Neuro-All October 2019

neuro-all@lists.umanitoba.ca

1 participants
3 discussions

Manitoba Neuroscience Network | Visiting Speaker Alyson Foundation Nov 13/19

by networking＠manitobaneuroscience.ca

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 5 months

Centre on Aging Speaker Series | Public Talk: Miyoung Suh

by networking＠manitobaneuroscience.ca

/sent on behalf of Miyoung Suh Date: Friday, November 1, 2019 2:30 PM Location: Fort Garry Library 1360 Pembina Hwy., Winnipeg SPEAKER: Miyoung Suh, PhD Professor, Department of Human Nutritional Sciences, Faculty of Agricultural & Food Sciences, University of Manitoba Nutrition management of aging eyes Over 65% of individuals over the age of 50 have some form of visual impairment. These visually impaired individuals are 1.7 times more likely to fall than individuals with adequate vision, which can lead to a reduction in quality of life. The retina, the inner most layer of the eye, is highly enriched with polyunsaturated fatty acids (PUFA)s. With plenty of light exposure over time, PUFAs can become oxidized, damaging the sensitive tissues of the retina. However, some nutrients play a protective role within the eye by maintaining the structure and function of the retina, and providing protection from light induced damage. This talk will provide evidence that consuming these nutrients in the diet can improve retina function, thereby improving vision with aging. Overall our research will contribute to the development of valuable prevention strategies for the eye health for older adults. For more information, visit www.umanitoba.ca/aging <http://www.umanitoba.ca/aging> This presentation will be available via facebook live Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 5 months

MNN Seminar - Friday Oct 25, 2019 @ 9am | Px236/238 PsycHealth Bldg.

by networking＠manitobaneuroscience.ca

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 6 months

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Neuro-All October 2019