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Reminder: Registration deadline - MNN 2019 meeting *TODAY
by Manitoba Neuroscience Network 17 May '19

17 May '19

cid:image001.jpg@01D158FE.B69B8D00 *TODAY IS YOUR LAST DAY TO REGISTER! The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: mnn2019(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar: - Tamra Ogilvie | Friday May 31 @ 9am
by Manitoba Neuroscience Network 17 May '19

17 May '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, May 31, 2019 9:00 AM L O C AT I O N PX236/238 PsycHealth Blding S P E A K E R Tamra Ogilvie, Ph.D. <http://umanitoba.ca/medicine/units/biochem/faculty/t_werbowetski-ogilvie.ht ml> Canada Research Chair in Neuro-oncology and Human Stem Cells Associate Professor, Regenerative Medicine Program Biochemistry & Medical Genetics and Physiology & Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Novel gene networks regulating self-renewal and differentiation in medulloblastoma A B S T R AC T OTX2 is a potent oncogenic driver of tumor growth and cell cycle progression in Group 3 medulloblastoma. However, the specific mechanisms by which OTX2 represses neural differentiation in these highly aggressive tumors are not well characterized. We have utilized ChIP-sequencing combined with extensive medulloblastoma patient transcriptome and proteomics data to identify and subsequently validate a novel OTX2 regulatory network that controls Group 3 medulloblastoma cell fate decisions. OTX2 directly restricts the expression of neuronal differentiation genes encoding transcription factors including the novel target genes PAX3 and PAX6. Expression of PAX3 and PAX6 is significantly lower in Group 3 MB patients and is correlated with reduced survival. Similar to OTX2 silencing, PAX3 and PAX6 overexpression inhibit self-renewal and enhance neuronal differentiation in vitro while PAX3, on its own, increases survival in vivo. Finally, we identify mTORC1 and EPHB2 forward signaling as downstream effectors of OTX2-PAX3, thus highlighting axon guidance and protein synthesis pathways as novel therapeutic targets and key players in Group 3 medulloblastoma pathogenesis. O B J E C T I V E S * Understand the genetic, molecular and cellular heterogeneity associated with the pediatric brain tumor medulloblastoma * Understand the multifaceted role of OTX2 in medulloblastoma pathogenesis * Describe the functional outcome of increased PAX gene expression on medulloblastoma tumorigenic properties in vitro and in vivo For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Scientific Meeting ONLY THREE DAYS LEFT - REGISTER NOW!
by Manitoba Neuroscience Network 14 May '19

14 May '19

cid:image001.jpg@01D158FE.B69B8D00 ONLY THREE DAYS LEFT - REGISTER NOW! So you dont miss out, we have extended the MNN meeting deadline to May 17. The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more The abstract and registration deadline is extended to MAY 17. Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Neuroscience lectureship and trainee travel awards DEADLINE EXTENDED TO MAY 20
by Manitoba Neuroscience Network 14 May '19

14 May '19

We are pleased to announce that the Manitoba Neuroscience Network will again be accepting applications for 2019/20 TRAVEL AWARDS FOR NEUROSCIENCE PROJECTS and the 2020 VIKTOR HAVLICEK MEMORIAL NEUROSCIENCE LECTURESHIP. TRAVEL AWARDS: A legacy fund created by the estate of Nancy Hettie Clark is used to enrich neuroscience training and support opportunities to network within the wider neuroscience community. Two travel awards of up to $700 each are intended to be awarded annually to a graduate student and a postdoctoral fellow at the University of Manitoba. The application deadline is MAY 20. The eligible travel period is between May 1, 2019 and April 30, 2020, BUT all eligible travel claims must be complete by March 31, 2020. Eligibility: Eligible trainees are either graduate students or postdoctoral fellows. Student candidates must be enrolled as full-time graduate (PhD or MSc) students in the Faculty of Graduate Studies, University of Manitoba, and have a cumulative graduate grade point average of 3.5 or greater (University of Manitoba scale). Postdoctoral fellow candidates must be within the first five years after awarding of their doctoral degree and have a full-time appointment at the University of Manitoba or an affiliated hospital or institute. Candidates must demonstrate excellent research performance and potential in a neurosciences-related discipline, and must demonstrate they will disseminate research results that reflect a high-quality contribution by The University of Manitoba. How to apply: A complete application package consists of the following: * Cover letter stating the following (1 page maximum): o Application category (student or postdoctoral fellow) and your start date in that position o The conference title, location and dates o Type of presentation (e.g. poster or oral) o The importance of the meeting and significance for career development o Any information that would allow reviewers to assess the significance or impact of the conference (e.g. abstracts are peer-reviewed) o Clearly state your graduate GPA (students only) * Graduate level academic transcript (students only) * Listing of scholarly output (publications and presentations) * Support letter from the primary research advisor with (a) a merit assessment of the candidate and project, and (b) confirmation that there is a commitment to cover all eligible travel expenses less the award value * Copy of the submitted abstract Submit all materials to <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca by MAY 15. The support letter may be appended or sent separately by the research advisor. LECTURESHIP: Viktor Havlicek, MD, PhD, DSc, was a Professor in the Department of Physiology (now Physiology and Pathophysiology) at the University of Manitoba from 1968 to 1981. The Viktor Havlicek Memorial fund was established through gifts to the University of Manitoba in his memory. This fund yields $3,000 once every two years to support a visit to the University of Manitoba by an internationally-renowned neuroscientist in a manner that encourages interactions with trainees. Applications are now being accepted until MAY 20, 2019 for a visit and lecture to take place between April 1, 2020 and March 31, 2021. Applications for the next Lectureship will be accepted in 2021 for 2022/2023 fiscal year. Nominations must be made by a faculty member but trainees and staff are encouraged to suggest names to their advisors. Faculty from any MNN contributing institution (ie. not only the University of Manitoba) may submit nominations. A complete nomination consists of a letter to the Neuroscience Awards Committee (NAC) Chair explaining the rationale for choice of candidate (1 page maximum), along with any supporting materials the applicant deems useful for assessing the merit of the candidate and the benefits of his or her visit to the University of Manitoba. Please send nominations by email to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> by May 20. The NAC will determine an order of invitation priority for submitted nominees and the top-priority candidate invited at a time determined in consultation with the nominator. If this candidate is not available, the next candidate will be invited. All candidates on the priority list must be considered worthy of the Lectureship by the NAC. We hope you find these opportunities helpful and exciting. If there are any questions, you may respond to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> . Thank you. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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FW: Reminder: MNN Visiting Speaker - Dr. David Amaral TODAY
by Kelly Jorundson 07 May '19

07 May '19

Subject: Reminder: MNN Visiting Speaker - Dr. David Amaral TODAY [cid:image001.jpg@01D158FE.B69B8D00] U N I V E R S I T Y O F M A N I T O B A ' S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus (FOLLOWED BY A TRAINEE LUNCH IN SR415) S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN 2019 Scientific Meeting \ DEADLINE EXTENDED TO MAY 17
by Manitoba Neuroscience Network 06 May '19

06 May '19

cid:image001.jpg@01D158FE.B69B8D00 REGISTER NOW! So you dont miss out, we have extended the MNN meeting deadline to May 17. The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: <https://manitobaneuroscience.ca/annual-meeting/2019mnn/> https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca Highlights Three visiting national speakers Taco bar lunch (Om nom nom!) Poster competition Stellas goodies at coffee breaks SWAG bags and vendor tables WAG Networking mixer after-party Neuroscience art silent auction And more The abstract and registration deadline is extended to MAY 17. Registration takes 5 minutes or less! NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: mnn2019(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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*updated*: Reminder: MNN Visiting Speaker - Dr. David Amaral May 6/7
by Kelly Jorundson 03 May '19

