- Neuro-All - University of Manitoba Mailing Lists

Mohammad Norouzi: Drug delivery systems for glioblastoma therapy
by networking＠manitobaneuroscience.ca 18 Dec '19

18 Dec '19

/sent on behalf of Ben Albensi balbensi(a)sbrc.ca <mailto:balbensi@sbrc.ca> Kelly Jorundson Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN's Brain Awareness Week Visiting Speaker Tuan Trang March 17th 2020
by Kelly Jorundson 17 Dec '19

17 Dec '19

Deaf academic/clinician, Dr. Tuan Trang<https://hbi.ucalgary.ca/profiles/dr-tuan-trang> has been invited to come to Winnipeg as our Brain Awareness Week Visiting Speaker. Please see attached bio. He will be giving a lecture in Theatre C on Tuesday, March 17th 2020. If you are interested in meeting with Tuan Trang on March 17th, please let me know and I will try to schedule you in. Thanks! Kelly Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Albretchsen Research Centre & University of Manitoba Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> or kjorundson(a)sbgh.mb.ca<mailto:Kelly.jorundson@umanitoba.ca> Tel: 204.235.3939 Fax: 204.237.4092 [cid:image001.jpg@01D2883E.86D93F20]

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Graduate course announcement
by networking＠manitobaneuroscience.ca 02 Dec '19

02 Dec '19

/sent on behalf of Dr. Ji Hyun Ko from the Department of Human Anatomy & Cell Science | Neuroscience Research Program Graduate Course Announcement (2019-2020) There are two new courses being offered in the winter term 2020 that will be running back-to-back (see below and attachment for details). Both courses may be completed within the same term, or completed in two terms (winter 2020 and winter 2021). Registration is open to all graduate students enrolled in any Faculty/College/Department interested in Neuroscience from the Fort Garry or Bannatyne Campuses, and the St. Boniface Research Centre. Classes will take place in SR4, Kleysen Institute for Advanced Medicine Building/Bannatyne campus, unless otherwise indicated by the Course Director. 1) Human Brain Imaging Methods (IMED 7004) This is a 1.5 credit hour course held on the Bannatyne Campus (Jan. 7, 2020 - Feb. 20, 2020). It will be of particular interest to graduate students whose research is in neuroscience. This course will provide an overview of the in vivo brain imaging methods and how imaging data are analysed (e.g., MRI and PET). Students will have opportunity to perform hands-on practice in computer labs with sample data. The course has 2 components: 1. Lectures that will provide a systematic survey of different brain imaging modalities, and 2. Computer Laboratory sessions in which students will perform computer analysis using real brain imaging data. 2) Advanced Level Human Brain Imaging Methods (ANAT 7012) This is a 1.5 credit hour course held on the Bannatyne Campus (Feb. 25, 2020 - Apr. 14, 2020). This course is intended for those graduate students who intend to broaden their skills in more advanced brain imaging methods that was not covered in the Human Brain Imaging Methods (IMED 7004). Students may take both IMED 7004 and ANAT 7012 back-to-back within the same semester, or wait until the next year(s) when it is offered again. The course has 2 components: 1. Lectures/student presentation: systematic survey of different brain imaging modalities and analytic methods, and 2. Computer Laboratory sessions: students will perform computer analysis using real brain imaging data including machine learning. For more information contact: Dr. Ji Hyun Ko (Course Director) Dept. of Human Anatomy & Cell Science ji.ko(a)umanitoba.ca 204-318-2566

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REMINDER: MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg
by networking＠manitobaneuroscience.ca 27 Nov '19

27 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Seminar - Friday Nov 29, 2019 @ 9am | Px236/238 PsycHealth Bldg.
by networking＠manitobaneuroscience.ca 13 Nov '19

13 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Outreach opportunity - Royal Manitoba Theatre Centre
by outreach＠manitobaneuroscience.ca 12 Nov '19

