The Manitoba Neuroimaging Platform was recently established with funding from Brain Canada. The Platform is designed to be a central resource for MR an PET imaging sequence design, standardization and analysis. It is intended to serve investigators engaged in animal AND human research, helping to facilitate translation between them. Please consider joining platform members at an open house event on June 10 at HSC in MS795. You are encouraged to come and learn how the platform might serve your research interests. Primary members of the Manitoba Neuroimaging Platform include:
Dr. Md Nasir Uddin, Staff Scientist & Brain Canada Manitoba Neuroimaging Platform Coordinator
Ms. Kae Normandeau, Brain Canada Manitoba Neuroimaging Platform Facilitator
Dr. Marco Essig, Professor and Chair, Department of Radiology
Dr. Chase Figley, Assistant Professor, Department of Radiology
Dr. Jennifer Kornelsen, Assistant Professor, Department of Radiology
Dr. Melanie Martin, Associate Professor, Department of Physics, University of Winnipeg
Dr. Chris Anderson, Professor and Director, Neuroscience Research Program (Brain Canada grant PI)
[cid:image001.jpg@01D1ACF7.512B5930]
Kae Normandeau
Administrative Manager, Neuroscience Research Program
Kleysen Institute for Advanced Medicine
T: 204.318.2569
E: kaeleen.normandeau(a)umanitoba.ca<mailto:kaeleen.normandeau@umanitoba.ca>
Please ensure to register for the Manitoba Neuroscience Network Meeting by
next WEDNESDAY, JUNE 1
Although you can still register right up until June 15th - you risk not
having any of your contact info, etc. included in our participant listing
section of our printed program.
Please show your support by attending the meeting and also encourage your
trainees and research staff to participate in this event! We have an
excellent program lined up this year, with more than 60 poster
presentations!
Please follow the link (www.sbrc.ca/mnn2016
<http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me
eting/event-summary-5c5901246d2046629015a1587f1705d0.aspx> ) to view the
program, register.
Thank you and see you there.
Sincerely,
Ben
/sent on behalf of
Ben Albensi
Chair, Manitoba Neuroscience Network 2016 Meeting
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
cid:image001.jpg@01D158FE.B69B8D00
Please ensure to register for the Manitoba Neuroscience Network Meeting by
next WEDNESDAY, JUNE 1
Although you can still register right up until June 15th - you risk not
having any of your contact info, etc. included in our participant listing
section of our printed program.
Please show your support by attending the meeting and also encourage your
trainees and research staff to participate in this event! We have an
excellent program lined up this year, with more than 60 poster
presentations!
Please follow the link (www.sbrc.ca/mnn2016
<http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me
eting/event-summary-5c5901246d2046629015a1587f1705d0.aspx> ) to view the
program, register.
Thank you and see you there.
Sincerely,
Ben
/sent on behalf of
Ben Albensi
Chair, Manitoba Neuroscience Network 2016 Meeting
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
cid:image001.jpg@01D158FE.B69B8D00
Manitoba Neuroscience Network Visiting Speaker & Seminar Series
DATE: Friday, May 27th, 2016
Time: 9:00am
Location: PX236/238 PsycHealth Bldg.
Dr. Benedict Albensi
Manitoba Dementia Research Chair
Everett Endowment Fund Chair
Professor of Pharmacology & Therapeutics
Biomedical Engineering Graduate Program Core Member
University of Manitoba
Principal Investigator
St. Boniface General Hospital Research
TOPIC: The Involvement of NF-kB Signaling in Learning, Memory and Dementia.
Objective: to learn about the role of NF-kB signaling in normal memory / learning and also in dementia.
Research Focus: The major focus of our laboratory is to understand the biological basis of memory and to also understand what happens to memory when it is impaired. To this end, we attempt to identify molecular signaling pathways and mechanisms that could be targeted with promising therapeutics for enhancing memory and for preventing and/or reversing memory impairments, in diseases or conditions such as Alzheimer’s disease, stroke, head trauma, etc. Much of our work is centered on the signaling pathway involving the transcription factor, nuclear factor kappa B (NF-kB), which is central to not only in inflammatory processes and immune system function, but also plays a central role in basic mechanisms of memory formation and recall.
Why is this work important?
