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MNN Seminar Cancelled Friday May 30th
by Winnipeg Chapter Society for Neuroscience 27 May '14

27 May '14

Please note that the talk originally scheduled for Friday May 30th at 9am has been cancelled. Apologies for inconvenience. Regards, Kelly Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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BME Invited Seminar Thursday May 29 -- Dr. Chris Ellis, University of Western Ontario
by Winnipeg Chapter Society for Neuroscience 26 May '14

26 May '14

BME Seminar Speaker: Dr. Chris Ellis Ph.D. Title: Microvasculature Regulation of Oxygen Supply: the most important control system on planet Earth? Time: 4:00-5:00 PM Date: Thursday, May 29, 2014 Location: E2-330 Engineering Building, Fort Gary Campus Some refreshment will be provided for after the seminar. To see the list of next scheduled BME seminars, please seehere: http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html Abstract of the talk Oxygen plays a critical role in almost every cell of the body, from energy production in the mitochondria to generation of key signaling molecules such as nitric oxide and carbon monoxide. To fulfill these functions, O2 must diffuse from an O2 source (e.g. erythrocyte in a capillary) through the cell (or cells) to the site where it will be used (consumed). But diffusion into an O2 consuming tissue places a biophysical limitation on the maximum cell size and the maximum distance between O2 sources within an organ. Ninety five years ago Krogh was the first to recognize that it was not adequate to simply deliver the correct amount of O2 to an organ, the vasculature needed to match the distribute the O2 supply to the O2 needs of the tissue to within a few 10's of micrometers of where it would be consumed. To meet this design constraint Krogh proposed that capillary density was actively controlled; as O2 consumption increased more capillaries would be recruited to minimize diffusion distances. Despite the importance of Krogh's insights, there was a fundamental flaw in his model of tissue oxygenation and his concept of capillary recruitment has never been proven. This talk will describe our current understanding of how the microvasculature regulates the distribution of O2 supply within a tissue. The situation is far more complex than controlling capillary density due to a wide range of factors such as the unique fluid dynamic properties of blood flow in the network of very small vessels that make up the microvasculature (arterioles, capillaries and venules), the complex three dimensional geometry of the microvasculature and diffusional exchange of O2 among all levels of the microvasculature as well as with the tissue. Our hypothesis is that the O2 supply to individual capillary units (capillaries supplied by a single terminal arteriole) is regulated by the hemoglobin O2 saturation dependent release of ATP (adenosine triphosphate) from red blood cells in capillaries and that receptors on the capillary endothelium detect the ATP levels and signal upstream arterioles to dilate via conducted hyperpolarization of endothelial membrane potential. To test the hypothesis that individual capillary units can regulate their O2 supply, we used a microfluidic device to perturb O2 levels in small groups of capillaries at the surface of skeletal muscle in rat hindlimb and a dual wavelength intravital video microscopy system for measuring red blood cell flow and O2 saturation in these capillaries. BME PhD student, Nour Ghonaim, demonstrated that individual capillary units were able to signal for an increase in O2 supply when capillaries were exposed to low O2 levels. Since O2 levels in arterioles were not affected this result supports our hypothesis of a conducted signal from capillaries to arterioles. Our conclusion is that discrete networks of capillaries, with the red blood cell as the O2 sensor, are able to regulate upstream arteriolar resistance to ensure that the distribution of O2 supply matches the O2 needs of the tissue and that O2 regulation occurs at the level of capillary units not individual capillaries as proposed by Krogh. Bio of the Speaker Dr. Christopher Ellis graduated from McMaster University in Hamilton with a B.Eng. degree in Chemical Engineering. In 1980 he completed his Ph.D. in Chemical Engineering at Northwestern University in Evanston, Illinois. He began his postdoctoral training with Alan C. Groom in Biophysics at The University of Western Ontario in 1979 and in 1982 he was appointed as an Assistant Professor supported initially by a Senior Scholarship (1982-89) and later a Career Investigator Award of the Heart and Stroke Foundation of Ontario (1989-94). From 1995 through 2004 he served as Graduate Chair for Medical Biophysics. From June 2006 to June 2009 he served as Assistant Dean - Research, Schulich School of Medicine & Dentistry and from July 2009 to December 2009 as Associate Dean - Research. He is currently a Professor in the Departments of Medical Biophysics and Medicine. Dr. Ellis has trained over 20 graduate students, clinical trainees and post-doctoral fellows. He has published over 80 journal articles with total of ~3200 citations. His research on oxygen transport in the microvasculature has been funded by grants from CIHR, Heart and Stroke Foundation of Ontario, NSERC and NIH. His research interests include the application of a novel optical imaging system to investigate microvascular oxygen transport in living tissue in animal models of disease, the exploration of the mechanisms responsible for the local regulation of oxygen delivery by the microvasculature in vivo, with particular emphasis on the role of red blood cell as the sensor and regulator of oxygen delivery, and the application of microfluidics to microvascular research. --- Looking forward to your attendance and support for BME. Zahra Zahra Moussavi, Ph.D., P.Eng. Director, Biomedical Engineering Program Professor & Canada Research Chair in Biomedical Engineering; http://umanitoba.ca/biomedical_engineering/ <http://umanitoba.ca/biomedical_engineering/> Main Office: E3-513 Eng. Bldg. Dept. of Elect. & Comp. Engineering, University of Manitoba 75 Chancellor Circle, Winnipeg MB R3T 5V6 Phone: 204-474-7023 Fax: 204-261-4639 Email: Zahra_Moussavi(a)Umanitoba.ca <mailto:Zahra_Moussavi@Umanitoba.ca> http:/home.cc.umanitoba.ca/~mousavi <http://www.ee.umanitoba.ca/~moussavi> Research Page: http://bme.ee.umanitoba.ca/bmelab <http://bme.ee.umanitoba.ca/bmelab> Riverview Office: PE-458, 1 Morley Ave, Riverview Health Center Winnipeg, MB Phone: 478-6163 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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Reminder: MNN Speaker - Dr. Jerry Silver - May 16 @ Noon
by Kelly Jorundson 15 May '14

