January 2019 - Neuro-All - University of Manitoba Mailing Lists

Edge of Science & Medicine Visiting Speaker Series - Dr. George Perry Feb 4/2019
by Manitoba Neuroscience Network 03 Feb '19

03 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Ben Albensi Everyone is invited! D A T E: Monday, Feb 4, 2019 12:00 Noon L O C A T I O N: Theatre A Bannatyne Campus **followed by a trainee lunch in 207 A&B Chown Bldg. S P E A K E R: Image result for dr george perryGeorge Perry PhD Professor of Biology and Chemistry Chief Scientist, Brain Health Consortium Semmes Foundation Distinguished University Chair in Neurobiology The University of Texas at San Antonio T O P I C: Mitochondria At The Center Of Alzheimers Disease Dr. Perrys studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimers disease. The lab has shown that oxidative damage is the initial cytopathology in Alzheimers disease. They are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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**REVISED***Special Lecture - John Wallace Feb 1 @ 9am
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Mary Fry All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information. Special Cross-Disciplinary Seminar hosted by Department of Biological Sciences Date: Friday, Feb 1st, 2019 Time: 9:00am Location: Room 207 Buller BLDG Speaker: John L. Wallace Professor of Physiology & Pharmacology University of Calgary Topic: A gas from the Past: Adventures in Drug Discovery". Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Seminar - Feb 22 - Stephanie Booth ***CANCELLED**
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] Please note that the MNN seminar scheduled for February 22nd, 2019 has been cancelled. Apologies for any inconvenience. /sent on behalf of Tabrez Siddiqui Chair, Seminar Series Manitoba Neuroscience Network Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Special Lecture - John Wallace Feb 1 @ 9am
by Kelly Jorundson 31 Jan '19

31 Jan '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Mary Fry All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information. Special Cross-Disciplinary Seminar hosted by Department of Biological Sciences Date: Friday, Feb 1st, 2019 Time: 9:00am Location: Room 207 JBRC Speaker: John L. Wallace Professor of Physiology & Pharmacology University of Calgary Topic: A gas from the Past: Adventures in Drug Discovery". Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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Reminder: MNN Seminar Series - Dr. Saeid Ghavami Fri Jan 25th @9am
by Manitoba Neuroscience Network 21 Jan '19

21 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, January 25th, 2019 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Saeid Ghavami Assistant Professor Human Anatomy & Cell Science Rady Faculty of Health Sciences T O P I C Glioblastoma and Cholesterol Metabolism Pathway Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ treatment causes DNA damage and results in tumor cell apoptosis. TMZ also induces autophagy and causes tumor cell resistance and thus fails to improve the survival rate among patients. Statins are competitive inhibitors of the rate determining enzyme of the mevalonate (MEV) cascade and best known for their cholesterol (CH) lowering effect. Recently, it was reported that long-term consumption of statins, prior to and in parallel with other cancer therapeutic approaches, increased the survival rate of patients with various forms of cancers. In this talk, I present our latest investigation about the mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human GBM cell lines and in primary human GBM cells in both cell monolayers and in three-dimensional (3D) cell culture systems. Learning Objectives: 1- The attendee will learn the concept of Cholesterol biosynthesis pathway and its possible effect in glioblastoma new therapy strategies. 2- The participant will learn concept of autophagy pathway. 3- The participant will understand how autophagy is involved in regulation of apoptosis. 4- The participant will learn the principal of glioblastoma 3D culture model. Short Biography: Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz, Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical Biochemistry. His Postdoctoral training was focused on the application of apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell fate. His research program is focused on regulation of cellular phenotype via targeting autophagy and unfolded protein response in the Department of Human Anatomy and Cell Science, University of Manitoba, He has been the recipient of a number of prestigious awards including CIHR/GSK/CLA postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career Development Award (top 10 in North America, 2009), ATS Science and Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early Career Research Award (2017). He has published more than 150 peer reviewed article (google scholar: >12,800 citation, h-index 40) (scopous > 7800 citations, h-index 33). Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar Series - Dr. Saeid Ghavami Fri Jan 25th @9am
by Manitoba Neuroscience Network 15 Jan '19

15 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, January 25th, 2019 9am L O C A T I O N: Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Dr. Saeid Ghavami Assistant Professor Human Anatomy & Cell Science Rady Faculty of Health Sciences T O P I C Glioblastoma and Cholesterol Metabolism Pathway Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ treatment causes DNA damage and results in tumor cell apoptosis. TMZ also induces autophagy and causes tumor cell resistance and thus fails to improve the survival rate among patients. Statins are competitive inhibitors of the rate determining enzyme of the mevalonate (MEV) cascade and best known for their cholesterol (CH) lowering effect. Recently, it was reported that long-term consumption of statins, prior to and in parallel with other cancer therapeutic approaches, increased the survival rate of patients with various forms of cancers. In this talk, I present our latest investigation about the mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human GBM cell lines and in primary human GBM cells in both cell monolayers and in three-dimensional (3D) cell culture systems. Learning Objectives: 1- The attendee will learn the concept of Cholesterol biosynthesis pathway and its possible effect in glioblastoma new therapy strategies. 2- The participant will learn concept of autophagy pathway. 3- The participant will understand how autophagy is involved in regulation of apoptosis. 4- The participant will learn the principal of glioblastoma 3D culture model. Short Biography: Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz, Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical Biochemistry. His Postdoctoral training was focused on the application of apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell fate. His research program is focused on regulation of cellular phenotype via targeting autophagy and unfolded protein response in the Department of Human Anatomy and Cell Science, University of Manitoba, He has been the recipient of a number of prestigious awards including CIHR/GSK/CLA postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career Development Award (top 10 in North America, 2009), ATS Science and Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early Career Research Award (2017). He has published more than 150 peer reviewed article (google scholar: >12,800 citation, h-index 40) (scopous > 7800 citations, h-index 33). Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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TODAY MNN Visiting Speaker | Dr. Keith Murai Jan 14th @ 12 noon
by Manitoba Neuroscience Network 14 Jan '19

