- Neuro-All - University of Manitoba Mailing Lists

CANCELLED: Special BioTech Feature: Introduction to Cubresa BrainPET - March 18
by networking＠manitobaneuroscience.ca 13 Mar '20

13 Mar '20

SPECIAL FEATURE TALK BY CUBRESA CANCELLED ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Brain Awareness Week events cancelled
by outreach＠manitobaneuroscience.ca 12 Mar '20

12 Mar '20

Good afternoon everyone, In the interest of public health and in accordance with the measures just announced by the University of Manitoba, we will be cancelling all outreach events for Brain Awareness Week. While disappointing, it is the only responsible course of action. Thank you to everyone who volunteered for these events. We hope to reschedule them for later in the year. Best wishes, Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science University of Manitoba

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CANCELLED! Edge of Science and Medicine Visiting Speaker Series: Brian MacVicar, March 16th
by networking＠manitobaneuroscience.ca 12 Mar '20

12 Mar '20

SEMINAR & LUNCH HAVE BEEN CANCELLED

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CANCELLED: MNN / BAW Visiting Speaker Dr. Tuan Trang March 17th, 2020
by networking＠manitobaneuroscience.ca 12 Mar '20

12 Mar '20

SEMINAR & LUNCH HAVE BEEN CANCELLED B R A I N A W A R E N E S S W E E K V I S I T I N G S P E A K E R 2020/BAW D AT E Tuesday, March 17, 2020 | 12 PM LO C AT I O N Theatre C | Basic Medical Sciences Building | Bannatyne *Followed by a trainee lunch in room SR415 Kleysen Bldg. S P E A K E R Dr. Tuan Trang Associate Professor | Faculty of Veterinary Medicine & Cumming School of Medicine | University of Calgary T O P I C Microglia and pannexin1: a cellular Rubik's cube B I O Dr. Tuan Trang is an Associate Professor in the Faculty of Veterinary Medicine and Cumming School of Medicine at the University of Calgary. His research is directed towards unlocking the mysteries of chronic pain, and how to better treat it. By understanding the cellular and molecular causes of chronic pain, his goal is to develop better pain therapies and to improve the safety of opioid drugs. Dr. Trang has received Young Investigator Awards from CIHR, the Canadian Association for Neuroscience, and Canadian Society for Pharmacology and Therapeutics. He has also gained international recognition from the American Pain Society, Rita Allen Foundation, and the International Narcotics Research Conference. Dr. Trang leads the Alberta Pain Research Network, University of Calgary Spinal Cord and Pain NeuroTeam, and Chairs the Scientific Program Committee for the Canadian Pain Society. A B S T R AC T Opioid analgesics are an essential class of drugs for treating pain. The increasing use of opioids is concerning and has contributed to a striking rise in opioid related deaths. Adverse opioid side effects are increasingly linked to activity of microglia, which are immune cells that reside in the central nervous system. This presentation will focus on the interplay between microglia and opioids, as well as the emerging sexual dimorphic role of microglia in chronic pain. We are beginning to unlocked pieces of the cellular puzzle that will allow us to better understand the inner workings of microglia. O B J E C T I V E S 1. Understand the importance of microglia in chronic pain 2. Define how sex differences contribute to chronic pain 3. Learn how opioids modulate microglia activity and its implications for use of opioid medications.

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FW: Edge of Science and Medicine Seminar: March 23, Chetan Patil and Mateusz Tomczyk
by networking＠manitobaneuroscience.ca 12 Mar '20

12 Mar '20

/sent on behalf of Department of Pharmacology & Therapeutics All are welcome to attend: Janelle Metcalfe Office Assistant (Wednesday to Friday 8:30am - 4:30pm) Department of Pharmacology and Therapeutics Max Rady College of Medicine, Rady Faculty of Health Sciences Tel: 204-789-3553 Email: Janelle.Metcalfe(a)umanitoba.ca <mailto:Janelle.Metcalfe@umanitoba.ca>

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REMINDER! Edge of Science and Medicine Visiting Speaker Series: Brian MacVicar, March 16th
by networking＠manitobaneuroscience.ca 12 Mar '20

12 Mar '20

/sent on behalf of Dr. Tiina Kauppinen from the Department of Pharmacology & Therapeutics | Neuroscience Research Program

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MNN Seminar - Dr. Eftekharpour - Friday, March 27, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 10 Mar '20

10 Mar '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Trainee reception with Tuan Trang - Mar 17th 1pm Joe Doupe Concourse
by Kelly Jorundson 09 Mar '20

09 Mar '20

Please inform your trainees! Thanks, Kelly [cid:image001.jpg@01D5F600.FBF29670] Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Dr. Tuan Trang | Mar. 17th @ 12noon Theatre C
by Kelly Jorundson 09 Mar '20

09 Mar '20

[cid:image001.jpg@01D158FE.B69B8D00] B R A I N A W A R E N E S S W E E K V I S I T I N G S P E A K E R D AT E Tuesday, March 17, 2020 | 12 PM LO C AT I O N Theatre C | Basic Medical Sciences Building | Bannatyne (followed by a trainee reception, Joe Doupe Concourse) S P E A K E R Dr. Tuan Trang Associate Professor | Faculty of Veterinary Medicine & Cumming School of Medicine | University of Calgary T O P I C Microglia and pannexin1: a cellular Rubik's cube B I O Dr. Tuan Trang is an Associate Professor in the Faculty of Veterinary Medicine and Cumming School of Medicine at the University of Calgary. His research is directed towards unlocking the mysteries of chronic pain, and how to better treat it. By understanding the cellular and molecular causes of chronic pain, his goal is to develop better pain therapies and to improve the safety of opioid drugs. Dr. Trang has received Young Investigator Awards from CIHR, the Canadian Association for Neuroscience, and Canadian Society for Pharmacology and Therapeutics. He has also gained international recognition from the American Pain Society, Rita Allen Foundation, and the International Narcotics Research Conference. Dr. Trang leads the Alberta Pain Research Network, University of Calgary Spinal Cord and Pain NeuroTeam, and Chairs the Scientific Program Committee for the Canadian Pain Society. A B S T R AC T Opioid analgesics are an essential class of drugs for treating pain. The increasing use of opioids is concerning and has contributed to a striking rise in opioid related deaths. Adverse opioid side effects are increasingly linked to activity of microglia, which are immune cells that reside in the central nervous system. This presentation will focus on the interplay between microglia and opioids, as well as the emerging sexual dimorphic role of microglia in chronic pain. We are beginning to unlocked pieces of the cellular puzzle that will allow us to better understand the inner workings of microglia. O B J E C T I V E S 1. Understand the importance of microglia in chronic pain 2. Define how sex differences contribute to chronic pain 3. Learn how opioids modulate microglia activity and its implications for use of opioid medications. [cid:image009.jpg@01D5ED5B.70A97BE0] Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Special BioTech Feature: Introduction to Cubresa BrainPET - March 18
by networking＠manitobaneuroscience.ca 04 Mar '20

