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S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D AT E
Friday, September 21st, 2018
12:00 Noon
LO C AT I O N
Theatre C
Bannatyne Campus
S P E A K E R
Jonathan Geiger, Ph.D. <https://und.edu/directory/jonathan.geiger>
Chester Fritz Distinguished Professor
UND School of Medicine and Health Sciences
Department of Basic Biomedical Sciences
T O P I C
An ‘iron-ic’ story about endolysosomes, inter-organellar signaling and
neurodegenerative diseases
O B J E C T I V E S
1. Appreciate that endolysosomes contain readily releasable stores of
cations including iron and calcium.
2. Discuss specific examples of inter-organellar signaling.
3. Know that de-acification of endolysosomes profoundly affects endolysosome
structure, distribution and function.
4. Appreciate that endolysosome pH and cation release from endolysosomes are
early and upstream events central to the pathogenesis of neurodegenerative
diseases including HIV-1 associated neurocognitive disorder and Alzheimer’s
disease.
B I O S K E T C H
After two years as a postdoctoral fellow at the University of Manitoba (’
82-’84), I accepted a faculty position in the Department of Pharmacology
and Therapeutics at the University of Manitoba where I remained for 19 years
(‘84-‘03) rising to the rank of Professor and Founding Director (‘99-
‘03) of the Division of Neurovirology and Neurodegenerative Diseases at the
St. Boniface General Hospital Research Centre. From July 2003 to July 2013 I
served as Chair of the UND Department of Pharmacology, Physiology and
Therapeutics. From July 2003 to present I continue to serve as Principal
Investigator on our NIGMS-funded neuroscience center grant. In addition,
from July 2010 to July 2013 I served as Interim Chair of the Department of
Anatomy and Cell Biology. I have consistently held multiple federal
operating grants simultaneously throughout my career, and I received highly
prestigious Scholarship and Scientist awards (separate grants that pay an
investigator’s salary independent of research operating grants) from the
Canadian Institutes of Health Research. I am currently funded by one P30
NIGMS grant, two five-year R01 NIMH grants, one R21 NIDA grant, and hold the
position of Chester Fritz Distinguished Professor.
The main focus of my research continues to be on brain energy metabolism in
general and purines in particular, regulation of levels of intracellular
calcium with emphasis on intracellular pools of calcium, the control of
neuronal cell life and death in neurodegenerative diseases, and neurological
complications associated with HIV-1 infection. Currently, my laboratory has
the following research interests: (1) The role of brain energy metabolism
(with particular emphasis on adenosine and ATP) in the pathogenesis of
epilepsy and neurodegenerative diseases and the ability of ketogenic diets
to protect against these pathophysiological responses; (2) The role of
endolysosome dysfunction in animals models of Alzheimer’s disease and HIV-1
associated neurocognitive disorder; (3) The protective actions of caffeine
in animal models of neurodegenerative disorders; and (4) The ability of
calcium in endolysosomes to influence capacitative influx of calcium and
calcium-induced calcium release. I have published over 150 manuscripts and
have delivered over 100 invited talks worldwide. I have served on over 120
local, national and international grant review study sections including
those for the NIH (I am currently serving a 6-year term as a standing member
of the NAED study section) and I have served as Chair or co-Chair on over 20
of these panels. I am now serving as Chair of the NAED study section for
the next 2 years.
I have extensive mentoring experience. Since 2000, as a Director or
Department Chair I hired 11 new faculty members. I have graduated seven
Ph.D. and four M.S. students from my laboratory and trained 17 postdoctoral
fellows, research associates and visiting professors as well as 48
undergraduate students, medical and dental students, and technicians. I have
also served on and been President of major advisory boards as well as on
many high level committees for UND. I currently serve on advisory boards for
two COBRE grants, and I serve on the North Dakota EPSCoR Steering Committee.
My publications have been cited over 5,500 times of which about 200 are
self-citations. I have published 15 manuscripts that have been cited greater
than 80 times and 10 manuscripts have been cited greater than 100 times. My
h-index (Scopus) is 45. I am President of the Society of NeuroImmune
Pharmacology and serve on the scientific meeting organizing committee for
the American Society of Neurochemistry.
