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Nick Shepel Neuroscience Trainee Travel Award
by Manitoba Neuroscience Network 25 Apr '19

25 Apr '19

Nick Shepel Neuroscience Trainee Travel Award Application deadline: Friday, May 31, 2019 Background: The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his laboratory partners and brought fire, humor, and a desire to always excel. His insistence to always try better has had a permanent effect on his lab mates and peers. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator(s) (specifically in the neuroscience area) by providing an annual award(s) to support travel costs associated with the applicants attendance at an upcoming national/international conference where the applicant is presenting a poster or oral presentation. This year, the value of the award may range from $600 to $1000. Eligibility: At the time of application the following conditions are required: · Students must be registered as a full-time graduate student in the College of Medicine at the University of Manitoba. · The area of research being presented at the conference must relate to the field of neuroscience. · A student admitted under the Provisional Status may not receive the award during the provisional period. · Amount of award(s) may vary each year. · Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international). · Students who have received this award previously should not apply. Submission Instructions: A complete application consists of the following information *If your application is not complete, it will not be considered: · Introductory letter describing meeting, location and date · Copy of abstract · Curriculum vitae · Current GPA, transcripts not needed · Proposed budget of travel costs · Submit your completed application materials to: Paul Fernyhough Director Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 351 Tache Avenue Winnipeg, MB R2H 2A6 Email: pfernyhough(a)sbrc.ca How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Request for reimbursement must be done within 2 weeks following travel otherwise eligibility may be voided. (contact: Kelly Jorundson kjorund(a)sbrc.ca) Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: MNN Lecture: Idan Menashe, Ben-Gurion Univ Mon, Apr 29 @ 10am
by Manitoba Neuroscience Network 24 Apr '19

24 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, April 29, 2019 10am L O C A T I O N Theatre C, BMSB Bannatyne Campus S P E A K E R Idan Menashe, PhD School of Public Health, Faculty of Health Sciences, Negev Autism Center Ben-Gurion University T O P I C Deciphering the etiological puzzle of autism spectrum disorder (ASD) results from the Negev Autism Center O B J E C T I V E S 1. Introduce the current challenges in ASD research 2. Discuss the activities and research findings of the Negev Autism Center A B S T R A C T Autism spectrum disorder (ASD) is a remarkably heterogeneous condition with multiple genetic and non-genetic causes leading to a wide variety of phenotypic outcomes. Elucidating the heterogeneous etiological puzzle of autism requires comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established the Negev Autism Center (NAC), which comprises clinicians from Soroka University Medical Center (SUMC) and scientists from Ben-Gurion University (BGU). In this initiative, we collect comprehensive behavioral, clinical, neurological and biological data on all children who are referred to SUMC with a suspicion of autism. Moreover, children with a positive diagnosis of autism are invited to the SUMC clinics for follow-up visits every 6 to 12 months until the age six. During these visits, their diagnosis is re-evaluated and families are invited to participate in additional ongoing experiments. The wide variety of data collected from each child with ASD and his family, enable us to synthesize findings across different clinical and biological disciplines in order to connect the dots between specific risk factors through associated brain abnormalities to precise behavioral and cognitive phenotypes in various subtypes of autism. Such an understanding of ASD is essential for translating the science into personalized treatments for the disorder. In this seminar, I will introduce the current challenges in ASD research and discuss recent research findings from the NAC. Specifically, I will introduce new approaches for digital phenotyping of children with ASD that can accelerate both research and diagnosis of ASD. In addition, I will present new insights regarding the genetics of ASD as well as potential environmental risk factors of the disorder. Finally, I will talk about the future goals of the NAC. B I O S K E T C H: Dr. Menashe, earned his PhD in Human Genetics and Bioinformatics from the Weizmann Institute of Science, Israel in 2007. He then completed four years of post-doctoral fellowship in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, USA and one year as a senior scientist at MindSpec, a nonprofit organization that utilizes innovative bioinformatics strategies to accelerate research on common neurodevelopmental disorders. In 2012, Dr. Menashe joined the Faculty of Health Sciences and the Zlotowski center for neuroscience at the Ben-Gurion University (BGU), Beer-Sheva, Israel as an assistant professor. At BGU Dr. Menashe is the head of the genetic epidemiology team at the school of public health. In addition, Dr. Menashe is a co-founder of the Negev Autism Center (www.negevautism.org), which is the leading autism research center in Israel. At the Negev Autism Center, Dr. Menashe and his colleagues collect and analyze comprehensive clinical, behavioral and biological data from hundreds of children with autism with the goal to elucidate the etiology of autism and its variable phenotypic manifestations. For more information, please visit: www.idanmen.com <file:///C:\Users\kjorund\AppData\Local\Microsoft\Windows\Temporary%20Intern et%20Files\Content.Outlook\US4Z0TRO\www.idanmen.com> For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Visiting Speaker - Dr. David Amaral
by Manitoba Neuroscience Network 23 Apr '19

