May 2014 - Neuro-All - University of Manitoba Mailing Lists

Important Funding Opportunity
by Kelly Jorundson 29 May '14

29 May '14

View this email in your browser<http://us3.campaign-archive1.com/?u=eae5bfcdc68eabe292cb4c3b1&id=4405526175…> [https://gallery.mailchimp.com/eae5bfcdc68eabe292cb4c3b1/images/brain_canada…] To all, Brain Canada is pleased to launch a new funding program in partnership with CQDM that will provide $10 million to support the development of innovative tools, technologies and platforms to accelerate the discovery of new, safe and effective drugs for disorders of the brain and nervous system. This new program intends to bridge the gap in neuroscience by supporting innovative translational research with tangible results that impact the drug discovery process, with the ultimate goal to prevent, treat or cure neurological or mental health disorders for the benefit of patients and their families. The program aims to foster multidisciplinary research collaborations linking Quebec and other Canadian researchers, as well as the academic and Small and Medium Enterprises (SMEs). The deadline to submit a Letter of Intent (LOI) is August 20th, 2014. For more information, please visit Brain Canada's website: http://braincanada.ca/en/Focus_on_Brain<http://braincanada.us3.list-manage1.com/track/click?u=eae5bfcdc68eabe292cb4…> We thank you in advance for disseminating in your networks. The Brain Canada Team

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Important neuroscience research funding opportunity from the Weston Brain Institute
by Kelly Jorundson 29 May '14

29 May '14

The Weston Brain Institute has new funding opportunities available. Please have a close look: All funding programs support translational research to accelerate the development of therapeutics for neurodegenerative diseases of aging. As the Institute defines it, these diseases include: * Alzheimer's disease * Amyotrophic lateral sclerosis (ALS) * Dementia with Lewy bodies * Frontotemporal dementia * Mild cognitive impairment as prodromal to one of the other listed diseases * Multiple system atrophy * Parkinson's disease * Progressive supranuclear palsy Submissions open: approximately August 2014 Seed funding (up to $150,000 for up to 18 months) for high-risk, high-reward, totally novel ideas. One Time Program: 2014 Targeted Diseases: FTD and PSP* Application deadline: Friday, June 6th, 2014 The Institute will commit up to $1.35 million to this program. Per project, funding can range from $50,000 to $150,000 per year over 1 to 3 years to a maximum of $450,000. The Institute will commit up to $1.35 million to this program. Funding can range from $50,000 to $150,000 per year over 1 to 3 years to a maximum of $450,000. research in frontotemporal dementia (FTD) and/or progressive supranuclear palsy (PSP). Research in other overlapping tauopathies, such as corticobasal degeneration, is not supported at this time. /sent on behalf of Chris M. Anderson, PhD President - Winnipeg Chapter Society for Neuroscience Associate Professor and Director, Neuroscience Research Program Kleysen Institute for Advanced Medicine Health Sciences Centre and University of Manitoba T: 204-318-2565 E: chris.anderson(a)med.umanitoba.ca<mailto:chris.anderson@med.umanitoba.ca> Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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MNN Seminar Friday May 30th 9am | NEW speaker confirmed
by Winnipeg Chapter Society for Neuroscience 27 May '14

