- Neuro-All - University of Manitoba Mailing Lists

Goldowitz Seminar
by Winnipeg Chapter Society for Neuroscience 14 Feb '13

14 Feb '13

/sent on behalf of Geoff Hicks..... Dear Colleagues, I want to bring your attention to a visiting professor seminar next week by Dr Dan Goldowitz (poster attached). Would be terrific if you could send the seminar notice out to your own email list. I have taken the liberty to include the faculty's neuroscience programs as "co-hosts," recognizing that his seminar may be of high interest to your research groups. Please also note, all trainees (and in particular those in your own programs) are invited to join later in the afternoon for a Developmental Biology class lecture on brain development and neuro-developmental diseases. This will be followed by a robust open discussion and plenty of time to interact with Dr Goldowitz. Dan has quite a full day, but please let me know if you would like to meet with him personally, and I'll be happy to make whatever arrangements I can. with best regards, Geoff Hicks, PhD Director, Regenerative Medicine University of Manitoba Office: 204-787-2133 Fax: 204-787-2190 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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FW: Student Seminar/Lunch
by Winnipeg Chapter Society for Neuroscience 12 Feb '13

12 Feb '13

please pass along to your neuroscience students.... Dear Neuroscience students, You are invited to attend a student lunch following the Edge of Science Seminar on Monday February 25, 2013. The Lunch will be held in the Pharmacology and Therapeutics Library A229 Chown Building at 1:15 pm. Please RSVP if you will be attending by Friday February 15, 2013. Please note: If you are planning to attend the lunch ,you are also required to attend the seminar. Best Regards, Raquel Nowlin Department of Pharmacology & Therapeutics Faculty of Medicine University of Manitoba A203-753 McDermot Avenue Winnipeg MB R3T 0T6 Phone: 204-789-3520 Fax: 204-789-3932 Email: raquel.nowlin(a)med.umanitoba.ca Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Neuroscience Seminar Series - Feb. 22nd
by Winnipeg Chapter Society for Neuroscience 12 Feb '13

12 Feb '13

**Please note time/location change for this seminar. Manitoba Neuroscience Network Seminar Series Friday, February 22nd, 2013 | 2:00 pm Dr. Derek van der Kooy Professor Department of Molecular Genetics University of Toronto Topic: Where Brains Come From Location: Theatre B Derek van der Kooy served as Professor in the Department of Anatomy and Cell Biology at the University of Toronto from 1991 until 2002, when he became a Professor in the Department of Molecular Genetics. Derek received a M.Sc. in Psychology at the University of British Columbia, and a Ph.D in Anatomy, first at Erasmus University in the Netherlands, and finishing in the Department of Anatomy at the University of Toronto. Dr. van der Kooy gained postdoctoral research experience at Cambridge University in England and at the Salk Institute in California. The van der Kooy lab works on various stem cell biology and developmental biology research projects; specifically, stem cells in organisms from Drosophila to humans. We produced the first report of stem cells in the adult mammalian eye, published in 2000 in Science. We also have isolated a rare stem cell from the adult mouse and human pancreas that can show extensive proliferation under defined conditions in vitro. Of interest to the lab is the lineage of neural stem cells from pluripotent embryonic stem cells, with relevance to the origin of the earliest neural stem cell in the developing embryo. ABSTRACT: One of the few neurobiological facts not anticipated by Cajal is the existence of neural stem cells in the embryonic and adult mammalian brain that can produce new neurons in the adult brain (new neurons first shown by Altman). The earliest mammalian neural stem cells differentiate from pluripotent embryonic stem cells. These primitive neural stem cells emerge in response to LIF and have a wider non-neural phenotypic potential than later neural stem cells. By embryonic day 8.5 in mouse, true FGF2 dependent neural stem cells emerge and by embryonic day 14 they have given rise to copies of themselves and to EGF dependent neural stem cells. The separate FGF2 and EGF dependent neural stem cells increase greatly in numbers later in neurogenesis, but by E14 appear identical to adult neural stem cells. The adult mammalian neural stem cells are mostly quiescent, dividing asymmetrically only once every few weeks. Mouse embryonic stem (ES) cells cultured in low cell density, completely defined media adopt a neural identity. Using a clonal colony-forming assay, we identify the novel primitive neural stem cell stage as a component of neural lineage specification (this cell is similar to the one we isolate from the early embryo), which is negatively regulated by TGFb-related signaling. These results are consistent with a default mechanism for neural fate specification. Primitive neural stem cells are formed directly from single ES cells in a LIF-dependent manner, express multiple neural precursor markers and give rise to neurons and glia. Moreover, in vivo mouse chimera experiments reveal that these primitive ES-derived neural stem cells have a broad range of neural and non-neural lineage potential. These results support a model whereby definitive neural stem cell formation is preceded by a primitive neural stem cell stage during neural lineage commitment. Most recently, we have found that the LIF-dependent, primitive neural stem cells persist in adult organisms and can repopulate a depleted definitive neural stem cell pool in the adult. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca From: Krystyna Kruczek [mailto:KKruczek@exchange.hsc.mb.ca] Sent: February 12, 2013 10:48 AM To: Kelly Jorundson Subject: FW: Neuroscience Seminar Series - Feb. 22nd Hi Kelly, I am sending out the notice for February 22nd Neuroscience Rounds as Marie is away. Can you email me the information I need on the Neuroscience Seminar Series for that day? Thanks. Krys Kruczek Administrative Assistant to, Neil Berrington, MMed, FRCS, FCS (SA) Assistant Professor Head - Section of Neurosurgery Phone: 204-787-7261 Fax: 204-787-3851 Email: KKruczek(a)exchange.hsc.mb.ca P Please consider the environment before printing this email From: Marie Field Sent: Wednesday, February 06, 2013 9:39 AM To: Krystyna Kruczek Subject: Neuroscience Seminar Series Hi Krys, I receive info re the Neuroscience Seminar Series from: Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca I appreciate you contacting her for the February 22nd info and for sending out the Neuroscience Rounds notice while I am away. _______________________________ Marie Field Education Coordinator Dermatology, Infectious Diseases, Neurology and Physician Assistant Program Department of Internal Medicine University of Manitoba GF328, Health Sciences Centre Tel: (204) 787-8624 l Fax: (204) 787-4528 mfield(a)hsc.mb.ca