Complete Bibliography
http://www.ncbi.nlm.nih.gov/pubmed/?term=geiger+JD+NOT+(surgery+OR+pediatric
)
Recent publications (selected from 30 publications from the past 5 years):
1. Hui, L., Chen, X., Bhatt, D., Rosenberg, T.A., Haughey, N.J.,
Masino, S. and
<file:///C:\Users\debra.kroese\Documents\Geiger%20Documents\Publications\201
2\Hui%20et%20al.,%20J.%20of%20Neurochem%20122.pdf> J.D. Geiger. (2012)
Ketone Bodies Protection Against HIV-1 Tat Neurotoxicity. J. Neurochem. 122:
382-391.
2. Bae, M., Patel, N. Xu, H., Lee, M., Nath, A., Geiger, J.D., Gorospe,
M.M., Mattson, M.P., and Haughey, N.J. (2014) Activation of TRPML1 Clears
Intraneuronal Aβ in Pre-Clinical Models of HIV-Infection. J. Neurosci. 34
(34): 11485-11503.
3. Stevens, P.R., Ramonet, D., Gawryluk, J.W., Buscemi, L., and J.D.
Geiger. (2015) Mitochondrial Mechanisms Responsible for Creatine Protection
against HIV-1 Tat-Induced Neurotoxicity. Current HIV Research 12: 378-387.
4. Hui, L., Geiger, N.H., Bloor-Young, D., Churchill, G.C., Geiger,
J.D., and X. Chen (2015) Release of Calcium from Endolysosomes Increases
Calcium Influx Through N-Type Calcium Channels: Evidence for Acidic
Store-Operated Calcium Entry in Neurons. Cell Calcium 58(6): 617-627.
/sent on behalf of
Tabrez Siddiqui
Chair, Seminar Series
Manitoba Neuroscience Network
E: Tabrez.siddiqui(a)umanitoba.ca
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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Hello everyone,
I hope your summer has been equal parts relaxing and productive. As we look
ahead to September, the MNN has planned an exciting event to kick off the
academic year. Award-winning artist Rebecca Kamen will be visiting the
University of Manitoba as a guest of the Faculty of Science, and on
September 24th, she has graciously agreed to spend the day at the Bannatyne
campus interacting with neuroscience researchers and students. As you will
read below, Rebecca has a longstanding interest in neuroscience and she has
participated in projects at Harvard, MIT, NIH, and the Cajal Institute. You
can learn more about Rebecca and her work by visiting her website:
https://rebeccakamen.com/#1
We have planned three events that are open to neuroscience faculty, staff,
and students:
1. Sculpture workshop: 9-11:30 am. Rebecca will lead a workshop in
which the participants will work together to model scientific concepts such
as synapses and ion channels. Please see the attached outline for details.
The workshop is free and no experience is necessary. Individuals and groups
are welcome to sign up. Faculty members, please take note that this could
be a valuable team-building/brainstorming exercise for your lab. Please
RSVP to this email address to reserve your spot (include all names if you
are replying on behalf of a group).
2. Lecture: 12-1 pm, Theatre B. Rebecca will present a lecture
focusing on her work and her experiences at the Cajal Institute, where she
had the opportunity to study Cajal's original drawings. She has indicated
that she would like to meet as many neuroscientists as possible during her
visit, and to facilitate this, we have planned a free lunch reception that
will take place on the Joe Doupe Concourse immediately after the lecture.
3. Meetings with individual researchers. Rebecca will be available
for one-on-one meetings in the afternoon. She is very interested in the
cellular/molecular basis of curiosity, cognition, decision making, memory,
and networks related to visual processing and dyslexia. She is also very
interested in microscopy and would welcome the opportunity to see live
demonstrations of imaging techniques. If you are interested in meeting with
her, please contact me.
Thank you all for your interest and enjoy these last few days of August!
Best wishes, Sari
Sari S. Hannila, PhD
Director of Outreach, Manitoba Neuroscience Network
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Everyone is invited!
The Department of
Pharmacology and Therapeutics
Seminar Series
DATE: Monday, August 13, 2018
TIME: 12:00 pm
LOCATION: 071 Apotex Bldg.
Ravi Rungta
EMBO / Marie Curie Postdoctoral Fellow
INSERM U1128 and Université Paris
Descartes, Laboratory of Neurophysiology
and New Microscopy
TOPIC: "Linking synaptic activation to hemodynamic signals for functional imaging "
For more information
contact: Kelly Jorundson e: kjorund(a)sbrc.ca
Kelly Jorundson
Administrative Manager, Division of Neurodegenerative Disorders
St. Boniface Hospital Research
Department of Pharmacology & Therapeutics
University of Manitoba
Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> or kjorundson(a)sbgh.mb.ca <mailto:Kelly.jorundson@umanitoba.ca>
Tel: 204.235.3939
Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre
Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies.