November 2018 - Neuro-All - University of Manitoba Mailing Lists

MNN Visiting Speaker Dr. Shawn Hochman | Thurs. Dec 13 @ 12 Noon, Theatre B
by Manitoba Neuroscience Network 12 Dec '18

12 Dec '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E: Thursday December 13, 2018 12:00 Noon L O C A T I O N: Theatre B Bannatyne Campus **followed by a trainee lunch in 431 BMSB S P E A K E R Dr. Shawn Hochman Professor and Interim Chair Emory University School of Medicine Atlanta, GA T O P I C: Paravertebral sympathetic thoracic chain ganglia: recruitment principles and plasticity after spinal cord injury O b j e c t I v e s: Paravertebral chain sympathetic postganglionic neurons (SPNs) represent the final neural control element regulating vasomotor tone and can be thought of as a distribution system for sympathetic activity that must span the body vasculature. Alterations in sympathetic chain activity are implicated in various autonomic disorders. The thoracic SPNs (tSPNs) control vasomotor function in upper extremities and trunk (this includes vascular supply to integumentary, cardiorespiratory and digestive systems). tSPNs remain a barely-studied area of vertebrate autonomic neuroscience. 1. Use whole-cell patch clamp recordings in an adult mouse ex vivo preparation to uncover the operational principles governing tSPN recruitment. 2. Obtain a reliable cellular and synaptic data set for realistic computational simulation. The relative simplicity of the organization makes discovery of principles through modeling more assured than in more complex systems. 3. To determine whether changes in tSPNs contribute to autonomic dysfunction after spinal cord injury. B I O S K E T C H: Shawn Hochman is Professor and Interim Chair of Physiology at Emory University School of Medicine. His research embraces broad aspects of neuromodulation-based control of sensorimotor and autonomic integration. Current research focuses on emergent dysfunction in mouse models of spinal cord injury. Efforts include; (i) continuous non-invasive capture of changes in physio-behavioral variables in the vivarium home-cage, and (ii) the role of the peripheral NS in driving emergent sensory and autonomic dysfunction For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal club - Dr Puig
by Manitoba Neuroscience Network 30 Nov '18

30 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Dr Puig's presentation from yesterday (whole body #MRI clinical study, n=1030) can now be viewed on our Dementia Manitoba website: http://dementiamanitoba.wixsite.com/mysite/dementia-journal-club B. Albensi, PhD Dementia Research Chair Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: Tomorrow - Jeremy Chopek | Fri Nov 30 @ 9am
by Manitoba Neuroscience Network 29 Nov '18

29 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, November 30th, 2018 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Jeremy Chopek Assistant Professor Physiology & Pathophysiology Rady Faculty of Health Sciences T O P I C Investigating brainstem and spinal cord movement circuits using mouse genetics O B J E C T I V E S 1) Understand the utility of mouse genetic for examining movement 2) Appreciate the complexity of local cellular connectivity 3) Understand the role of the brainstem and spinal cord in producing movement B I O S K E T C H: Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar: Jeremy Chopek | Fri Nov 30 @ 9am
by Manitoba Neuroscience Network 26 Nov '18

26 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, November 30th, 2018 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Jeremy Chopek Assistant Professor Physiology & Pathophysiology Rady Faculty of Health Sciences T O P I C Investigating brainstem and spinal cord movement circuits using mouse genetics O B J E C T I V E S 1) Understand the utility of mouse genetic for examining movement 2) Appreciate the complexity of local cellular connectivity 3) Understand the role of the brainstem and spinal cord in producing movement B I O S K E T C H: Dr. Jeremy Chopek received his Msc (2009) in Kinesiology and PhD (2014) in the Department of Physiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Afterwards, Jeremy completed a post-doctoral position at Dalhousie University (2014-2017) and University College London (2017-2018) working with both Dr. Zhang and Dr. Brownstone. His work has focused on microcircuit formation in both the medulla reticular formation and lumbar spinal cord, centres that are vital for the initiation and execution of movement. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal club - Presentation on Nov 29th noon at HSC - Dr Puig
by Manitoba Neuroscience Network 21 Nov '18