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New Neuroscience Funding Opportunity: The W. Garfield Weston Foundation
by Winnipeg Chapter Society for Neuroscience 07 Feb '13

07 Feb '13

This message is forwarded on behalf of Alexandra Stewart Executive Director, Neuroscience The W. Garfield Weston Foundation ------------------------------------ I am writing as the Executive Director, Neuroscience of The W. Garfield Weston Foundation. The Foundation is a private Canadian family foundation where donations are directed to qualified donees in the fields of education, land conservation, science in Canada's North and through unsolicited Trustee Initiated Grants. Last year, the Foundation launched a pilot funding program for neuroscience research within the Greater Toronto Area. I am excited to let you know the Foundation is launching another pilot funding program for neuroscience research this week open to institutions across Canada. We wanted to ensure you and the researchers at the University of Manitoba were aware of this opportunity. The goal of this request for proposals (RFP) is to provide funding for translational research or clinical trials that will have transformational impact in neurodegenerative diseases of aging. The Foundation will commit up to $4 million to this program. Grants will be for up to $500,000 per year for up to three years to a maximum of $1.5 million per project. Application requires a one to two page Letter of Intent due Monday, March 25th, 2013. High potential applicants will be invited to submit a short proposal, and grantees will be announced in the summer. Details are attached and are also at www.westonfoundation.org/pages/neuroscience.aspx<http://www.westonfounda tion.org/pages/neuroscience.aspx>. Please let me know if a follow up phone call would be helpful. Questions about the RFP are also welcome at info(a)westonneuroscience.ca<mailto:info@westonneuroscience.ca> or 416 935-4056. Best wishes, Alex Alexandra Stewart Executive Director, Neuroscience The W. Garfield Weston Foundation 22 St. Clair Avenue East, Suite 2001 Toronto, ON M4T 2S3 alexandra.stewart(a)weston.ca<mailto:alexandra.stewart@weston.ca> w: 416 922-1383 x 5764 f: 416 967-7949 <<Transformational RFP on Neurodegenerative Diseases of Aging.docx>> <<ATT00001.htm>>

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Dr. Derek van der Kooy's visit
by Winnipeg Chapter Society for Neuroscience 30 Jan '13

