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Reminder TODAY - 9AM - MNN Seminar Series - Dr. Ben Albensi
by Manitoba Neuroscience Network 27 May '16

27 May '16

cid:image001.jpg@01D158FE.B69B8D00 Manitoba Neuroscience Network Visiting Speaker & Seminar Series DATE: Friday, May 27th, 2016 Time: 9:00am Location: PX236/238 PsycHealth Bldg. Dr. Benedict Albensi Manitoba Dementia Research Chair Everett Endowment Fund Chair Professor of Pharmacology & Therapeutics Biomedical Engineering Graduate Program Core Member University of Manitoba Principal Investigator St. Boniface General Hospital Research TOPIC: The … [View More]Involvement of NF-kB Signaling in Learning, Memory and Dementia. Objective: to learn about the role of NF-kB signaling in normal memory / learning and also in dementia. Research Focus: The major focus of our laboratory is to understand the biological basis of memory and to also understand what happens to memory when it is impaired. To this end, we attempt to identify molecular signaling pathways and mechanisms that could be targeted with promising therapeutics for enhancing memory and for preventing and/or reversing memory impairments, in diseases or conditions such as Alzheimer’s disease, stroke, head trauma, etc. Much of our work is centered on the signaling pathway involving the transcription factor, nuclear factor kappa B (NF-kB), which is central to not only in inflammatory processes and immune system function, but also plays a central role in basic mechanisms of memory formation and recall. Why is this work important? -It provides a valuable platform for scientists to understand how brain cells and biochemical processes change at the molecular level during the formation of normal memory -By understanding transcriptional regulation during memory encoding, we can identify a gene (or genes) that are utilized during normal memory formation -Characterizing the biological basis of normal memory will lend great insight into treating age-related central nervous system diseases and/or conditions of brain injury that contribute to memory impairment -Our research could ultimately lead to the development of new drug targets and/or new interventions to enhance normal memory and to treat memory disorders and related neurodegenerative conditions About Dr. Benedict Albensi Dr. Albensi’s background is diverse where he has received training in both basic and clinical research. He has also worked in both academic and in industrial sectors on several drug discovery and drug development projects. For example, prior to PhD training, he worked at NPS Pharmaceuticals in Salt Lake City, UT, USA, investigating molecular structures obtained from natural products (e.g., spider venoms) for their potential application in treating CNS disorders. Dr. Albensi continued his academic training and received a Ph.D. in Neuroscience from the University of Utah’s Medical School in 1995, where he developed novel MRI methods for characterizing neonatal hypoxic-ischemic injury. Subsequently, he was awarded a Postdoctoral Fellowship at Georgetown University in Washington, DC, USA (working with Drs. Faden and Pekar), where he further developed novel MRI methods for investigating TBI and brain cognition. Following this, he went on to work as a Postdoctoral Scholar with Dr. Mark Mattson, an internationally recognized leader in neurodegenerative research, at the Sanders-Brown Center on Aging – University of Kentucky. While working with Dr. Mattson and using electrophysiological methods, he published the ground breaking study that TNF and NF-kB play important roles in synaptic plasticity and memory (Albensi and Mattson, Synapse 2000). Subsequently, he joined the Clinical Research Department at Parke-Davis/Warner-Lambert in Ann Arbor, MI (Pfizer acquired PD-WL in 2000) to obtain additional experience in clinical trials. Following