03 May '19

[cid:image001.jpg@01D158FE.B69B8D00] **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A ' S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Reminder: MNN Visiting Speaker - Dr. David Amaral May 6/7
by Manitoba Neuroscience Network 03 May '19

03 May '19

cid:image001.jpg@01D158FE.B69B8D00 **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: MNN Lecture: Idan Menashe, Ben-Gurion Univ Mon, Apr 29 @ 10am
by Kelly Jorundson 29 Apr '19

29 Apr '19

[cid:image001.jpg@01D158FE.B69B8D00] M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, April 29, 2019 10am L O C A T I O N Theatre C, BMSB Bannatyne Campus S P E A K E R Idan Menashe, PhD School of Public Health, Faculty of Health Sciences, Negev Autism Center Ben-Gurion University T O P I C Deciphering the etiological puzzle of autism spectrum disorder (ASD) – results from the Negev Autism Center O B J E C T I V E S 1. Introduce the current challenges in ASD research 2. Discuss the activities and research findings of the Negev Autism Center A B S T R A C T Autism spectrum disorder (ASD) is a remarkably heterogeneous condition with multiple genetic and non-genetic causes leading to a wide variety of phenotypic outcomes. Elucidating the heterogeneous etiological puzzle of autism requires comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established the Negev Autism Center (NAC), which comprises clinicians from Soroka University Medical Center (SUMC) and scientists from Ben-Gurion University (BGU). In this initiative, we collect comprehensive behavioral, clinical, neurological and biological data on all children who are referred to SUMC with a suspicion of autism. Moreover, children with a positive diagnosis of autism are invited to the SUMC clinics for follow-up visits every 6 to 12 months until the age six. During these visits, their diagnosis is re-evaluated and families are invited to participate in additional ongoing experiments. The wide variety of data collected from each child with ASD and his family, enable us to synthesize findings across different clinical and biological disciplines in order to “connect the dots” between specific risk factors through associated brain abnormalities to precise behavioral and cognitive phenotypes in various subtypes of autism. Such an understanding of ASD is essential for translating the science into personalized treatments for the disorder. In this seminar, I will introduce the current challenges in ASD research and discuss recent research findings from the NAC. Specifically, I will introduce new approaches for digital phenotyping of children with ASD that can accelerate both research and diagnosis of ASD. In addition, I will present new insights regarding the genetics of ASD as well as potential environmental risk factors of the disorder. Finally, I will talk about the future goals of the NAC. B I O S K E T C H: Dr. Menashe, earned his PhD in Human Genetics and Bioinformatics from the Weizmann Institute of Science, Israel in 2007. He then completed four years of post-doctoral fellowship in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, USA and one year as a senior scientist at MindSpec, a nonprofit organization that utilizes innovative bioinformatics strategies to accelerate research on common neurodevelopmental disorders. In 2012, Dr. Menashe joined the Faculty of Health Sciences and the Zlotowski center for neuroscience at the Ben-Gurion University (BGU), Beer-Sheva, Israel as an assistant professor. At BGU Dr. Menashe is the head of the genetic epidemiology team at the school of public health. In addition, Dr. Menashe is a co-founder of the Negev Autism Center (www.negevautism.org<http://www.negevautism.org>), which is the leading autism research center in Israel. At the Negev Autism Center, Dr. Menashe and his colleagues collect and analyze comprehensive clinical, behavioral and biological data from hundreds of children with autism with the goal to elucidate the etiology of autism and its variable phenotypic manifestations. For more information, please visit: www.idanmen.com<file:///C:/Users/kjorund/AppData/Local/Microsoft/Windows/Temporary%20Intern…> For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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CANCELLED - MNN Seminar Scheduled for Friday May 26 @ 9am
by Manitoba Neuroscience Network 25 Apr '19

25 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 Just a reminder that there is no MNN seminar tomorrow morning. Regards, Kelly Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Nick Shepel Neuroscience Trainee Travel Award
by Manitoba Neuroscience Network 25 Apr '19

25 Apr '19

Nick Shepel Neuroscience Trainee Travel Award Application deadline: Friday, May 31, 2019 Background: The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his laboratory partners and brought fire, humor, and a desire to always excel. His insistence to always try better has had a permanent effect on his lab mates and peers. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator(s) (specifically in the neuroscience area) by providing an annual award(s) to support travel costs associated with the applicants attendance at an upcoming national/international conference where the applicant is presenting a poster or oral presentation. This year, the value of the award may range from $600 to $1000. Eligibility: At the time of application the following conditions are required: · Students must be registered as a full-time graduate student in the College of Medicine at the University of Manitoba. · The area of research being presented at the conference must relate to the field of neuroscience. · A student admitted under the Provisional Status may not receive the award during the provisional period. · Amount of award(s) may vary each year. · Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international). · Students who have received this award previously should not apply. Submission Instructions: A complete application consists of the following information *If your application is not complete, it will not be considered: · Introductory letter describing meeting, location and date · Copy of abstract · Curriculum vitae · Current GPA, transcripts not needed · Proposed budget of travel costs · Submit your completed application materials to: Paul Fernyhough Director Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 351 Tache Avenue Winnipeg, MB R2H 2A6 Email: pfernyhough(a)sbrc.ca How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Request for reimbursement must be done within 2 weeks following travel otherwise eligibility may be voided. (contact: Kelly Jorundson kjorund(a)sbrc.ca) Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: MNN Lecture: Idan Menashe, Ben-Gurion Univ Mon, Apr 29 @ 10am
by Manitoba Neuroscience Network 24 Apr '19

24 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, April 29, 2019 10am L O C A T I O N Theatre C, BMSB Bannatyne Campus S P E A K E R Idan Menashe, PhD School of Public Health, Faculty of Health Sciences, Negev Autism Center Ben-Gurion University T O P I C Deciphering the etiological puzzle of autism spectrum disorder (ASD) results from the Negev Autism Center O B J E C T I V E S 1. Introduce the current challenges in ASD research 2. Discuss the activities and research findings of the Negev Autism Center A B S T R A C T Autism spectrum disorder (ASD) is a remarkably heterogeneous condition with multiple genetic and non-genetic causes leading to a wide variety of phenotypic outcomes. Elucidating the heterogeneous etiological puzzle of autism requires comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established the Negev Autism Center (NAC), which comprises clinicians from Soroka University Medical Center (SUMC) and scientists from Ben-Gurion University (BGU). In this initiative, we collect comprehensive behavioral, clinical, neurological and biological data on all children who are referred to SUMC with a suspicion of autism. Moreover, children with a positive diagnosis of autism are invited to the SUMC clinics for follow-up visits every 6 to 12 months until the age six. During these visits, their diagnosis is re-evaluated and families are invited to participate in additional ongoing experiments. The wide variety of data collected from each child with ASD and his family, enable us to synthesize findings across different clinical and biological disciplines in order to connect the dots between specific risk factors through associated brain abnormalities to precise behavioral and cognitive phenotypes in various subtypes of autism. Such an understanding of ASD is essential for translating the science into personalized treatments for the disorder. In this seminar, I will introduce the current challenges in ASD research and discuss recent research findings from the NAC. Specifically, I will introduce new approaches for digital phenotyping of children with ASD that can accelerate both research and diagnosis of ASD. In addition, I will present new insights regarding the genetics of ASD as well as potential environmental risk factors of the disorder. Finally, I will talk about the future goals of the NAC. B I O S K E T C H: Dr. Menashe, earned his PhD in Human Genetics and Bioinformatics from the Weizmann Institute of Science, Israel in 2007. He then completed four years of post-doctoral fellowship in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, USA and one year as a senior scientist at MindSpec, a nonprofit organization that utilizes innovative bioinformatics strategies to accelerate research on common neurodevelopmental disorders. In 2012, Dr. Menashe joined the Faculty of Health Sciences and the Zlotowski center for neuroscience at the Ben-Gurion University (BGU), Beer-Sheva, Israel as an assistant professor. At BGU Dr. Menashe is the head of the genetic epidemiology team at the school of public health. In addition, Dr. Menashe is a co-founder of the Negev Autism Center (www.negevautism.org), which is the leading autism research center in Israel. At the Negev Autism Center, Dr. Menashe and his colleagues collect and analyze comprehensive clinical, behavioral and biological data from hundreds of children with autism with the goal to elucidate the etiology of autism and its variable phenotypic manifestations. For more information, please visit: www.idanmen.com <file:///C:\Users\kjorund\AppData\Local\Microsoft\Windows\Temporary%20Intern et%20Files\Content.Outlook\US4Z0TRO\www.idanmen.com> For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker - Dr. David Amaral
by Manitoba Neuroscience Network 23 Apr '19