27 May '14

Please Circulate! Manitoba Neuroscience Network Seminar Series Friday, May 30, 2014 | 9:00 AM Dr. Eftekhar Eftekharpour Assistant Professor, Regenerative Medicine Program Spinal Cord Research Centre Department of Physiology University of Manitoba Topic: Manipulation of Redox Regulation for Neurotrauma Repair. Location: PX236/238 Psych Health Bldg. Research in Neuroprotection: My laboratory is interested in understanding the cellular and molecular events after Neurotrauma . Our overall aim is to find clinically relevant neuroprotective approaches to decrease the extent of cell death and to enhance cell survival after injury/stroke. Increasing evidence indicate that limiting the extent of cell death will result in improved tissue repair and functional recovery for patients. Despite extensive research in this field, there is currently no effective treatment available. In our laboratory, we focus on the oxidative stress as a major underlying mechanism in injury and stroke pathophysiology. We aim to: 1) use antioxidant therapy to enhance neural cell survival immediately after injury. 2) enhance cell preservation and regeneration for enhancement of repair. Short Biosketch: Eftekhar received his BSc and MSc from Tehran University, Iran. He moved to Canada in 1996 to study Neuroscience at the Department of Anatomy and Cell Biology University of Saskatchewan. After graduating in 2001, he moved to Toronto Western Hospital Research Institute for a postdoctoral training in Spinal Cord Injury in the Laboratory of Dr. Michael Fehlings. His work focused on understanding the cellular and molecular systems involved in spinal cord injury and repair with special interests in stem cell therapy. His work has been published in the leading journals of the field including the Journal of Neuroscience. After completion of post-doctoral training, he worked as a staff scientist at the University Health Network Spinal Cdrd Injury Group in Toronto until 2010, when he moved to the Spinal Cord Research Centre at the University of Manitoba. Eftekhar has established his laboratory in 2012 and his research focuses on neuroprotection strategies for treatment of neurotrauma. Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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MNN Seminar Cancelled Friday May 30th
by Winnipeg Chapter Society for Neuroscience 27 May '14

27 May '14

Please note that the talk originally scheduled for Friday May 30th at 9am has been cancelled. Apologies for inconvenience. Regards, Kelly Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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BME Invited Seminar Thursday May 29 -- Dr. Chris Ellis, University of Western Ontario
by Winnipeg Chapter Society for Neuroscience 26 May '14