30 Jan '13

Dear All, As you may know, The Manitoba Neuroscience Network will be hosting Dr. Derek van der Kooy on Feb 22, 2013. He is currently a Professor at the Department of Medical Genetics. Dr. van der Kooy is one of the pioneers of the field of adult stem cells. His publications in the field of Neural stem cells, Retinal stem cells and pancreatic stem cells are published in top journals such as Cell, Science, Nature, Neuron,Development and J Neuroscience are highly cited. Dr. van der Kooy is also a great speaker and I will hope that you will try to attend his lecture on Feb 22, at noon, Room 626 in Regenerative Medicine. I am trying to schedule his short day visit on Feb 22nd and therefore I am asking those interested in meeting him to contact me at eftekhar(a)cc.umanitoba.ca. We may have to arrange for group meetings if individual meetings are not possible. The meetings will be planned in a meting room in Regen Med for the sake of time. Thank you for your time, Regards --

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Upcoming neuroscience-related talks....
by Winnipeg Chapter Society for Neuroscience 28 Jan '13

28 Jan '13

Edge of Science and Medicine Seminar Series | Dr. Paul Fernyhough Monday, February 04, 2013 12:00 - 1:00 PM Theatre B - Basic Medical Sciences Dr. Paul Fernyhough Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Director, Division of Neurodegenerative Disorders -St. Boniface Research Centre TOPIC: Drug discovery for neurological disease ------------------------------------------------------------- Manitoba Neuroscience Network Seminar Series | Dr. Derek van der Kooy Friday, February 22nd, 2013 | 12:00 noon Location: Regenerative Medicine Lecture Theatre (626 BMSB) Dr. Derek van der Kooy Professor, Department of Molecular Genetics University of Toronto Topic: Where Brains Come From For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds ------------------------------------------------------------- Edge of Science and Medicine Seminar Series | Dr. Detlev Boison Monday, February 25, 2013 Theatre B Basic Medical Sciences 12:00 - 1:00 PM Dr. Detlev Boison Interim Dow Chair of Neurology & Director of Neurobiology Research Director of Basic and Translational Research, Legacy Research Institute Adjunct Professor - Oregon Health & Science University, Portland, OR TOPIC: Therapeutic Epilepsy Research: Focus on Adenosine. ------------------------------------------------------------- Manitoba Neuroscience Network Seminar | Dr. X.-M. Li Date: Friday, March 22, 2013 Time: 9:00 am - 10:00 am Location: PZ236/238 PsychHealth Centre, Bannatyne Campus Dr. Xin-Min Li Professor, Department of Psychiatry University of Manitoba Topic: Depression: from clinical guidelines to neurobiology. ------------------------------------------------------------- Message from the Winnipeg Chapter of the Society for Neuroscience Please reserve MONDAY JUNE 10, 2013 for the 4th annual meeting of the Manitoba Neuroscience Network. The theme for 2013 will be "Neurodegeneration" and the meeting will be held jointly with the Manitoba-Ontario endMS Regional Research and Training Centre. The format will be similar to previous meetings, featuring: * Visiting expert speakers * Speakers showcasing local research * Networking opportunities * Poster session with trainee awards The official meeting and website announcement will follow early in 2013, with a MAY abstract deadline. Please plan on attending and thank you for making these meetings successful. Chris Anderson, Conference Chair Gilbert Kirouac, Program Committee Chair Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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MNN Seminar - Feb 22 @ 12noon | Dr. Derek van der Kooy
by Winnipeg Chapter Society for Neuroscience 25 Jan '13

