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Neuroscience Seminar: Dr. Sheena Josselyn
by Winnipeg Chapter Society for Neuroscience 24 May '12

24 May '12

Please circulate/post: St. Boniface Hospital Research Neuroscience Seminar Series (Hosted by the Division of Neurodegenerative Disorders) Friday, June 1st, 2012 PX236/238 PsychHealth Bldg., Bannatyne Campus 12:00 Noon Dr. Sheena Josselyn Senior Scientist, Neurosciences & Mental Health Canada Research Chair, Molecular and Cellular Cognition Associate Professor, Department of Physiology University of Toronto Hospital for Sick Children, Toronto, ON Topic: Making and Breaking Memories Abstract: A fundamental goal of neuroscience is to understand how memories are encoded and stored in the brain. Indeed, identifying the physical basis of memory within the brain (the memory trace) has been a long-standing challenge for scientists since Karl Lashley's "search for the engram" in the 1950's. Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased CREB are preferentially activated by fear memory expression, suggesting they are selectively recruited into the memory trace. Here we used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, suggesting that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace. Short bio: The research in Dr. Josselyn's lab is dedicated to understanding the neural basis of cognitive function and dysfunction. To unravel the molecular, cellular and circuit processes that underlie learning and memory, her lab uses a multidisciplinary approach include the use of genetically-engineered mice, viral vectors, cellular imaging, electrophysiology and detailed behavioral analysis. Her program of research focuses on two main elements 1) examining the brain regions and molecules responsible for normal memory formation and 2) using this knowledge to intervene in conditions in which memory is impaired (for instance in neurodegenerative diseases such as Alzheimer's disease). She has published extensively in the top scientific journals on these subjects and has shown that fear memories in mice can be "erased" and is currently examining novel treatments for the memory disorders that characterize Alzheimer's disease. Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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MNN Seminar this Friday - CANCELLED
by Winnipeg Chapter Society for Neuroscience 24 May '12

24 May '12

Dear Neuro-all, The MNN Seminar scheduled for Friday, May 25, 2012 at 9am has been CANCELLED. /send on behalf of Chris Anderson Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Visiting Speraker - Dr. Subrata Chakrabarti May 18th
by Winnipeg Chapter Society for Neuroscience 15 May '12

15 May '12

DND Visiting Speaker - Dr. Subrata Chakrabarti <http://www.sbrc.ca/2012/05/05182012-dnd-visiting-speaker-dr-subrata-chakrab…> Posted on: May 15, 2012 Print PDF <http://www.printfriendly.com/print/v2?url=http://www.sbrc.ca/2012/05/051820…> Friday, May 18th, 2012 12:00 Noon - Samuel Cohen Auditorium St. Boniface Hospital Research (Video-linked to Bannatyne Campus, A229 Chown Bldg.) <http://www.sbrc.ca/wp-content/uploads/2012/05/chakrabarti.jpg> Dr. Subrata Chakrabarti Dept. of Pathology, Schulich School of Medicine and Dentistry, Western University and London Health Sciences Center, London, Ontario. Topic: Novel mechanisms in the pathogenesis of diabetic retinopathy. Dysfunction of endothelial cell (ECs) causing increased production of vasoactive factors and extracellular matrix (ECM) proteins are characteristic features of chronic diabetic complications such as diabetic retinopathy. Glucose-induced biochemical alterations in the ECs activate a cascade of signaling pathways leading to such changes. Chronic diabetes leads to the activation of a number of signaling proteins including protein kinase C and advanced glycation end product formation. These signaling cascades are activated in response to hyperglycemia-induced oxidative stress. Such aberrant signaling leads to activation of transcription factors, such as nuclear factor-κB and activating protein-1. Although transcription factors are of importance in the regulation of protein production, they remain ineffective without transcriptional co-activators. In diabetes, transcriptional co-activator p300, with histone acetyl transferase activity, regulates several transcription factors. In addition, microRNA alterations regulate gene expression and the downstream effects eg. increased vasoactive factor and ECM protein production. Blockers of oxidative stress and histone acetylation as well as selected miRNA mimics prevent such alteration. Hence a complex web of pathways including intracellular signaling, epigenetics and miRNA alterations are involved in the pathogenesis of functional and structural changes in chronic diabetic complications. We have identified specific changes in the ECs and in the organs affected by diabetic complications such as retina. We have also identified novel adjunct treatment strategies, targeting epigenetic and transcriptional machinery for chronic diabetic complications such as retinopathy. (Supported by Grants from Canadian Institute of health Research, Canadian Diabetes Association and Heart and Stroke Foundation of Ontario) For more information contact DND Office: (T) 235.3939 or (E) dnd(a)sbrc.ca Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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Visiting Speaker Dr. Subrata Chakrabarti
by Winnipeg Chapter Society for Neuroscience 07 May '12