26 May '14

BME Seminar Speaker: Dr. Chris Ellis Ph.D. Title: Microvasculature Regulation of Oxygen Supply: the most important control system on planet Earth? Time: 4:00-5:00 PM Date: Thursday, May 29, 2014 Location: E2-330 Engineering Building, Fort Gary Campus Some refreshment will be provided for after the seminar. To see the list of next scheduled BME seminars, please seehere: http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html Abstract of the talk Oxygen plays a critical role in almost every cell of the body, from energy production in the mitochondria to generation of key signaling molecules such as nitric oxide and carbon monoxide. To fulfill these functions, O2 must diffuse from an O2 source (e.g. erythrocyte in a capillary) through the cell (or cells) to the site where it will be used (consumed). But diffusion into an O2 consuming tissue places a biophysical limitation on the maximum cell size and the maximum distance between O2 sources within an organ. Ninety five years ago Krogh was the first to recognize that it was not adequate to simply deliver the correct amount of O2 to an organ, the vasculature needed to match the distribute the O2 supply to the O2 needs of the tissue to within a few 10's of micrometers of where it would be consumed. To meet this design constraint Krogh proposed that capillary density was actively controlled; as O2 consumption increased more capillaries would be recruited to minimize diffusion distances. Despite the importance of Krogh's insights, there was a fundamental flaw in his model of tissue oxygenation and his concept of capillary recruitment has never been proven. This talk will describe our current understanding of how the microvasculature regulates the distribution of O2 supply within a tissue. The situation is far more complex than controlling capillary density due to a wide range of factors such as the unique fluid dynamic properties of blood flow in the network of very small vessels that make up the microvasculature (arterioles, capillaries and venules), the complex three dimensional geometry of the microvasculature and diffusional exchange of O2 among all levels of the microvasculature as well as with the tissue. Our hypothesis is that the O2 supply to individual capillary units (capillaries supplied by a single terminal arteriole) is regulated by the hemoglobin O2 saturation dependent release of ATP (adenosine triphosphate) from red blood cells in capillaries and that receptors on the capillary endothelium detect the ATP levels and signal upstream arterioles to dilate via conducted hyperpolarization of endothelial membrane potential. To test the hypothesis that individual capillary units can regulate their O2 supply, we used a microfluidic device to perturb O2 levels in small groups of capillaries at the surface of skeletal muscle in rat hindlimb and a dual wavelength intravital video microscopy system for measuring red blood cell flow and O2 saturation in these capillaries. BME PhD student, Nour Ghonaim, demonstrated that individual capillary units were able to signal for an increase in O2 supply when capillaries were exposed to low O2 levels. Since O2 levels in arterioles were not affected this result supports our hypothesis of a conducted signal from capillaries to arterioles. Our conclusion is that discrete networks of capillaries, with the red blood cell as the O2 sensor, are able to regulate upstream arteriolar resistance to ensure that the distribution of O2 supply matches the O2 needs of the tissue and that O2 regulation occurs at the level of capillary units not individual capillaries as proposed by Krogh. Bio of the Speaker Dr. Christopher Ellis graduated from McMaster University in Hamilton with a B.Eng. degree in Chemical Engineering. In 1980 he completed his Ph.D. in Chemical Engineering at Northwestern University in Evanston, Illinois. He began his postdoctoral training with Alan C. Groom in Biophysics at The University of Western Ontario in 1979 and in 1982 he was appointed as an Assistant Professor supported initially by a Senior Scholarship (1982-89) and later a Career Investigator Award of the Heart and Stroke Foundation of Ontario (1989-94). From 1995 through 2004 he served as Graduate Chair for Medical Biophysics. From June 2006 to June 2009 he served as Assistant Dean - Research, Schulich School of Medicine & Dentistry and from July 2009 to December 2009 as Associate Dean - Research. He is currently a Professor in the Departments of Medical Biophysics and Medicine. Dr. Ellis has trained over 20 graduate students, clinical trainees and post-doctoral fellows. He has published over 80 journal articles with total of ~3200 citations. His research on oxygen transport in the microvasculature has been funded by grants from CIHR, Heart and Stroke Foundation of Ontario, NSERC and NIH. His research interests include the application of a novel optical imaging system to investigate microvascular oxygen transport in living tissue in animal models of disease, the exploration of the mechanisms responsible for the local regulation of oxygen delivery by the microvasculature in vivo, with particular emphasis on the role of red blood cell as the sensor and regulator of oxygen delivery, and the application of microfluidics to microvascular research. --- Looking forward to your attendance and support for BME. Zahra Zahra Moussavi, Ph.D., P.Eng. Director, Biomedical Engineering Program Professor & Canada Research Chair in Biomedical Engineering; http://umanitoba.ca/biomedical_engineering/ <http://umanitoba.ca/biomedical_engineering/> Main Office: E3-513 Eng. Bldg. Dept. of Elect. & Comp. Engineering, University of Manitoba 75 Chancellor Circle, Winnipeg MB R3T 5V6 Phone: 204-474-7023 Fax: 204-261-4639 Email: Zahra_Moussavi(a)Umanitoba.ca <mailto:Zahra_Moussavi@Umanitoba.ca> http:/home.cc.umanitoba.ca/~mousavi <http://www.ee.umanitoba.ca/~moussavi> Research Page: http://bme.ee.umanitoba.ca/bmelab <http://bme.ee.umanitoba.ca/bmelab> Riverview Office: PE-458, 1 Morley Ave, Riverview Health Center Winnipeg, MB Phone: 478-6163 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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Reminder: MNN Speaker - Dr. Jerry Silver - May 16 @ Noon
by Kelly Jorundson 15 May '14

15 May '14

Reminder...... Manitoba Neuroscience Network Seminar Series Friday, May 16, 2014 | 12:00 Noon [Jerry Silver, Ph.D.] Dr. Jerry Silver<http://neurowww.cwru.edu/faculty/silver/index> Professor - Department of Neurosciences Case Western Reserve University Topic: Functional regeneration into and beyond the glial scar Location: Theatre B - Basic Med Sciences Bldg. Biosketch: Dr. Silver received his Ph.D. from Case Western Reserve in 1974 and was the recipient of the Herbert S. Steuer Memorial Award for Meritorious Original Research in Anatomy. He did post-doctoral work at Harvard University in the Department of Neurosciences at The Children's Hospital and in the Neuropathology Department at Harvard Medical School. Dr. Silver is currently Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation. Dr. Silver is a recipient of several prestigious awards. Dr. Silver has served on a number of editorial boards including the journals Glia, The Journal of Neurocytology, Developmental Neurobiology, The Journal of Neuroscience and Experimental Neurology (where he is a Section Editor). He regularly reviews articles for over 35 high impact journals and he reviews grants for 18 national and international organizations /sent on behalf of Eftekhar Eftekharpour Seminar Coordinator, Manitoba Neuroscience Network [cid:part1.07040404.07050801@cc.umanitoba.ca] Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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2014 Nick Shepel Student Travel Award
by Winnipeg Chapter Society for Neuroscience 07 May '14