15 May '14

Reminder...... Manitoba Neuroscience Network Seminar Series Friday, May 16, 2014 | 12:00 Noon [Jerry Silver, Ph.D.] Dr. Jerry Silver<http://neurowww.cwru.edu/faculty/silver/index> Professor - Department of Neurosciences Case Western Reserve University Topic: Functional regeneration into and beyond the glial scar Location: Theatre B - Basic Med Sciences Bldg. Biosketch: Dr. Silver received his Ph.D. from Case Western Reserve in 1974 and was the recipient of the Herbert S. Steuer Memorial Award for Meritorious Original Research in Anatomy. He did post-doctoral work at Harvard University in the Department of Neurosciences at The Children's Hospital and in the Neuropathology Department at Harvard Medical School. Dr. Silver is currently Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation. Dr. Silver is a recipient of several prestigious awards. Dr. Silver has served on a number of editorial boards including the journals Glia, The Journal of Neurocytology, Developmental Neurobiology, The Journal of Neuroscience and Experimental Neurology (where he is a Section Editor). He regularly reviews articles for over 35 high impact journals and he reviews grants for 18 national and international organizations /sent on behalf of Eftekhar Eftekharpour Seminar Coordinator, Manitoba Neuroscience Network [cid:part1.07040404.07050801@cc.umanitoba.ca] Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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2014 Nick Shepel Student Travel Award
by Winnipeg Chapter Society for Neuroscience 07 May '14