12 Nov '19

cid:image001.jpg@01D158FE.B69B8D00 cid:image003.jpg@01D5994E.D962B040 Hello everyone, I have a very unique outreach opportunity to share with you! The Royal Manitoba Theatre Centre has asked if one of our members would be willing to write a short article (350 words) related to mental health and gratitude (this could extend to the practice of mindfulness as well). The article will be included in the program for an upcoming play that will be staged in January. Additional details are provided in the forwarded email below. If you are interested, please contact me ASAP as this is somewhat time-sensitive. As you will see, it includes a nice little perk too! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Associate Professor, Department of Human Anatomy and Cell Science Rady Faculty of Health Sciences, University of Manitoba cid:image003.jpg@01D5994E.D962B040 cid:image004.jpg@01D158FE.B69B8D00 Begin forwarded message: From: Kathleen Cerrer <kcerrer(a)royalmtc.ca> Date: Nov. 12, 2019 at 10:43 a.m. To: info <info(a)manitobaneuroscience.ca> Subject: Manitoba Neuroscience Network in Royal MTC Program Good morning, I’m writing from the Royal Manitoba Theatre Centre. In January, we are presenting a show called “Every Brilliant Thing” which focuses on mental health and the power of gratitude for physical and mental healing. We’d like to include an article in our program about the power of gratitude and the scientific evidence behind it. Might there be someone at the Manitoba Neuroscience Network that could contribute to our program? The piece would be approximately 350 words and the deadline is Thurs, Nov 28. We would be happy to give you a pair of tickets to the show. Show information https://royalmtc.ca/Current-Plays/Every-Brilliant-Thing.aspx Please let me know if you have any questions. Many thanks, Kathleen Kathleen Cerrer, Publicist ROYAL MANITOBA THEATRE CENTRE Box Office 204 942 6537 | 1 877 446 4500 ROYALMTC.CA | WINNIPEGFRINGE.COM

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Dementia Journal Club - TODAY Noon SBRC Main Boardroom R1003
by networking＠manitobaneuroscience.ca 07 Nov '19

07 Nov '19

/sent on behalf of Benedict C. Albensi, PhD, BCMAS, CRQM Professor & Manitoba Dementia Research Chair Dept. of Pharmacology & Therapeutics Biomedical Engineering Core Member Faculties of Health Sciences, Engineering, & Science Research Affiliate, Centre on Aging Principal Investigator & Everett Endowment Fund Chair (Alzheimer's research) St. Boniface Hospital Research

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Reminder: Manitoba Neuroscience Network | Visiting Speaker - Alyson Fournier Nov 13/19 @12noon Theatre C
by networking＠manitobaneuroscience.ca 06 Nov '19

06 Nov '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Manitoba Neuroscience Network | Visiting Speaker Alyson Foundation Nov 13/19
by networking＠manitobaneuroscience.ca 29 Oct '19

29 Oct '19

S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Wednesday, November 13, 2019 12:00 PM (Noon) *** Followed by a trainee lunch in SR415 Kleysen Institute for Advanced Medicine , Boardroom LO C AT I O N BMSB, Theatre C, Bannatyne Campus S P E A K E R Alyson Fournier, PhD Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein interactions to promote axon regeneration A B S T R A C T Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage. O B J E C T I V E S 1. Define 14-3-3- adaptor proteins and small molecules targeting these proteins 2. Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model 3. Discuss the mechanism used by these small molecules to promote axon regeneration B I O Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signaling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. Tabrez Sidddiqui Chair, MNN Visiting Speaker & Seminar Series Tabrez.siddiqui(a)umanitoba.ca <mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Centre on Aging Speaker Series | Public Talk: Miyoung Suh
by networking＠manitobaneuroscience.ca 23 Oct '19

23 Oct '19

/sent on behalf of Miyoung Suh Date: Friday, November 1, 2019 2:30 PM Location: Fort Garry Library 1360 Pembina Hwy., Winnipeg SPEAKER: Miyoung Suh, PhD Professor, Department of Human Nutritional Sciences, Faculty of Agricultural & Food Sciences, University of Manitoba Nutrition management of aging eyes Over 65% of individuals over the age of 50 have some form of visual impairment. These visually impaired individuals are 1.7 times more likely to fall than individuals with adequate vision, which can lead to a reduction in quality of life. The retina, the inner most layer of the eye, is highly enriched with polyunsaturated fatty acids (PUFA)s. With plenty of light exposure over time, PUFAs can become oxidized, damaging the sensitive tissues of the retina. However, some nutrients play a protective role within the eye by maintaining the structure and function of the retina, and providing protection from light induced damage. This talk will provide evidence that consuming these nutrients in the diet can improve retina function, thereby improving vision with aging. Overall our research will contribute to the development of valuable prevention strategies for the eye health for older adults. For more information, visit www.umanitoba.ca/aging <http://www.umanitoba.ca/aging> This presentation will be available via facebook live Kelly Jorundson Executive Assistant Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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