07 May '14

2014 Nick Shepel Student Travel Award Competition deadline: June 13, 2014 The Nick Shepel Student Travel Award was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his lab partners and brought fire, humor, and a desire to always do better. His insistence to always try better will have a permanent effect on his lab mates. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator (graduate student within the Faculty of Medicine - University of Manitoba) by providing an annual award(s) (up to $1,000 max) to support travel costs associated with the applicant's attendance at a future national/international conference where the applicant is presenting a poster or oral presentation. Eligibility: At the time of application, students must be registered in the Faculty of Medicine at the University of Manitoba. 1. "Registered" includes being accepted by the major department of study, admitted by the Faculty of Graduate Studies, or eligible to register in the Faculty of Graduate Studies. 2. A student admitted under the "Provisional Status" may not receive the award during the provisional period. 3. Amount of award(s) may vary each year (minimum value - $400). 4. Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international) Submission Instructions: A complete application consists of the following: 1. Introductory letter describing meeting 2. Copy of abstract 3. Curriculum vitae 4. Current GPA, transcripts not needed 5. Proposed budget of travel costs 6. Submit your completed application materials to: Dr. Paul Fernyhough Director - Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Only original receipts will be accepted. Copies may be accepted only where proof of submission to another agency is provided. For more information, contact: Kelly Jorundson, Administrative Manager Division of Neurodegenerative Disorders R4046-351 Tache Ave., Winnipeg, MB R2H 2A6 E: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> T:204.235.3939 F: 204.237.4092 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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BME Seminar Thursday May 8 -- functional Near-Infrared Spectroscopy (fNIRS) for Brain Imaging
by Winnipeg Chapter Society for Neuroscience 06 May '14

06 May '14

Everyone is invited! BME seminar - Younes Rakhsani M.Sc. Date: Thursday, May 8, 2014 Time: 4:00-5:00 PM Location: E2-330 Engineering Building, Fort Gary Campus Speaker: Younes Rakhsani M.Sc. Title: functional Near-Infrared Spectroscopy (fNIRS) for Brain Imaging Some refreshment will be provided for after the seminar. To see the list of next scheduled BME seminars, please see here: http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html <http://umanitoba.ca/biomedical_engineering/courses/bme_seminars.html> Abstract of the talk Noninvasive measurements of blood volume and blood oxygenation changes in tissue is possible using near-infrared spectroscopy (NIRS) with high temporal resolution. Diffuse optical imaging (DOI) is inexpensive and portable compared to other vascular imaging modalities such as MRI or positron emission tomography (PET). One of the advantages of the DOS systems is that they are portable, so it provides the ability to measure cerebral blood oxygenation, volume, or flow using portable instrumentation. DOS can be used for different types of bedside monitoring. Using multi-channel DOS and DOI systems, optical brain imaging can be applied to various psychology functional tests in adults, children, and more recently infants. In this presentation I am going to talk about optical properties of the brain, basic types of NIRS systems, fNIRS signal processing and applications of NIRS. Also, I will talk about the CW-NIRS system that we have built in our lab and its results. Short Bio of the speaker Younes received his B.Sc., and first M.Sc. in Electrical engineering from Iran University of Science and Technology and Tehran University, respectively. Currently, he is enrolled in the M.Sc. BME program at U of Manitoba with focus on fNIRS design, implementation and evaluation. /sent on behalf of Chris Anderson Chris M. Anderson, President - Winnipeg Chapter Society for Neuroscience Associate Professor and Director, Neuroscience Research Program Kleysen Institute for Advanced Medicine Health Sciences Centre and University of Manitoba T: 204-318-2565 E: chris.anderson(a)med.umanitoba.ca

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MNN Visiting Speaker - Dr. Jerry Silver May 16 2014 12 Noon
by Winnipeg Chapter Society for Neuroscience 05 May '14

