Neuro-All May 2019

neuro-all@lists.umanitoba.ca

2 participants
10 discussions

REMINDER: Tomorrow MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am

by Kelly Jorundson

[cid:image001.jpg@01D158FE.B69B8D00] S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, May 31, 2019 9:00 AM L O C AT I O N PX236/238 PsycHealth Blding S P E A K E R Tamra Ogilvie, Ph.D.<http://umanitoba.ca/medicine/units/biochem/faculty/t_werbowetski-ogilvie.ht…> Canada Research Chair in Neuro-oncology and Human Stem Cells Associate Professor, Regenerative Medicine Program Biochemistry & Medical Genetics and Physiology & Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Novel gene networks regulating self-renewal and differentiation in medulloblastoma A B S T R AC T OTX2 is a potent oncogenic driver of tumor growth and cell cycle progression in Group 3 medulloblastoma. However, the specific mechanisms by which OTX2 represses neural differentiation in these highly aggressive tumors are not well characterized. We have utilized ChIP-sequencing combined with extensive medulloblastoma patient transcriptome and proteomics data to identify and subsequently validate a novel OTX2 regulatory network that controls Group 3 medulloblastoma cell fate decisions. OTX2 directly restricts the expression of neuronal differentiation genes encoding transcription factors including the novel target genes PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 MB patients and is correlated with reduced survival. Similar to OTX2 silencing, PAX3 and PAX6 overexpression inhibit self-renewal and enhance neuronal differentiation in vitro while PAX3, on its own, increases survival in vivo. Finally, we identify mTORC1 and EPHB2 forward signaling as downstream effectors of OTX2-PAX3, thus highlighting axon guidance and protein synthesis pathways as novel therapeutic targets and key players in Group 3 medulloblastoma pathogenesis. O B J E C T I V E S * Understand the genetic, molecular and cellular heterogeneity associated with the pediatric brain tumor medulloblastoma * Understand the multifaceted role of OTX2 in medulloblastoma pathogenesis * Describe the functional outcome of increased PAX gene expression on medulloblastoma tumorigenic properties in vitro and in vivo For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

4 years, 11 months

REMINDER: MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, May 31, 2019 9:00 AM L O C AT I O N PX236/238 PsycHealth Blding S P E A K E R Tamra Ogilvie, Ph.D. <http://umanitoba.ca/medicine/units/biochem/faculty/t_werbowetski-ogilvie.ht ml> Canada Research Chair in Neuro-oncology and Human Stem Cells Associate Professor, Regenerative Medicine Program Biochemistry & Medical Genetics and Physiology & Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Novel gene networks regulating self-renewal and differentiation in medulloblastoma A B S T R AC T OTX2 is a potent oncogenic driver of tumor growth and cell cycle progression in Group 3 medulloblastoma. However, the specific mechanisms by which OTX2 represses neural differentiation in these highly aggressive tumors are not well characterized. We have utilized ChIP-sequencing combined with extensive medulloblastoma patient transcriptome and proteomics data to identify and subsequently validate a novel OTX2 regulatory network that controls Group 3 medulloblastoma cell fate decisions. OTX2 directly restricts the expression of neuronal differentiation genes encoding transcription factors including the novel target genes PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 MB patients and is correlated with reduced survival. Similar to OTX2 silencing, PAX3 and PAX6 overexpression inhibit self-renewal and enhance neuronal differentiation in vitro while PAX3, on its own, increases survival in vivo. Finally, we identify mTORC1 and EPHB2 forward signaling as downstream effectors of OTX2-PAX3, thus highlighting axon guidance and protein synthesis pathways as novel therapeutic targets and key players in Group 3 medulloblastoma pathogenesis. O B J E C T I V E S * Understand the genetic, molecular and cellular heterogeneity associated with the pediatric brain tumor medulloblastoma * Understand the multifaceted role of OTX2 in medulloblastoma pathogenesis * Describe the functional outcome of increased PAX gene expression on medulloblastoma tumorigenic properties in vitro and in vivo For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

4 years, 11 months

Reminder: Registration deadline - MNN 2019 meeting *TODAY

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 *TODAY IS YOUR LAST DAY TO REGISTER! The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: mnn2019(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

4 years, 11 months

MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am

by Manitoba Neuroscience Network

4 years, 11 months

MNN Scientific Meeting ONLY THREE DAYS LEFT - REGISTER NOW!