23 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Travel Awards for University of Manitoba Neuroscience Trainees - DEADLINE MAY 15
by Manitoba Neuroscience Network 22 Apr '19

22 Apr '19

We are pleased to announce that the Manitoba Neuroscience Network will again be accepting applications for 2019/20 TRAVEL AWARDS FOR NEUROSCIENCE PROJECTS A legacy fund created by the estate of Nancy Hettie Clark is used to enrich neuroscience training and support opportunities to network within the wider neuroscience community. Two travel awards of up to $700 each are intended to be awarded annually to a graduate student and a postdoctoral fellow at the University of Manitoba. The application deadline is MAY 15. The eligible travel period is between May 1, 2019 and April 30, 2020, BUT all eligible travel claims must be complete by March 31, 2020. Eligibility: Eligible trainees are either graduate students or postdoctoral fellows. Student candidates must be enrolled as full-time graduate (PhD or MSc) students in the Faculty of Graduate Studies, University of Manitoba, and have a cumulative graduate grade point average of 3.5 or greater (University of Manitoba scale). Postdoctoral fellow candidates must be within the first five years after awarding of their doctoral degree and have a full-time appointment at the University of Manitoba or an affiliated hospital or institute. Candidates must demonstrate excellent research performance and potential in a neurosciences-related discipline, and must demonstrate they will disseminate research results that reflect a high-quality contribution by The University of Manitoba. How to apply: A complete application package consists of the following: * Cover letter stating the following (1 page maximum): o Application category (student or postdoctoral fellow) and your start date in that position o The conference title, location and dates o Type of presentation (e.g. poster or oral) o The importance of the meeting and significance for career development o Any information that would allow reviewers to assess the significance or impact of the conference (e.g. abstracts are peer-reviewed) o Clearly state your graduate GPA (students only) * Graduate level academic transcript (students only) * Listing of scholarly output (publications and presentations) * Support letter from the primary research advisor with (a) a merit assessment of the candidate and project, and (b) confirmation that there is a commitment to cover all eligible travel expenses less the award value * Copy of the submitted abstract Submit all materials to <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca by MAY 15. The support letter may be appended or sent separately by the research advisor. Good luck! ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Neuroscience Lectureship Award - $3,000
by Manitoba Neuroscience Network 22 Apr '19

22 Apr '19

The MNN is pleased to announce that we are accepting applications for the 2020 VIKTOR HAVLICEK MEMORIAL NEUROSCIENCE LECTURESHIP. Viktor Havlicek, MD, PhD, DSc, was a Professor in the Department of Physiology (now Physiology and Pathophysiology) at the University of Manitoba from 1968 to 1981. The Viktor Havlicek Memorial fund was established through gifts to the University of Manitoba in his memory. This fund yields $3,000 once every two years to support a visit to the University of Manitoba by an internationally-renowned neuroscientist in a manner that encourages interactions with trainees. Applications are now being accepted until MAY 15, 2019 for a visit and lecture to take place between April 1, 2020 and March 31, 2021. Applications for the next Lectureship will be accepted in 2021 for 2022/2023 fiscal year. Nominations must be made by a faculty member but trainees and staff are encouraged to suggest names to their advisors. Faculty from any MNN contributing institution (ie. not only the University of Manitoba) may submit nominations. A complete nomination consists of a letter to the Neuroscience Awards Committee (NAC) Chair explaining the rationale for choice of candidate (1 page maximum), along with any supporting materials the applicant deems useful for assessing the merit of the candidate and the benefits of his or her visit to the University of Manitoba. Please send nominations by email to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> by May 15. The NAC will determine an order of invitation priority for submitted nominees and the top-priority candidate invited at a time determined in consultation with the nominator. If this candidate is not available, the next candidate will be invited. All candidates on the priority list must be considered worthy of the Lectureship by the NAC. We hope you find this opportunity helpful and exciting. If there are any questions, you may respond to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> . Thank you. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Nick Shepel Neuroscience Trainee Travel Award Available
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Paul Fernyhough Nick Shepel Neuroscience Trainee Travel Award Application deadline: Friday, May 31, 2019 Background: The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his laboratory partners and brought fire, humor, and a desire to always excel. His insistence to always try better has had a permanent effect on his lab mates and peers. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator(s) (specifically in the neuroscience area) by providing an annual award(s) to support travel costs associated with the applicants attendance at an upcoming national/international conference where the applicant is presenting a poster or oral presentation. This year, the value of the award may range from $600 to $1000. Eligibility: At the time of application the following conditions are required: · Students must be registered as a full-time graduate student in the College of Medicine at the University of Manitoba. · The area of research being presented at the conference must relate to the field of neuroscience. · A student admitted under the Provisional Status may not receive the award during the provisional period. · Amount of award(s) may vary each year. · Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international). · Students who have received this award previously should not apply. Submission Instructions: A complete application consists of the following information *If your application is not complete, it will not be considered: · Introductory letter describing meeting, location and date · Copy of abstract · Curriculum vitae · Current GPA, transcripts not needed · Proposed budget of travel costs · Submit your completed application materials to: Paul Fernyhough Director Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 351 Tache Avenue Winnipeg, MB R2H 2A6 How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Request for reimbursement must be done within 2 weeks following travel otherwise eligibility may be voided. (contact: Kelly Jorundson kjorund(a)sbrc.ca) Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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2019 MNN Scientific Meeting - Registration now OPEN
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca The abstract and registration deadline is MAY 10. NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: info(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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**Cancelled** MNN Seminar - Dr. Geoff Hicks Apr 26 @ 9am
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Lecture: Idan Menashe, Ben-Gurion Univ Mon, Apr 29 @ 10am
by Manitoba Neuroscience Network 03 Apr '19