-It provides a valuable platform for scientists to understand how brain cells and biochemical processes change at the molecular level during the formation of normal memory -By understanding transcriptional regulation during memory encoding, we can identify a gene (or genes) that are utilized during normal memory formation -Characterizing the biological basis of normal memory will lend great insight into treating age-related central nervous system diseases and/or conditions of brain injury that contribute to memory impairment
-Our research could ultimately lead to the development of new drug targets and/or new interventions to enhance normal memory and to treat memory disorders and related neurodegenerative conditions
About Dr. Benedict Albensi
Dr. Albensi’s background is diverse where he has received training in both basic and clinical research. He has also worked in both academic and in industrial sectors on several drug discovery and drug development projects. For example, prior to PhD training, he worked at NPS Pharmaceuticals in Salt Lake City, UT, USA, investigating molecular structures obtained from natural products (e.g., spider venoms) for their potential application in treating CNS disorders. Dr. Albensi continued his academic training and received a Ph.D. in Neuroscience from the University of Utah’s Medical School in 1995, where he developed novel MRI methods for characterizing neonatal hypoxic-ischemic injury. Subsequently, he was awarded a Postdoctoral Fellowship at Georgetown University in Washington, DC, USA (working with Drs. Faden and Pekar), where he further developed novel MRI methods for investigating TBI and brain cognition. Following this, he went on to work as a Postdoctoral Scholar with Dr. Mark Mattson, an internationally recognized leader in neurodegenerative research, at the Sanders-Brown Center on Aging – University of Kentucky. While working with Dr. Mattson and using electrophysiological methods, he published the ground breaking study that TNF and NF-kB play important roles in synaptic plasticity and memory (Albensi and Mattson, Synapse 2000). Subsequently, he joined the Clinical Research Department at Parke-Davis/Warner-Lambert in Ann Arbor, MI (Pfizer acquired PD-WL in 2000) to obtain additional experience in clinical trials. Following this clinical research training, he was appointed as Project Staff in the Department of Neurological Surgery – Cleveland Clinic Foundation and also as an Adjunct Assistant Professor of Biology at Case Western Reserve University in Ohio, where he conducted novel work on mechanisms of deep brain stimulation (DBS). He now has several appointments in Canada, which include serving as a Professor of Pharmacology and Therapeutics at the University of Manitoba and as a Principal Investigator at St. Boniface Hospital Research. He is also a Core Member of the Biomedical Engineering Graduate Program at the University of Manitoba. In addition, he is the new Manitoba Dementia Research Chair and the Everett Endowment Fund Chair. He is also currently a Director of the Board for MitoCanada and the Movement Ctr. of Manitoba. He previously served on the Board of the Alzheimer’s Society of Manitoba. He has reviewed grants for numerous foundations worldwide including NIH, CIHR, NSERC, US DOD, FASEB, to name a few.
Recent Publications:
2014 M.Z. Kastyak-Ibrahim, D.L. Di Curzio, R. Buist, S. Herrera, S. Feng, J. Kong, X.M. Li, B.C. ALBENSI, M.R. Del Bigio, M. Martin. Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice. Magnetic Resonance Imaging. Nov;31(9):1515-21, 2014. B.C. Albensi C U R R I C U L U M V I T A E
Updated April 2016 10
2014 W.M. Snow, B.M. Stoesz, D. Kelly and B.C. ALBENSI. Roles for NF-kB and Gene Targets of NF-kB in Synaptic Plasticity, Memory, and Spatial Orientation. Molecular Neurobiology. Apr;49(2):757-7, 2014.
2014 C. Cadonic and B.C. ALBENSI. Oscillations and NMDA receptors: their interplay create memories. Aims Neuroscience. 1(1):52-64, 2014. Invited Review.
2015 S. Nafez, K. Oikawa, G.L. Odero, M. Sproule, N. Ge, J. Schapansky, B. Abrenica, A. Hatherell, C. Cadonic, S. Zhang, X. Song, T. Kauppinen, G.W. Glazner, M. Grilli, M.P. Czubryt, D.D. Eisenstat and B.C. ALBENSI. Early Growth Response 2 (Egr-2) Expression is Triggered by NF-B Activation. Molecular and Cellular Neuroscience. 64:95-103, 2015.
2015 W.M. Snow, P.S. Pahlavan, J. Djordjevic, G. McAllister, E.E. Platt, S. Alashmali, M.J. Bernstein, M. Suh, and B.C. ALBENSI. Morris water maze training in mice elevates hippocampal levels of transcription factors nuclear factor (erythroid-derived 2)-like 2 and nuclear factor kappa B p65. Frontiers Molecular Neuroscience, 8:70, 2015.