04 Mar '20

****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Request for volunteers - Neuroscience for Kids
by outreach＠manitobaneuroscience.ca 28 Feb '20

28 Feb '20

Hello everyone, PIs, please forward this email to your trainees if they are not on the MNN mailing list. These volunteering opportunities are intended for students and postdocs, but if you are out shopping with your family while the events are going on, I encourage you to drop by, check things out, and give your kids the chance to participate in the activities. To our MNN trainees, this is your chance to share your love of neuroscience with kids of all ages! We are looking for volunteers to help out with the outreach events that will be held March 14 and 21 during Brain Awareness Week. Read on to find out how you can take part! At these events you will be working alongside other student volunteers from Let's Talk Science to lead a variety of neuroscience-themed activities. There will be five different activities available: 1. Brain hats - help the kids colour and assemble their own paper brain hat while explaining how different functions are localized to specific parts of the brain. 2. Protect that brain! - a variation on the classic egg drop challenge, only here we're pretending that the egg is the brain. Help the kids use different materials to create a protective shell for their "brain" and then drop it to see if it works! You can explain how the skull protects the brain, why it's important to protect our brain from impact, and how concussions occur. 3. Make your own neuron - for the neurobiologists! Help the kids make neurons out of pipe cleaners - complete with soma, dendrites, and axon. You can explain what these structures do and how neurons communicate with each other through synapses. 4. Memory match game - this will be mainly for younger kids. They will have to match pictures from a series of cards and you get to hand out candy when they get it right! You can explain how memory works and how the brain helps us to remember things, learn new skills and improve those skills with practice. 5. Play-Doh brains - help the kids to sculpt a brain out of Play-Doh using a model as a guide. You can highlight the different lobes and other anatomical features of the CNS, and their functions. There will also be colouring and activity pages at each station and you can help the kids with those as well. Here's how to sign up: 1. For the event at the Outlet Collection on March 14, follow this link: https://docs.google.com/spreadsheets/d/1zpCTtHpbmveNt8vE_Dc8t0vEU3pA0oADtU66 bSZ0HJc/edit#gid=0 For the event at Garden City on March 21, follow this link: https://docs.google.com/spreadsheets/d/1HhoYtQSv3vHQyOLEzIH2iOHsuk0gslKM1dUe Acd8dco/edit#gid=0 2. Choose your activity and time slot. The first two shifts are 2 hours long and the last shift of the day is 3 hours long. You may sign up for more than one shift and you can also participate in different activities on the same day. 3. Enter your name in the corresponding blue slot(s) on the spreadsheet. These slots have been reserved for MNN volunteers. 4. Immediately after you have signed up, please confirm your participation by emailing me at outreach(a)manitobaneuroscience.ca <mailto:outreach@manitobaneuroscience.ca> . This will give me the contact information that I will need to communicate with you directly as we get closer to the event. Please include the dates, activities, and shifts that you have signed up for, whether you're from U of M or U of W, and your position (undergrad, grad, postdoc). For the latter two, please include the name of your supervisor as well. This process is first come, first served, so sign up ASAP to reserve your spot. If you see that your preferred activity or time has been taken, please DO NOT erase someone else's name or write your name in random places on the spreadsheet. Send me an email and indicate your preferences and I will look into creating additional spots. I cannot guarantee that everyone who is interested will be able to participate but I will do my best. Please feel free to contact me with any questions. These events promise to be a lot of fun and I look forward to seeing you there! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science University of Manitoba

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Brain Awareness Week 2020
by outreach＠manitobaneuroscience.ca 27 Feb '20

27 Feb '20

Hello everyone, On behalf of the MNN, I am pleased to announce our schedule of upcoming events for Brain Awareness Week 2020. They will include talks by two outstanding visiting speakers, a Café Scientifique on Parkinsons disease, and the 6th Annual Winnipeg Brain Bee. New for this year, we have partnered with the University of Manitoba chapter of Lets Talk Science to host two public outreach events featuring free neuroscience activities for kids. Students and postdocs will have the opportunity to volunteer for these events and the sign-up information will be sent out tomorrow, so keep an eye on your inbox! Thank you for your support of the MNN and our outreach program. We look forward to celebrating Brain Awareness Week with you! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science University of Manitoba

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MNN / BAW Visiting Speaker Dr. Tuan Trang March 17th, 2020
by Kelly Jorundson 24 Feb '20

24 Feb '20

[cid:image001.jpg@01D158FE.B69B8D00] B R A I N A W A R E N E S S W E E K V I S I T I N G S P E A K E R 2020/BAW D AT E Tuesday, March 17, 2020 | 12 PM LO C AT I O N Theatre C | Basic Medical Sciences Building | Bannatyne *Followed by a trainee lunch in room SR415 Kleysen Bldg. S P E A K E R Dr. Tuan Trang Associate Professor | Faculty of Veterinary Medicine & Cumming School of Medicine | University of Calgary T O P I C Microglia and pannexin1: a cellular Rubik's cube B I O Dr. Tuan Trang is an Associate Professor in the Faculty of Veterinary Medicine and Cumming School of Medicine at the University of Calgary. His research is directed towards unlocking the mysteries of chronic pain, and how to better treat it. By understanding the cellular and molecular causes of chronic pain, his goal is to develop better pain therapies and to improve the safety of opioid drugs. Dr. Trang has received Young Investigator Awards from CIHR, the Canadian Association for Neuroscience, and Canadian Society for Pharmacology and Therapeutics. He has also gained international recognition from the American Pain Society, Rita Allen Foundation, and the International Narcotics Research Conference. Dr. Trang leads the Alberta Pain Research Network, University of Calgary Spinal Cord and Pain NeuroTeam, and Chairs the Scientific Program Committee for the Canadian Pain Society. A B S T R AC T Opioid analgesics are an essential class of drugs for treating pain. The increasing use of opioids is concerning and has contributed to a striking rise in opioid related deaths. Adverse opioid side effects are increasingly linked to activity of microglia, which are immune cells that reside in the central nervous system. This presentation will focus on the interplay between microglia and opioids, as well as the emerging sexual dimorphic role of microglia in chronic pain. We are beginning to unlocked pieces of the cellular puzzle that will allow us to better understand the inner workings of microglia. O B J E C T I V E S 1. Understand the importance of microglia in chronic pain 2. Define how sex differences contribute to chronic pain 3. Learn how opioids modulate microglia activity and its implications for use of opioid medications. /sent on behalf of Tabrez Siddiqui Chair, MNN Visiting Speaker/Seminar Series Email: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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REMINDER: MNN Seminar - Friday, February 28, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 21 Feb '20