03 Apr '19

Mark your calendars! cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, April 29, 2019 10am L O C A T I O N Theatre C, BMSB Bannatyne Campus S P E A K E R Idan Menashe, PhD School of Public Health, Faculty of Health Sciences, Negev Autism Center Ben-Gurion University T O P I C Deciphering the etiological puzzle of autism spectrum disorder (ASD) results from the Negev Autism Center O B J E C T I V E S 1. Introduce the current challenges in ASD research 2. Discuss the activities and research findings of the Negev Autism Center A B S T R A C T Autism spectrum disorder (ASD) is a remarkably heterogeneous condition with multiple genetic and non-genetic causes leading to a wide variety of phenotypic outcomes. Elucidating the heterogeneous etiological puzzle of autism requires comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established the Negev Autism Center (NAC), which comprises clinicians from Soroka University Medical Center (SUMC) and scientists from Ben-Gurion University (BGU). In this initiative, we collect comprehensive behavioral, clinical, neurological and biological data on all children who are referred to SUMC with a suspicion of autism. Moreover, children with a positive diagnosis of autism are invited to the SUMC clinics for follow-up visits every 6 to 12 months until the age six. During these visits, their diagnosis is re-evaluated and families are invited to participate in additional ongoing experiments. The wide variety of data collected from each child with ASD and his family, enable us to synthesize findings across different clinical and biological disciplines in order to connect the dots between specific risk factors through associated brain abnormalities to precise behavioral and cognitive phenotypes in various subtypes of autism. Such an understanding of ASD is essential for translating the science into personalized treatments for the disorder. In this seminar, I will introduce the current challenges in ASD research and discuss recent research findings from the NAC. Specifically, I will introduce new approaches for digital phenotyping of children with ASD that can accelerate both research and diagnosis of ASD. In addition, I will present new insights regarding the genetics of ASD as well as potential environmental risk factors of the disorder. Finally, I will talk about the future goals of the NAC. B I O S K E T C H: Dr. Menashe, earned his PhD in Human Genetics and Bioinformatics from the Weizmann Institute of Science, Israel in 2007. He then completed four years of post-doctoral fellowship in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, USA and one year as a senior scientist at MindSpec, a nonprofit organization that utilizes innovative bioinformatics strategies to accelerate research on common neurodevelopmental disorders. In 2012, Dr. Menashe joined the Faculty of Health Sciences and the Zlotowski center for neuroscience at the Ben-Gurion University (BGU), Beer-Sheva, Israel as an assistant professor. At BGU Dr. Menashe is the head of the genetic epidemiology team at the school of public health. In addition, Dr. Menashe is a co-founder of the Negev Autism Center (www.negevautism.org), which is the leading autism research center in Israel. At the Negev Autism Center, Dr. Menashe and his colleagues collect and analyze comprehensive clinical, behavioral and biological data from hundreds of children with autism with the goal to elucidate the etiology of autism and its variable phenotypic manifestations. For more information, please visit: www.idanmen.com <file:///C:\Users\kjorund\AppData\Local\Microsoft\Windows\Temporary%20Intern et%20Files\Content.Outlook\US4Z0TRO\www.idanmen.com> For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: MNN Seminar Series: Dr. Spencer Gibson | Fri., Mar 29 @ 9am
by Manitoba Neuroscience Network 26 Mar '19

26 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, March 29, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Spencer Gibson, PhD Professor, Department of Immunology & Biochemistry and Medical Genetics Director, Manitoba Institute of Cell Biology Senior Scientist, Research Institute in Oncology and Hematology Director, Translational Research University of Manitoba T O P I C Understanding the regulation of cell death in glioblastoma. Context Matters? O B J E C T I V E S · Context (location, microenvironment, and time) matters in cell death · Understand different forms of cell death · Role this plays in glioblastoma treatment. A B S T R A C T Cells undergo different forms of cell death depending on the context. In cancer including glioblastoma (GBM), the context depends upon location, microenvironment and time. This will determine whether a cancer cell dies or survives. The context is dynamic and changes over time leading to drug resistance in cancer. The location of cell death regulatory gene changes their function, we found that a BH3 only Bcl-2 family member BNIP3 switch from pro-cell death to pro-survival depending on subcellular localization. The microenvironment also changes where hypoxic regions develop and drive GBM drug resistance and growth factor signaling that changes cell survival. Finally time changes cell death responses where different types of cell death could occur at different times. We found that ferroptosis (iron dependent cell death)is induced at early times during hypoxia but switches to autophagy (self-eating) during late times. Thus, understanding this balance between cell death and survival will allow more rationale therapeutic strategies to be develop and hopefully prevent drug resistance in GBM. B I O S K E T C H: Dr. Gibson graduate the University of Toronto where he gained his Ph.D. in the Department of Laboratory Medicine and Pathobiology. During his Ph.D. studies, he traveled to M.D. Anderson Cancer Center in Houston, Texas as a pre-doctoral fellow where he completed his Ph.D. studies. Dr. Gibson was a post-doctoral fellow at the National Jewish Medical and Research Center in Denver, Colorado. Dr. Spencer B. Gibson is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba and is a Senior Investigator at the Research Institute of Oncology and Hematology (formally the Manitoba Institute of Cell Biology, MICB) since 1999. In 2008, the Manitoba Health Research Council awarded Dr. Gibson a Manitoba Research Chair to support his research efforts. At the Research Insitute, Dr. Gibson is Director of Translational Research where he contributed to the creation of the expansion of the Manitoba Tumor Bank and initiated new translational research projects. He is also appointed as Director, MICB from 2012-2014, to provide leadership for cancer research with the province of Manitoba and is currently Section Head, Cell Biology for the Research Institute at CancerCare Manitoba. Dr. Gibson has 130 peer-reviewed publication with an h-index of 49. The focus of his research is to define the signal transduction pathways leading to cell death or survival in cancer including leukemia. This will elucidate targets that could tip balance in favour of cell death and will be the foundation to establish clinical trials using molecular targeted therapies to increase effectiveness of chemotherapy in cancer. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar Series: Dr. Spencer Gibson | Fri., Mar 29 @ 9am
by Manitoba Neuroscience Network 22 Mar '19

22 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, March 29, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Spencer Gibson, PhD Professor, Department of Immunology & Biochemistry and Medical Genetics Director, Manitoba Institute of Cell Biology Senior Scientist, Research Institute in Oncology and Hematology Director, Translational Research University of Manitoba T O P I C Understanding the regulation of cell death in glioblastoma. Context Matters? O B J E C T I V E S · Context (location, microenvironment, and time) matters in cell death · Understand different forms of cell death · Role this plays in glioblastoma treatment. A B S T R A C T Cells undergo different forms of cell death depending on the context. In cancer including glioblastoma (GBM), the context depends upon location, microenvironment and time. This will determine whether a cancer cell dies or survives. The context is dynamic and changes over time leading to drug resistance in cancer. The location of cell death regulatory gene changes their function, we found that a BH3 only Bcl-2 family member BNIP3 switch from pro-cell death to pro-survival depending on subcellular localization. The microenvironment also changes where hypoxic regions develop and drive GBM drug resistance and growth factor signaling that changes cell survival. Finally time changes cell death responses where different types of cell death could occur at different times. We found that ferroptosis (iron dependent cell death)is induced at early times during hypoxia but switches to autophagy (self-eating) during late times. Thus, understanding this balance between cell death and survival will allow more rationale therapeutic strategies to be develop and hopefully prevent drug resistance in GBM. B I O S K E T C H: Dr. Gibson graduate the University of Toronto where he gained his Ph.D. in the Department of Laboratory Medicine and Pathobiology. During his Ph.D. studies, he traveled to M.D. Anderson Cancer Center in Houston, Texas as a pre-doctoral fellow where he completed his Ph.D. studies. Dr. Gibson was a post-doctoral fellow at the National Jewish Medical and Research Center in Denver, Colorado. Dr. Spencer B. Gibson is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba and is a Senior Investigator at the Research Institute of Oncology and Hematology (formally the Manitoba Institute of Cell Biology, MICB) since 1999. In 2008, the Manitoba Health Research Council awarded Dr. Gibson a Manitoba Research Chair to support his research efforts. At the Research Insitute, Dr. Gibson is Director of Translational Research where he contributed to the creation of the expansion of the Manitoba Tumor Bank and initiated new translational research projects. He is also appointed as Director, MICB from 2012-2014, to provide leadership for cancer research with the province of Manitoba and is currently Section Head, Cell Biology for the Research Institute at CancerCare Manitoba. Dr. Gibson has 130 peer-reviewed publication with an h-index of 49. The focus of his research is to define the signal transduction pathways leading to cell death or survival in cancer including leukemia. This will elucidate targets that could tip balance in favour of cell death and will be the foundation to establish clinical trials using molecular targeted therapies to increase effectiveness of chemotherapy in cancer. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Graduate student positions available at UofManitoba
by Manitoba Neuroscience Network 19 Mar '19