2015 C. Cadonic, M.G. Sabbir and B.C. ALBENSI. Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease. Molecular Neurobiology, 2015.
2016 S.R. Chowdhury, J. Djordjevic*, B.C. ALBENSI and P. Fernyhough. Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria, Bioscience Reports, 36, e00286, 2016. *This author is a co-first author.
2016 J. Djordjevic, M.G. Sabbir and B.C. ALBENSI. Traumatic brain injury as a risk factor for Alzheimer’s disease: Is inflammatory signaling a key player? New Concepts in Alzheimer's Research in Current Alzheimer Research, 13:1-9, 2016.
2016 S.I. Omar, B.C. ALBENSI and K. Gough. Modelling the binding of Ca2+ and Zn2+ to Calbindin D28k and understanding their competition through protein structural analysis. Current Alzheimer Research, In Press, 2016.
2016 K. Oikawa, G.L. Odero, S. Nafez, N. Ging, D. Zhang, H. Kobayashi, K. Sato, S. Kimura, M. Tateno and B.C. ALBENSI. Visinin-like protein-3 modulates the interaction between cytochrome b5 and NADH-cytochrome b5-reductase in a Ca++ dependent manner. Cell Biochemistry and Biophysics, Conditionally Accepted. 2016.
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image003.png@01D1AC33.A34F0730 <https://www.instagram.com/manitobaneuroscience/> cid:image004.jpg@01D1AC33.A34F0730 <https://twitter.com/manitobaneuro> cid:image005.png@01D1AC33.A34F0730
cid:image001.jpg@01D158FE.B69B8D00
Last day to submit abstract is tomorrow! May 20, 2016
Please show your support by attending the meeting and also encourage your
trainees and research staff to participate in this event and submit their
work for poster presentation.
The DEADLINE for abstract submission is May 20th, 2016. Please follow the
link (www.sbrc.ca/mnn2016
<http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me
eting/event-summary-5c5901246d2046629015a1587f1705d0.aspx> ) to view the
program, register and submit an abstract.
Thank you and see you there.
Sincerely,
Ben
/sent on behalf of
Ben Albensi
Chair, Manitoba Neuroscience Network 2016 Meeting
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
Everyone is invited!
cid:image001.jpg@01D158FE.B69B8D00
Friday, May 20th, 2016
12:00 Noon | Theatre C, Bannatyne Campus
S p e a k e r
Dr. Derek Bowie
Professor - Department of Pharmacology & Therapeutics, McGill University
Director - GEPRO M
Topic: Ionotropic glutamate receptors and Fragile-X syndrome
(abstract below)
....FOLLOWED BY......
NEUROSCIENCE TRAINEE LUNCH
ALL NEUROSCIENCE STUDENTS, POST-DOC FELLOWS AND RESEARCH ASSOCIATED
INVITED!!
1:00 P.M. | SR415 Kleysen Institute for Advanced Medicine
Abstract: The Bowie Lab uses a combination of techniques to study ionotropic
glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+
channels. All ion-channel families are widespread in the vertebrate brain
and fulfill many important roles in healthy individuals as well as being
implicated in disease states associated with postnatal development (e.g.
autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging
disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at
iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In
molecular terms, we are examining the events that occur when each
ion-channel family is activated with the aim of developing novel therapeutic
compounds. At the cellular level, we are studying the role that iGluRs,
GABA-A receptors and Na+ channels fulfill in shaping the behaviour of
neuronal circuits and how these processes may be corrected in disease
states. The talk will focus on recent work on NMDA-type iGluRs and how it
relates to deficits in Fragile-X syndrome.
Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group,
GEPRO M, and has been a Professor at McGill University since 2002. He is
the recipient of the Canada Research Chair award in Receptor Pharmacology
and serves on the editorial boards of the Journal of Physiology, Current
Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University
of London after completing his undergraduate degree at Strathclyde
University in Scotland. He then carried out postdoctoral training in France
(Université Louis Pasteur), Switzerland (University of Zurich) and the USA
(National Institutes of Health) before holding a faculty position at Emory
University in Atlanta. The Bowie lab focuses on the structure-function
properties of ionotropic glutamate receptors, GABA-A receptors and sodium
channels as well as examining their role in neuronal circuit behaviour.
http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
kjorund(a)sbrc.ca
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image006.png@01D17075.90C94890
<https://www.instagram.com/manitobaneuroscience/>
cid:image007.jpg@01D17075.90C94890 <https://twitter.com/manitobaneuro>
cid:image008.png@01D17075.90C94890
cid:image001.jpg@01D158FE.B69B8D00
Abstract Deadline EXTENSION - May 20, 2016
Good News! The ABSTRACT DEADLINE for our Manitoba Neuroscience Network
meeting has been extended to Friday, May 20th, 2016 end of day.