21 Feb '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Seminar - Friday, February 28, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 13 Feb '20

13 Feb '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Mark your Calendars! Brain Awareness Week Speaker - Dr. Tuan Trang Mar 17th @ 12noon Theatre C
by Kelly Jorundson 11 Feb '20

11 Feb '20

[cid:image001.jpg@01D158FE.B69B8D00] B R A I N A W A R E N E S S W E E K V I S I T I N G S P E A K E R DAT E Tuesday, March 17, 2020 | 12 PM LOCAT I O N Theatre C | Basic Medical Sciences Bldg. | Bannatyne Campus ***Trainee lunch to follow in room SR415 Kleysen Bldg., Health Sciences Centre S P E A K E R Dr. Tuan Trang Associate Professor | Faculty of Veterinary Medicine & Cumming School of Medicine | University of Calgary T O P I C Microglia and pannexin1: a cellular Rubik's cube B I O Dr. Tuan Trang is an Associate Professor in the Faculty of Veterinary Medicine and Cumming School of Medicine at the University of Calgary. His research is directed towards unlocking the mysteries of chronic pain, and how to better treat it. By understanding the cellular and molecular causes of chronic pain, his goal is to develop better pain therapies and to improve the safety of opioid drugs. Dr. Trang has received Young Investigator Awards from CIHR, the Canadian Association for Neuroscience, and Canadian Society for Pharmacology and Therapeutics. He has also gained international recognition from the American Pain Society, Rita Allen Foundation, and the International Narcotics Research Conference. Dr. Trang leads the Alberta Pain Research Network, University of Calgary Spinal Cord and Pain NeuroTeam, and Chairs the Scientific Program Committee for the Canadian Pain Society. Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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REMINDER: EDGE OF SCIENCE & MEDICINE: Dr. Todd Constable MONDAY, February 10, 2020
by networking＠manitobaneuroscience.ca 07 Feb '20

07 Feb '20

/sent on behalf of Dr. Ji Hyun Ko from the Department of Human Anatomy & Cell Science | Neuroscience Research Program

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Edge of Science and Medicine Visiting Speaker Series: Brian MacVicar, March 16th
by networking＠manitobaneuroscience.ca 06 Feb '20

06 Feb '20

/sent on behalf of Dr. Tiina Kauppinen from the Department of Pharmacology & Therapeutics | Neuroscience Research Program

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REMINDER: MNN Seminar - TOMORROW January 31, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 30 Jan '20

30 Jan '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Please share, post, or distribute - Dr Menec presents to our Dementia Journal Club Jan 30th Thursday at noon
by Kelly Jorundson 27 Jan '20

27 Jan '20

[cid:image001.jpg@01D158FE.B69B8D00] Please share, post, or distribute. Dementia journal club on Jan 30th. Univ. of Manitoba HSC, room D112B Dentistry Bldg., Winnipeg [cid:image003.jpg@01D5D506.57E652D0] ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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REMINDER: MNN Seminar - Friday January 31, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 27 Jan '20

27 Jan '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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EDGE OF SCIENCE & MEDICINE: Dr. Todd Constable February 10, 2020
by networking＠manitobaneuroscience.ca 21 Jan '20

21 Jan '20

/sent on behalf of Dr. Ji Hyun Ko from the Department of Human Anatomy & Cell Science | Neuroscience Research Program

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Canadian Physiological Society Symposium and Membership
by networking＠manitobaneuroscience.ca 20 Jan '20

20 Jan '20

/sent on behalf of Dr. Brent Fedirchuk Dear colleague, We are writing to you in our roles on the Canadian Physiological Society Executive. We are working to engage the community of Canadian physiologists, and provide support and opportunities for trainees and early career scientists. We are taking several initiatives to engage new members and plan for future events: 1. We have prepared a survey that we would ask you to forward to members of your department, in order to get a better idea of commonly attended international meetings to target for partnerships. Please use the following link. https://forms.gle/1ZzwwhB7u8pTDGKR8 2. We are offering complimentary 2020 membership in the society for faculty and students of Canadian departments linked to the discipline of Physiology. Please encourage your department members to officially join by using the following link: https://forms.gle/6KLcsSfCvkmGEjFT7 3. We will be hosting a symposium in affiliation with the 2020 CAN/ACN meeting in Montreal, May 30. We have attached a poster with a preliminary list of speakers and will be sending updates regularly. We ask that you please circulate these opportunities to your students and faculties. Sincerely, Graham Collingridge, President Harley Kurata, Vice-President Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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PhD Trainee opening at Laval University
by networking＠manitobaneuroscience.ca 10 Jan '20

10 Jan '20

/sent on behalf of Dr. Frederic Bretzner from the Department of Psychiatry and Neuroscience | Laval University Dear all, Please see attached ad for a graduate student for an exciting project combining mouse genetics, optogenetics, kinematic, and electrophysiological recordings to investigate supraspinal pathways important to locomotor recovery after spinal cord injury. Thanks in advance, Frederic Bretzner, PhD Associate Professor Department of Psychiatry and Neuroscience Laval University

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MNN Seminar - Friday January 31, 2020 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 09 Jan '20

09 Jan '20

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Dr. Todd Constable meeting
by networking＠manitobaneuroscience.ca 07 Jan '20