07 May '14

2014 Nick Shepel Student Travel Award Competition deadline: June 13, 2014 The Nick Shepel Student Travel Award was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his lab partners and brought fire, humor, and a desire to always do better. His insistence to always try better will have a permanent effect on his lab mates. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator (graduate student within the Faculty of Medicine - University of Manitoba) by providing an annual award(s) (up to $1,000 max) to support travel costs associated with the applicant's attendance at a future national/international conference where the applicant is presenting a poster or oral presentation. Eligibility: At the time of application, students must be registered in the Faculty of Medicine at the University of Manitoba. 1. "Registered" includes being accepted by the major department of study, admitted by the Faculty of Graduate Studies, or eligible to register in the Faculty of Graduate Studies. 2. A student admitted under the "Provisional Status" may not receive the award during the provisional period. 3. Amount of award(s) may vary each year (minimum value - $400). 4. Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international) Submission Instructions: A complete application consists of the following: 1. Introductory letter describing meeting 2. Copy of abstract 3. Curriculum vitae 4. Current GPA, transcripts not needed 5. Proposed budget of travel costs 6. Submit your completed application materials to: Dr. Paul Fernyhough Director - Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Only original receipts will be accepted. Copies may be accepted only where proof of submission to another agency is provided. For more information, contact: Kelly Jorundson, Administrative Manager Division of Neurodegenerative Disorders R4046-351 Tache Ave., Winnipeg, MB R2H 2A6 E: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> T:204.235.3939 F: 204.237.4092 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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BME Seminar Thursday May 8 -- functional Near-Infrared Spectroscopy (fNIRS) for Brain Imaging
by Winnipeg Chapter Society for Neuroscience 06 May '14

06 May '14

Everyone is invited! BME seminar - Younes Rakhsani M.Sc. Date: Thursday, May 8, 2014 Time: 4:00-5:00 PM Location: E2-330 Engineering Building, Fort Gary Campus Speaker: Younes Rakhsani M.Sc. Title: functional Near-Infrared Spectroscopy (fNIRS) for Brain Imaging Some refreshment will be provided for after the seminar. To see the list of next scheduled BME seminars, please see here: http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html <http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html> Abstract of the talk Noninvasive measurements of blood volume and blood oxygenation changes in tissue is possible using near-infrared spectroscopy (NIRS) with high temporal resolution. Diffuse optical imaging (DOI) is inexpensive and portable compared to other vascular imaging modalities such as MRI or positron emission tomography (PET). One of the advantages of the DOS systems is that they are portable, so it provides the ability to measure cerebral blood oxygenation, volume, or flow using portable instrumentation. DOS can be used for different types of bedside monitoring. Using multi-channel DOS and DOI systems, optical brain imaging can be applied to various psychology functional tests in adults, children, and more recently infants. In this presentation I am going to talk about optical properties of the brain, basic types of NIRS systems, fNIRS signal processing and applications of NIRS. Also, I will talk about the CW-NIRS system that we have built in our lab and its results. Short Bio of the speaker Younes received his B.Sc., and first M.Sc. in Electrical engineering from Iran University of Science and Technology and Tehran University, respectively. Currently, he is enrolled in the M.Sc. BME program at U of Manitoba with focus on fNIRS design, implementation and evaluation. /sent on behalf of Chris Anderson Chris M. Anderson, President - Winnipeg Chapter Society for Neuroscience Associate Professor and Director, Neuroscience Research Program Kleysen Institute for Advanced Medicine Health Sciences Centre and University of Manitoba T: 204-318-2565 E: chris.anderson(a)med.umanitoba.ca

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MNN Visiting Speaker - Dr. Jerry Silver May 16 2014 12 Noon
by Winnipeg Chapter Society for Neuroscience 05 May '14