23 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 **PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH) U N I V E R S I T Y O F M A N I T O B A S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium) L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder RESEARCH LECTURE D AT E Tuesday, May 7, 2019 12:00 PM (noon) LO C AT I O N Theatre B, BMSB, Bannatyne Campus S P E A K E R Dr. David Amaral Professor, Faculty of Medicine McGill University T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features. O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Travel Awards for University of Manitoba Neuroscience Trainees - DEADLINE MAY 15
by Manitoba Neuroscience Network 22 Apr '19

22 Apr '19

We are pleased to announce that the Manitoba Neuroscience Network will again be accepting applications for 2019/20 TRAVEL AWARDS FOR NEUROSCIENCE PROJECTS A legacy fund created by the estate of Nancy Hettie Clark is used to enrich neuroscience training and support opportunities to network within the wider neuroscience community. Two travel awards of up to $700 each are intended to be awarded annually to a graduate student and a postdoctoral fellow at the University of Manitoba. The application deadline is MAY 15. The eligible travel period is between May 1, 2019 and April 30, 2020, BUT all eligible travel claims must be complete by March 31, 2020. Eligibility: Eligible trainees are either graduate students or postdoctoral fellows. Student candidates must be enrolled as full-time graduate (PhD or MSc) students in the Faculty of Graduate Studies, University of Manitoba, and have a cumulative graduate grade point average of 3.5 or greater (University of Manitoba scale). Postdoctoral fellow candidates must be within the first five years after awarding of their doctoral degree and have a full-time appointment at the University of Manitoba or an affiliated hospital or institute. Candidates must demonstrate excellent research performance and potential in a neurosciences-related discipline, and must demonstrate they will disseminate research results that reflect a high-quality contribution by The University of Manitoba. How to apply: A complete application package consists of the following: * Cover letter stating the following (1 page maximum): o Application category (student or postdoctoral fellow) and your start date in that position o The conference title, location and dates o Type of presentation (e.g. poster or oral) o The importance of the meeting and significance for career development o Any information that would allow reviewers to assess the significance or impact of the conference (e.g. abstracts are peer-reviewed) o Clearly state your graduate GPA (students only) * Graduate level academic transcript (students only) * Listing of scholarly output (publications and presentations) * Support letter from the primary research advisor with (a) a merit assessment of the candidate and project, and (b) confirmation that there is a commitment to cover all eligible travel expenses less the award value * Copy of the submitted abstract Submit all materials to <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca by MAY 15. The support letter may be appended or sent separately by the research advisor. Good luck! ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Neuroscience Lectureship Award - $3,000
by Manitoba Neuroscience Network 22 Apr '19

22 Apr '19

The MNN is pleased to announce that we are accepting applications for the 2020 VIKTOR HAVLICEK MEMORIAL NEUROSCIENCE LECTURESHIP. Viktor Havlicek, MD, PhD, DSc, was a Professor in the Department of Physiology (now Physiology and Pathophysiology) at the University of Manitoba from 1968 to 1981. The Viktor Havlicek Memorial fund was established through gifts to the University of Manitoba in his memory. This fund yields $3,000 once every two years to support a visit to the University of Manitoba by an internationally-renowned neuroscientist in a manner that encourages interactions with trainees. Applications are now being accepted until MAY 15, 2019 for a visit and lecture to take place between April 1, 2020 and March 31, 2021. Applications for the next Lectureship will be accepted in 2021 for 2022/2023 fiscal year. Nominations must be made by a faculty member but trainees and staff are encouraged to suggest names to their advisors. Faculty from any MNN contributing institution (ie. not only the University of Manitoba) may submit nominations. A complete nomination consists of a letter to the Neuroscience Awards Committee (NAC) Chair explaining the rationale for choice of candidate (1 page maximum), along with any supporting materials the applicant deems useful for assessing the merit of the candidate and the benefits of his or her visit to the University of Manitoba. Please send nominations by email to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> by May 15. The NAC will determine an order of invitation priority for submitted nominees and the top-priority candidate invited at a time determined in consultation with the nominator. If this candidate is not available, the next candidate will be invited. All candidates on the priority list must be considered worthy of the Lectureship by the NAC. We hope you find this opportunity helpful and exciting. If there are any questions, you may respond to info(a)manitobaneuroscience.ca <mailto:info@manitobaneuroscience.ca> . Thank you. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Nick Shepel Neuroscience Trainee Travel Award Available
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Paul Fernyhough Nick Shepel Neuroscience Trainee Travel Award Application deadline: Friday, May 31, 2019 Background: The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his laboratory partners and brought fire, humor, and a desire to always excel. His insistence to always try better has had a permanent effect on his lab mates and peers. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator(s) (specifically in the neuroscience area) by providing an annual award(s) to support travel costs associated with the applicants attendance at an upcoming national/international conference where the applicant is presenting a poster or oral presentation. This year, the value of the award may range from $600 to $1000. Eligibility: At the time of application the following conditions are required: · Students must be registered as a full-time graduate student in the College of Medicine at the University of Manitoba. · The area of research being presented at the conference must relate to the field of neuroscience. · A student admitted under the Provisional Status may not receive the award during the provisional period. · Amount of award(s) may vary each year. · Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international). · Students who have received this award previously should not apply. Submission Instructions: A complete application consists of the following information *If your application is not complete, it will not be considered: · Introductory letter describing meeting, location and date · Copy of abstract · Curriculum vitae · Current GPA, transcripts not needed · Proposed budget of travel costs · Submit your completed application materials to: Paul Fernyhough Director Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 351 Tache Avenue Winnipeg, MB R2H 2A6 How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Request for reimbursement must be done within 2 weeks following travel otherwise eligibility may be voided. (contact: Kelly Jorundson kjorund(a)sbrc.ca) Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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2019 MNN Scientific Meeting - Registration now OPEN
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