19 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Benjamin W. Lindsey, PhD I have two graduate student positions open for Fall 2019 in my lab in the Department of Human Anatomy & Cell Science. Please post/circulate the attached. Thank you kindly, Ben Benjamin W. Lindsey, PhD Laboratory of Neural Stem Cell Plasticity & Regeneration Department of Human Anatomy and Cell Science Benjamin.Lindsey(a)umanitoba.ca Office Phone: 204-789-3781 Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN 9th Scientific Meeting - Save the Date!
by Manitoba Neuroscience Network 15 Mar '19

15 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 JUNE 7th, 2019 Manitoba Neuroscience Network 9th SCIENTIFIC MEETING UNIVERSITY OF WINNIPEG Convocation Hall & Leatherdale Hall PROGRAM THEMES · Genetics of neurodevelopment · Emotional/cognitive neuroscience · Neuro-oncology · Historical perspectives on neuropathology · Focus on ALS R STRATION OPENS PROGRAM HIGHLIGHTS · Refreshment & exercise breaks · Taco bar lunch · Poster session · Exhibitor tables · Breakout sessions · WAG networking mixer & neuroscience art silent auction KEYNOTE SPEAKERS Dr. Daniel Goldowitz University of British Columbia Dr. Janice Robertson University of Toronto *REGISTRATION OPENS APRIL 1 , 2019 www.manitobaneuroscience.ca CHAIRS Dr. Domenico Di Curzio University of Winnipeg Dr. Renée Douville University of Winnipeg For more information: mnn2019(a)manitobaneuroscience.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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CAN elections
by Manitoba Neuroscience Network 14 Mar '19

14 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tabrez Siddiqui Could you please forward to all Neuroscience faculty. From: "Alyson Fournier, Dr." <alyson.fournier(a)mcgill.ca> Subject: CAN elections Dear Tabrez, CAN has recently opened its call for nominations for the Spring election. Openings are available for vice president, secretary and 2 board members. It is important for CAN to have great cross-Canada representation and diversity on the executive so please bring this to the attention of any faculty at your institute who may be interested. Thanks for your time, Sincerely, Alyson Secretary - CAN https://can-acn.org/call-for-nominations-spring-2019-elections Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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****CANCELLED**** MNN Speaker | Alyson Fournier Mar 20th
by Kelly Jorundson 12 Mar '19

12 Mar '19

-----CANCELLED----- [cid:image001.jpg@01D158FE.B69B8D00] S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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John P. Zubek Memorial Lecture Series | Matthew Hill
by Manitoba Neuroscience Network 11 Mar '19

11 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tammy Ivanco Department of Psychology Colloquium JOHN P. ZUBEK MEMORIAL LECTURE Friday, March 15, 2019, 3:00 p.m., P412 Duff Roblin Refreshments served at 2:30 p.m., P408 Duff Roblin Wine & Cheese to follow talk Dr. Matthew Hill, PhD Department of Psychiatry, University of Calgary; Hotchkiss Brain Institute; The Mathison Centre for Mental Health research & Education Endocannabinoids: Multi-modal regulators of the stress response For more information: Dr. T.L. Ivanco, Associate Professor Department Of Psychology University of Manitoba 204-474-7375 Tammy.ivanco(a)umanitoba.ca Kelly Jorundson Administrative Manager, Division of Neurodegenerative Disorders St. Boniface Hospital Research & Department of Pharmacology & Therapeutics University of Manitoba Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca or <mailto:Kelly.jorundson@umanitoba.ca> kjorundson(a)sbgh.mb.ca Tel: 204.235.3939 Fax: 204.237.4092 cid:image001.jpg@01D2883E.86D93F20

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Reminder....MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm
by Kelly Jorundson 11 Mar '19

11 Mar '19

[cid:image001.jpg@01D158FE.B69B8D00] M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm
by Manitoba Neuroscience Network 07 Mar '19

07 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal Club - March 13 10 AM at Ft Garry EITC - please post and/or distribute
by Kelly Jorundson 07 Mar '19

07 Mar '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Ben Albensi Come to our journal club on March 13th. Info below. Paper can be found at our Dementia Research website: http://dementiamanitoba.wixsite.com/m.../dementia-journal-club<http://dementiamanitoba.wixsite.com/mysite/dementia-journal-club?fbclid=IwA…> [cid:image003.jpg@01D4D4D1.722F1A90] Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker | Dr.Alyson Fournier Mar 20 @ 12noon Theatre B
by Manitoba Neuroscience Network 28 Feb '19

28 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University T O P I C Small Molecule Stabilization of protein interactions to promote axon regeneration Objectives: - Define 14-3-3- adaptor proteins and small molecules targeting these proteins - Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model - Discuss the mechanism used by these small molecules to promote axon regeneration Abstract: Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Brief Bio: Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fournier's group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series

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FW: Dementia Manitoba website - request for updates
by Manitoba Neuroscience Network 14 Feb '19

14 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Hi All Our Dementia Manitoba website is currently being updated. If you have any new studies or reviews on Alzheimer's and/or dementia and would like to have your lab recognized then please send me your information for posting. Or just check out what's new and upcoming. Thanks, http://dementiamanitoba.wixsite.com/mysite/research-blog Dr George Perry visits the TMS and EVestG labs in Winnipeg. Benedict C. Albensi, PhD Dementia Research Chair University of Manitoba & St Boniface Hospital Research 204-235-3942

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MNN Visiting Speaker - Dr. Alyson Fournier | Wed Mar 20 @ 12 noon
by Manitoba Neuroscience Network 07 Feb '19

07 Feb '19

Please mark your calendar cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, Mar 20, 2019 12 noon L O C A T I O N: Theatre B Bannatyne Campus fourniersmall.jpgS P E A K E R Dr. Alyson Fournier <https://www.mcgill.ca/neuro/research/researchers/fournier> Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein Interactions to promote axon regeneration Abstract Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Objectives * Define 14-3-3- adaptor proteins and small molecules targeting these proteins * Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model * Discuss the mechanism used by these small molecules to promote axon regeneration Short Bio Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Video link to Dr Perry's talk
by Manitoba Neuroscience Network 07 Feb '19

07 Feb '19

/sent on behalf of Ben Albensi cid:image001.jpg@01D158FE.B69B8D00 All We were able to record Dr. Perry's talk held on Monday Feb 4th, 2019. Here is the link for those interested. http://media1.cc.umanitoba.ca/legacy/bann/eos/eos_2019_02_04.mp4 Regards, Ben D A T E: Monday, Feb 4, 2019 12:00 Noon L O C A T I O N: Theatre A Bannatyne Campus **followed by a trainee lunch in 207 A&B Chown Bldg. S P E A K E R: Image result for dr george perryGeorge Perry PhD Professor of Biology and Chemistry Chief Scientist, Brain Health Consortium Semmes Foundation Distinguished University Chair in Neurobiology The University of Texas at San Antonio T O P I C: Mitochondria At The Center Of Alzheimer's Disease Dr. Perry's studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer's disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimer's disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals.