14 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, January 14, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre C, Bannatyne Campus S P E A K E R D r. Keith Murai, Ph.D. Director for the Centre for Research in Neuroscience Professor, Neurology & Neurosurgery, Faculty and Department of Medicine Research Institute of the McGill University Health Centre T O P I C Astrocyte diversity and brain circuit microenvironments Objectives: 1) Discuss the complexity and heterogeneity of astrocyte populations in the CNS which may confer differential responses in the injured brain 2) Discuss the future potential of manipulating brain astrocytes for treating brain injuries, increasing resiliency of neurons in brain diseases, and promoting repair Abstract: Astrocytes are key partners for neurons in the healthy brain and contribute to the physiology and homeostasis of neural circuits. The complex molecular, functional, and structural properties of astrocytes enable these cells to precisely regulate extracellular ionic balance, neurotransmission, brain energetics, and cerebrovasculature. However, the mechanisms that enable astrocytes to perform highly diverse and specialized functions in the brain remain poorly understood. In this presentation, results will be provided showing the remarkable anatomical and functional complexity of astrocytes using advanced electron microscopy and molecular techniques. Furthermore, new findings will be shown demonstrating how mature neurons signal to neighbouring astrocytes to guide their molecular and physiological features in multiple brain regions. This neuron to astrocyte communication is both necessary and sufficient for astrocyte molecular diversification including the expression of important molecules including glutamate transporters and receptors, potassium channels, and water channels. Thus, ongoing communication between neurons and astrocytes plays an fundamental role in optimizing local neural circuit microenvironments to ensure optimal brain health and function. Brief Bio: Keith Murai is the Director of the Centre for Research in Neuroscience at McGill University, Leader of the Brain Repair and Integrative Neuroscience (BRaIN) Program at the Research Institute of the McGill University Health Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill University. He is a recipient of a Canada Research Chair position and is an EJLB Scholar for Schizophrenia Research. His research has two main areas of focus: (1) Understanding how neurons and glial cells cooperate to regulate brain development and homeostasis and (2) Discovering mechanism that regulate the plasticity of synapses that underlie memory formation, neurodevelopmental disorders, and neurodegenerative diseases. His laboratory uses advanced mouse genetic, imaging, electrophysiological, and optogenetic techniques and has pioneered approaches for understanding glial cells in brain function. He is an Associate (handling) Editor at Frontiers in Cellular Neuroscience, Section Editor in Development and Plasticity at the Journal of Experimental Neuroscience, and a Member of the editorial board at Developmental Neurobiology. He has been an author on high impact research studies published in journals such as the Journal of Neuroscience, PNAS, Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell, and Science. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker | Dr. Keith Murai Jan 14th @ 12 noon
by Manitoba Neuroscience Network 08 Jan '19

08 Jan '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, January 14, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre C, Bannatyne Campus S P E A K E R D r. Keith Murai, Ph.D. Director for the Centre for Research in Neuroscience Professor, Neurology & Neurosurgery, Faculty and Department of Medicine Research Institute of the McGill University Health Centre T O P I C Astrocyte diversity and brain circuit microenvironments Objectives: 1) Discuss the complexity and heterogeneity of astrocyte populations in the CNS which may confer differential responses in the injured brain 2) Discuss the future potential of manipulating brain astrocytes for treating brain injuries, increasing resiliency of neurons in brain diseases, and promoting repair Abstract: Astrocytes are key partners for neurons in the healthy brain and contribute to the physiology and homeostasis of neural circuits. The complex molecular, functional, and structural properties of astrocytes enable these cells to precisely regulate extracellular ionic balance, neurotransmission, brain energetics, and cerebrovasculature. However, the mechanisms that enable astrocytes to perform highly diverse and specialized functions in the brain remain poorly understood. In this presentation, results will be provided showing the remarkable anatomical and functional complexity of astrocytes using advanced electron microscopy and molecular techniques. Furthermore, new findings will be shown demonstrating how mature neurons signal to neighbouring astrocytes to guide their molecular and physiological features in multiple brain regions. This neuron to astrocyte communication is both necessary and sufficient for astrocyte molecular diversification including the expression of important molecules including glutamate transporters and receptors, potassium channels, and water channels. Thus, ongoing communication between neurons and astrocytes plays an fundamental role in optimizing local neural circuit microenvironments to ensure optimal brain health and function. Brief Bio: Keith Murai is the Director of the Centre for Research in Neuroscience at McGill University, Leader of the Brain Repair and Integrative Neuroscience (BRaIN) Program at the Research Institute of the McGill University Health Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill University. He is a recipient of a Canada Research Chair position and is an EJLB Scholar for Schizophrenia Research. His research has two main areas of focus: (1) Understanding how neurons and glial cells cooperate to regulate brain development and homeostasis and (2) Discovering mechanism that regulate the plasticity of synapses that underlie memory formation, neurodevelopmental disorders, and neurodegenerative diseases. His laboratory uses advanced mouse genetic, imaging, electrophysiological, and optogenetic techniques and has pioneered approaches for understanding glial cells in brain function. He is an Associate (handling) Editor at Frontiers in Cellular Neuroscience, Section Editor in Development and Plasticity at the Journal of Experimental Neuroscience, and a Member of the editorial board at Developmental Neurobiology. He has been an author on high impact research studies published in journals such as the Journal of Neuroscience, PNAS, Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell, and Science. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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