cid:image001.jpg@01D158FE.B69B8D00 The MNN is pleased to announce that the 2019 Scientific Meeting will be held JUNE 7. The meeting is co-chaired by Dr. Domenico Di Curzio and Dr. Renée Douville and will be held at the University of Winnipeg. There is an engaging program planned, featuring a visit and talk by Canadian Research Council Chair in Developmental Neurogenetics Dr. Daniel Goldowitz (University of British Columbia) a public lecture by Dr. Janice Robertson (University of Toronto), a leading expert in Amyotrophic Lateral Sclerosis neuropathology and therapeutic development. The scientific event will be capped off with a networking mixer and neuroscience art silent auction at the Winnipeg Art Gallery. Abstracts and registrations are now being accepted. These links and the program can be found at: https://manitobaneuroscience.ca/annual-meeting/2019mnn/ Annual Scientific Meeting | Manitoba Neuroscience Network manitobaneuroscience.ca The abstract and registration deadline is MAY 10. NEW this year the student meeting registration rate has been reduced to only $15. Postdocs and community members are $25 and Faculty are $50. Discounted rates apply if attending both scientific session and networking mixer. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately, but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to: info(a)manitobaneuroscience.ca -The MNN Team Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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**Cancelled** MNN Seminar - Dr. Geoff Hicks Apr 26 @ 9am
by Manitoba Neuroscience Network 04 Apr '19

04 Apr '19

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Lecture: Idan Menashe, Ben-Gurion Univ Mon, Apr 29 @ 10am
by Manitoba Neuroscience Network 03 Apr '19