21 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Dementia Journal club - Dr Josep Puig DATE: NOV 29TH, 2018 TIME: 12 PM - NOON LOCATION: UNIV MANITOBA - HEALTH SCI CTR., GG147 Topic: Aging Imageomics Study: Looking at imaging, seeing health See attached poster for upcoming presentation. For more information please contact: Ben Albensi balbensi(a)sbrc.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder TODAY: Dr. Wei Lu | Lecture @ 12 noon Theatre C
by Manitoba Neuroscience Network 15 Nov '18

15 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E: Thursday November 15th, 2018 12:00 Noon L O C A T I O N: Theatre C Bannatyne Campus **followed by a trainee lunch in SR415 Kleysen Bldg. S P E A K E R Dr. Wei Lu Synapse and Neural Circuit Section Porter Neuroscience Research Center National Institute of Neurological Disorders and Stroke National Institutes of Health T O P I C: Making the brains own brake | Molecular mechanisms of inhibitory synapse development. O b j e c t I v e s: Discuss the recent progress from my lab in understanding the molecular and cellular mechanisms for inhibitory synapse development B I O S K E T C H: Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York University School of Medicine, New York, 2006 M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000 B.S. (Biochemistry). Sichuan University, China, 1997 Recent publications: Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. 128 (2) Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. 23, 1213-1225. Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E, Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron. 99(3):493-510 For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker - Dr. Wei Lu | Thursday Nov 15th @ 12 noon Theatre C
by Manitoba Neuroscience Network 13 Nov '18

13 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E: Thursday November 15th, 2018 12:00 Noon L O C A T I O N: Theatre C Bannatyne Campus **followed by a trainee lunch in SR415 Kleysen Bldg. S P E A K E R Dr. Wei Lu Synapse and Neural Circuit Section Porter Neuroscience Research Center National Institute of Neurological Disorders and Stroke National Institutes of Health T O P I C: Making the brains own brake | Molecular mechanisms of inhibitory synapse development. O b j e c t I v e s: Discuss the recent progress from my lab in understanding the molecular and cellular mechanisms for inhibitory synapse development B I O S K E T C H: Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York University School of Medicine, New York, 2006 M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000 B.S. (Biochemistry). Sichuan University, China, 1997 Recent publications: Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. 128 (2) Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. 23, 1213-1225. Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E, Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron. 99(3):493-510 For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: New Winter Term 2019 Neuroscience Graduate Courses
by Manitoba Neuroscience Network 07 Nov '18

07 Nov '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Brent Fedirchuk Greetings Manitoba Neuroscience Community, You may recall that back in the summer, a notice was sent out that the "Fundamental Neuroscience" graduate courses (IMED7101 & IMED7102) have been replaced with a suite of 4 separate 1.5 credit hour courses. The first 2 of these new courses (IMED7112 and IMED7114) have been offered during the Fall 2018 semester. I wanted to remind you that the next two 1.5 credit hour courses will be offered in the upcoming Winter 2019 session (Jan - Apr 2019). They are: "IMED7116 - Fundamental Systems Neuroscience" (Jan - Feb 2019) and "IMED7118 - Fundamental Neurobiology of Disease" (Mar - Apr 2019) Please see the attached notice for more information (and please print it / post it to help make sure all prospective students know about it!). Feel free to contact either me (for IMED7116) or Dr. Marc Del Bigio marc.delbigio(a)umanitoba.ca (for IMED7118) for additional information. Thanks, Brent ====================================== Brent Fedirchuk, Ph.D. Associate Professor Department of Physiology and Pathophysiology Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba 745 Bannatyne Avenue; Rm 410 BMSB Winnipeg, MB R3E 0J9 CANADA tel (204) 789-3762 (sorry, no voice mail) fax (204) 789-3934 <http://www.scrc.umanitoba.ca/> www.scrc.umanitoba.ca ======================================

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