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SCRC Journal Club Feb.8 - Nagakannan Pandian
by Manitoba Neuroscience Network 07 Feb '19

07 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Mona Nazzal and Katinka Stecina Subject: SCRC Journal Club Feb.8 - Nagakannan Pandian Hello all, For this Friday's Journal club we will have a presentation by Nagakannan Pandian, a PhD student from the Eftekharpour lab. He will be presenting a talk entitled "Ferroptosis in Neuronal Cell Death" See you all on Friday! 11am to noon room 405 of Brodie Centre ----------------------------------------------------------------------- Mona Nazzal PhD Student Spinal Cord Research Centre Department of Physiology and Pathophysiology University of Manitoba 425 BMSB-745 Bannatyne Ave Winnipeg, MB R3E 0J9

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Edge of Science & Medicine Visiting Speaker Series - Dr. George Perry Feb 4/2019
by Manitoba Neuroscience Network 03 Feb '19

03 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Ben Albensi Everyone is invited! D A T E: Monday, Feb 4, 2019 12:00 Noon L O C A T I O N: Theatre A Bannatyne Campus **followed by a trainee lunch in 207 A&B Chown Bldg. S P E A K E R: Image result for dr george perryGeorge Perry PhD Professor of Biology and Chemistry Chief Scientist, Brain Health Consortium Semmes Foundation Distinguished University Chair in Neurobiology The University of Texas at San Antonio T O P I C: Mitochondria At The Center Of Alzheimers Disease Dr. Perrys studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimers disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimers disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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**REVISED***Special Lecture - John Wallace Feb 1 @ 9am
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Mary Fry All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information. Special Cross-Disciplinary Seminar hosted by Department of Biological Sciences Date: Friday, Feb 1st, 2019 Time: 9:00am Location: Room 207 Buller BLDG Speaker: John L. Wallace Professor of Physiology & Pharmacology University of Calgary Topic: A gas from the Past: Adventures in Drug Discovery". Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Seminar - Feb 22 - Stephanie Booth ***CANCELLED**
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] Please note that the MNN seminar scheduled for February 22nd, 2019 has been cancelled. Apologies for any inconvenience. /sent on behalf of Tabrez Siddiqui Chair, Seminar Series Manitoba Neuroscience Network Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Special Lecture - John Wallace Feb 1 @ 9am
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Mary Fry All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information. Special Cross-Disciplinary Seminar hosted by Department of Biological Sciences Date: Friday, Feb 1st, 2019 Time: 9:00am Location: Room 207 JBRC Speaker: John L. Wallace Professor of Physiology & Pharmacology University of Calgary Topic: A gas from the Past: Adventures in Drug Discovery". Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Reminder: MNN Seminar Series - Dr. Saeid Ghavami Fri Jan 25th @9am
by Manitoba Neuroscience Network 21 Jan '19

21 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, January 25th, 2019 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Saeid Ghavami Assistant Professor Human Anatomy & Cell Science Rady Faculty of Health Sciences T O P I C Glioblastoma and Cholesterol Metabolism Pathway Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ treatment causes DNA damage and results in tumor cell apoptosis. TMZ also induces autophagy and causes tumor cell resistance and thus fails to improve the survival rate among patients. Statins are competitive inhibitors of the rate determining enzyme of the mevalonate (MEV) cascade and best known for their cholesterol (CH) lowering effect. Recently, it was reported that long-term consumption of statins, prior to and in parallel with other cancer therapeutic approaches, increased the survival rate of patients with various forms of cancers. In this talk, I present our latest investigation about the mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human GBM cell lines and in primary human GBM cells in both cell monolayers and in three-dimensional (3D) cell culture systems. Learning Objectives: 1- The attendee will learn the concept of Cholesterol biosynthesis pathway and its possible effect in glioblastoma new therapy strategies. 2- The participant will learn concept of autophagy pathway. 3- The participant will understand how autophagy is involved in regulation of apoptosis. 4- The participant will learn the principal of glioblastoma 3D culture model. Short Biography: Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz, Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical Biochemistry. His Postdoctoral training was focused on the application of apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell fate. His research program is focused on regulation of cellular phenotype via targeting autophagy and unfolded protein response in the Department of Human Anatomy and Cell Science, University of Manitoba, He has been the recipient of a number of prestigious awards including CIHR/GSK/CLA postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career Development Award (top 10 in North America, 2009), ATS Science and Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early Career Research Award (2017). He has published more than 150 peer reviewed article (google scholar: >12,800 citation, h-index 40) (scopous > 7800 citations, h-index 33). Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar Series - Dr. Saeid Ghavami Fri Jan 25th @9am
by Manitoba Neuroscience Network 15 Jan '19

15 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, January 25th, 2019 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Saeid Ghavami Assistant Professor Human Anatomy & Cell Science Rady Faculty of Health Sciences T O P I C Glioblastoma and Cholesterol Metabolism Pathway Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ treatment causes DNA damage and results in tumor cell apoptosis. TMZ also induces autophagy and causes tumor cell resistance and thus fails to improve the survival rate among patients. Statins are competitive inhibitors of the rate determining enzyme of the mevalonate (MEV) cascade and best known for their cholesterol (CH) lowering effect. Recently, it was reported that long-term consumption of statins, prior to and in parallel with other cancer therapeutic approaches, increased the survival rate of patients with various forms of cancers. In this talk, I present our latest investigation about the mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human GBM cell lines and in primary human GBM cells in both cell monolayers and in three-dimensional (3D) cell culture systems. Learning Objectives: 1- The attendee will learn the concept of Cholesterol biosynthesis pathway and its possible effect in glioblastoma new therapy strategies. 2- The participant will learn concept of autophagy pathway. 3- The participant will understand how autophagy is involved in regulation of apoptosis. 4- The participant will learn the principal of glioblastoma 3D culture model. Short Biography: Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz, Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical Biochemistry. His Postdoctoral training was focused on the application of apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell fate. His research program is focused on regulation of cellular phenotype via targeting autophagy and unfolded protein response in the Department of Human Anatomy and Cell Science, University of Manitoba, He has been the recipient of a number of prestigious awards including CIHR/GSK/CLA postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career Development Award (top 10 in North America, 2009), ATS Science and Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early Career Research Award (2017). He has published more than 150 peer reviewed article (google scholar: >12,800 citation, h-index 40) (scopous > 7800 citations, h-index 33). Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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TODAY MNN Visiting Speaker | Dr. Keith Murai Jan 14th @ 12 noon
by Manitoba Neuroscience Network 14 Jan '19

