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V I S I T I N G S P E A K E R & S E M I N A R S E R I E S
NEUROSCIENCE TRAINEE LUNCH
Thursday, April 6th, 2017
12:00 Noon | SR415 Kleysen Institute for Advanced Medicine
V I S I T I N G S P E A K E R
JEFFREY KLEIM, PH.D
<https://sbhse.engineering.asu.edu/faculty-and-staff/faculty/jeff-kleim/>
ASSOCIATE DIRECTOR
SCHOOL OF BIOLOGICAL AND HEALTH SYSTEMS ENGINEERING
ARIZONA STATE UNIVERSITY
Abstract: The capacity for the nervous system to structurally and
functionally adapt (neural plasticity) has been described for more than a
century. Decades of neuroanatomical, neurophysiological and molecular
studies have revealed that neural plasticity is an evolutionarily conserved,
fundamental property of all
nervous tissue. It is critical for maintaining normal brain function and yet
can also manifest into various forms of brain dysfunction. While we still do
not fully understand the complexity of the human nervous system, its
response to disease/injury and capacity for recovery, treatments designed to
harness endogenous neural plasticity to overcome neurological impairment
continue to emerge. Specifically, the characterization of key behavioral and
neurobiological signals that drive neural plasticity, in combination with
advances in biomedical engineering, regenerative medicine and genomics, have
created opportunities to develop novel therapeutic interventions. Evidence
from both animal and clinical studies will be presented that demonstrate how
modulating specific elements of motor rehabilitation can enhance functional
outcome and cortical reorganization after stroke. Further, the viability of
many adjuvant therapies for augmenting neural plasticity to enhance the
impact of motor rehabilitation will be presented.
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D AT E
Friday, March 31, 2017
9:00AM
L O C AT I O N
PX236/238
PsychHealth Building
S P E A K E R
Tiina M. Kauppinen, Ph.D.
<http://umanitoba.ca/faculties/health_sciences/medicine/units/pharmacology/f
aculty_members/7919.html>
Assistant Professor - Department of Pharmacology and Therapeutics,
Rady Faculty of Health Sciences, University of Manitoba
Principal Investigator Neuroscience Research Program,
Kleysen Institute for Advanced Medicine
TOPIC: Exposure to gestational diabetes mellitus induces cognitive changes
in offspring
My research lab studies the role of microglia and neuroinflammation in
central nervous system disorders. Microglia are the resident immune cells of
the central nervous system and believed to drive neuroinflammation, the
nervous system-specific inflammatory-like responses to insult. Inflammatory
responses are meant to protect tissue from pathogens and promote
recovery/healing, however, they can generate environment that promotes
neurodegeneration and jeopardize neurogenesis and interferes with
development and maintenance of neuronal networks. One of our projects
investigates how chronic inflammation induced by gestational diabetes
mellitus affects offspring brain development and their cognitive function
upon early adulthood. We utilize in vivo and in vitro models, and molecular
biology tools to dissect how gestational diabetes induced neuroinflammation
and how postnatal diet could affect neurocognitive development. The overall
goals of my research program are to 1) understand how microglial functions
affect neurodegeneration, neurogenesis and neuronal functions; 2) establish
approaches to modulate microglial responses towards phenotype that supports
brain health; and 3) develop new therapeutic strategies with multiple
disease relevance. The project has been funded by Childrens Hospital
Foundation of Manitoba, Research Manitoba, Manitoba Health Research Council
and Health Sciences Centre Foundation.
S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D AT E
Thursday, April 6th, 2017
3:00PM
LO C AT I O N
Theatre C
S P E A K E R
Dr. Jeffrey Kleim
Associate Director
School of Biological and Health Systems Engineering
Arizona State University
TOPIC: Neural Plasticity and Neurorehabilitation: Encouraging the Brain to
Change
ABSTRACT: The capacity for the nervous system to structurally and
functionally adapt (neural plasticity) has been described for more than a
century. Decades of neuroanatomical, neurophysiological and molecular
studies have revealed that neural plasticity is an evolutionarily conserved,
fundamental property of all nervous tissue. It is critical for maintaining
normal brain function and yet can also manifest into various forms of brain
dysfunction. While we still do not fully understand the complexity of the
human nervous system, its response to disease/injury and capacity for
recovery, treatments designed to harness endogenous neural plasticity to
overcome neurological impairment continue to emerge. Specifically, the
characterization of key behavioral and
neurobiological signals that drive neural plasticity, in combination with
advances in biomedical engineering, regenerative medicine and genomics, have
created opportunities to develop novel therapeutic interventions. Evidence
from both animal and clinical studies will be presented that demonstrate how
modulating specific elements of motor rehabilitation can enhance functional
outcome and cortical reorganization after stroke. Further, the viability of
many
adjuvant therapies for augmenting neural plasticity to enhance the impact of
motor rehabilitation will be presented.