03 Apr '19

Mark your calendars! cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, April 29, 2019 10am L O C A T I O N Theatre C, BMSB Bannatyne Campus S P E A K E R Idan Menashe, PhD School of Public Health, Faculty of Health Sciences, Negev Autism Center Ben-Gurion University T O P I C Deciphering the etiological puzzle of autism spectrum disorder (ASD) results from the Negev Autism Center O B J E C T I V E S 1. Introduce the current challenges in ASD research 2. Discuss the activities and research findings of the Negev Autism Center A B S T R A C T Autism spectrum disorder (ASD) is a remarkably heterogeneous condition with multiple genetic and non-genetic causes leading to a wide variety of phenotypic outcomes. Elucidating the heterogeneous etiological puzzle of autism requires comprehensive longitudinal data acquisition from large community based cohorts. With this in mind, we have established the Negev Autism Center (NAC), which comprises clinicians from Soroka University Medical Center (SUMC) and scientists from Ben-Gurion University (BGU). In this initiative, we collect comprehensive behavioral, clinical, neurological and biological data on all children who are referred to SUMC with a suspicion of autism. Moreover, children with a positive diagnosis of autism are invited to the SUMC clinics for follow-up visits every 6 to 12 months until the age six. During these visits, their diagnosis is re-evaluated and families are invited to participate in additional ongoing experiments. The wide variety of data collected from each child with ASD and his family, enable us to synthesize findings across different clinical and biological disciplines in order to connect the dots between specific risk factors through associated brain abnormalities to precise behavioral and cognitive phenotypes in various subtypes of autism. Such an understanding of ASD is essential for translating the science into personalized treatments for the disorder. In this seminar, I will introduce the current challenges in ASD research and discuss recent research findings from the NAC. Specifically, I will introduce new approaches for digital phenotyping of children with ASD that can accelerate both research and diagnosis of ASD. In addition, I will present new insights regarding the genetics of ASD as well as potential environmental risk factors of the disorder. Finally, I will talk about the future goals of the NAC. B I O S K E T C H: Dr. Menashe, earned his PhD in Human Genetics and Bioinformatics from the Weizmann Institute of Science, Israel in 2007. He then completed four years of post-doctoral fellowship in the Biostatistics Branch of the Division of Cancer Epidemiology and Genetics at the National Cancer Institute, USA and one year as a senior scientist at MindSpec, a nonprofit organization that utilizes innovative bioinformatics strategies to accelerate research on common neurodevelopmental disorders. In 2012, Dr. Menashe joined the Faculty of Health Sciences and the Zlotowski center for neuroscience at the Ben-Gurion University (BGU), Beer-Sheva, Israel as an assistant professor. At BGU Dr. Menashe is the head of the genetic epidemiology team at the school of public health. In addition, Dr. Menashe is a co-founder of the Negev Autism Center (www.negevautism.org), which is the leading autism research center in Israel. At the Negev Autism Center, Dr. Menashe and his colleagues collect and analyze comprehensive clinical, behavioral and biological data from hundreds of children with autism with the goal to elucidate the etiology of autism and its variable phenotypic manifestations. For more information, please visit: www.idanmen.com <file:///C:\Users\kjorund\AppData\Local\Microsoft\Windows\Temporary%20Intern et%20Files\Content.Outlook\US4Z0TRO\www.idanmen.com> For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Reminder: MNN Seminar Series: Dr. Spencer Gibson | Fri., Mar 29 @ 9am
by Manitoba Neuroscience Network 26 Mar '19

26 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Friday, March 29, 2019 9am L O C A T I O N Px236/238 PsycHealth Bldg. Bannatyne Campus S P E A K E R Spencer Gibson, PhD Professor, Department of Immunology & Biochemistry and Medical Genetics Director, Manitoba Institute of Cell Biology Senior Scientist, Research Institute in Oncology and Hematology Director, Translational Research University of Manitoba T O P I C Understanding the regulation of cell death in glioblastoma. Context Matters? O B J E C T I V E S · Context (location, microenvironment, and time) matters in cell death · Understand different forms of cell death · Role this plays in glioblastoma treatment. A B S T R A C T Cells undergo different forms of cell death depending on the context. In cancer including glioblastoma (GBM), the context depends upon location, microenvironment and time. This will determine whether a cancer cell dies or survives. The context is dynamic and changes over time leading to drug resistance in cancer. The location of cell death regulatory gene changes their function, we found that a BH3 only Bcl-2 family member BNIP3 switch from pro-cell death to pro-survival depending on subcellular localization. The microenvironment also changes where hypoxic regions develop and drive GBM drug resistance and growth factor signaling that changes cell survival. Finally time changes cell death responses where different types of cell death could occur at different times. We found that ferroptosis (iron dependent cell death)is induced at early times during hypoxia but switches to autophagy (self-eating) during late times. Thus, understanding this balance between cell death and survival will allow more rationale therapeutic strategies to be develop and hopefully prevent drug resistance in GBM. B I O S K E T C H: Dr. Gibson graduate the University of Toronto where he gained his Ph.D. in the Department of Laboratory Medicine and Pathobiology. During his Ph.D. studies, he traveled to M.D. Anderson Cancer Center in Houston, Texas as a pre-doctoral fellow where he completed his Ph.D. studies. Dr. Gibson was a post-doctoral fellow at the National Jewish Medical and Research Center in Denver, Colorado. Dr. Spencer B. Gibson is currently a Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba and is a Senior Investigator at the Research Institute of Oncology and Hematology (formally the Manitoba Institute of Cell Biology, MICB) since 1999. In 2008, the Manitoba Health Research Council awarded Dr. Gibson a Manitoba Research Chair to support his research efforts. At the Research Insitute, Dr. Gibson is Director of Translational Research where he contributed to the creation of the expansion of the Manitoba Tumor Bank and initiated new translational research projects. He is also appointed as Director, MICB from 2012-2014, to provide leadership for cancer research with the province of Manitoba and is currently Section Head, Cell Biology for the Research Institute at CancerCare Manitoba. Dr. Gibson has 130 peer-reviewed publication with an h-index of 49. The focus of his research is to define the signal transduction pathways leading to cell death or survival in cancer including leukemia. This will elucidate targets that could tip balance in favour of cell death and will be the foundation to establish clinical trials using molecular targeted therapies to increase effectiveness of chemotherapy in cancer. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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