- Neuro-All - University of Manitoba Mailing Lists

MNN 9th Scientific Meeting - Save the Date!
by Manitoba Neuroscience Network 15 Mar '19

15 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 JUNE 7th, 2019 Manitoba Neuroscience Network 9th SCIENTIFIC MEETING UNIVERSITY OF WINNIPEG Convocation Hall & Leatherdale Hall PROGRAM THEMES · Genetics of neurodevelopment · Emotional/cognitive neuroscience · Neuro-oncology · Historical perspectives on neuropathology · Focus on ALS R STRATION OPENS PROGRAM HIGHLIGHTS · Refreshment & exercise breaks · Taco bar lunch · Poster session · Exhibitor tables · Breakout sessions · WAG networking mixer & neuroscience art silent auction KEYNOTE SPEAKERS Dr. Daniel Goldowitz University of British Columbia Dr. Janice Robertson University of Toronto *REGISTRATION OPENS APRIL 1 , 2019 www.manitobaneuroscience.ca CHAIRS Dr. Domenico Di Curzio University of Winnipeg Dr. Renée Douville University of Winnipeg For more information: mnn2019(a)manitobaneuroscience.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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CAN elections
by Manitoba Neuroscience Network 14 Mar '19

14 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tabrez Siddiqui Could you please forward to all Neuroscience faculty. From: "Alyson Fournier, Dr." <alyson.fournier(a)mcgill.ca> Subject: CAN elections Dear Tabrez, CAN has recently opened its call for nominations for the Spring election. Openings are available for vice president, secretary and 2 board members. It is important for CAN to have great cross-Canada representation and diversity on the executive so please bring this to the attention of any faculty at your institute who may be interested. Thanks for your time, Sincerely, Alyson Secretary - CAN https://can-acn.org/call-for-nominations-spring-2019-elections Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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****CANCELLED**** MNN Speaker | Alyson Fournier Mar 20th
by Kelly Jorundson 12 Mar '19

12 Mar '19

-----CANCELLED----- [cid:image001.jpg@01D158FE.B69B8D00] S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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John P. Zubek Memorial Lecture Series | Matthew Hill
by Manitoba Neuroscience Network 11 Mar '19

11 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Tammy Ivanco Department of Psychology Colloquium JOHN P. ZUBEK MEMORIAL LECTURE Friday, March 15, 2019, 3:00 p.m., P412 Duff Roblin Refreshments served at 2:30 p.m., P408 Duff Roblin Wine & Cheese to follow talk Dr. Matthew Hill, PhD Department of Psychiatry, University of Calgary; Hotchkiss Brain Institute; The Mathison Centre for Mental Health research & Education Endocannabinoids: Multi-modal regulators of the stress response For more information: Dr. T.L. Ivanco, Associate Professor Department Of Psychology University of Manitoba 204-474-7375 Tammy.ivanco(a)umanitoba.ca Kelly Jorundson Administrative Manager, Division of Neurodegenerative Disorders St. Boniface Hospital Research & Department of Pharmacology & Therapeutics University of Manitoba Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca or <mailto:Kelly.jorundson@umanitoba.ca> kjorundson(a)sbgh.mb.ca Tel: 204.235.3939 Fax: 204.237.4092 cid:image001.jpg@01D2883E.86D93F20

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Reminder....MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm
by Kelly Jorundson 11 Mar '19

11 Mar '19

[cid:image001.jpg@01D158FE.B69B8D00] M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca<mailto:Tabrez.siddiqui@umanitoba.ca> Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker: Dr. Steven Connor | Monday Mar 11 @ 2:30pm
by Manitoba Neuroscience Network 07 Mar '19

07 Mar '19

cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Monday, March 11, 2019 2:30 PM L O C A T I O N: BMSB, Theatre C Bannatyne Campus S P E A K E R Steven Connor, Ph.D. Assistant Professor, Department of Biology York University T O P I C Taming the wild synapse: MDGAs as negative regulators of synapse development O B J E C T I V E S 1. Understand what negative synapse organizers such as MDGAs are. 2. Understand how loss of negative synapse organizers alters neuronal circuit properties and contributes to corresponding behavioral deficits. 3. Gain insight into alternative molecular targeting strategies that could be used for restoring physiological and behavioral functions that are compromised in neurodevelopmental disorders. B I O S K E T C H: Exciting advancements in our understanding of synapse development suggest that powerful positive and negative synapse organizers control when and where synapses form. Chief among the negative regulators are MDGAs, which are found throughout the brain where they help regulate how synaptic connections form and respond to neural activity. MDGAs exist in two forms; MDGA1 appears to regulate inhibitory synapses that limit cell firing whereas MDGA2 regulates excitatory synapses which increase cell activity. This discussion will begin with recent discoveries about the contributions of MDGA1 to synaptic and circuit properties in vivo. Next, MDGA2, which has been identified as a candidate gene in Autism Spectrum Disorder (ASD), will be discussed in the context of synaptic plasticity, cortical circuit dynamics and rodent behavioral analogs of ASD. Finally, I will introduce ongoing projects focused on countering molecular deficits observed in our autism model as a means for restoring the capacity of autistic brain circuits to undergo synaptic changes, which may hold promise for curtailing the behavioral features of this disorder. Given the rapidly increasing rates of autism, it is essential that we determine if manipulating molecular pathologies associated with loss of MDGA function has therapeutic benefits in neurodevelopmental disorder models. For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Dementia Journal Club - March 13 10 AM at Ft Garry EITC - please post and/or distribute
by Kelly Jorundson 07 Mar '19

