Neuro-All February 2019

neuro-all@lists.umanitoba.ca

2 participants
6 discussions

MNN Visiting Speaker | Dr.Alyson Fournier Mar 20 @ 12noon Theatre B

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University T O P I C Small Molecule Stabilization of protein interactions to promote axon regeneration Objectives: - Define 14-3-3- adaptor proteins and small molecules targeting these proteins - Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model - Discuss the mechanism used by these small molecules to promote axon regeneration Abstract: Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Brief Bio: Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fournier's group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series

5 years, 1 month

FW: Dementia Manitoba website - request for updates

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Hi All Our Dementia Manitoba website is currently being updated. If you have any new studies or reviews on Alzheimer's and/or dementia and would like to have your lab recognized then please send me your information for posting. Or just check out what's new and upcoming. Thanks, http://dementiamanitoba.wixsite.com/mysite/research-blog Dr George Perry visits the TMS and EVestG labs in Winnipeg. Benedict C. Albensi, PhD Dementia Research Chair University of Manitoba & St Boniface Hospital Research 204-235-3942

5 years, 2 months

MNN Visiting Speaker - Dr. Alyson Fournier | Wed Mar 20 @ 12 noon

by Manitoba Neuroscience Network

Please mark your calendar cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, Mar 20, 2019 12 noon L O C A T I O N: Theatre B Bannatyne Campus fourniersmall.jpgS P E A K E R Dr. Alyson Fournier <https://www.mcgill.ca/neuro/research/researchers/fournier> Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein Interactions to promote axon regeneration Abstract Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Objectives * Define 14-3-3- adaptor proteins and small molecules targeting these proteins * Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model * Discuss the mechanism used by these small molecules to promote axon regeneration Short Bio Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 2 months

Video link to Dr Perry's talk

by Manitoba Neuroscience Network

/sent on behalf of Ben Albensi cid:image001.jpg@01D158FE.B69B8D00 All We were able to record Dr. Perry's talk held on Monday Feb 4th, 2019. Here is the link for those interested. http://media1.cc.umanitoba.ca/legacy/bann/eos/eos_2019_02_04.mp4 Regards, Ben D A T E: Monday, Feb 4, 2019 12:00 Noon L O C A T I O N: Theatre A Bannatyne Campus **followed by a trainee lunch in 207 A&B Chown Bldg. S P E A K E R: Image result for dr george perryGeorge Perry PhD Professor of Biology and Chemistry Chief Scientist, Brain Health Consortium Semmes Foundation Distinguished University Chair in Neurobiology The University of Texas at San Antonio T O P I C: Mitochondria At The Center Of Alzheimer's Disease Dr. Perry's studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer's disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimer's disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals.

5 years, 2 months

SCRC Journal Club Feb.8 - Nagakannan Pandian

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Mona Nazzal and Katinka Stecina Subject: SCRC Journal Club Feb.8 - Nagakannan Pandian Hello all, For this Friday's Journal club we will have a presentation by Nagakannan Pandian, a PhD student from the Eftekharpour lab. He will be presenting a talk entitled "Ferroptosis in Neuronal Cell Death" See you all on Friday! 11am to noon room 405 of Brodie Centre ----------------------------------------------------------------------- Mona Nazzal PhD Student Spinal Cord Research Centre Department of Physiology and Pathophysiology University of Manitoba 425 BMSB-745 Bannatyne Ave Winnipeg, MB R3E 0J9

5 years, 2 months

Edge of Science & Medicine Visiting Speaker Series - Dr. George Perry Feb 4/2019

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Ben Albensi Everyone is invited! D A T E: Monday, Feb 4, 2019 12:00 Noon L O C A T I O N: Theatre A Bannatyne Campus **followed by a trainee lunch in 207 A&B Chown Bldg. S P E A K E R: Image result for dr george perryGeorge Perry PhD Professor of Biology and Chemistry Chief Scientist, Brain Health Consortium Semmes Foundation Distinguished University Chair in Neurobiology The University of Texas at San Antonio T O P I C: Mitochondria At The Center Of Alzheimers Disease Dr. Perrys studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimers disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimers disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

5 years, 2 months

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Neuro-All February 2019