07 May '12

Neuroscience Seminar Series Hosted by the Division of Neurodegenerative Disorders Friday, May 18th, 2012 Samuel Cohen Auditorium St. Boniface Hospital Research 12:00 Noon (Video-linked to Bannatyne Campus, A229 Chown Bldg.) Dr. Subrata Chakrabarti Dept. of Pathology, Schulich School of Medicine and Dentistry, Western University and London Health Sciences Center, London, Ontario Topic: Novel mechanisms in the pathogenesis of diabetic retinopathy. Dysfunction of endothelial cell (ECs) causing increased production of vasoactive factors and extracellular matrix (ECM) proteins are characteristic features of chronic diabetic complications such as diabetic retinopathy. Glucose-induced biochemical alterations in the ECs activate a cascade of signaling pathways leading to such changes. Chronic diabetes leads to the activation of a number of signaling proteins including protein kinase C and advanced glycation end product formation. These signaling cascades are activated in response to hyperglycemia-induced oxidative stress. Such aberrant signaling leads to activation of transcription factors, such as nuclear factor-κB and activating protein-1. Although transcription factors are of importance in the regulation of protein production, they remain ineffective without transcriptional co-activators. In diabetes, transcriptional co-activator p300, with histone acetyl transferase activity, regulates several transcription factors. In addition, microRNA alterations regulate gene expression and the downstream effects eg. increased vasoactive factor and ECM protein production. Blockers of oxidative stress and histone acetylation as well as selected miRNA mimics prevent such alteration. Hence a complex web of pathways including intracellular signaling, epigenetics and miRNA alterations are involved in the pathogenesis of functional and structural changes in chronic diabetic complications. We have identified specific changes in the ECs and in the organs affected by diabetic complications such as retina. We have also identified novel adjunct treatment strategies, targeting epigenetic and transcriptional machinery for chronic diabetic complications such as retinopathy. (Supported by Grants from Canadian Institute of health Research, Canadian Diabetes Association and Heart and Stroke Foundation of Ontario) For more information contact DND Office: (T) 235.3939 or (E) dnd(a)sbrc.ca Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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SEMINAR tomorrow - last reminder
by Winnipeg Chapter Society for Neuroscience 26 Apr '12

26 Apr '12

DATE: FRIDAY APRIL 27 TIME: 9:00 - 10:00 am LOCATION: PsychHealth Building Room PX236/238 SPEAKER: Dr. Soheila Karimi Spinal Cord Research Centre Regenerative Medicine Program Biochemistry and Medical Genetics University of Manitoba TITLE: Regenerative Potential of Neural Stem Cells for the Repair of Spinal Cord Injury --------------------------------------------------------------------------------------- Chris M. Anderson, Ph.D. President, Winnipeg Chapter, Society for Neuroscience Director, Manitoba Neuroscience Network T: 204.235.3946 │ F: 204.237.4092 │ E: wcsn(a)sbrc.ca

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Date correction
by Winnipeg Chapter Society for Neuroscience 24 Apr '12

24 Apr '12

Apologies - the MNN seminar date advertised earlier today is this Friday APRIL 27.