this clinical research training, he was appointed as Project Staff in the Department of Neurological Surgery – Cleveland Clinic Foundation and also as an Adjunct Assistant Professor of Biology at Case Western Reserve University in Ohio, where he conducted novel work on mechanisms of deep brain stimulation (DBS). He now has several appointments in Canada, which include serving as a Professor of Pharmacology and Therapeutics at the University of Manitoba and as a Principal Investigator at St. Boniface Hospital Research. He is also a Core Member of the Biomedical Engineering Graduate Program at the University of Manitoba. In addition, he is the new Manitoba Dementia Research Chair and the Everett Endowment Fund Chair. He is also currently a Director of the Board for MitoCanada and the Movement Ctr. of Manitoba. He previously served on the Board of the Alzheimer’s Society of Manitoba. He has reviewed grants for numerous foundations worldwide including NIH, CIHR, NSERC, US DOD, FASEB, to name a few. Recent Publications: 2014 M.Z. Kastyak-Ibrahim, D.L. Di Curzio, R. Buist, S. Herrera, S. Feng, J. Kong, X.M. Li, B.C. ALBENSI, M.R. Del Bigio, M. Martin. Neurofibrillary tangles and plaques are not accompanied by white matter pathology in aged triple transgenic-Alzheimer disease mice. Magnetic Resonance Imaging. Nov;31(9):1515-21, 2014. B.C. Albensi C U R R I C U L U M V I T A E Updated April 2016 10 2014 W.M. Snow, B.M. Stoesz, D. Kelly and B.C. ALBENSI. Roles for NF-kB and Gene Targets of NF-kB in Synaptic Plasticity, Memory, and Spatial Orientation. Molecular Neurobiology. Apr;49(2):757-7, 2014. 2014 C. Cadonic and B.C. ALBENSI. Oscillations and NMDA receptors: their interplay create memories. Aims Neuroscience. 1(1):52-64, 2014. Invited Review. 2015 S. Nafez, K. Oikawa, G.L. Odero, M. Sproule, N. Ge, J. Schapansky, B. Abrenica, A. Hatherell, C. Cadonic, S. Zhang, X. Song, T. Kauppinen, G.W. Glazner, M. Grilli, M.P. Czubryt, D.D. Eisenstat and B.C. ALBENSI. Early Growth Response 2 (Egr-2) Expression is Triggered by NF-B Activation. Molecular and Cellular Neuroscience. 64:95-103, 2015. 2015 W.M. Snow, P.S. Pahlavan, J. Djordjevic, G. McAllister, E.E. Platt, S. Alashmali, M.J. Bernstein, M. Suh, and B.C. ALBENSI. Morris water maze training in mice elevates hippocampal levels of transcription factors nuclear factor (erythroid-derived 2)-like 2 and nuclear factor kappa B p65. Frontiers Molecular Neuroscience, 8:70, 2015. 2015 C. Cadonic, M.G. Sabbir and B.C. ALBENSI. Mechanisms of Mitochondrial Dysfunction in Alzheimer's Disease. Molecular Neurobiology, 2015. 2016 S.R. Chowdhury, J. Djordjevic*, B.C. ALBENSI and P. Fernyhough. Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria, Bioscience Reports, 36, e00286, 2016. *This author is a co-first author. 2016 J. Djordjevic, M.G. Sabbir and B.C. ALBENSI. Traumatic brain injury as a risk factor for Alzheimer’s disease: Is inflammatory signaling a key player? New Concepts in Alzheimer's Research in Current Alzheimer Research, 13:1-9, 2016. 2016 S.I. Omar, B.C. ALBENSI and K. Gough. Modelling the binding of Ca2+ and Zn2+ to Calbindin D28k and understanding their competition through protein structural analysis. Current Alzheimer Research, In Press, 2016. 2016 K. Oikawa, G.L. Odero, S. Nafez, N. Ging, D. Zhang, H. Kobayashi, K. Sato, S. Kimura, M. Tateno and B.C. ALBENSI. Visinin-like protein-3 modulates the interaction between cytochrome b5 and NADH-cytochrome b5-reductase in a Ca++ dependent manner. Cell Biochemistry and Biophysics, Conditionally Accepted. 2016. Kelly Jorundson Manitoba Neuroscience Network R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image003.png@01D1AC33.A34F0730 <https://www.instagram.com/manitobaneuroscience/> cid:image004.jpg@01D1AC33.A34F0730 <https://twitter.com/manitobaneuro> cid:image005.png@01D1AC33.A34F0730 [View Less]