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 ONLY THREE DAYS LEFT - REGISTER NOW! So you dont miss out, we have extended the MNN meeting deadline to May 17. The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more The abstract and registration deadline is extended to MAY 17. Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

4 years, 11 months

Neuroscience lectureship and trainee travel awards DEADLINE EXTENDED TO MAY 20

by Manitoba Neuroscience Network

We are pleased to announce that the Manitoba Neuroscience Network will again be accepting applications for 2019/20 TRAVEL AWARDS FOR NEUROSCIENCE PROJECTS and the 2020 VIKTOR HAVLICEK MEMORIAL NEUROSCIENCE LECTURESHIP. TRAVEL AWARDS: A legacy fund created by the estate of Nancy Hettie Clark is used to enrich neuroscience training and support opportunities to network within the wider neuroscience community. Two travel awards of up to $700 each are intended to be awarded annually to a graduate student and a postdoctoral fellow at the University of Manitoba. The application deadline is MAY 20. The eligible travel period is between May 1, 2019 and April 30, 2020, BUT all eligible travel claims must be complete by March 31, 2020. Eligibility: Eligible trainees are either graduate students or postdoctoral fellows. Student candidates must be enrolled as full-time graduate (PhD or MSc) students in the Faculty of Graduate Studies, University of Manitoba, and have a cumulative graduate grade point average of 3.5 or greater (University of Manitoba scale). Postdoctoral fellow candidates must be within the first five years after awarding of their doctoral degree and have a full-time appointment at the University of Manitoba or an affiliated hospital or institute. Candidates must demonstrate excellent research performance and potential in a neurosciences-related discipline, and must demonstrate they will disseminate research results that reflect a high-quality contribution by The University of Manitoba. How to apply: A complete application package consists of the following: * Cover letter stating the following (1 page maximum): o Application category (student or postdoctoral fellow) and your start date in that position o The conference title, location and dates o Type of presentation (e.g. poster or oral) o The importance of the meeting and significance for career development o Any information that would allow reviewers to assess the significance or impact of the conference (e.g. abstracts are peer-reviewed) o Clearly state your graduate GPA (students only) * Graduate level academic transcript (students only) * Listing of scholarly output (publications and presentations) * Support letter from the primary research advisor with (a) a merit assessment of the candidate and project, and (b) confirmation that there is a commitment to cover all eligible travel expenses less the award value * Copy of the submitted abstract Submit all materials to <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca by MAY 15. The support letter may be appended or sent separately by the research advisor. LECTURESHIP: Viktor Havlicek, MD, PhD, DSc, was a Professor in the Department of Physiology (now Physiology and Pathophysiology) at the University of Manitoba from 1968 to 1981. The Viktor Havlicek Memorial fund was established through gifts to the University of Manitoba in his memory. This fund yields $3,000 once every two years to support a visit to the University of Manitoba by an internationally-renowned neuroscientist in a manner that encourages interactions with trainees. Applications are now being accepted until MAY 20, 2019 for a visit and lecture to take place between April 1, 2020 and March 31, 2021. Applications for the next Lectureship will be accepted in 2021 for 2022/2023 fiscal year. Nominations must be made by a faculty member but trainees and staff are encouraged to suggest names to their advisors. Faculty from any MNN contributing institution (ie. not only the University of Manitoba) may submit nominations. A complete nomination consists of a letter to the Neuroscience Awards Committee (NAC) Chair explaining the rationale for choice of candidate (1 page maximum), along with any supporting materials the applicant deems useful for assessing the merit of the candidate and the benefits of his or her visit to the University of Manitoba. Please send nominations by email to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> by May 20. The NAC will determine an order of invitation priority for submitted nominees and the top-priority candidate invited at a time determined in consultation with the nominator. If this candidate is not available, the next candidate will be invited. All candidates on the priority list must be considered worthy of the Lectureship by the NAC. We hope you find these opportunities helpful and exciting. If there are any questions, you may respond to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> . Thank you. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

4 years, 11 months

FW: Reminder: MNN Visiting Speaker - Dr. David Amaral TODAY

by Kelly Jorundson

Subject: Reminder: MNN Visiting Speaker - Dr. David Amaral TODAY [cid:image001.jpg@01D158FE.B69B8D00] U N I V E R S I T Y O F M A N I T O B A ' S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus (FOLLOWED BY A TRAINEE LUNCH IN SR415) S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

4 years, 11 months

MNN 2019 Scientific Meeting \ DEADLINE EXTENDED TO MAY 17

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 REGISTER NOW! So you dont miss out, we have extended the MNN meeting deadline to May 17. The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more The abstract and registration deadline is extended to MAY 17. Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: mnn2019(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

4 years, 11 months

*updated*: Reminder: MNN Visiting Speaker - Dr. David Amaral May 6/7

by Kelly Jorundson

[cid:image001.jpg@01D158FE.B69B8D00] **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A ' S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

4 years, 11 months

Reminder: MNN Visiting Speaker - Dr. David Amaral May 6/7

by Manitoba Neuroscience Network

cid:image001.jpg@01D158FE.B69B8D00 **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

4 years, 11 months

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Neuro-All May 2019