Please show your support by attending the meeting and also encourage your
trainees and research staff to participate in this event and submit their
work for poster presentation.
The DEADLINE for abstract submission is May 20th, 2016. Please follow the
link (www.sbrc.ca/mnn2016
<http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me
eting/event-summary-5c5901246d2046629015a1587f1705d0.aspx> ) to view the
program, register and submit an abstract.
Thank you and see you there.
Sincerely,
Ben
/sent on behalf of
Ben Albensi
Chair, Manitoba Neuroscience Network 2016 Meeting
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
cid:image001.jpg@01D158FE.B69B8D00
Reminder - Abstract Deadline - May 13, 2016
This is a friendly reminder that the ABSTRACT DEADLINE for our Manitoba
Neuroscience Network meeting is only 1 DAY AWAY!
Please show your support by attending the meeting and also encourage your
trainees and research staff to participate in this event and submit their
work for poster presentation.
The DEADLINE for abstract submission is May 13st, 2016. Please follow the
link (www.sbrc.ca/mnn2016
<http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me
eting/event-summary-5c5901246d2046629015a1587f1705d0.aspx> ) to view the
program, register and submit an abstract.
Thank you and see you there.
Sincerely,
Ben
/sent on behalf of
Ben Albensi
Chair, Manitoba Neuroscience Network 2016 Meeting
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
/sent on behalf of Dr. Ben Albensi
Everyone invited!
Dear All
Dr. Sherry Krawitz, MD will present the attached paper tomorrow,
Thursday at 12:30 PM at Health Sci Ctr, - 4th floor Thorlakson Bldg,
MS473 (at end of long hall leading from the elevators). She will
accomplish the following goals:
1) present the theory of prion-like propagation of tau - based on:
Neuropathol Appl Neurobiol. 2015 Feb;41(1):47-58.
Invited review: Prion-like transmission and spreading of tau pathology.
Clavaguera F1, Hench J, Goedert M, Tolnay M.
PMID: 25399729
2) illustrate how the neuropathologic diagnosis of Alzheimer's disease
is made (what we actually do).
------------------
See you there,
Ben
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/>
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>
cid:image001.jpg@01D158FE.B69B8D00
Friday, May 20th, 2016
1:00 P.M. | SR415 Kleysen Institute for Advanced Medicine
S p e a k e r
Dr. Derek Bowie
Professor - Department of Pharmacology & Therapeutics, McGill University
Director - GEPRO M
NEUROSCIENCE TRAINEE LUNCH
ALL NEUROSCIENCE STUDENTS, POST-DOC FELLOWS AND RESEARCH ASSOCIATED
INVITED!!
Abstract: The Bowie Lab uses a combination of techniques to study ionotropic
glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+
channels. All ion-channel families are widespread in the vertebrate brain
and fulfill many important roles in healthy individuals as well as being
implicated in disease states associated with postnatal development (e.g.
autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging
disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at
iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In
molecular terms, we are examining the events that occur when each
ion-channel family is activated with the aim of developing novel therapeutic
compounds. At the cellular level, we are studying the role that iGluRs,
GABA-A receptors and Na+ channels fulfill in shaping the behaviour of
neuronal circuits and how these processes may be corrected in disease
states. The talk will focus on recent work on NMDA-type iGluRs and how it
relates to deficits in Fragile-X syndrome.
Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group,
GEPRO M, and has been a Professor at McGill University since 2002. He is
the recipient of the Canada Research Chair award in Receptor Pharmacology
and serves on the editorial boards of the Journal of Physiology, Current
Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University
of London after completing his undergraduate degree at Strathclyde
University in Scotland. He then carried out postdoctoral training in France
(Université Louis Pasteur), Switzerland (University of Zurich) and the USA
(National Institutes of Health) before holding a faculty position at Emory
University in Atlanta. The Bowie lab focuses on the structure-function
properties of ionotropic glutamate receptors, GABA-A receptors and sodium
channels as well as examining their role in neuronal circuit behaviour.
http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html
Kelly Jorundson
Manitoba Neuroscience Network
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939 Fax: 204.237.4092
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
<https://www.instagram.com/manitobaneuroscience/>
<https://twitter.com/manitobaneuro>