For more information contact:
Eftekhar Eftekharpour, Visiting Speaker & Seminar Series Coordinator
T: 204.789.3214 E: eftekhar.eftekharpour(a)umanitoba.ca
<mailto:eftekhar.eftekharpour@umanitoba.ca>
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca>
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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Hello everyone,
At this time, I would like to extend my deepest thanks to all of the
volunteers who made our Brain Awareness Week events such a success this
year. By sharing their time and expertise, these individuals have made
tremendous contributions to the MNNs mission of advancing public awareness
of neuroscience in our community.
I would especially like to acknowledge Crystal Acosta, PhD student with Drs.
Hope and Chris Anderson, who has worked tirelessly to promote and document
every one of our events on social media. As a result of her efforts and
enthusiasm, our message has reached more people than ever before. Thank you
Crystal!
Here are the faculty and trainees who contributed to this years events:
Winnipeg Brain Bee
Faculty Dr. Barb Shay
Dr. Katinka Stecina
Dr. Soheila Karimi
Dr. Jun-Feng Wang
Dr. Tabrez Siddiqui
Dr. Sabine Hombach-Klonisch
Trainees Crystal Acosta (Anderson lab)
Scott Dyck (Karimi lab)
Chris Hart (Karimi lab)
Dr. Sarah Chen (Stecina lab)
Shreya Dhume (Siddiqui lab)
Benyamin Karimi (Siddiqui lab)
Cristen Hamed (MPT student)
Carly McLeod (MPT student)
Randi Marshall (MPT student)
Café Scientifique
Moderator Dr. Tom Klonisch
Panelists Dr. Tamra Ogilvie
Dr. Sachin Katyal
Dr. Marshall Pitz
Neurocraft panel discussion (in partnership with the Manitoba Craft Council)
Panelists Dr. Tabrez Siddiqui
Dr. Melanie Martin
Dr. Mike Jackson
Thank you once again to everyone who took part, and to all of you for
supporting the MNN and our outreach activities. We look forward to making
our events even bigger and better next year!
Best wishes, Sari
Sari S. Hannila, PhD
Director of Outreach, Manitoba Neuroscience Network
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Hello everyone,
It is with great sadness that I inform you that we have had to close our
Neurocraft show two weeks early. As some of you may have already seen on
the CBC, the show was vandalized on Saturday and two pieces were damaged
beyond repair. Other pieces were also damaged, but not irreparably. As you
can imagine, this was very distressing for the artists, and yesterday, we
decided to close the show to ensure the safety of the remaining pieces. We
knew that there was a risk associated with holding the show in a public
space, but we also felt that it was very important to make both art and
science accessible to all.
While the last few days have been unpleasant, it should not detract from the
fact that we have had an incredible response to the show over the last two
weeks. I also want to assure you that this is not the end for Neurocraft!
We still have our exhibition in Montreal to look forward to in May, and I
hope that all of you attending the CAN meeting will have a chance to see the
pieces and attend our reception at the Visual Voice gallery. We are also
pursuing opportunities to hold additional shows here in Winnipeg in the near
future. Finally, we still have the John Buhler atrium for the next two
weeks, and MCC and I are now creating a new installation for the remaining
time - one that will give people a chance to reflect on the importance of
art and science in their lives. You will all have the opportunity to
participate in this one. Stay tuned.
Best wishes, Sari
Sari S. Hannila, PhD
Director of Outreach, Manitoba Neuroscience Network
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Hi All,
I'm looking for an expert on the physiological effects of ethanol to potentially appear on camera in a Global News interview today (10 min). If anyone is interested, please let me know. Thanks.
Chris
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Chris M. Anderson, PhD
Professor of Pharmacology and Director, Neuroscience Research Program
Kleysen Institute for Advanced Medicine
Health Sciences Centre and University of Manitoba
T: 204-318-2565
E: chris.anderson(a)umanitoba.ca
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Happy Brain Awareness Week everyone! We hope to see you at Dr. Diatchenko's
talk today (1 pm, Theatre B) and at our other events throughout the week.
One of those events is our craft workshop with local bookbinder and
Neurocraft artist Ann Stinner, which will be held Friday, March 17th in the
Brodie Centre atrium. All are welcome to attend - faculty, staff, and
students - but there are only 12 spots available! This invitation is going
out to the entire Rady Faculty of Health Sciences today, so to reserve your
spot, send an email to outreach(a)manitobaneuroscience.ca
Follow our Twitter and Instagram accounts for more updates and photos
throughout the week!