07 Jan '20

/sent on behalf of Dr. Ji Hyun Ko from the Department of Human Anatomy & Cell Science | Neuroscience Research Program Hello all, This year's Edge of Science speaker in the department of human anatomy and cell science is Dr. Todd Constable. Dr. Constable is a professor of Radiology and Biomedical Imaging and of Neurosurgery at Yale University. He pioneered functional connectivity analysis using fMRI, and he is currently interested using fMRI to aid neurosurgery and human brain mapping of cognition in general. For more info, please visit: https://medicine.yale.edu/profile/todd_constable/?tab=bio He is visiting us on February 10th, 2020. Please let me know if you are interested in meeting with him in person. I would appreciate it if you indicate what time you are available (he will give a seminar at noon-1pm and will have a student lunch at 1-2pm). Best, JI Hyun Ji Hyun Ko, PhD Assistant Professor Department of Human Anatomy and Cell Science Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba Principal Investigator Neuroscience Research Program Kleysen Institute for Advanced Medicine Health Science Centre Mailing Address: SR452 - 710 William Avenue Winnipeg, MB R3E 0Z3 Canada Tel: +1-204-318-2566 Email: <mailto:ji.ko@umanitoba.ca> ji.ko(a)umanitoba.ca <http://www.kolabneuro.com/> http://www.kolabneuro.com/

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Mohammad Norouzi: Drug delivery systems for glioblastoma therapy
by networking＠manitobaneuroscience.ca 18 Dec '19

18 Dec '19

/sent on behalf of Ben Albensi balbensi(a)sbrc.ca <mailto:balbensi@sbrc.ca> Kelly Jorundson Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN's Brain Awareness Week Visiting Speaker Tuan Trang March 17th 2020
by Kelly Jorundson 17 Dec '19

17 Dec '19

Deaf academic/clinician, Dr. Tuan Trang<https://hbi.ucalgary.ca/profiles/dr-tuan-trang> has been invited to come to Winnipeg as our Brain Awareness Week Visiting Speaker. Please see attached bio. He will be giving a lecture in Theatre C on Tuesday, March 17th 2020. If you are interested in meeting with Tuan Trang on March 17th, please let me know and I will try to schedule you in. Thanks! Kelly Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Albretchsen Research Centre & University of Manitoba Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> or kjorundson(a)sbgh.mb.ca<mailto:Kelly.jorundson@umanitoba.ca> Tel: 204.235.3939 Fax: 204.237.4092 [cid:image001.jpg@01D2883E.86D93F20]

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Graduate course announcement
by networking＠manitobaneuroscience.ca 02 Dec '19

02 Dec '19

/sent on behalf of Dr. Ji Hyun Ko from the Department of Human Anatomy & Cell Science | Neuroscience Research Program Graduate Course Announcement (2019-2020) There are two new courses being offered in the winter term 2020 that will be running back-to-back (see below and attachment for details). Both courses may be completed within the same term, or completed in two terms (winter 2020 and winter 2021). Registration is open to all graduate students enrolled in any Faculty/College/Department interested in Neuroscience from the Fort Garry or Bannatyne Campuses, and the St. Boniface Research Centre. Classes will take place in SR4, Kleysen Institute for Advanced Medicine Building/Bannatyne campus, unless otherwise indicated by the Course Director. 1) Human Brain Imaging Methods (IMED 7004) This is a 1.5 credit hour course held on the Bannatyne Campus (Jan. 7, 2020 - Feb. 20, 2020). It will be of particular interest to graduate students whose research is in neuroscience. This course will provide an overview of the in vivo brain imaging methods and how imaging data are analysed (e.g., MRI and PET). Students will have opportunity to perform hands-on practice in computer labs with sample data. The course has 2 components: 1. Lectures that will provide a systematic survey of different brain imaging modalities, and 2. Computer Laboratory sessions in which students will perform computer analysis using real brain imaging data. 2) Advanced Level Human Brain Imaging Methods (ANAT 7012) This is a 1.5 credit hour course held on the Bannatyne Campus (Feb. 25, 2020 - Apr. 14, 2020). This course is intended for those graduate students who intend to broaden their skills in more advanced brain imaging methods that was not covered in the Human Brain Imaging Methods (IMED 7004). Students may take both IMED 7004 and ANAT 7012 back-to-back within the same semester, or wait until the next year(s) when it is offered again. The course has 2 components: 1. Lectures/student presentation: systematic survey of different brain imaging modalities and analytic methods, and 2. Computer Laboratory sessions: students will perform computer analysis using real brain imaging data including machine learning. For more information contact: Dr. Ji Hyun Ko (Course Director) Dept. of Human Anatomy & Cell Science ji.ko(a)umanitoba.ca 204-318-2566

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REMINDER: MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 27 Nov '19

27 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg.
by networking＠manitobaneuroscience.ca 13 Nov '19

13 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Outreach opportunity - Royal Manitoba Theatre Centre
by outreach＠manitobaneuroscience.ca 12 Nov '19

12 Nov '19

cid:image001.jpg@01D158FE.B69B8D00 cid:image003.jpg@01D5994E.D962B040 Hello everyone, I have a very unique outreach opportunity to share with you! The Royal Manitoba Theatre Centre has asked if one of our members would be willing to write a short article (350 words) related to mental health and gratitude (this could extend to the practice of mindfulness as well). The article will be included in the program for an upcoming play that will be staged in January. Additional details are provided in the forwarded email below. If you are interested, please contact me ASAP as this is somewhat time-sensitive. As you will see, it includes a nice little perk too! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science Rady Faculty of Health Sciences, University of Manitoba cid:image003.jpg@01D5994E.D962B040 cid:image004.jpg@01D158FE.B69B8D00 Begin forwarded message: From: Kathleen Cerrer <kcerrer(a)royalmtc.ca> Date: Nov. 12, 2019 at 10:43 a.m. To: info <info(a)manitobaneuroscience.ca> Subject: Manitoba Neuroscience Network in Royal MTC Program Good morning, I’m writing from the Royal Manitoba Theatre Centre. In January, we are presenting a show called “Every Brilliant Thing” which focuses on mental health and the power of gratitude for physical and mental healing. We’d like to include an article in our program about the power of gratitude and the scientific evidence behind it. Might there be someone at the Manitoba Neuroscience Network that could contribute to our program? The piece would be approximately 350 words and the deadline is Thurs, Nov 28. We would be happy to give you a pair of tickets to the show. Show information https://royalmtc.ca/Current-Plays/Every-Brilliant-Thing.aspx Please let me know if you have any questions. Many thanks, Kathleen Kathleen Cerrer, Publicist ROYAL MANITOBA THEATRE CENTRE Box Office 204 942 6537 | 1 877 446 4500 ROYALMTC.CA | WINNIPEGFRINGE.COM