05 May '14

Everyone is invited to attend! Manitoba Neuroscience Network Seminar Series - Dr. Jerry Silver Friday, May 16, 2014 | 12:00 Noon Theatre B - Basic Med Sciences Bldg. Dr. Jerry Silver <http://neurowww.cwru.edu/faculty/silver/index> Professor - Department of Neurosciences Case Western Reserve University Topic: Functional regeneration into and beyond the glial scar Biosketch: Dr. Silver is currently a Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation. Dr. Silver received his Ph.D. from Case Western Reserve in 1974, with further post-doctoral training at Harvard Medical School. He is recognized internationally for his long lasting research in the field of regeneration, spinal cord injury and paralysis. Dr. Silver is the recipient of several prestigious awards/recognitions including: * Herbert S. Steuer Memorial Award (1974) * Ameritec Prize for significant accomplishments toward a cure for paralysis (2003) * Christopher Reeve-Joan Irvine Research Medal (2003), for critical contributions that may lead to the promotion of repair of the damaged spinal cord * Jacob Javits Neuroscience Investigator Award (2004 , that recognizes a select group of NIH grantees with seminal contributions to their field of neuroscience * Erica Nader Award (2008), for breakthrough research in the field of spinal cord injury * Member of the American Association for the Advancement of Science (AAAS) (2011) Dr. Silver has served on a number of editorial boards including the journals Glia, The Journal of Neurocytology, Developmental Neurobiology, The Journal of Neuroscience and Experimental Neurology (where he is a Section Editor). He regularly reviews articles for over 35 high impact journals and he reviews grants for 18 national and international organizations. He has served on a variety of NIH study sections since 1982 including the Neurobiology Review Group, Neurology B2, The Visual Sciences C Study Section, and the Clinical Neurology, Neurotransmitters and Transplantation Study Section. He serves as a regular member of the Scientific Advisory Council of the Christopher Reeve Foundation and of the Scientific Board of the International Spinal Research Trust (England). He has served as lead or senior author on more than 160 publications. A brief synopsis of Dr. Silver's work: Over the past several decades, Dr. Silver has concentrated his research efforts learning whether molecules that glia produce after spinal cord injury may play a major role in blocking regeneration. Of particular interest, the chondroitin sulfate proteoglycans (CSPGs), were first discovered by the Silver's lab in the early 1990's to be involved in impeding regeneration. His lab has pioneered the use of the CSPG degrading enzyme chondroitinase to reveal the important role of the glycosaminoglycan (GAG) sugar chains. Dr. Silver's lab has shown that adult nerve cells could regenerate their axons with high efficiency and at high rates of speed even in fully degenerating white matter and even at long chronic stages after injury, challenging long held beliefs that this was impossible. Currently, his research focuses on the regenerative approaches that target the CSPG receptors. These receptors identified originally by his laboratory may hold the key for enhancing regeneration after Spinal Cord Injury. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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2014 WCSN Membership Dues
by Kelly Jorundson 02 May '14

02 May '14

Dear all, The 2014 online membership form is now available. If you are not already a member of the Winnipeg Chapter Society for Neuroscience (WCSN), we encourage you to join today. Click here<http://sfn-manitoba.ca/about.html> to learn more about the benefits of becoming a member . 2014 Fee Schedule: *Membership fees are for the calendar year (January-December). Faculty, Professionals $60.00 Postdocs, Residents, Technicians, Research Associates $30.00 Students $15.00 All-inclusive Lab Rate $100.00 To pay your 2014 membership dues, please complete the WCSN Membership Application<http://sfn-manitoba.ca/application/> . Payment methods include: credit card, cheque, and FOAP. If you are paying by cheque, please make payment to: St. Boniface Hospital c/o Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Regards, Chris Anderson President - Winnipeg Chapter Society for Neuroscience Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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Post-doc position available in Dr. Ole Kiehn's lab, Sweden
by Winnipeg Chapter Society for Neuroscience 29 Apr '14

