November 2012 - Neuro-All - University of Manitoba Mailing Lists

Will to Win International Research Symposium, May 13 & 14, 2013
by Winnipeg Chapter Society for Neuroscience 29 Nov '12

29 Nov '12

----------------------------------- Mark your calendars everyone! The Spinal Cord Research Centre invites you to the Will to Win International Research Symposium: In honor of Dr. Larry Jordan May 13 & 14, 2013 Two days of stimulating research presentations by 35 world renown international and national neuroscience researchers. Details to follow. Speakers: Patrick Whelan David Bennett Monica Gorassini Richard Stein Arthur Prochazka Keir Pearson Vivian Mushahwar Karim Fouad Serge Rossignol Trevor Drew Rejean Dubuc Jean-Pierre Gossard Brian Noga Shawn Hochman Marie-Claude Perreault David Magnuson Ron Harris-Warrick Robert Skinner Robert Burke Charles J Heckman Paul Stein Lorne Mendell Doug Stuart Marc Binder Reggie Edgerton Martyn Goulding Jorge Quevedo Pablo Rudomin Urszula Slawinska Elzbieta Jankowska Ole Kiehn Hans Hultborn Sten Grillner Alain Frigon Gregoire Courtine Contact: Sharon McCartney Spinal Cord Research Centre University of Manitoba 204-789-3770 sharon(a)scrc.umanitoba.ca Organizers: Brian Schmidt, Dave McCrea, Rob Brownstone (Dalhousie University), John Steeves (UBC) Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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Manitoba Neuroscience Network meeting 2013
by Winnipeg Chapter Society for Neuroscience 29 Nov '12

29 Nov '12

From: The Winnipeg Chapter of the Society for Neuroscience Please reserve MONDAY JUNE 10, 2013 for the 4th annual meeting of the Manitoba Neuroscience Network. The theme for 2013 will be "Neurodegeneration" and the meeting will be held jointly with the Manitoba-Ontario endMS Regional Research and Training Centre. The format will be similar to previous meetings, featuring: · Visiting expert speakers · Speakers showcasing local research · Networking opportunities · Poster session with trainee awards The official meeting and website announcement will follow early in 2013, with a MAY abstract deadline. Please plan on attending and thank you for making these meetings successful. Chris Anderson, Conference Chair Gilbert Kirouac, Program Committee Chair

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Reminder: MNN Talk Friday Nov 30/12 @9am Dr. J. Kong
by Winnipeg Chapter Society for Neuroscience 28 Nov '12

28 Nov '12

Manitoba Neuroscience Network Seminar | Dr. Jiming Kong http://www.sbrc.ca/2012/11/mnn-seminar-series-dr-jiming-kong/ Date: Friday, November 30, 2012 Time: 9:00 - 10:00am Location: PZ236/238 PsychHealth, Bannatyne Campus Dr. Jiming Kong Professor - Department of Human Anatomy & Cell Science University of Manitoba Topic: Neuronal death in neurodegenerative diseases: the BNIP3 pathway Dr. Jiming Kong earned his Bachelor of Medicine in 1983 from Luzhou Medical College and PhD degree in 1994 from the First Military Medical University in China. After a short visiting scholarship in Baylor College of Medicine, he did three postdoctoral fellowships in University of Massachusetts and University of Manitoba. He joined the Department of Human Anatomy and Cell Science, University of Manitoba as an Assistant Professor in 2002. He was promoted to Associate Professor in 2006 and Professor in 2011. Dr. Kong's research program is directed to the understanding of molecular regulation of neuronal cell death in neurodegenerative diseases. Using in vivo and in vitro models of stroke, amyotrophic lateral sclerosis, Alzheim-er's disease, schizophrenia and depression, his group examines posttranslational oxidative modification of SOD1 as a factor of age-related onset of neurodegenerative diseases, investi-gates the role of mitochondrial death-inducing proteins in regulating mitophagy and delayed neuronal death in stroke, and tests a demyelinating hypothesis of schizophrenia. Dr. Kong is a recipient of the prestigious Heart and Stroke Foundation of Canada New Investigator award (2004-2009) and a principal investigator of the Canadian Stroke Network (since 2007), which is one of the Centers of Excellence of Canada. His research program is continuously support-ed by international and national grant agencies such as the Muscular Dystrophy Association (USA), National Natural Science Foundation of China, Canadian Institutes of Health Research, Canadian Stroke Network, Canada Foundation for Innovation, and Heart and Stroke Foun-dation of Canada. He has about 70 publications. In recent 5 years, he has 36 peer-reviewed publications and 3 book chapters. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds An initiative of: Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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MNN Seminar - Dr. J. Kong Nov 30/12
by Winnipeg Chapter Society for Neuroscience 16 Nov '12