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Dementia Journal Club - TODAY Noon SBRC Main Boardroom R1003
by networking＠manitobaneuroscience.ca 07 Nov '19

07 Nov '19

/sent on behalf of Benedict C. Albensi, PhD, BCMAS, CRQM Professor & Manitoba Dementia Research Chair Dept. of Pharmacology & Therapeutics Biomedical Engineering Core Member Faculties of Health Sciences, Engineering, & Science Research Affiliate, Centre on Aging Principal Investigator & Everett Endowment Fund Chair (Alzheimer's research) St. Boniface Hospital Research

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Reminder: Manitoba Neuroscience Network | Visiting Speaker - Alyson Fournier Nov 13/19 @12noon Theatre C
by networking＠manitobaneuroscience.ca 06 Nov '19

06 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Manitoba Neuroscience Network | Visiting Speaker Alyson Foundation Nov 13/19
by networking＠manitobaneuroscience.ca 29 Oct '19

29 Oct '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Centre on Aging Speaker Series | Public Talk: Miyoung Suh
by networking＠manitobaneuroscience.ca 23 Oct '19

23 Oct '19

/sent on behalf of Miyoung Suh Date: Friday, November 1, 2019 2:30 PM Location: Fort Garry Library 1360 Pembina Hwy., Winnipeg SPEAKER: Miyoung Suh, PhD Professor, Department of Human Nutritional Sciences, Faculty of Agricultural & Food Sciences, University of Manitoba Nutrition management of aging eyes Over 65% of individuals over the age of 50 have some form of visual impairment. These visually impaired individuals are 1.7 times more likely to fall than individuals with adequate vision, which can lead to a reduction in quality of life. The retina, the inner most layer of the eye, is highly enriched with polyunsaturated fatty acids (PUFA)s. With plenty of light exposure over time, PUFAs can become oxidized, damaging the sensitive tissues of the retina. However, some nutrients play a protective role within the eye by maintaining the structure and function of the retina, and providing protection from light induced damage. This talk will provide evidence that consuming these nutrients in the diet can improve retina function, thereby improving vision with aging. Overall our research will contribute to the development of valuable prevention strategies for the eye health for older adults. For more information, visit www.umanitoba.ca/aging <http://www.umanitoba.ca/aging> This presentation will be available via facebook live Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Seminar - Friday Oct 25, 2019 @ 9am | Px236/238 PsycHealth Bldg.
by networking＠manitobaneuroscience.ca 17 Oct '19

17 Oct '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Seminar - Friday Sept 27/19 @ 9am | Px236/238 PsycHealth Bldg.
by networking＠manitobaneuroscience.ca 23 Sep '19

23 Sep '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, September 27th, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Tiina Kauppinen Associate Professor, Department of Pharmacology and Therapeutics, University of Manitoba Principal Investigator, Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre Researcher, Childrens Hospital Research Institute of Manitoba T O P I C Microglial modulation rescues cognitive impairment caused by fetal exposure to gestational diabetes O B J E C T I V E S * To explain the impact of gestational diabetes exposure to offspring neurodevelopment * To evaluate how microglial activation can influence neuronal function and viability * To identify targets/means to modulate microglial functions B I O Dr. Kauppinen was born and educated in Kuopio, Finland. She obtained her M.Sc. in Biotechnology (1998) and Ph.D. in Biotechnology and Molecular Neuroscience (2001) from the University of Kuopio, Finland. She did her postdoctoral training (2002-2006) at the University of California, San Francisco, while earning a Docent degree in Neuroinflammation (2007) from University of Kuopio, Finland. She continued in the Department of Neurology, UCSF as an Adjunct Assistant Professor (2006-2012). Dr. Kauppinen joined the Faculty of Medicine, University of Manitoba in July 2012. Currently she is an associate professor in the Department of Pharmacology and Therapeutics, a principle investigator in the Neuroscience Research Program at Kleysen Institute for Advanced Medicine, Health Sciences Centre, and researcher in Childrens Hospital Research Institute of Manitoba. Dr. Kauppinens research laboratory investigates how microglial functions are regulated and how to harness them to promote brain health and recovery in acute (stroke, traumatic brain injury) and chronic (Alzheimers disease) central nervous system disorders, brain tumour, and in neurodevelopmental disturbances (fetal exposure to gestational diabetes). Her research is funded by grants from Alzheimer Society of Canada (ASV), Canada Foundation for Innovation (CFI), Canadian Institutes of Health Research (CIHR), Childrens Hospital Research Institute of Manitoba Foundation (CHRIM), Heart and Stroke Foundation Canada (HSFC), Manitoba Health Research Council (MHRC), Natural Sciences and Engineering Research Council of Canada (NSERC) and University of Manitoba. Recent publications: <https://www.ncbi.nlm.nih.gov/pubmed/?term=Kauppinen+Tiina+or+Tikka+Tiina+or +Tikka+T+and+minocycline> https://www.ncbi.nlm.nih.gov/pubmed/?term=Kauppinen+Tiina+or+Tikka+Tiina+or+ Tikka+T+and+minocycline For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Reminder: Alzheimer Society Public Talk: Spotlight on Dementia Research
by networking＠manitobaneuroscience.ca 18 Sep '19

18 Sep '19

/sent on behalf of Benedict C. Albensi, PhD, BCMAS, CRQM Manitoba Dementia Research Chair Everyone is invited! Spotlight on Dementia Research: Whats Happening Now and its Impact on the Future <https://alzheimer.mb.ca/wp-content/uploads/2019/07/Spotlight-on-Research-Se pt-24-2019.pdf> Click here to view the poster. Keynote Speaker Dr. Saskia Sivananthan Chief Research & KTE Officer, Alzheimer Society of Canada Tuesday, September 24, 2019 7 8:30 pm Samuel N. Cohen Auditorium St. Boniface Hospital Research 351 Tache Avenue, Winnipeg, MB Around the world, researchers are taking significant strides to look for ways to prevent dementia, to improve the quality of life of those impacted and to ultimately find a cure. Come to hear Dr. Sivananthan, a neuroscientist, global policy leader and Chief Science Officer at the Alzheimer Society of Canada talk about the latest research, new findings and what it means for the future of dementia. Chair: Dr. Benedict C. Albensi, Manitoba Dementia Research Chair; Everett Endowment Fund Chair, St. Boniface Hospital Research Centre Limited seating! Three easy ways to register! 1. Email alzmb(a)alzheimer.mb.ca <mailto:alzmb@alzheimer.mb.ca> 2. Call 204-943-6622 or 1-800-378-6699 3. <https://secure2.convio.net/alzmb/site/Ecommerce;jsessionid=00000000.app216a ?store_id=1741&NONCE_TOKEN=02328DC99D5C253737865993A9786753> Click here to register online today! Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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*Updated* MNN Seminar & Speaker Series 2019/2020
by networking＠manitobaneuroscience.ca 13 Sep '19