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MNN MTG - ABSTRACT DEADLINE ***TOMORROW MAY 20TH
by Manitoba Neuroscience Network 19 May '16

19 May '16

cid:image001.jpg@01D158FE.B69B8D00 Last day to submit abstract is tomorrow! May 20, 2016 Please show your support by attending the meeting and also encourage your trainees and research staff to participate in this event and submit their work for poster presentation. The DEADLINE for abstract submission is May 20th, 2016. Please follow the link (www.sbrc.ca/mnn2016 <http://www.cvent.com/events/manitoba-neuroscience-network-6th-scientific-me eting/event-summary-… [View More]

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Reminder: MNN Visiting Speaker Seminar & Trainee Lunch - Dr. Derek Bowie - May 20th
by Manitoba Neuroscience Network 16 May '16

16 May '16

Everyone is invited! cid:image001.jpg@01D158FE.B69B8D00 Friday, May 20th, 2016 12:00 Noon | Theatre C, Bannatyne Campus S p e a k e r Dr. Derek Bowie Professor - Department of Pharmacology & Therapeutics, McGill University Director - GEPRO M Topic: Ionotropic glutamate receptors and Fragile-X syndrome (abstract below) ....FOLLOWED BY...... NEUROSCIENCE TRAINEE LUNCH ALL NEUROSCIENCE STUDENTS, POST-DOC FELLOWS AND RESEARCH ASSOCIATED INVITED!! … [View More]1:00 P.M. | SR415 Kleysen Institute for Advanced Medicine Abstract: The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states. The talk will focus on recent work on NMDA-type iGluRs and how it relates to deficits in Fragile-X syndrome. Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group, GEPRO M, and has been a Professor at McGill University since 2002. He is the recipient of the Canada Research Chair award in Receptor Pharmacology and serves on the editorial boards of the Journal of Physiology, Current Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University of London after completing his undergraduate degree at Strathclyde University in Scotland. He then carried out postdoctoral training in France (Université Louis Pasteur), Switzerland (University of Zurich) and the USA (National Institutes of Health) before holding a faculty position at Emory University in Atlanta. The Bowie lab focuses on the structure-function properties of ionotropic glutamate receptors, GABA-A receptors and sodium channels as well as examining their role in neuronal circuit behaviour. http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html Kelly Jorundson Manitoba Neuroscience Network R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 kjorund(a)sbrc.ca ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image006.png@01D17075.90C94890 <https://www.instagram.com/manitobaneuroscience/> cid:image007.jpg@01D17075.90C94890 <https://twitter.com/manitobaneuro> cid:image008.png@01D17075.90C94890 [View Less]

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MNN MTG - ABSTRACT DEADLINE EXTENDED TO **MAY 20TH***
by Manitoba Neuroscience Network 13 May '16

13 May '16

cid:image001.jpg@01D158FE.B69B8D00 Abstract Deadline EXTENSION - May 20, 2016 Good News! The ABSTRACT DEADLINE for our Manitoba Neuroscience Network meeting has been extended to Friday, May 20th, 2016 end of day. Please show your support by attending the meeting and also encourage your trainees and research staff to participate in this event and submit their work for poster presentation. The DEADLINE for abstract submission is May 20th, 2016. Please follow the link (www.sbrc.ca/… [View More]

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IMPORTANT REMINDER: MNN MTG - ABSTRACT DEADLINE **MAY 13TH
by Manitoba Neuroscience Network 12 May '16

12 May '16

cid:image001.jpg@01D158FE.B69B8D00 Reminder - Abstract Deadline - May 13, 2016 This is a friendly reminder that the ABSTRACT DEADLINE for our Manitoba Neuroscience Network meeting is only 1 DAY AWAY! Please show your support by attending the meeting and also encourage your trainees and research staff to participate in this event and submit their work for poster presentation. The DEADLINE for abstract submission is May 13st, 2016. Please follow the link (www.sbrc.ca/mnn2016 <… [View More]

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Dementia Journal Club - Thurs May 12 at HSC - at 12:30 pm - 4th floor Thorlakson Bldg, MS473
by Kelly Jorundson 11 May '16

11 May '16

/sent on behalf of Dr. Ben Albensi Everyone invited! Dear All Dr. Sherry Krawitz, MD will present the attached paper tomorrow, Thursday at 12:30 PM at Health Sci Ctr, - 4th floor Thorlakson Bldg, MS473 (at end of long hall leading from the elevators). She will accomplish the following goals: 1) present the theory of prion-like propagation of tau - based on: Neuropathol Appl Neurobiol. 2015 Feb;41(1):47-58. Invited review: Prion-like transmission and spreading of … [View More]

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MNN Visiting Speaker Series | Dr. Derek Bowie - Fri May 20 @ 1PM ***NEUROSCIENCE TRAINEE LUNCH**
by Manitoba Neuroscience Network 10 May '16