16 Nov '12

Manitoba Neuroscience Network Seminar | Dr. Jiming Kong Date: Friday, November 30, 2012 Time: 9:00 - 10:00am Location: PZ236/238 PsychHealth, Bannatyne Campus Dr. Jiming Kong Professor - Department of Human Anatomy & Cell Science University of Manitoba Topic: Neuronal death in neurodegenerative diseases: the BNIP3 pathway Dr. Jiming Kong earned his Bachelor of Medicine in 1983 from Luzhou Medical College and PhD degree in 1994 from the First Military Medical University in China. After a short visiting scholarship in Baylor College of Medicine, he did three postdoctoral fellowships in University of Massachusetts and University of Manitoba. He joined the Department of Human Anatomy and Cell Science, University of Manitoba as an Assistant Professor in 2002. He was promoted to Associate Professor in 2006 and Professor in 2011. Dr. Kong's research program is directed to the understanding of molecular regulation of neuronal cell death in neurodegenerative diseases. Using in vivo and in vitro models of stroke, amyotrophic lateral sclerosis, Alzheim-er's disease, schizophrenia and depression, his group examines posttranslational oxidative modification of SOD1 as a factor of age-related onset of neurodegenerative diseases, investi-gates the role of mitochondrial death-inducing proteins in regulating mitophagy and delayed neuronal death in stroke, and tests a demyelinating hypothesis of schizophrenia. Dr. Kong is a recipient of the prestigious Heart and Stroke Foundation of Canada New Investigator award (2004-2009) and a principal investigator of the Canadian Stroke Network (since 2007), which is one of the Centers of Excellence of Canada. His research program is continuously support-ed by international and national grant agencies such as the Muscular Dystrophy Association (USA), National Natural Science Foundation of China, Canadian Institutes of Health Research, Canadian Stroke Network, Canada Foundation for Innovation, and Heart and Stroke Foun-dation of Canada. He has about 70 publications. In recent 5 years, he has 36 peer-reviewed publications and 3 book chapters. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds An initiative of: Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Visiting Speaker Lecture - Dr. Long-Jun Wu
by Winnipeg Chapter Society for Neuroscience 13 Nov '12