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Manitoba Neuroscience Network SEMINAR
by Winnipeg Chapter Society for Neuroscience 24 Apr '12

24 Apr '12

Please remember to attend the APRIL MNN seminar this Friday. All are welcome. DATE: FRIDAY APRIL 28 TIME: 9:00 - 10:00 am LOCATION: PsychHealth Building Room PX236/238 SPEAKER: Dr. Soheila Karimi Spinal Cord Research Centre Regenerative Medicine Program Biochemistry and Medical Genetics University of Manitoba TITLE: Regenerative Potential of Neural Stem Cells for the Repair of Spinal Cord Injury --------------------------------------------------------------------------------------- Chris M. Anderson, Ph.D. President, Winnipeg Chapter, Society for Neuroscience Director, Manitoba Neuroscience Network T: 204.235.3946 │ F: 204.237.4092 │ E: wcsn(a)sbrc.ca

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Neuroscience Research Program Candidate- Dr. Rao M. Adhibatla - April 26, 2012...
by Winnipeg Chapter Society for Neuroscience 23 Apr '12

23 Apr '12

Dear Neuroscientists, Please attend the public lecture of Neuroscience Program faculty candidate, Dr. Rao M. Adhibatla on April 26. See attachments. --------------------------------------------------------------------------------------- Chris M. Anderson, Ph.D. President, Winnipeg Chapter, Society for Neuroscience Director, Manitoba Neuroscience Network T: 204.235.3946 │ F: 204.237.4092 │ E: wcsn(a)sbrc.ca _______________________________________ MED-ACADEMICS mailing list MED-ACADEMICS(a)lists.umanitoba.ca http://lists.umanitoba.ca/mailman/listinfo/med-academics

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MSCIRC Call for Proposals: 2012 Spinal Cord Injury Research Projects
by Winnipeg Chapter Society for Neuroscience 13 Apr '12

13 Apr '12

Call for Proposals for 2012 Spinal Cord Injury Research Projects The Manitoba Spinal Cord Injury Research Committee (MSCIRC) is pleased to announce that the 2012 Grants and Awards competition is now underway and accepting applications for spinal cord injury research projects in Manitoba. Purpose Grants provided through this initiative aim to increase understanding of spinal cord function; reduce the disability related to spinal cord injury; increase functional capacity after spinal cord injury; reduce the incidence and effects of secondary complications after spinal cord injury; and increase quality of life and community integration after spinal cord injury. Eligibility Grant applications will only be considered from accredited educational institutions, disability related organizations, research institutions or members of hospital staff. Deadline All project applications must be submitted by 4:00 p.m. on April 23, 2012. Application Package All forms are available from the Canadian Paraplegic Association (Manitoba) Inc.'s website at www.cpamanitoba.ca <http://www.cpamanitoba.ca/> . Inquiries Inquiries about the application process are to be directed to: MSCIRC, c/o Canadian Paraplegic Association (Manitoba) Inc. Telephone: 204-786-4753, ext. 222 Toll Free within Manitoba 1-800-720-4933 Fax: 204-786-1140 Email: aconley(a)canparaplegic.org

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Manitoba Schools Science Symposium
by Winnipeg Chapter Society for Neuroscience 13 Apr '12

13 Apr '12

Dear Manitoba Neuroscientists, The Manitoba Schools Science Symposium (MSSS) is being hosted at the University of Manitoba from April 26th to April 29th. This is an event that showcases the hard work of students in Manitoba at all levels, from elementary to high school. The WCSN will continue our involvement in the MSSS again this year by offering 3 project awards related to neuroscience. We feel that this is part of our contribution to growing the neuroscience discipline at the grassroots level in Manitoba. To make this happen, I am looking for volunteer project judges from within our membership to rank the top neuroscience-related projects. Projects will be displayed in the Max Bell Centre and judging will take place Saturday morning, April 28, from 9AM to Noon. Lunch will be provided after the judging is complete. If this is an area or service you think you can contribute to, please reply to this email as soon as possible. Thank you! Chris --------------------------------------------------------------------------------------- Chris M. Anderson, Ph.D. President, Winnipeg Chapter, Society for Neuroscience T: 204.235.3946 │ F: 204.237.4092 │ E: wcsn(a)sbrc.ca

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