10 May '16

cid:image001.jpg@01D158FE.B69B8D00 Friday, May 20th, 2016 1:00 P.M. | SR415 Kleysen Institute for Advanced Medicine S p e a k e r Dr. Derek Bowie Professor - Department of Pharmacology & Therapeutics, McGill University Director - GEPRO M NEUROSCIENCE TRAINEE LUNCH ALL NEUROSCIENCE STUDENTS, POST-DOC FELLOWS AND RESEARCH ASSOCIATED INVITED!! Abstract: The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors … [View More]and more recently, Na+ channels. All ion-channel families are widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states. The talk will focus on recent work on NMDA-type iGluRs and how it relates to deficits in Fragile-X syndrome. Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group, GEPRO M, and has been a Professor at McGill University since 2002. He is the recipient of the Canada Research Chair award in Receptor Pharmacology and serves on the editorial boards of the Journal of Physiology, Current Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University of London after completing his undergraduate degree at Strathclyde University in Scotland. He then carried out postdoctoral training in France (Université Louis Pasteur), Switzerland (University of Zurich) and the USA (National Institutes of Health) before holding a faculty position at Emory University in Atlanta. The Bowie lab focuses on the structure-function properties of ionotropic glutamate receptors, GABA-A receptors and sodium channels as well as examining their role in neuronal circuit behaviour. http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html Kelly Jorundson Manitoba Neuroscience Network R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro> [View Less]

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MNN Visiting Speaker Series | Dr. Derek Bowie - Fri May 20 @ 12 Noon LECTURE
by Manitoba Neuroscience Network 10 May '16

10 May '16

cid:image001.jpg@01D158FE.B69B8D00 Friday, May 20th, 2016 12:00 Noon | Theatre C, Bannatyne Campus S p e a k e r Dr. Derek Bowie Professor - Department of Pharmacology & Therapeutics, McGill University Director - GEPRO M Topic: Ionotropic glutamate receptors and Fragile-X syndrome Abstract: The Bowie Lab uses a combination of techniques to study ionotropic glutamate receptors (iGluRs), GABA-A receptors and more recently, Na+ channels. All ion-channel families are … [View More]widespread in the vertebrate brain and fulfill many important roles in healthy individuals as well as being implicated in disease states associated with postnatal development (e.g. autism, schizophrenia), cerebral insult (e.g. stroke, epilepsy) and aging disorders (e.g. Alzheimer's disease, Parkinsonism). We are looking at iGluRs, GABA-A receptors and Na+ channels at two inter-related levels. In molecular terms, we are examining the events that occur when each ion-channel family is activated with the aim of developing novel therapeutic compounds. At the cellular level, we are studying the role that iGluRs, GABA-A receptors and Na+ channels fulfill in shaping the behaviour of neuronal circuits and how these processes may be corrected in disease states. The talk will focus on recent work on NMDA-type iGluRs and how it relates to deficits in Fragile-X syndrome. Bio: Dr. Derek Bowie is the Director of the FRQS-funded research group, GEPRO M, and has been a Professor at McGill University since 2002. He is the recipient of the Canada Research Chair award in Receptor Pharmacology and serves on the editorial boards of the Journal of Physiology, Current Neuropharmacology and Channels. Dr. Bowie earned his Ph.D. at the University of London after completing his undergraduate degree at Strathclyde University in Scotland. He then carried out postdoctoral training in France (Université Louis Pasteur), Switzerland (University of Zurich) and the USA (National Institutes of Health) before holding a faculty position at Emory University in Atlanta. The Bowie lab focuses on the structure-function properties of ionotropic glutamate receptors, GABA-A receptors and sodium channels as well as examining their role in neuronal circuit behaviour. http://www.medicine.mcgill.ca/pharma/dbowielab/publications.html Kelly Jorundson Manitoba Neuroscience Network R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro> [View Less]

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IMPORTANT REMINDER: MNN MTG - ABSTRACT DEADLINE MAY 13TH
by Manitoba Neuroscience Network 10 May '16

10 May '16

cid:image001.jpg@01D158FE.B69B8D00 Reminder - Abstract Deadline - May 13, 2016 This is a friendly reminder that the ABSTRACT DEADLINE for our Manitoba Neuroscience Network meeting is only 3 DAYS AWAY! Please show your support by attending the meeting and also encourage your trainees and research staff to participate in this event and submit their work for poster presentation. The DEADLINE for abstract submission is May 13st, 2016. Please follow the link (www.sbrc.ca/mnn2016 <… [View More]

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Nick Shepel Travel Award
by Kelly Jorundson 05 May '16

05 May '16

We are pleased to announce this year's recipient(s) of the St. Boniface Hospital Foundation - Nick Shepel Travel Award. Congratulations to Scott Dyck (Supervisor: Soheila Karimi) and Glen Sequiera (Supervisor: Sanjiv Dhingra) who were both selected to receive awards. This year's recipients will receive up to $750 CDN each, to be used for reimbursement of eligible travel expenses as identified in their applications. (as per SBH travel policies). For more information on the … [View More]

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