Neuro-All November 2017

neuro-all@lists.umanitoba.ca

1 participants
4 discussions

Dementia Journal Club by Dr Wang's lab - Nov 28 noon, Apotex Ctr 061 at HSC

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Everyone invited to attend! date Tuesday, November 28, 2017 Time 12:00 PM Location Univ. Manitoba HSC Campus (Apotex Ctr. 061) Dr Wang's lab will present the paper: Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis ABSTRACT The major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E4 (ApoE4), has been suggested to have detrimental effects on neurons, including direct toxicity via apoptosis. Thioredoxin-1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the regulation of apoptosis through the inhibition of apoptosis signalregulating kinase-1 (Ask-1). In this study, we have investigated the effects of ApoE on Trx1 in the brain. Our results showed that the protein levels of Trx1 were reduced in the hippocampus of ApoE4 targeted replacement (TR) mice compared to ApoE3 TR mice. The reduction was also seen in vitro after treatment of both human primary cortical neurons and neuroblastoma cells with human recombinant ApoE4 (rApoE4). Furthermore, ApoE4 caused a disruption of lysosomal integrity and a shift in the localization of Cathepsin D, an enzyme known to degrade Trx1. ApoE4 treatment induced in addition apoptosis through translocation of Death-domain associated protein-6 (Daxx) from the nucleus to the cytosol, suggesting an activation of the Ask-1 pathway. This toxicity was prevented by overexpression of Trx1 and other endogenous Ask-1 inhibitors. Our data suggests that down-regulation of Trx1 is involved in the toxicity caused by ApoE4. An activated ASK-1 pathway might indeed make cells more vulnerable to other insults such as amyloid-_, which could partially explain the mechanism behind the strongest genetic risk factor for AD.

6 years, 5 months

Relaunch Flyer

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Sachin Katyal cid:image002.jpg@01D36371.A4A557F0

6 years, 5 months

Reminder Tomorrow - MNN Lecture: Hassan Marzban Nov 24 @ 9am

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Friday, November 24th, 2017 9:00am L O C AT I O N PX236/238 Psychealth Building S P E A K E R Dr. Hassan Marzban <http://chrim.ca/researcher/hassan-marzban/> Assistant Professor Department of Human Anatomy & Cell Science, University of Manitoba Topic: Cerebellar development in health and disease: Early mossy fiber afferent and cerebellar circuit formation BIO: Dr. Marzban received his Bachelor of Science (B.Sc.) degree in Physiotherapy from Iran University of Medical Sciences, followed by a Master of Science degree (M.Sc.) in Human Anatomy from Mashhad University of Medical Sciences, Iran. He then obtained a Philosophy of Doctoral (PhD) in Anatomical Science from the Department of Human Anatomy, Tehran University of Medical Sciences, Tehran, Iran. Dr. Marzban was recruited as an Assistant Professor at the Medical School in Tehran University of Medical Sciences. He joined Dr. R. Hawkes laboratory as a Visiting Scientist and subsequently was recruited as an Assistant Professor (research) at the Department of Cell Biology and Anatomy, University of Calgary. Soon after, Dr. Marzban joined the University of Manitoba as an Assistant Professor in the Department of Human Anatomy and Cell Science. Dr. Marzban research interests focus on understanding the cellular and molecular mechanisms of the developing cerebellum, specifically the etiology of neurodevelopmental disorders and neurodegenerative disease using mouse models (E.g. ACP2 and SNCA mutant lines). Abstract; Cerebellar defects result in significant intellectual and motor function impairment that influences both the patients and their families. My research goal is to understand the cellular and molecular processes of normal and abnormal cerebellar development and how these processes are disrupted in cerebellar defects. I anticipate this fundamental research will provide solid knowledge to elucidate cerebellar disorders, prevent birth-defects and develop therapeutics that will improve the lives of affected individuals. My ongoing research program is focused on early cerebellar circuit formation; early connectivity between cerebellar nuclei neurons and afferent pioneer axon, which is affected in nax (Acp2 -/-) mutant mice as model. In my presentation I will discuss the early pioneer axons to reach the cerebellum arise from the trigeminal system (not vestibular system) and target cerebellar nuclei neurons (not Purkinje cell), initiating the formation of the early cerebellar circuit. It will address a critical knowledge gap by providing essential developmental information that the trigeminal system develops in close proximity to the cerebellum and probably mechanisms that are affected in some cerebellar disorders. Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

6 years, 5 months

MNN Lecture: Hassan Marzban Nov 24 @ 9am

by Manitoba Neuroscience Network

6 years, 5 months

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Neuro-All November 2017