cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E:
Thursday December 13, 2018
12:00 Noon
L O C A T I O N:
Theatre B Bannatyne Campus
**followed by a trainee lunch in 431 BMSB
S P E A K E R
Dr. Shawn Hochman
Professor and Interim Chair
Emory University
School of Medicine
Atlanta, GA
T O P I C: Paravertebral sympathetic thoracic chain ganglia: recruitment
principles and plasticity after spinal cord injury
O b j e c t I v e s:
Paravertebral chain sympathetic postganglionic neurons (SPNs) represent the
final neural control element regulating vasomotor tone and can be thought of
as a distribution system for sympathetic activity that must span the body
vasculature. Alterations in sympathetic chain activity are implicated in
various autonomic disorders. The thoracic SPNs (tSPNs) control vasomotor
function in upper extremities and trunk (this includes vascular supply to
integumentary, cardiorespiratory and digestive systems). tSPNs remain a
barely-studied area of vertebrate autonomic neuroscience.
1. Use whole-cell patch clamp recordings in an adult mouse ex vivo
preparation to uncover the operational principles governing tSPN
recruitment.
2. Obtain a reliable cellular and synaptic data set for realistic
computational simulation. The relative simplicity of the organization makes
discovery of principles through modeling more assured than in more complex
systems.
3. To determine whether changes in tSPNs contribute to autonomic
dysfunction after spinal cord injury.
B I O S K E T C H:
Shawn Hochman is Professor and Interim Chair of Physiology at Emory
University School of Medicine. His research embraces broad aspects of
neuromodulation-based control of sensorimotor and autonomic integration.
Current research focuses on emergent dysfunction in mouse models of spinal
cord injury. Efforts include; (i) continuous non-invasive capture of changes
in physio-behavioral variables in the vivarium home-cage, and (ii) the role
of the peripheral NS in driving emergent sensory and autonomic dysfunction
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui
Chair, MNN Seminar Series
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
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<https://www.instagram.com/manitobaneuroscience/>
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M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Friday, November 30th, 2018
9am
L O C A T I O N:
Px236/238 PsycHealth Bldg.
Bannatyne Campus
S P E A K E R
Dr. Jeremy Chopek
Assistant Professor
Physiology & Pathophysiology
Rady Faculty of Health Sciences
T O P I C
Investigating brainstem and spinal cord movement circuits using mouse genetics
O B J E C T I V E S
1) Understand the utility of mouse genetic for examining movement
2) Appreciate the complexity of local cellular connectivity
3) Understand the role of the brainstem and spinal cord in producing movement
B I O S K E T C H:
Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons.
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui
Chair, MNN Seminar Series
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Friday, November 30th, 2018
9am
L O C A T I O N:
Px236/238 PsycHealth Bldg.
Bannatyne Campus
S P E A K E R
Dr. Jeremy Chopek
Assistant Professor
Physiology & Pathophysiology
Rady Faculty of Health Sciences
T O P I C
Investigating brainstem and spinal cord movement circuits using mouse genetics
O B J E C T I V E S
1) Understand the utility of mouse genetic for examining movement
2) Appreciate the complexity of local cellular connectivity
3) Understand the role of the brainstem and spinal cord in producing movement
B I O S K E T C H:
Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons.
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui
Chair, MNN Seminar Series
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
/sent on behalf of Ben Albensi
Dementia Journal club - Dr Josep Puig
DATE: NOV 29TH, 2018
TIME: 12 PM - NOON
LOCATION: UNIV MANITOBA - HEALTH SCI CTR., GG147
Topic: Aging Imageomics Study: Looking at imaging, seeing health
See attached poster for upcoming presentation.
For more information please contact:
Ben Albensi balbensi(a)sbrc.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E:
Thursday November 15th, 2018
12:00 Noon
L O C A T I O N:
Theatre C Bannatyne Campus
**followed by a trainee lunch in SR415 Kleysen Bldg.
S P E A K E R
Dr. Wei Lu
Synapse and Neural Circuit Section
Porter Neuroscience Research Center
National Institute of Neurological Disorders and Stroke
National Institutes of Health
T O P I C: Making the brains own brake | Molecular mechanisms of
inhibitory synapse development.