13 Nov '12

View online: http://www.sbrc.ca/2012/11/pharmacology-invited-speaker-lecture-dr-long- jun-wu/ Invited Speaker Lecture - Dr. Long-Jun Wu DATE: Friday, Nov 16, 2012 TIME: 12:00 noon LOCATION: A229 Chown Bldg., Bannatyne Campus ** **Video-linked to R1002 SBHR Bldg. (St. Boniface Campus) <http://www.sbrc.ca/wp-content/uploads/2012/11/web_Long-Jun-photo.jpg> Long-Jun Wu, PhD Assistant Professor Department of Cell Biology and Neuroscience Rutgers University New Brunswick, NJ TOPIC: Microglia-neuron communication in normal and diseased brain The long-term goal of my lab is to understand microglia-neuron communication in the brain. Microglia are the principal immune-response cells in the central nervous system. Resting microglia constantly survey the microenvironment in the normal brain. Upon brain dysfunction, microglia are activated and exert detrimental or beneficial effects on the surrounding neurons. Microglia have remarkably fast and dynamic activities in both the normal and pathological brain. An exciting possibility is that they are communicating with neurons through ion channel mechanisms. In neuronal circuits, microglia are assumed to be crucial to synaptic pruning and plasticity, yet no direct evidence has been identified. Microglia are strongly activated in pathological conditions such as pain, stroke and neurodegeneration, however, the molecular mechanisms for microglial activation and function in brain diseases are still controversial. Overall, we are interested in three interrelated topics on microglia-neuron communication: (1) The ion channel mechanism of microglia-neuron communication; (2) Microglia in synaptic function; and (3) Microglia's contribution to neuropathic pain. We have been exploring microglia chemotaxis (Wu et al., Glia, 2007, Fig.1), microglia in synaptic plasticity (Wu and Zhuo, J Neurophysiol, 2008), as well as an unique microglial voltage-gated proton channel, Hv1, in the brain (Wu et al., Nat Neurosci, 2012). Taking Hv1 proton channel as an entry point, our initial project will study direct communication from microglia to neurons through microglial Hv1. We will then explore how microglia function in neuronal circuits under normal and pain conditions. The results from our studies would advance the understanding of microglia function in the brain and provide therapeutic targets for neuropathic pain treatment. SELECTED PUBLICATIONS Research Articles 1. Wu LJ*, Wu G*, Sharif MR, Baker A, Jia Y, Fahey FH, Luo HR, Feener EP, Clapham DE. 2012. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 15(4): 565-573. 2. Jin J, Wu LJ, Jun J, Cheng X, Xu H, Andrews NC, Clapham DE. 2012. The channel kinase, TRPM7, is required for early embryonic development. Proceedings of the National Academy of Science, USA, 109(5): E225-233. 3. Wang H*, Xu H*, Wu LJ*, Kim SS*, Chen T, Koga K, Descalzi G, Gong B, Vadakkan KI, Zhang X, Kaang BK, Zhuo M. 2011. Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Science Translational Medicine, 3 (65): 65ra3 4. Slusky I, Abumaria N, Wu LJ, Huang C, Zhang L, Li B, Zhao X, Govindarajan A, Zhao MG, Zhuo M, Tonegawa S, Liu G. 2010. Enhancement of learning and memory by elevating brain magnesium. Neuron, 65 (2): 165-177. 5. Wu LJ, Mellstrom B, Wang H, Ren M, Domingo S, Kim SS, Li XY, Chen T, Naranjo JR, Zhuo M. 2010. DREAM (Downstream Regulatory Element Antagonist Modulator) contributes to synaptic depression and contextual fear memory. Molecular Brain, 3 (1): 3. 6. Wu LJ, Li X, Chen T, Ren M, Zhuo M. 2009. Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording. Molecular Brain, 2 (1): 32. 7. Wu LJ, Steenland HK, Kim SS, Isiegas C, Ted A, Kaang BK, Zhuo M. 2008. Enhancement of presynaptic glutamate release and persistent inflammatory pain by increasing neuronal cAMP in the anterior cingulate cortex. Molecular Pain, 4 (1): 40. 8. Wang H*, Wu LJ*, Kim SS*, Lee FJ, Gong B, Toyoda H, Ren M, Xu H, Liu F, Zhao MG, Zhuo M. 2008. FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron, 59 (4): 634-647. 9. Xu H*, Wu LJ*, Wang H*, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M. 2008. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. Journal of Neuroscience, 28 (29): 7445-7453. 10. Hines RM*, Wu LJ*, Hines DJ, Steenland H, Mansour S, Dahlhaus R, Singaraja RR, Cao X, Sammler E, Hormuzdi SG, Zhuo M, El-Husseini A. 2008. Synaptic imbalance, stereotypies and impaired social interactions in mice with altered neuroligin 2 expression. Journal of Neuroscience, 28 (24): 6055-6067. 11. Wang H, Wu LJ, Zhang F, Zhuo M. 2008. Roles of calcium-stimulated adenylyl cyclase and calmodulin-dependent protein kinase IV in the regulation of FMRP by Group I metabotropic glutamate receptors. Journal of Neuroscience, 28 (17): 4385-4397. 