Neuro-All November 2019

neuro-all@lists.umanitoba.ca

2 participants
5 discussions

REMINDER: MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg

by networking＠manitobaneuroscience.ca

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 4 months

MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg.

by networking＠manitobaneuroscience.ca

4 years, 5 months

Outreach opportunity - Royal Manitoba Theatre Centre

by outreach＠manitobaneuroscience.ca

cid:image001.jpg@01D158FE.B69B8D00 cid:image003.jpg@01D5994E.D962B040 Hello everyone, I have a very unique outreach opportunity to share with you! The Royal Manitoba Theatre Centre has asked if one of our members would be willing to write a short article (350 words) related to mental health and gratitude (this could extend to the practice of mindfulness as well). The article will be included in the program for an upcoming play that will be staged in January. Additional details are provided in the forwarded email below. If you are interested, please contact me ASAP as this is somewhat time-sensitive. As you will see, it includes a nice little perk too! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science Rady Faculty of Health Sciences, University of Manitoba cid:image003.jpg@01D5994E.D962B040 cid:image004.jpg@01D158FE.B69B8D00 Begin forwarded message: From: Kathleen Cerrer <kcerrer(a)royalmtc.ca> Date: Nov. 12, 2019 at 10:43 a.m. To: info <info(a)manitobaneuroscience.ca> Subject: Manitoba Neuroscience Network in Royal MTC Program Good morning, I’m writing from the Royal Manitoba Theatre Centre. In January, we are presenting a show called “Every Brilliant Thing” which focuses on mental health and the power of gratitude for physical and mental healing. We’d like to include an article in our program about the power of gratitude and the scientific evidence behind it. Might there be someone at the Manitoba Neuroscience Network that could contribute to our program? The piece would be approximately 350 words and the deadline is Thurs, Nov 28. We would be happy to give you a pair of tickets to the show. Show information https://royalmtc.ca/Current-Plays/Every-Brilliant-Thing.aspx Please let me know if you have any questions. Many thanks, Kathleen Kathleen Cerrer, Publicist ROYAL MANITOBA THEATRE CENTRE Box Office 204 942 6537 | 1 877 446 4500 ROYALMTC.CA | WINNIPEGFRINGE.COM

4 years, 5 months

Dementia Journal Club - TODAY Noon SBRC Main Boardroom R1003

by networking＠manitobaneuroscience.ca

/sent on behalf of Benedict C. Albensi, PhD, BCMAS, CRQM Professor & Manitoba Dementia Research Chair Dept. of Pharmacology & Therapeutics Biomedical Engineering Core Member Faculties of Health Sciences, Engineering, & Science Research Affiliate, Centre on Aging Principal Investigator & Everett Endowment Fund Chair (Alzheimer's research) St. Boniface Hospital Research

4 years, 5 months

Reminder: Manitoba Neuroscience Network | Visiting Speaker - Alyson Fournier Nov 13/19 @12noon Theatre C

by networking＠manitobaneuroscience.ca

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 5 months

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Neuro-All November 2019