14 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, January 14, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre C, Bannatyne Campus S P E A K E R D r. Keith Murai, Ph.D. Director for the Centre for Research in Neuroscience Professor, Neurology & Neurosurgery, Faculty and Department of Medicine Research Institute of the McGill University Health Centre T O P I C Astrocyte diversity and brain circuit microenvironments Objectives: 1) Discuss the complexity and heterogeneity of astrocyte populations in the CNS which may confer differential responses in the injured brain 2) Discuss the future potential of manipulating brain astrocytes for treating brain injuries, increasing resiliency of neurons in brain diseases, and promoting repair Abstract: Astrocytes are key partners for neurons in the healthy brain and contribute to the physiology and homeostasis of neural circuits. The complex molecular, functional, and structural properties of astrocytes enable these cells to precisely regulate extracellular ionic balance, neurotransmission, brain energetics, and cerebrovasculature. However, the mechanisms that enable astrocytes to perform highly diverse and specialized functions in the brain remain poorly understood. In this presentation, results will be provided showing the remarkable anatomical and functional complexity of astrocytes using advanced electron microscopy and molecular techniques. Furthermore, new findings will be shown demonstrating how mature neurons signal to neighbouring astrocytes to guide their molecular and physiological features in multiple brain regions. This neuron to astrocyte communication is both necessary and sufficient for astrocyte molecular diversification including the expression of important molecules including glutamate transporters and receptors, potassium channels, and water channels. Thus, ongoing communication between neurons and astrocytes plays an fundamental role in optimizing local neural circuit microenvironments to ensure optimal brain health and function. Brief Bio: Keith Murai is the Director of the Centre for Research in Neuroscience at McGill University, Leader of the Brain Repair and Integrative Neuroscience (BRaIN) Program at the Research Institute of the McGill University Health Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill University. He is a recipient of a Canada Research Chair position and is an EJLB Scholar for Schizophrenia Research. His research has two main areas of focus: (1) Understanding how neurons and glial cells cooperate to regulate brain development and homeostasis and (2) Discovering mechanism that regulate the plasticity of synapses that underlie memory formation, neurodevelopmental disorders, and neurodegenerative diseases. His laboratory uses advanced mouse genetic, imaging, electrophysiological, and optogenetic techniques and has pioneered approaches for understanding glial cells in brain function. He is an Associate (handling) Editor at Frontiers in Cellular Neuroscience, Section Editor in Development and Plasticity at the Journal of Experimental Neuroscience, and a Member of the editorial board at Developmental Neurobiology. He has been an author on high impact research studies published in journals such as the Journal of Neuroscience, PNAS, Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell, and Science. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker | Dr. Keith Murai Jan 14th @ 12 noon
by Manitoba Neuroscience Network 08 Jan '19

08 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, January 14, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre C, Bannatyne Campus S P E A K E R D r. Keith Murai, Ph.D. Director for the Centre for Research in Neuroscience Professor, Neurology & Neurosurgery, Faculty and Department of Medicine Research Institute of the McGill University Health Centre T O P I C Astrocyte diversity and brain circuit microenvironments Objectives: 1) Discuss the complexity and heterogeneity of astrocyte populations in the CNS which may confer differential responses in the injured brain 2) Discuss the future potential of manipulating brain astrocytes for treating brain injuries, increasing resiliency of neurons in brain diseases, and promoting repair Abstract: Astrocytes are key partners for neurons in the healthy brain and contribute to the physiology and homeostasis of neural circuits. The complex molecular, functional, and structural properties of astrocytes enable these cells to precisely regulate extracellular ionic balance, neurotransmission, brain energetics, and cerebrovasculature. However, the mechanisms that enable astrocytes to perform highly diverse and specialized functions in the brain remain poorly understood. In this presentation, results will be provided showing the remarkable anatomical and functional complexity of astrocytes using advanced electron microscopy and molecular techniques. Furthermore, new findings will be shown demonstrating how mature neurons signal to neighbouring astrocytes to guide their molecular and physiological features in multiple brain regions. This neuron to astrocyte communication is both necessary and sufficient for astrocyte molecular diversification including the expression of important molecules including glutamate transporters and receptors, potassium channels, and water channels. Thus, ongoing communication between neurons and astrocytes plays an fundamental role in optimizing local neural circuit microenvironments to ensure optimal brain health and function. Brief Bio: Keith Murai is the Director of the Centre for Research in Neuroscience at McGill University, Leader of the Brain Repair and Integrative Neuroscience (BRaIN) Program at the Research Institute of the McGill University Health Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill University. He is a recipient of a Canada Research Chair position and is an EJLB Scholar for Schizophrenia Research. His research has two main areas of focus: (1) Understanding how neurons and glial cells cooperate to regulate brain development and homeostasis and (2) Discovering mechanism that regulate the plasticity of synapses that underlie memory formation, neurodevelopmental disorders, and neurodegenerative diseases. His laboratory uses advanced mouse genetic, imaging, electrophysiological, and optogenetic techniques and has pioneered approaches for understanding glial cells in brain function. He is an Associate (handling) Editor at Frontiers in Cellular Neuroscience, Section Editor in Development and Plasticity at the Journal of Experimental Neuroscience, and a Member of the editorial board at Developmental Neurobiology. He has been an author on high impact research studies published in journals such as the Journal of Neuroscience, PNAS, Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell, and Science. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker Dr. Shawn Hochman | Thurs. Dec 13 @ 12 Noon, Theatre B
by Manitoba Neuroscience Network 12 Dec '18

12 Dec '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E: Thursday December 13, 2018 12:00 Noon L O C A T I O N: Theatre B Bannatyne Campus **followed by a trainee lunch in 431 BMSB S P E A K E R Dr. Shawn Hochman Professor and Interim Chair Emory University School of Medicine Atlanta, GA T O P I C: Paravertebral sympathetic thoracic chain ganglia: recruitment principles and plasticity after spinal cord injury O b j e c t I v e s: Paravertebral chain sympathetic postganglionic neurons (SPNs) represent the final neural control element regulating vasomotor tone and can be thought of as a distribution system for sympathetic activity that must span the body vasculature. Alterations in sympathetic chain activity are implicated in various autonomic disorders. The thoracic SPNs (tSPNs) control vasomotor function in upper extremities and trunk (this includes vascular supply to integumentary, cardiorespiratory and digestive systems). tSPNs remain a barely-studied area of vertebrate autonomic neuroscience. 1. Use whole-cell patch clamp recordings in an adult mouse ex vivo preparation to uncover the operational principles governing tSPN recruitment. 2. Obtain a reliable cellular and synaptic data set for realistic computational simulation. The relative simplicity of the organization makes discovery of principles through modeling more assured than in more complex systems. 3. To determine whether changes in tSPNs contribute to autonomic dysfunction after spinal cord injury. B I O S K E T C H: Shawn Hochman is Professor and Interim Chair of Physiology at Emory University School of Medicine. His research embraces broad aspects of neuromodulation-based control of sensorimotor and autonomic integration. Current research focuses on emergent dysfunction in mouse models of spinal cord injury. Efforts include; (i) continuous non-invasive capture of changes in physio-behavioral variables in the vivarium home-cage, and (ii) the role of the peripheral NS in driving emergent sensory and autonomic dysfunction For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Mark your calendars... MNN Visiting Speaker | Dr. Keith Murai Jan 14th @ 12 noon
by Manitoba Neuroscience Network 07 Dec '18