12. Zhang F, Vadakkan K, Kim SS, Wu LJ, Shang Y, Zhuo M. 2008. Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Molecular Pain, 4 (1): 15. 13. Wu LJ*, Zhang XH*, Fukushima H, Zhang F, Wang H, Toyoda H, Li BM, Kida S, Zhuo M. 2008. Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. European Journal of Neuroscience, 27 (8): 1923-1932. 14. Wu LJ, Zhuo M. 2008. Resting microglial motility is independent of synaptic plasticity in mammalian brain. Journal of Neurophysiology, 99 (4): 2026-2032. 15. Wu LJ*, Ren M*, Wang H*, Kim SS, Cao X, Zhuo M. 2008. Neurabin contributes to hippocampal long-term potentiation and contextual fear memory. PLoS ONE, 3 (1): e1407. 16. Duan B*, Wu LJ*, Yu YQ, Ding Y, Jing L, Xu L, Chen J, Xu TL. 2007. Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. Journal of Neuroscience, 27 (41): 11139-11148. 17. Wu LJ, Vadakkan KI, Zhuo M. 2007. ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia, 55 (8): 810-821. 18. Wu LJ, Xu H, Ren M, Cao X, Zhuo M. 2007. Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Molecular Pain, 3 (1): 11. 19. Wu LJ, Xu H, Ren M, Zhuo M. 2007. Genetic and Pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Developmental Neurobiology, 67 (2): 146-157. 20. Wu LJ*, Ko S*, Toyoda H*, Zhao MG*, Xu H, Vadakkan KI, Ren M, Knifed E, Shum F, Quan J, Zhang XH, Zhuo M. 2007. Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS ONE, 2 (1): e167. 21. Zhao MG*, Ko S*, Wu LJ*, Toyoda H*, Xu H, Quan J, Jia Y, Li JG, Ren M, Xu Z, Zhuo M. 2006. Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of the mice with chronic pain. Journal of Neuroscience, 26 (35): 8923-8930. 22. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko S, Jia Y, Shum F, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M. 2005. Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. Journal of Neuroscience, 25 (48): 11107-11116. 23. Zhao MG*, Toyoda H*, Lee YS*, Wu LJ*, Ko S*, Zhang XH*, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M. 2005. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron, 47 (6): 859-872. 24. Wu LJ, Zhao MG, Toyoda H, Ko S, Zhuo M. 2005. Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. Journal of Neurophysiology, 94 (3): 1805-1813. 25. Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, Xu TL. 2004. Characterizations of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. Journal of Biological Chemistry, 279 (42): 43716-43724. 26. Wu LJ, Li Y, Xu TL. 2002. Co-release and interaction of two inhibitory co-transmitters in rat sacral dorsal commissural neurons. NeuroReport, 13 (7): 977-981. 27. Wu LJ, Lu Y, Xu TL. 2001. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. Journal of Neuroscience Methods, 108 (2): 199-206. Reviews 1. Wu LJ, Sweet TB, Clapham DE. 2010. Current progress in the mammalian TRP ion channel family. Pharmacological Reviews, 62 (3): 381-404. 2. Wu LJ, Zhuo M. 2009. Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics, 6 (4): 693-702. 3. Wu LJ, Wang YT, Zhuo M. 2009. Hook-up of GluA2, GRIP and liprin-alpha for cholinergic muscarinic receptor-dependent LTD in the hippocampus. Molecular Brain, 2 (1): 17. 4. Wu LJ, Kim SS, Zhuo M. 2008. Molecular targets of anxiety: from membrane to nucleus. Neurochemical Research, 33 (10): 1925-1932. 5. Wu LJ, Ko S, Zhuo M. 2007. Kainate receptor and pain: from dorsal root ganglion to the anterior cingulate cortex. Current Pharmaceutical Design, 13 (15): 1597-1605. 6. Wu LJ, Zhuo M. 2006. Supraspinal electrophysiological models for studying chronic pain. Drug Discovery Today: Disease Models, 3 (4): 405-411. 7. Wu LJ, Xu H, Ko S, Yoshimura M, Zhuo M. 2005. Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P. Molecular Pain, 1 (1): 34 For more information: Ben Albensi Seminar Coordinator & Associate Professor, Pharmacology & Therapeutics T: 204.235.3942 E: balbensi(a)sbrc.ca Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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Erika Couto - tomorrow at SCRC Journal Club
by Winnipeg Chapter Society for Neuroscience 08 Nov '12

08 Nov '12

Hi everyone, This is a reminder that tomorrow (November 9th) we have SCRC Journal Club session. This Friday Erika Couto, MSc student from Dr. Larry Jordan lab is presenting her data about: "Counting serotoninergic neurons in the parapydamidal region after unrestrained locomotion" Come and learn about our Stereo Investigator microscopy/software system sitting in Room 418!! Esteli Esteli Vasquez PhD Student Spinal Cord Research Centre Department of Physiology, University of Manitoba 745 Bannatyne Avenue Winnipeg, Manitoba R3E 0J9 Phone: (204) 789-3274, Fax: (204) 789-3930 E-Mail: esteli(a)scrc.umanitoba.ca Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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