05 May '14

Everyone is invited to attend! Manitoba Neuroscience Network Seminar Series - Dr. Jerry Silver Friday, May 16, 2014 | 12:00 Noon Theatre B - Basic Med Sciences Bldg. Dr. Jerry Silver <http://neurowww.cwru.edu/faculty/silver/index> Professor - Department of Neurosciences Case Western Reserve University Topic: Functional regeneration into and beyond the glial scar Biosketch: Dr. Silver is currently a Professor in the Department of Neurosciences at the Case Western Reserve University School of Medicine and adjunct Professor in the Department of Neurosurgery at the Cleveland Clinic Foundation. Dr. Silver received his Ph.D. from Case Western Reserve in 1974, with further post-doctoral training at Harvard Medical School. He is recognized internationally for his long lasting research in the field of regeneration, spinal cord injury and paralysis. Dr. Silver is the recipient of several prestigious awards/recognitions including: * Herbert S. Steuer Memorial Award (1974) * Ameritec Prize for significant accomplishments toward a cure for paralysis (2003) * Christopher Reeve-Joan Irvine Research Medal (2003), for critical contributions that may lead to the promotion of repair of the damaged spinal cord * Jacob Javits Neuroscience Investigator Award (2004 , that recognizes a select group of NIH grantees with seminal contributions to their field of neuroscience * Erica Nader Award (2008), for breakthrough research in the field of spinal cord injury * Member of the American Association for the Advancement of Science (AAAS) (2011) Dr. Silver has served on a number of editorial boards including the journals Glia, The Journal of Neurocytology, Developmental Neurobiology, The Journal of Neuroscience and Experimental Neurology (where he is a Section Editor). He regularly reviews articles for over 35 high impact journals and he reviews grants for 18 national and international organizations. He has served on a variety of NIH study sections since 1982 including the Neurobiology Review Group, Neurology B2, The Visual Sciences C Study Section, and the Clinical Neurology, Neurotransmitters and Transplantation Study Section. He serves as a regular member of the Scientific Advisory Council of the Christopher Reeve Foundation and of the Scientific Board of the International Spinal Research Trust (England). He has served as lead or senior author on more than 160 publications. A brief synopsis of Dr. Silver's work: Over the past several decades, Dr. Silver has concentrated his research efforts learning whether molecules that glia produce after spinal cord injury may play a major role in blocking regeneration. Of particular interest, the chondroitin sulfate proteoglycans (CSPGs), were first discovered by the Silver's lab in the early 1990's to be involved in impeding regeneration. His lab has pioneered the use of the CSPG degrading enzyme chondroitinase to reveal the important role of the glycosaminoglycan (GAG) sugar chains. Dr. Silver's lab has shown that adult nerve cells could regenerate their axons with high efficiency and at high rates of speed even in fully degenerating white matter and even at long chronic stages after injury, challenging long held beliefs that this was impossible. Currently, his research focuses on the regenerative approaches that target the CSPG receptors. These receptors identified originally by his laboratory may hold the key for enhancing regeneration after Spinal Cord Injury. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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2014 WCSN Membership Dues
by Kelly Jorundson 02 May '14

02 May '14

Dear all, The 2014 online membership form is now available. If you are not already a member of the Winnipeg Chapter Society for Neuroscience (WCSN), we encourage you to join today. Click here<http://sfn-manitoba.ca/about.html> to learn more about the benefits of becoming a member . 2014 Fee Schedule: *Membership fees are for the calendar year (January-December). Faculty, Professionals $60.00 Postdocs, Residents, Technicians, Research Associates $30.00 Students $15.00 All-inclusive Lab Rate $100.00 To pay your 2014 membership dues, please complete the WCSN Membership Application<http://sfn-manitoba.ca/application/> . Payment methods include: credit card, cheque, and FOAP. If you are paying by cheque, please make payment to: St. Boniface Hospital c/o Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Regards, Chris Anderson President - Winnipeg Chapter Society for Neuroscience Kelly Jorundson Executive Assistant Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> OR Kelly.jorundson(a)med.umanitoba.ca<mailto:Kelly.jorundson@med.umanitoba.ca> Website: www.sfn-manitoba.ca<http://www.sfn-manitoba.ca>

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