day scientific visualization workshop to the University of Manitoba on Tuesday, December 1st. This event is part of the visualization support program at WestGrid / Compute Canada to help researchers with data analysis on both desktops and HPC systems. The workshop will be aimed at a diverse audience from multiple scientific fields and will guide participants through a series of hands-on exercises during the day. You can find more information at https://www.westgrid.ca/events/visualization_workshop_university_manitoba.
I encourage you and your research group members to register for this event at http://bit.ly/uofmreg. If attending full day is not possible, you can attend just the introductory part in the morning or the more advanced session on scripting, animation and large-scale visualization in the afternoon. Please feel free to bring your own datasets to the workshop if you wish to discuss the ways to visualize them with the workshop instructor. And of course, don't hesitate to send me questions at any time before or after the event.
Regards,
--
Alex Razoumov
WestGrid Visualization Coordinator, Compute Canada
--