25 Jan '13

Manitoba Neuroscience Network Seminar Series Friday, February 22nd, 2013 | 12:00 noon Dr. Derek van der Kooy Professor Department of Molecular Genetics University of Toronto Topic: Where Brains Come From Location: Regenerative Medicine Lecture Theatre (626 BMSB) Derek van der Kooy served as Professor in the Department of Anatomy and Cell Biology at the University of Toronto from 1991 until 2002, when he became a Professor in the Department of Molecular Genetics. Derek received a M.Sc. in Psychology at the University of British Columbia, and a Ph.D in Anatomy, first at Erasmus University in the Netherlands, and finishing in the Department of Anatomy at the University of Toronto. Dr. van der Kooy gained postdoctoral research experience at Cambridge University in England and at the Salk Institute in California. The van der Kooy lab works on various stem cell biology and developmental biology research projects; specifically, stem cells in organisms from Drosophila to humans. We produced the first report of stem cells in the adult mammalian eye, published in 2000 in Science. We also have isolated a rare stem cell from the adult mouse and human pancreas that can show extensive proliferation under defined condi-tions in vitro. Of interest to the lab is the lineage of neural stem cells from pluripotent embryonic stem cells, with relevance to the origin of the earliest neural stem cell in the developing embryo. ABSTRACT: One of the few neurobiological facts not anticipated by Cajal is the existence of neural stem cells in the embryonic and adult mammalian brain that can produce new neurons in the adult brain (new neurons first shown by Altman). The earliest mammalian neural stem cells differentiate from pluripotent embryonic stem cells. These primitive neural stem cells emerge in response to LIF and have a wider non-neural phenotypic potential than later neural stem cells. By embryonic day 8.5 in mouse, true FGF2 dependent neural stem cells emerge and by embryonic day 14 they have given rise to copies of themselves and to EGF dependent neural stem cells. The separate FGF2 and EGF dependent neural stem cells increase greatly in numbers later in neurogenesis, but by E14 appear identical to adult neural stem cells. The adult mammalian neural stem cells are mostly quiescent, dividing asymmetrically only once every few weeks. Mouse embryonic stem (ES) cells cultured in low cell density, completely defined media adopt a neural identity. Using a clonal colony-forming assay, we identify the novel primitive neural stem cell stage as a component of neural lineage specification (this cell is similar to the one we isolate from the early embryo), which is negatively regulated by TGFb-related signaling. These results are consistent with a default mechanism for neural fate specification. Primitive neural stem cells are formed directly from single ES cells in a LIF-dependent manner, express multiple neural precursor markers and give rise to neurons and glia. Moreover, in vivo mouse chimera experiments reveal that these primitive ES-derived neural stem cells have a broad range of neural and non-neural lineage potential. These results support a model whereby definitive neural stem cell formation is preceded by a primitive neural stem cell stage during neural lineage commitment. Most recently, we have found that the LIF-dependent, primitive neural stem cells persist in adult organisms and can repopulate a depleted definitive neural stem cell pool in the adult. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca <mailto:mnn@sbrc.ca> Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sfn-manitoba.ca

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2013 WCSN Membership Dues
by Winnipeg Chapter Society for Neuroscience 25 Jan '13

25 Jan '13

You are receiving this message either because you are a Winnipeg Chapter Society for Neuroscience (WCSN) member due for 2013 renewal or because you are a person we think may benefit from membership in your local Chapter of the international Society for Neuroscience. The WCSN organizes and promotes events in Manitoba designed to fuel excellence in Neuroscience research, education and outreach. We are the driving force behind the Manitoba Neuroscience Network annual meetings, seminar series and visiting speaker program. We also organize Brain Awareness Week activities and contribute to the development of local neuroscientists by awarding prizes for excellence at the Manitoba Science Schools Symposium. Please support initiatives such as these and help us build a strong and vibrant neuroscience community in Manitoba by clicking on this link www.sfn-manitoba.ca/application <http://www.sfn-manitoba.ca/application> to pay your dues by credit card, University of Manitoba FOAP, or cheque. A receipt will be issued by e-mail. 2013 MEMBERSHIP FEE SCHEDULE Students $ 15 Postdocs, Residents, Associates, Technicians $ 30 Faculty, Professionals $ 60 *All-inclusive Lab rate $ 100 *PI and names and affiliations of each individual lab member must be provided. If you have any questions about our vision, please contact the Chapter president at canderson(a)sbrc.ca <mailto:canderson@sbrc.ca> . Sincerely, Chris Anderson, PhD President - Winnipeg Chapter Society for Neuroscience Associate Professor, University of Manitoba Winnipeg Chapter Society for Neuroscience General Office: R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: wcsn(a)sbrc.ca <mailto:wcsn@sbrc.ca> <mailto:wcsn@sbrc.ca <mailto:wcsn@sbrc.ca> > Website: www.sfn-manitoba.ca <http://www.sfn-manitoba.ca>

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Manitoba Neuroscience Network Seminar - Tomorrow 9am - Dr. Tamra Werbowetski-Ogilvie
by Winnipeg Chapter Society for Neuroscience 24 Jan '13