13 Sep '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S Time: 9 : 0 0 A M Location: PX236/238 PSYCH HEALTH BLDG Speaker Date Dr. Tiina Kauppinen September 27, 2019 Associate Professor, Department of Pharmacology & Therapeutics, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine Dr. Mandana Modirrousta October 25, 2019 Associate Professor, Neuropsychiatrist & Director, Neuromodulation & Neuropsychiatry Unit, Department of Psychiatry, University of Manitoba | Principal Investigator, DND St. Boniface Hospital Research Dr. Jun-Feng Wang November 29, 2019 Associate Professor, Department of Pharmacology & Therapeutics, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine Dr. Ana Hanlon-Dearman January 31, 2020 Associate Professor, Pediatrics & Child Health, University of Manitoba Dr. Benjamin Lindsey February 28, 2020 Assistant Professor, Department of Human Anatomy & Cell Science, University of Manitoba Brain Awareness Week March 9 -13, 2020 Dr. Eftekhar Eftekharpour March 27, 2020 Assistant Professor, Department of Physiology & Pathophysiology, University of Manitoba Dr. Geoffrey Hicks April 24, 2020 Professor, Department of Biochemistry & Medical Genetics | Director, Regnerative Medicine Program Director, Mammalian Functional Genomics Centre Senior Investigator, RIOH Dr. Ji-Hyun Ko May 29, 2020 Assistant Professor, Department of Human Anatomy & Cell Science, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine For more information, contact the MNN office networking(a)manitobaneuroscience.ca <mailto:networking@manitobaneuroscience.ca> or T: 204-235-3939 /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Suggestions for visiting speakers
by Kelly Jorundson 11 Sep '19

11 Sep '19

[cid:image001.jpg@01D158FE.B69B8D00] Dear faculty member, As part of our visiting speaker series, I am looking for suggestions for speakers. I would appreciate if you could give me your suggestions by the end of this week. Thank you, Tabrez Siddiqui Chair, MNN Visiting Speaker & Seminar Series Program Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Manitoba Neuroscience Network | Seminar Series 2019-2020
by networking＠manitobaneuroscience.ca 10 Sep '19

10 Sep '19

Manitoba Neuroscience Network 2019/2020 SEMINAR SERIES The following seminars will be held @ 9:00 AM PX236/238 PsychHealth Bldg. Speaker Date Dr. Tiina Kauppinen September 27, 2019 Associate Professor, Department of Pharmacology & Therapeutics, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine Title: TBA To be announced October 25, 2019 Dr. Jun-Feng Wang November 29, 2019 Associate Professor, Department of Pharmacology & Therapeutics, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine Title: TBA Dr. Ana Hanlon-Dearman January 31, 2020 Associate Professor, Pediatrics & Child Health, University of Manitoba Title: TBA Dr. Benjamin Lindsey February 28, 2020 Assistant Professor, Department of Human Anatomy & Cell Science, University of Manitoba Title: TBA Brain Awareness Week March 9 -13, 2020 Dr. Eftekhar Eftekharpour March 27, 2020 Assistant Professor, Department of Physiology & Pathophysiology, University of Manitoba Title: TBA To be announced April 24, 2020 Dr. Ji-Hyun Ko May 29, 2020 Assistant Professor, Department of Human Anatomy & Cell Science, University of Manitoba | Principal Investigator, Kleysen Institute for Advanced Medicine Title: TBA Our Sponsors: Health Sciences Centre | St. Boniface Hospital Research Centre | University of Manitoba Thank you, Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Sept 24 -St Boniface Hosp. Res Cohen auditorium - Chief Science Officer from the Alz Soc will speak at St Boniface
by membership＠manitobaneuroscience.ca 09 Sep '19

09 Sep '19

/sent on behalf of Benedict C. Albensi, PhD, BCMAS, CRQM Manitoba Dementia Research Chair Everyone is invited! Spotlight on Dementia Research: Whats Happening Now and its Impact on the Future <https://alzheimer.mb.ca/wp-content/uploads/2019/07/Spotlight-on-Research-Se pt-24-2019.pdf> Click here to view the poster. Keynote Speaker Dr. Saskia Sivananthan Chief Research & KTE Officer, Alzheimer Society of Canada Tuesday, September 24, 2019 7 8:30 pm Samuel N. Cohen Auditorium St. Boniface Hospital Research 351 Tache Avenue, Winnipeg, MB Around the world, researchers are taking significant strides to look for ways to prevent dementia, to improve the quality of life of those impacted and to ultimately find a cure. Come to hear Dr. Sivananthan, a neuroscientist, global policy leader and Chief Science Officer at the Alzheimer Society of Canada talk about the latest research, new findings and what it means for the future of dementia. Chair: Dr. Benedict C. Albensi, Manitoba Dementia Research Chair; Everett Endowment Fund Chair, St. Boniface Hospital Research Centre Limited seating! Three easy ways to register! 1. Email alzmb(a)alzheimer.mb.ca <mailto:alzmb@alzheimer.mb.ca> 2. Call 204-943-6622 or 1-800-378-6699 3. <https://secure2.convio.net/alzmb/site/Ecommerce;jsessionid=00000000.app216a ?store_id=1741&NONCE_TOKEN=02328DC99D5C253737865993A9786753> Click here to register online today! Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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2019/20 MNN Seminar Series
by networking＠manitobaneuroscience.ca 27 Aug '19