07 Dec '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, January 14, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre C, Bannatyne Campus S P E A K E R D r. Keith Murai, Ph.D. Director for the Centre for Research in Neuroscience Professor, Neurology & Neurosurgery, Faculty and Department of Medicine Research Institute of the McGill University Health Centre T O P I C Astrocyte diversity and brain circuit microenvironments Objectives: 1) Discuss the complexity and heterogeneity of astrocyte populations in the CNS which may confer differential responses in the injured brain 2) Discuss the future potential of manipulating brain astrocytes for treating brain injuries, increasing resiliency of neurons in brain diseases, and promoting repair Abstract: Astrocytes are key partners for neurons in the healthy brain and contribute to the physiology and homeostasis of neural circuits. The complex molecular, functional, and structural properties of astrocytes enable these cells to precisely regulate extracellular ionic balance, neurotransmission, brain energetics, and cerebrovasculature. However, the mechanisms that enable astrocytes to perform highly diverse and specialized functions in the brain remain poorly understood. In this presentation, results will be provided showing the remarkable anatomical and functional complexity of astrocytes using advanced electron microscopy and molecular techniques. Furthermore, new findings will be shown demonstrating how mature neurons signal to neighbouring astrocytes to guide their molecular and physiological features in multiple brain regions. This neuron to astrocyte communication is both necessary and sufficient for astrocyte molecular diversification including the expression of important molecules including glutamate transporters and receptors, potassium channels, and water channels. Thus, ongoing communication between neurons and astrocytes plays an fundamental role in optimizing local neural circuit microenvironments to ensure optimal brain health and function. Brief Bio: Keith Murai is the Director of the Centre for Research in Neuroscience at McGill University, Leader of the Brain Repair and Integrative Neuroscience (BRaIN) Program at the Research Institute of the McGill University Health Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill University. He is a recipient of a Canada Research Chair position and is an EJLB Scholar for Schizophrenia Research. His research has two main areas of focus: (1) Understanding how neurons and glial cells cooperate to regulate brain development and homeostasis and (2) Discovering mechanism that regulate the plasticity of synapses that underlie memory formation, neurodevelopmental disorders, and neurodegenerative diseases. His laboratory uses advanced mouse genetic, imaging, electrophysiological, and optogenetic techniques and has pioneered approaches for understanding glial cells in brain function. He is an Associate (handling) Editor at Frontiers in Cellular Neuroscience, Section Editor in Development and Plasticity at the Journal of Experimental Neuroscience, and a Member of the editorial board at Developmental Neurobiology. He has been an author on high impact research studies published in journals such as the Journal of Neuroscience, PNAS, Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell, and Science. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dr Moussavi presents at our Dementia Journal club - Dec 7th at Riverview Health Ctr- 11:30 AM Please post or circulate
by Manitoba Neuroscience Network 03 Dec '18

03 Dec '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Ben Albensi Subject: Dr Moussavi presents at our Dementia Journal club - Dec 7th at Riverview Health Ctr- 11:30 AM Please post or circulate Come to our Dementia Journal Club on Friday, Dec. 7th, 11:30 AM Riverview Health Ctr, Winnipeg DH132 is the basement of the “Day Hospital” at Riverview Health Center. Day Hospital has an entrance through the back parking lot (east side of the campus facing the river) but also has connection to the main hospital through tunnels. Street parking around the RHC is for 1 or some for 2 hours free. One block south of the center like Baltimore street is free parking all day. ----------------- Brain Fitness APP for Aging with a Healthy Brain and Detecting Cognitive Declines Dr Zahra Moussavi While currently there is no cure or "vaccine" against dementia, there are hopes to delay the onset or progression of the disease by living a brain-healthy life style. In this study, we developed 7 games in a Brain Fitness App based on the premise of brain plasticity, targeting spatial orientation, associative memory and short-term memory that are known to decline with normal aging and dementia. Twenty cognitively healthy individuals (69.8±5.9 yr) and 20 (68.9±8.2 yr) with mild cognitive impairment (MCI) or mild stage of Alzheimer’s were enrolled in the study. Cognitively healthy participants used the App at home at their own pace but were advised and encouraged to use it daily. The MCI/Alzheimer’s group mostly (n=15) used the App in a supervised manner (with a tutor) 5 day/week for 4 consecutive weeks, two blocks of 30 minutes per day with half an hour break in between. The tutors were 5 different young students. The assessor also helped with tutoring one of the participants. The remaining 5 of the 20 in this group used the App at home with the help of their caregiver. The cognitive function of both groups’ participants was assessed by using WMS-IV at baseline and immediately post-intervention. Half of the healthy group was assessed at two baselines to establish the practice effect on the WMS-IV score. The results of the healthy group, on average, indicate a significant improvement in cognitive functioning from baseline to post-intervention; however, not significant when accounting for the practice effect of the WMS-IV test. For the MCI/Alzheimer’s group, we did not expect any practice effect for the assessment and that was apparent among the 4 individuals who used the App at their home with their caregiver at their own pace (less regimented and less frequently); they showed no difference in scores after the intervention. However, the group who were tutored showed a significant improvement post-intervention. The total score of their WMS-IV test increased by 22.6 on average (p<0.02, paired t-test). Having a tutor may be considered as a placebo effect for the main effect. While we believe the observed improvement is beyond the placebo effect (2 participants did not improve despite enjoying their sessions), we believe especially for MCI and Alzheimer’s individuals having a tutor for brain exercises and having a regimented tutoring/learning is the key for the brain exercises to be effective in improving the cognition. The results of the healthy group also indicate that when individuals use brain exercises at their own pace, the majority do not challenge themselves and do not use the games as frequently as instructed; thus, not surprising that those individuals do not benefit as much from any brain exercises. Our results, overall, indicate delivery of brain exercises by a personal trainer (tutor) can be the key for a beneficial outcome. ----------------------- B. Albensi, PhD Dementia Research Chair Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal club - Dr Puig
by Manitoba Neuroscience Network 30 Nov '18

30 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Dr Puig's presentation from yesterday (whole body #MRI clinical study, n=1030) can now be viewed on our Dementia Manitoba website: http://dementiamanitoba.wixsite.com/mysite/dementia-journal-club B. Albensi, PhD Dementia Research Chair Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: Tomorrow - Jeremy Chopek | Fri Nov 30 @ 9am
by Manitoba Neuroscience Network 29 Nov '18

29 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, November 30th, 2018 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Jeremy Chopek Assistant Professor Physiology & Pathophysiology Rady Faculty of Health Sciences T O P I C Investigating brainstem and spinal cord movement circuits using mouse genetics O B J E C T I V E S 1) Understand the utility of mouse genetic for examining movement 2) Appreciate the complexity of local cellular connectivity 3) Understand the role of the brainstem and spinal cord in producing movement B I O S K E T C H: Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar: Jeremy Chopek | Fri Nov 30 @ 9am
by Manitoba Neuroscience Network 26 Nov '18

26 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, November 30th, 2018 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Jeremy Chopek Assistant Professor Physiology & Pathophysiology Rady Faculty of Health Sciences T O P I C Investigating brainstem and spinal cord movement circuits using mouse genetics O B J E C T I V E S 1) Understand the utility of mouse genetic for examining movement 2) Appreciate the complexity of local cellular connectivity 3) Understand the role of the brainstem and spinal cord in producing movement B I O S K E T C H: Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal club - Presentation on Nov 29th noon at HSC - Dr Puig
by Manitoba Neuroscience Network 21 Nov '18

21 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Dementia Journal club - Dr Josep Puig DATE: NOV 29TH, 2018 TIME: 12 PM - NOON LOCATION: UNIV MANITOBA - HEALTH SCI CTR., GG147 Topic: Aging Imageomics Study: Looking at imaging, seeing health See attached poster for upcoming presentation. For more information please contact: Ben Albensi balbensi(a)sbrc.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder TODAY: Dr. Wei Lu | Lecture @ 12 noon Theatre C
by Manitoba Neuroscience Network 15 Nov '18

15 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E: Thursday November 15th, 2018 12:00 Noon L O C A T I O N: Theatre C Bannatyne Campus **followed by a trainee lunch in SR415 Kleysen Bldg. S P E A K E R Dr. Wei Lu Synapse and Neural Circuit Section Porter Neuroscience Research Center National Institute of Neurological Disorders and Stroke National Institutes of Health T O P I C: Making the brains own brake | Molecular mechanisms of inhibitory synapse development. O b j e c t I v e s: Discuss the recent progress from my lab in understanding the molecular and cellular mechanisms for inhibitory synapse development B I O S K E T C H: Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York University School of Medicine, New York, 2006 M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000 B.S. (Biochemistry). Sichuan University, China, 1997 Recent publications: Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. 128 (2) Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. 23, 1213-1225. Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E, Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron. 99(3):493-510 For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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