24 Jan '13

Manitoba Neuroscience Network Seminar Series: Friday, January 25th, 2013 | 9:00 am Dr. Tamra Werbowetski-Ogilvie Canada Research Chair in Neuro-oncology & Human Stem CellsAssistant Professor, Regenerative Medicine ProgramDepartment of Biochemistry & Medical Genetics and Physiology University of Manitoba Topic: Deconstructing medulloblastoma heterogeneity: targeting a spectrum of phenotypes. Location: PX236/238 PsychHealth Bldg. SHORT BIOSKETCH * Assistant Professor | Regenerative Medicine Program, Department of Biochemistry & Medical Genetics & Physiology, University of Manitoba * Honours Bachelor of Science in Biology, University of Western Ontario, London, ON * PhD Neuroscience (Department of Neurology and Neurosurgery) Montreal Neurological Institute, McGill University, Montreal, QC. Positions and Employment: - August 2005-October 2010 PDF, McMaster Stem Cell and Cancer Research Institute, McMaster Univ. - November 2010-present Assistant Professor, Regenerative Medicine Program, Department of Biochemistry & Medical Genetics And Physiology, University of Manitoba, Winnipeg, Manitoba, Canada Selected Peer Reviewed Publications (Selected from 18 peer-reviewed publications) 1. Werbowetski T, Bjerkvig R, Del Maestro R. 2004. Evidence for a secreted chemorepellent that directs glioma cell invasion. Journal of Neurobiology 60(1): 71-88. 2. Werbowetski-Ogilvie TE, Seyed Sadr M, Jabado N, Angers-Loustau A, Agar NY, Wu J, Bjerkvig R, Antel J, Faury D, Rao Y, Del Maestro RF. 2006. Inhibition of medulloblastoma cell invasion by Slit. Oncogene 25(37) 5103-5112. 3. Werbowetski-Ogilvie TE*, Agar NY*, Waldkircher de Oliveira RM, Faury D, Antel JP, Jabado N, Del Maestro RF. 2006. Isolation of a natural inhibitor of human malignant glial cell invasion: inter alpha trypsin inhibitor heavy chain 2. *These authors contributed equally to this work. Cancer Research 66(3) 1464-1472. 4. Cerdan C, Bendall SC, Wang L, Stewart M, Werbowetski T, Bhatia M. 2006. Complement targeting of nonhuman sialic acid does not mediate cell death of human ESCs. Nature Medicine 12(10) 1113-1114. 5. Bendall SC, Stewart MH, Menendez P, George D, Vijayaragavan K, Werbowetski-Ogilvie T, Ramos-Mejia V, Rouleau A, Yang J, Bossé M, Lajoie G, Bhatia M. 2007. IGF and FGF cooperatively establish the regulatory stem niche of pluripotent human cells. Nature. 448:1015-1021. 6. Werbowetski-Ogilvie TE, Bossé M, Stewart M, Schnerch A, Ramos-Mejia R, Rouleau A, Wynder T, Smith MJ, Dingwall S, Carter T, Williams C, Harris C, Dolling J, Wynder C, Boreham D. Bhatia M. 2009. Characterization of human embryonic stem cells with features of neoplastic progression. Nature Biotechnology. 27:91-97 7. Ji JF*, Werbowetski-Ogilvie TE*, Zhong B, Hong SH, Bhatia M. 2009. Pluripotent transcription factors possess distinct roles in normal versus transformed human stem cells. * These authors contributed equally to this work. PLoS ONE. 4:11 8. Werbowetski-Ogilvie TE, Schnerch A, Rampalli S, Lee JB, Levadoux-Martin M, Mills CE, Bhatia M. 2011. Evidence for the transmission of neoplastic properties from transformed to normal human stem cells. Oncogene. 30(46): 4632-44 9. Werbowetski-Ogilvie TE*, Coudière Morrison L, Fiebig-Comyn A, Bhatia M*. 2012. In vivo generation of neural tumors from neoplastic pluripotent stem cells models early human pediatric brain tumor formation. Stem Cells. 30(3): 392-404. * Denotes co-corresponding authorship. 10. Coudière Morrison *, McClelland R *, Aiken C, Bridges M, Wang X, Del Bigio MR, Taylor MD, Werbowetski-Ogilvie TE. 2012. Deconstruction of medulloblastoma cellular heterogeneity reveals differences between the most highly invasive and self-renewing phenotypes. Under Review, Neoplasia. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds An initiative of: Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Edge of Science and Medicine Seminar - Paul Fernyhough
by Winnipeg Chapter Society for Neuroscience 24 Jan '13

24 Jan '13

Everyone is invited.... Edge of Science and Medicine Seminar Series Monday, February 04, 2013 12:00 - 1:00 PM Theatre B - Basic Medical Sciences Dr. Paul Fernyhough Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Director, Division of Neurodegenerative Disorders -St. Boniface Research Centre TOPIC: Drug discovery for neurological disease Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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