27 Aug '19

Dear colleagues, Hope you have had a good summer. I am reaching out to you to identify speakers for our 2019/2020 MNN seminar series. Please let me know at the earliest possible your top 3 dates suitable for a talk. The current slots open are on the following dates @ 9AM. September 27th October 25th February 28th March 27th April 24th May 29th Thank you, Tabrez Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> /sent on behalf of Tabrez Siddiqui Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Outreach opportunity - Sport Manitoba Peak Performance Seminars
by outreach＠manitobaneuroscience.ca 19 Jul '19

19 Jul '19

cid:image001.jpg@01D158FE.B69B8D00 Dear colleagues, The MNN has received an invitation from Sport Manitoba to participate in their Peak Performance seminar series. They are looking for a speaker to present on the topic of sleep and athletic performance, and this could extend into areas such as attention, cognition, and circadian rhythms. Details are provided below and as you can see, an honorarium is also provided. If you are interested, please contact me and I will pass your information on to Sport Manitoba. Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science University of Manitoba cid:image004.jpg@01D158FE.B69B8D00 From: Neal Prokop [mailto:Neal.Prokop@sportmanitoba.ca] Sent: Monday, July 15, 2019 11:55 AM To: outreach(a)manitobaneuroscience.ca Cc: Jeff Wood Subject: MNN Community Outreach, Sport Manitoba Peak Performance Seminars Hi Dr. Sari, Sport Manitoba Performance delivers a series of Peak Performance Seminars (P-Series) that take place monthly from October to March. The talks are targeted to high performance amateur athletes, coaches and/or parents to help with development and preparing athletes for competition. We're very interested in incorporating the topic of 'sleep' as one of our topics this year. Is there anyone within the MNN network that would be interested in speaking on the importance of sleep for athletes, sleep strategies for a good night sleep, sleep cycles, naps or other related topics. When researching speakers, we came across Dr. Marcus Ng, but there may be another speaker within the network that could be good fit. All presentations take place at Sport Manitoba's Conference Room (capacity 80), located at 145 Pacific Avenue, Winnipeg Manitoba. The series is also broadcasted via webstream so that athletes in rural regions of the province are able to obtain the information presented. The talks are 45-50-minutes including a 5-10 minute period for questions. All presenters are compensated $200 for their time and efforts! Look forward to hearing your response! Have a great day! Neal Prokop MSc CSCS PES | Sport Performance Specialist Sport Manitoba P: 204.925.5698 | neal.prokop(a)sportmanitoba.ca

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F new IMED neuroscience course
by Kelly Jorundson 10 Jul '19

10 Jul '19

Sent on Behalf of Drs. Soheila Karimi and Eftekhar Eftekharpour Dept. Physiology and Pathophysiology, Regenerative Medicine Program We are pleased to offer a new interdisciplinary medicine course titled: Neural Stem Cells: Biology and Regenerative Medicine Applications. This course (IMED7104) will discuss the current concepts in neural stem cells from basic neurobiology (development, fate specification and maintenance) to their potential clinical applications in treating a broad range of neurological disorders through activation of endogenous cell population, cellular reprograming, cell transplantation as well as gene and drug delivery. Neural stem cells play critical roles in the developing and adult nervous system and the course is developed to build the necessary knowledge for graduate students and residents within all disciplines in neurosciences. Course schedule: March 11-April 22, 2020 (1.5 credit hour). Please see the attached flyer and syllabus for more information. Please direct your questions to Soheila Karimi (Soheila.Karimi(a)umanitoba.ca) Please follow us on Twitter @KarimiLab Lab Site: http://home.cc.umanitoba.ca/~karimis/ Soheila Karimi, PhD Associate Professor of Physiology and Pathophysiology Principal Investigator, Neural Regeneration and Stem Cell Program Senior Scientist, Regenerative Medicine Program Principal Investigator, Spinal Cord Research Center Rady Faculty of Health Sciences Max Rady College of Medicine University of Manitoba Address: 745 Bannatyne Avenue, 629 BMSB Winnipeg, MB R3E 0J9 Canada Phone: (204) 272-3109

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Announcing MNN's new art-science collaboration!
by Sari Hannila 03 Jul '19

03 Jul '19

[cid:image001.jpg@01D158FE.B69B8D00] [cid:image005.jpg@01D52048.82783DB0] Hello everyone, Following the success of Neurocraft, many of you have asked if there would be more opportunities to connect with local artists, and today I am pleased to announce the launch of Dura Mater: Reflections on Neurofeminism, our new collaboration with Mentoring Artists for Women's Art (MAWA). MAWA was founded in 1983 and provides mentoring, networking, and professional development opportunities for women artists in Manitoba. Their members include such distinguished artists as Ione Thorkelsson, Diana Thorneycroft, and Shawna Dempsey. You can find out more about them at www.mawa.ca<http://www.mawa.ca> Are you interested in participating? Here are a few key points to consider. * This collaboration is open to all MNN faculty members. Depending on the response, students and postdocs may be considered as well. * There are six spots available. * The artists will submit their applications by September 18th and pairings will be finalized in the fall. Participating scientists will have the opportunity to view the artists' applications and identify potential partners. * The program will run from January-December, 2020. An exhibition of the finished pieces will be held at the Buhler Gallery at St. Boniface Hospital in March, 2020. * MAWA has a very strong educational mandate, and so, this program will be far more structured than Neurocraft. Participants will be required to meet with their partners for a minimum of two hours per month, and there will also be six group meetings that will be held every two months at MAWA's offices. These meetings are mandatory and will involve group discussions, lectures, and opportunities to share the work that has been produced. * Participating in this collaboration will therefore involve a 36 hour time commitment (minimum) over the course of the year and it will also require flexibility in your schedule to accommodate the individual and group meetings. * Is this only open to women? Certainly not! The program is open to all genders. The vast majority of the artists will be women, and they will likely be interested in exploring feminist themes in their work, but participants are free to pursue any avenue of inquiry. Collaborative works are also encouraged. The attached flyer was distributed to MAWA members earlier this month and it provides some additional information about the program. It promises to be a unique and engaging intellectual experience, so I hope you will consider taking part. If you are interested, please send me an email prior to September 18th, and if you have any questions, feel free to send those along as well. As always, thank you for your support of the MNN and our outreach program. Thank you also to everyone who attended the annual meeting, and the organizers, Dom and Renee, who did an outstanding job! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science University of Manitoba [cid:image005.jpg@01D52048.82783DB0] [cid:image004.jpg@01D158FE.B69B8D00]

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Dr. Ed Boyden here tomorrow!
by Chris Anderson 12 Jun '19

