August 2018 - Neuro-All - University of Manitoba Mailing Lists

MNN Visiting Speaker - Dr. J. Geiger | Sept 21 @ 12 noon
by Manitoba Neuroscience Network 28 Aug '18

28 Aug '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Friday, September 21st, 2018 12:00 Noon LO C AT I O N Theatre C Bannatyne Campus S P E A K E R Jonathan Geiger, Ph.D. <https://und.edu/directory/jonathan.geiger> Chester Fritz Distinguished Professor UND School of Medicine and Health Sciences Department of Basic Biomedical Sciences T O P I C An ‘iron-ic’ story about endolysosomes, inter-organellar signaling and neurodegenerative diseases O B J E C T I V E S 1. Appreciate that endolysosomes contain readily releasable stores of cations including iron and calcium. 2. Discuss specific examples of inter-organellar signaling. 3. Know that de-acification of endolysosomes profoundly affects endolysosome structure, distribution and function. 4. Appreciate that endolysosome pH and cation release from endolysosomes are early and upstream events central to the pathogenesis of neurodegenerative diseases including HIV-1 associated neurocognitive disorder and Alzheimer’s disease. B I O S K E T C H After two years as a postdoctoral fellow at the University of Manitoba (’ 82-’84), I accepted a faculty position in the Department of Pharmacology and Therapeutics at the University of Manitoba where I remained for 19 years (‘84-‘03) rising to the rank of Professor and Founding Director (‘99- ‘03) of the Division of Neurovirology and Neurodegenerative Diseases at the St. Boniface General Hospital Research Centre. From July 2003 to July 2013 I served as Chair of the UND Department of Pharmacology, Physiology and Therapeutics. From July 2003 to present I continue to serve as Principal Investigator on our NIGMS-funded neuroscience center grant. In addition, from July 2010 to July 2013 I served as Interim Chair of the Department of Anatomy and Cell Biology. I have consistently held multiple federal operating grants simultaneously throughout my career, and I received highly prestigious Scholarship and Scientist awards (separate grants that pay an investigator’s salary independent of research operating grants) from the Canadian Institutes of Health Research. I am currently funded by one P30 NIGMS grant, two five-year R01 NIMH grants, one R21 NIDA grant, and hold the position of Chester Fritz Distinguished Professor. The main focus of my research continues to be on brain energy metabolism in general and purines in particular, regulation of levels of intracellular calcium with emphasis on intracellular pools of calcium, the control of neuronal cell life and death in neurodegenerative diseases, and neurological complications associated with HIV-1 infection. Currently, my laboratory has the following research interests: (1) The role of brain energy metabolism (with particular emphasis on adenosine and ATP) in the pathogenesis of epilepsy and neurodegenerative diseases and the ability of ketogenic diets to protect against these pathophysiological responses; (2) The role of endolysosome dysfunction in animals models of Alzheimer’s disease and HIV-1 associated neurocognitive disorder; (3) The protective actions of caffeine in animal models of neurodegenerative disorders; and (4) The ability of calcium in endolysosomes to influence capacitative influx of calcium and calcium-induced calcium release. I have published over 150 manuscripts and have delivered over 100 invited talks worldwide. I have served on over 120 local, national and international grant review study sections including those for the NIH (I am currently serving a 6-year term as a standing member of the NAED study section) and I have served as Chair or co-Chair on over 20 of these panels. I am now serving as Chair of the NAED study section for the next 2 years. I have extensive mentoring experience. Since 2000, as a Director or Department Chair I hired 11 new faculty members. I have graduated seven Ph.D. and four M.S. students from my laboratory and trained 17 postdoctoral fellows, research associates and visiting professors as well as 48 undergraduate students, medical and dental students, and technicians. I have also served on and been President of major advisory boards as well as on many high level committees for UND. I currently serve on advisory boards for two COBRE grants, and I serve on the North Dakota EPSCoR Steering Committee. My publications have been cited over 5,500 times of which about 200 are self-citations. I have published 15 manuscripts that have been cited greater than 80 times and 10 manuscripts have been cited greater than 100 times. My h-index (Scopus) is 45. I am President of the Society of NeuroImmune Pharmacology and serve on the scientific meeting organizing committee for the American Society of Neurochemistry. Complete Bibliography http://www.ncbi.nlm.nih.gov/pubmed/?term=geiger+JD+NOT+(surgery+OR+pediatric ) Recent publications (selected from 30 publications from the past 5 years): 1. Hui, L., Chen, X., Bhatt, D., Rosenberg, T.A., Haughey, N.J., Masino, S. and <file:///C:\Users\debra.kroese\Documents\Geiger%20Documents\Publications\201 2\Hui%20et%20al.,%20J.%20of%20Neurochem%20122.pdf> J.D. Geiger. (2012) Ketone Bodies Protection Against HIV-1 Tat Neurotoxicity. J. Neurochem. 122: 382-391. 2. Bae, M., Patel, N. Xu, H., Lee, M., Nath, A., Geiger, J.D., Gorospe, M.M., Mattson, M.P., and Haughey, N.J. (2014) Activation of TRPML1 Clears Intraneuronal Aβ in Pre-Clinical Models of HIV-Infection. J. Neurosci. 34 (34): 11485-11503. 3. Stevens, P.R., Ramonet, D., Gawryluk, J.W., Buscemi, L., and J.D. Geiger. (2015) Mitochondrial Mechanisms Responsible for Creatine Protection against HIV-1 Tat-Induced Neurotoxicity. Current HIV Research 12: 378-387. 4. Hui, L., Geiger, N.H., Bloor-Young, D., Churchill, G.C., Geiger, J.D., and X. Chen (2015) Release of Calcium from Endolysosomes Increases Calcium Influx Through N-Type Calcium Channels: Evidence for Acidic Store-Operated Calcium Entry in Neurons. Cell Calcium 58(6): 617-627. /sent on behalf of Tabrez Siddiqui Chair, Seminar Series Manitoba Neuroscience Network E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326. 7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Rebecca Kamen - workshop, lecture, and meetings on September 24th
by outreach＠manitobaneuroscience.ca 20 Aug '18