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Pharmacology and Therapeutics Seminar Series
Date: Friday, March 10, 2017
Time: 12:00 Noon
Location: Basic Medical Sciences 626
Dr. Katinka Stecina
<http://umanitoba.ca/faculties/health_sciences/medicine/units/physiology/con
tacts/Stecina.html>
Assistant Professor
Department of Physiology & Pathophysiology
University of Manitoba
Topic: Rodent "in vivo" electrophysiology to assess (and boost) spinal
neural contribution to the recovery of motor and sensory function.
Research Focus: In order to re-generate spinal neuronal networks, their
function in a healthy state needs to be understood. The neurons within the
spinal cord are a complex, plastic group of cells which respond to sensory
stimuli and can be "re-configured" - in fact, they are constantly being
re-configures throughout our life - much like our brain. Re-connecting the
brain cells and the spinal cord cells is important, but neurons will have to
re-establish connectivity within each other in a way that is functional.
How do spinal neuronal circuits function? How are they built for function? -
are the central questions of my research. The central nervous system
processes sensory input and incorporates our sensations with movements. We
often think of voluntary movements being different from reflexive movements,
yet our nervous system uses both of these types of movements in a very
intricate way to produce appropriate motor output. Sensory motor integration
is what I study in order improve our understanding on the neuronal control
of movement. The function of spinal networks is the focus of my research,
but I use various means to study how specific brain centres control spinal
neurons. Currently, I used rodent models for studying interactions between
the sensory and the motor neuronal networks. In addition, I am in the
process of establishing another line of research for the functional mapping
of human spinal circuits.
The main motivation for this work is to understand better how sensory
information and motor function is integrated into micro-circuit s within the
spinal cord. The more we know about how the spinal networks function, the
more opportunities we can create to intervene with the circuits so improved
rehabilitation strategies can be designed when training/re-training function
after an injury to the central nervous system. The currently ongoing
projects in my lab are the followings: i) Neuronal basis for bilateral
coordination of movement; ii) Key spinal neuronal populations for
coordinated (loco)motor activity; iii) Alternative" corticospinal pathways
as targets for improved strategies in the (re)training of motor function in
humans.
Looking into spinal cord circuit organization provides a way to test the
integrity of higher control systems - i.e. those neurons of the brain that
control spinal networks. This provides a theoretical possibility to look for
changes in spinal neuronal function and diagnose changes in neuronal
processing occurring not only at the spinal cord level but also at the level
of the brain. These changes could provide us clues into disease processes
early on, even before any structural changes occur in the brain. Thus the
functional mapping of human spinal circuits has an important clinical
aspect. Developing standard, clinical tests as early disease process markers
in the ultimate goal of this work.
For more information contact
Karen Donald
Tel. 204-789-3553
karen.donald(a)umanitoba.ca <mailto:karen.donald@umanitoba.ca>
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Good morning everyone,
The Manitoba Neuroscience Network is proud to announce its schedule of
public events for Brain Awareness Week 2017 (March 13-17). In addition to
these events, and our ongoing Neurocraft exhibition, we will also be hosting
our third annual Winnipeg Brain Bee this Saturday, March 11th. Please feel
free to share this calendar with others who may be interested and we hope to
see you at many of these events next week.
Best wishes, Sari
Sari S. Hannila, PhD
Director of Outreach, Manitoba Neuroscience Network
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Hello everyone,
Next week, SFN chapters around the world will be celebrating Brain Awareness
Week and ours is no exception. A full schedule of events will be sent out
soon, but for the moment, I would like to remind you of our first events,
which will take place next Monday, March 13th. Canada Excellence Research
Chair Dr. Luda Diatchenko from McGill University will be giving a talk at 1
pm in Theatre B. This will be preceded by a lunch at noon for students and
postdocs in the Kleysen Institute seminar room (SR415). All trainees are
strongly encouraged to attend! Please see the attached posters for further
details, and feel free to distribute them throughout your respective units.
I look forward to seeing you there!
Best wishes, Sari
Sari S. Hannila, PhD
Director of Outreach, Manitoba Neuroscience Network
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Department of Pharmacology and Therapeutics Seminar Series
<http://www.sbrc.ca/ccarm/faculty/dr-thomas-netticadan/>
Date: Friday, March 10, 2017
Time: 12:00 Noon
Location: Basic Medical Sciences 626
Dr. Katinka Stecina
Assistant Professor
Department of Physiology & Pathophysiology
University of Manitoba
Topic: Rodent "in vivo" electrophysiology to assess (and boost) spinal
neural contribution to the recovery of motor and sensory function.
For more information please contact:
Karen Donald
Department of Pharmacology and Therapeutics, College of Medicine
Tel. 204-789-3553
karen.donald(a)umanitoba.ca <mailto:karen.donald@umanitoba.ca>