12 Jun '19

[cid:image001.jpg@01D158FE.B69B8D00] Did you know that... The 2019 GAIRDNER SYMPOSIUM is happening tomorrow? Thursday, JUNE 13, 2019 [https://umanitoba.ca/outreach/conferences/research_days/media/CSHRF_2019_Sy…] Speakers include Professor in Neurotechnology, DR. EDWARD BOYDEN [http://umanitoba.ca/outreach/conferences/research_days/media/Ed_Boyden_Phot…] Dr. Ed Boyden Massachusetts Institute of Technology (MIT) "Tools for Analyzing and Controlling Complex Biological Systems" BASIC MEDICAL SCIENCES BUILDING 9:15 AM (Introduced by Dr. Jillian Stobart) OTHER SPEAKERS * Dr. Richard Hynes - Massachusetts Institute of Technology "Extracellular Matrix Vulnerabilities in Cancer" (Introduced by Dr. Ian Dixon) * Dr. Lewis Kay - Hospital for Sick Children & University of Toronto "The Important Role of Dynamics in the Function and Misfunction of Molecular Machines" (Introduced by Dr. Ji Hyun Ko) * Dr. Nada Jabado - McGill University "The Peter Pan Syndrome: Stalled Development in Pediatric Brain Tumors" (Introduced by Dr. Tamra Ogilivie) * Dr. Antoine Hakim - Ottawa Hospital Research Institute "Bringing Science to Society: The Recent Story of Stroke Care in Canada" (Introduced by Dr. Tabrez Siddiqui) STRATION OPENS FOR THE COMPLETE PROGRAM: 2019 Gairdner Symposium Program<http://umanitoba.ca/outreach/conferences/research_days/media/CSHRF_2019_Sym…> INFORMATION ON THE SPEAKERS: 2019 Gairdner Symposium Speakers<http://umanitoba.ca/outreach/conferences/research_days/symposium.html> For more information: sforum(a)umanitoba.ca<mailto:sforum@umanitoba.ca> ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<https://nam02.safelinks.protection.outlook.com/?url=http%3A%2F%2Fwww.manito…> [cid:image007.png@01D29326.7E26D480]<https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.faceb…> [cid:image009.jpg@01D29326.7E26D480] <https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.insta…> [cid:image010.png@01D29326.7E26D480] <https://nam02.safelinks.protection.outlook.com/?url=https%3A%2F%2Ftwitter.c…>

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REMINDER: Tomorrow MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am
by Kelly Jorundson 30 May '19

30 May '19

[cid:image001.jpg@01D158FE.B69B8D00] S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, May 31, 2019 9:00 AM L O C AT I O N PX236/238 PsycHealth Blding S P E A K E R Tamra Ogilvie, Ph.D.<http://umanitoba.ca/medicine/units/biochem/faculty/t_werbowetski-ogilvie.ht…> Canada Research Chair in Neuro-oncology and Human Stem Cells Associate Professor, Regenerative Medicine Program Biochemistry & Medical Genetics and Physiology & Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Novel gene networks regulating self-renewal and differentiation in medulloblastoma A B S T R AC T OTX2 is a potent oncogenic driver of tumor growth and cell cycle progression in Group 3 medulloblastoma. However, the specific mechanisms by which OTX2 represses neural differentiation in these highly aggressive tumors are not well characterized. We have utilized ChIP-sequencing combined with extensive medulloblastoma patient transcriptome and proteomics data to identify and subsequently validate a novel OTX2 regulatory network that controls Group 3 medulloblastoma cell fate decisions. OTX2 directly restricts the expression of neuronal differentiation genes encoding transcription factors including the novel target genes PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 MB patients and is correlated with reduced survival. Similar to OTX2 silencing, PAX3 and PAX6 overexpression inhibit self-renewal and enhance neuronal differentiation in vitro while PAX3, on its own, increases survival in vivo. Finally, we identify mTORC1 and EPHB2 forward signaling as downstream effectors of OTX2-PAX3, thus highlighting axon guidance and protein synthesis pathways as novel therapeutic targets and key players in Group 3 medulloblastoma pathogenesis. O B J E C T I V E S * Understand the genetic, molecular and cellular heterogeneity associated with the pediatric brain tumor medulloblastoma * Understand the multifaceted role of OTX2 in medulloblastoma pathogenesis * Describe the functional outcome of increased PAX gene expression on medulloblastoma tumorigenic properties in vitro and in vivo For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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REMINDER: MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am
by Manitoba Neuroscience Network 27 May '19

27 May '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, May 31, 2019 9:00 AM L O C AT I O N PX236/238 PsycHealth Blding S P E A K E R Tamra Ogilvie, Ph.D. <http://umanitoba.ca/medicine/units/biochem/faculty/t_werbowetski-ogilvie.ht ml> Canada Research Chair in Neuro-oncology and Human Stem Cells Associate Professor, Regenerative Medicine Program Biochemistry & Medical Genetics and Physiology & Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Novel gene networks regulating self-renewal and differentiation in medulloblastoma A B S T R AC T OTX2 is a potent oncogenic driver of tumor growth and cell cycle progression in Group 3 medulloblastoma. However, the specific mechanisms by which OTX2 represses neural differentiation in these highly aggressive tumors are not well characterized. We have utilized ChIP-sequencing combined with extensive medulloblastoma patient transcriptome and proteomics data to identify and subsequently validate a novel OTX2 regulatory network that controls Group 3 medulloblastoma cell fate decisions. OTX2 directly restricts the expression of neuronal differentiation genes encoding transcription factors including the novel target genes PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 MB patients and is correlated with reduced survival. Similar to OTX2 silencing, PAX3 and PAX6 overexpression inhibit self-renewal and enhance neuronal differentiation in vitro while PAX3, on its own, increases survival in vivo. Finally, we identify mTORC1 and EPHB2 forward signaling as downstream effectors of OTX2-PAX3, thus highlighting axon guidance and protein synthesis pathways as novel therapeutic targets and key players in Group 3 medulloblastoma pathogenesis. O B J E C T I V E S * Understand the genetic, molecular and cellular heterogeneity associated with the pediatric brain tumor medulloblastoma * Understand the multifaceted role of OTX2 in medulloblastoma pathogenesis * Describe the functional outcome of increased PAX gene expression on medulloblastoma tumorigenic properties in vitro and in vivo For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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