20 Aug '18

cid:image001.jpg@01D158FE.B69B8D00 Hello everyone, I hope your summer has been equal parts relaxing and productive. As we look ahead to September, the MNN has planned an exciting event to kick off the academic year. Award-winning artist Rebecca Kamen will be visiting the University of Manitoba as a guest of the Faculty of Science, and on September 24th, she has graciously agreed to spend the day at the Bannatyne campus interacting with neuroscience researchers and students. As you will read below, Rebecca has a longstanding interest in neuroscience and she has participated in projects at Harvard, MIT, NIH, and the Cajal Institute. You can learn more about Rebecca and her work by visiting her website: https://rebeccakamen.com/#1 We have planned three events that are open to neuroscience faculty, staff, and students: 1. Sculpture workshop: 9-11:30 am. Rebecca will lead a workshop in which the participants will work together to model scientific concepts such as synapses and ion channels. Please see the attached outline for details. The workshop is free and no experience is necessary. Individuals and groups are welcome to sign up. Faculty members, please take note that this could be a valuable team-building/brainstorming exercise for your lab. Please RSVP to this email address to reserve your spot (include all names if you are replying on behalf of a group). 2. Lecture: 12-1 pm, Theatre B. Rebecca will present a lecture focusing on her work and her experiences at the Cajal Institute, where she had the opportunity to study Cajal's original drawings. She has indicated that she would like to meet as many neuroscientists as possible during her visit, and to facilitate this, we have planned a free lunch reception that will take place on the Joe Doupe Concourse immediately after the lecture. 3. Meetings with individual researchers. Rebecca will be available for one-on-one meetings in the afternoon. She is very interested in the cellular/molecular basis of curiosity, cognition, decision making, memory, and networks related to visual processing and dyslexia. She is also very interested in microscopy and would welcome the opportunity to see live demonstrations of imaging techniques. If you are interested in meeting with her, please contact me. Thank you all for your interest and enjoy these last few days of August! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network cid:image004.jpg@01D158FE.B69B8D00

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Research Seminar: Dr. Ravi Rungta | Monday Aug. 13 @ 12 Noon
by Kelly Jorundson 01 Aug '18

01 Aug '18

Everyone is invited! The Department of Pharmacology and Therapeutics Seminar Series DATE: Monday, August 13, 2018 TIME: 12:00 pm LOCATION: 071 Apotex Bldg. Ravi Rungta EMBO / Marie Curie Postdoctoral Fellow INSERM U1128 and Université Paris Descartes, Laboratory of Neurophysiology and New Microscopy TOPIC: "Linking synaptic activation to hemodynamic signals for functional imaging " For more information contact: Kelly Jorundson e: kjorund(a)sbrc.ca Kelly Jorundson Administrative Manager, Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> or kjorundson(a)sbgh.mb.ca <mailto:Kelly.jorundson@umanitoba.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies.

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