29 Apr '14

Dear All, Postdoctoral Fellowship in Systems Neuroscience - In Kiehn lab A postdoc position is available in the Mammalian Locomotor Laboratory, at the Department of Neuroscience, Karolinska Institute, in Stockholm, Sweden in Kiehn lab. ( http://www.neuro.ki.se/kiehnlab/ <http://www.neuro.ki.se/kiehnlab/> ) The laboratory is offering a creative and international environment, focusing on functional operation and molecular logic of neural networks controlling movements. We are using an area of experimental approaches including molecular mouse genetics, imaging, optogenetics, electrophysiology and anatomy to decipher the function of the locomotor networks mammalian spinal cord and brain We are looking for an outstanding researcher that has extensive experience with electrophysiology/imaging either in vitro or in vivo. Candidates ideally have a PhD degree in systems neuroscience. It is an advantage also to have insights in mouse genetic and molecular biology. The candidate must be able to work in an integrated team. Strong dedication to science is an absolute requirement. The candidate must be fluent in English. Contact Ole Kiehn; Professor Department of Neuroscience The Karolinska Institute Retziusväg 8 171777, Stockholm Sweden 46 70685782 Email: Ole.Kiehn(a)ki.se Karolinska Institute is one of the world´s leading medical universities. Since 1901 the Nobel Assembly at Karolinska Institute has selected the Nobel laureates in Physiology or Medicine. Ole Kiehn, Professor Mammalian Locomotor Lab Department of Neuroscience The Karolinska Institute Retziusväg 8 17177 Stockholm Sweden 46 852483951 46706857821 /sent on behalf of/ Dr. Larry Jordan Spinal Cord Research Centre College of Medicine, Faculty of Health Sciences University of Manitoba Department of Physiology 409 - 745 Bannatyne Avenue Winnipeg, Manitoba R3E 0J9 Tel: 204-789-3770 Fax: 204-789-3934 E-mail: office(a)scrc.umanitoba.ca Website: www.scrc.umanitoba.ca <http://www.scrc.umanitoba.ca/> Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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Neuroscience Outresearch
by Kelly Jorundson 17 Apr '14

17 Apr '14

Dear Colleagues, I am so pleased to be the new Director of Outreach for our chapter, and I would like to thank Chris for giving me the opportunity to serve the neuroscience community in this way. As Chris has mentioned, our primary goal is to develop a consistent and meaningful program of outreach over the next several years. You will be hearing from me about our initiatives over the next several months. Engagement from neuroscientists at all levels will be key to the success of these programs, and I hope that you will consider participating. Our first project is to develop a Neuroscience Speaker's Bureau - a directory of neuroscientists who are willing to give public talks on neuroscience-related topics. This directory will be available to the public on the chapter website. At this time, we are compiling the names of interested individuals, and we will then contact you to build your profile. Once the directory is completed, we will then advertise it to attract groups who are interested in hosting speakers. At present, there is no time commitment on your part. Your participation just indicates that you are willing to be listed in the directory and make public presentations if invited to do so (please note that you are not obligated to accept speaking engagements if they do not fit your schedule). Please respond to Kelly's original email if you would like to be included. I look forward to working with all of you to enhance neuroscience awareness in our community. Best wishes, Sari Sari S. Hannila, PhD Assistant Professor, Department of Human Anatomy and Cell Science Associate Member, Spinal Cord Research Centre College of Medicine, Faculty of Health Sciences Room 130, Basic Medical Sciences Building 745 Bannatyne Avenue Winnipeg, Manitoba R3E 0J9 Tel: (204) 789-3483 Fax: (204) 789-3920 Sari.Hannila(a)med.umanitoba.ca<mailto:Sari.Hannila@med.umanitoba.ca> Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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Neuroscience Outreach
by Kelly Jorundson 17 Apr '14

17 Apr '14

Dear Neuroscientists, As you know, one of the primary responsibilities of the Winnipeg Chapter of the Society for Neuroscience is community outreach. The Chapter has been involved in Brain Awareness week and has given awards for neuroscience projects in school science fairs, among other initiatives recently. Our goal, however, is to gain a more consistent and meaningful outreach presence overall. To help achieve this goal, Dr. Sari Hannila has generously agreed to be the Director of Outreach for the Chapter. She has several initiatives planned and you will see emails from her from time to time describing them. One of her first plans is to develop a roster of scientists who would be willing to give public outreach presentations. Once the list is compiled, she will ask for specific information so she can prepare the roster for 'marketing' and posting on the Winnipeg Chapter website. If you would like to be on the outreach speaker roster, please reply to this email. Many thanks, Sari Hannila and Chris Anderson Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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