O b j e c t I v e s:
Discuss the recent progress from my lab in understanding the molecular and
cellular mechanisms for inhibitory synapse development
B I O S K E T C H:
Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York
University School of Medicine, New York, 2006
M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000
B.S. (Biochemistry). Sichuan University, China, 1997
Recent publications:
Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve
Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko
Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain
dopamine neurons. The Journal of Clinical Investigation. 128 (2)
Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic
synaptic transmission in two distinct types of central neurons. Neuroscience
Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS,
Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals
role of glutamatergic input to dopamine neurons in high-effort behavior.
Molecular Psychiatry. 23, 1213-1225.
Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E,
Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem
Cell Quiescence and Maintenance through a Dynamic Balance between Direct and
Indirect Pathways. Neuron. 99(3):493-510
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui
Chair, MNN Seminar Series
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E:
Thursday November 15th, 2018
12:00 Noon
L O C A T I O N:
Theatre C Bannatyne Campus
**followed by a trainee lunch in SR415 Kleysen Bldg.
S P E A K E R
Dr. Wei Lu
Synapse and Neural Circuit Section
Porter Neuroscience Research Center
National Institute of Neurological Disorders and Stroke
National Institutes of Health
T O P I C: Making the brains own brake | Molecular mechanisms of
inhibitory synapse development.
O b j e c t I v e s:
Discuss the recent progress from my lab in understanding the molecular and
cellular mechanisms for inhibitory synapse development
B I O S K E T C H:
Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York
University School of Medicine, New York, 2006
M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000
B.S. (Biochemistry). Sichuan University, China, 1997
Recent publications:
Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve
Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko
Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain
dopamine neurons. The Journal of Clinical Investigation. 128 (2)
Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic
synaptic transmission in two distinct types of central neurons. Neuroscience
Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS,
Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals
role of glutamatergic input to dopamine neurons in high-effort behavior.
Molecular Psychiatry. 23, 1213-1225.
Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E,
Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem
Cell Quiescence and Maintenance through a Dynamic Balance between Direct and
Indirect Pathways. Neuron. 99(3):493-510
For more information, contact the MNN office @ 204.235.3939
Tabrez Siddiqui
Chair, MNN Seminar Series
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
/sent on behalf of
Brent Fedirchuk
Greetings Manitoba Neuroscience Community,
You may recall that back in the summer, a notice was sent out that the
"Fundamental Neuroscience" graduate courses (IMED7101 & IMED7102) have been
replaced with a suite of 4 separate 1.5 credit hour courses. The first 2 of
these new courses (IMED7112 and IMED7114) have been offered during the Fall
2018 semester. I wanted to remind you that the next two 1.5 credit hour
courses will be offered in the upcoming Winter 2019 session (Jan - Apr
2019). They are:
"IMED7116 - Fundamental Systems Neuroscience" (Jan - Feb 2019)
and
"IMED7118 - Fundamental Neurobiology of Disease" (Mar - Apr 2019)
Please see the attached notice for more information (and please print it /
post it to help make sure all prospective students know about it!).
Feel free to contact either me (for IMED7116) or Dr. Marc Del Bigio
marc.delbigio(a)umanitoba.ca (for IMED7118) for additional information.
Thanks,
Brent
======================================
Brent Fedirchuk, Ph.D.
Associate Professor
Department of Physiology and Pathophysiology
Max Rady College of Medicine
Rady Faculty of Health Sciences
University of Manitoba
745 Bannatyne Avenue; Rm 410 BMSB
Winnipeg, MB
R3E 0J9 CANADA
tel (204) 789-3762 (sorry, no voice mail)
fax (204) 789-3934
<http://www.scrc.umanitoba.ca/> www.scrc.umanitoba.ca
======================================