07 Mar '19

[cid:image001.jpg@01D158FE.B69B8D00] /sent on behalf of Ben Albensi Come to our journal club on March 13th. Info below. Paper can be found at our Dementia Research website: http://dementiamanitoba.wixsite.com/m.../dementia-journal-club<http://dementiamanitoba.wixsite.com/mysite/dementia-journal-club?fbclid=IwA…> [cid:image003.jpg@01D4D4D1.722F1A90] Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/> [cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker | Dr.Alyson Fournier Mar 20 @ 12noon Theatre B
by Manitoba Neuroscience Network 28 Feb '19

28 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, March 20th, 2019 12:00 Noon (Followed by a trainee lunch in SR415 KIAM Bldg) L O C A T I O N Theatre B, Bannatyne Campus S P E A K E R Dr. Alyson Fournier Professor, Faculty of Medicine McGill University T O P I C Small Molecule Stabilization of protein interactions to promote axon regeneration Objectives: - Define 14-3-3- adaptor proteins and small molecules targeting these proteins - Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model - Discuss the mechanism used by these small molecules to promote axon regeneration Abstract: Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Brief Bio: Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fournier's group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair, MNN Seminar Series

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FW: Dementia Manitoba website - request for updates
by Manitoba Neuroscience Network 14 Feb '19

14 Feb '19

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Hi All Our Dementia Manitoba website is currently being updated. If you have any new studies or reviews on Alzheimer's and/or dementia and would like to have your lab recognized then please send me your information for posting. Or just check out what's new and upcoming. Thanks, http://dementiamanitoba.wixsite.com/mysite/research-blog Dr George Perry visits the TMS and EVestG labs in Winnipeg. Benedict C. Albensi, PhD Dementia Research Chair University of Manitoba & St Boniface Hospital Research 204-235-3942

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MNN Visiting Speaker - Dr. Alyson Fournier | Wed Mar 20 @ 12 noon
by Manitoba Neuroscience Network 07 Feb '19

07 Feb '19

Please mark your calendar cid:image001.jpg@01D158FE.B69B8D00 M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D A T E Wednesday, Mar 20, 2019 12 noon L O C A T I O N: Theatre B Bannatyne Campus fourniersmall.jpgS P E A K E R Dr. Alyson Fournier <https://www.mcgill.ca/neuro/research/researchers/fournier> Professor Faculty of Medicine McGill University T O P I C Small molecule stabilization of protein Interactions to promote axon regeneration Abstract Damaged central nervous system (CNS) neurons have a poor ability to spontaneously regenerate, causing persistent functional deficits after injury. Therapies that stimulate axon growth are needed to repair CNS damage. 14-3-3 adaptors are hub proteins that are attractive targets to manipulate cell signaling. We have identified a positive role for 14-3-3s in axon growth and have shown that fusicoccin-A (FC-A), a small-molecule stabilizer of 14-3-3 protein-protein interactions, stimulates axon growth in vitro and regeneration in vivo. Further screening of FC-A derivatives has revealed potent axon growth-promoting compounds. Through mass spectrometry, we find that FC-A and a potent derivative, stabilize interactions between 14-3-3 proteins and multiple components of the Rap1 pathway to facilitate axon growth. Thus, FC-A and its derivatives exhibit remarkable polypharmacology facilitating axon regeneration. These findings show that 14-3-3 adaptor protein complexes are druggable targets and identify a new class of small molecules that may be further optimized for the repair of CNS damage Objectives * Define 14-3-3- adaptor proteins and small molecules targeting these proteins * Describe the influence of small molecules targeting 14-3-3 proteins on axon regeneration in a pre-clinical optic nerve injury model * Discuss the mechanism used by these small molecules to promote axon regeneration Short Bio Dr. Alyson Fournier (PhD) is a Professor in the Faculty of Medicine at McGill University in Montreal, Canada. She completed her Ph.D. in Neuroscience at McGill University (1998) and conducted her postdoctoral training at Yale University with Dr. Strittmatter working on neurodevelopment and regeneration. Since 2003 Dr. Fournier has led a research lab at the Montreal Neurological Institute studying molecular mechanisms regulating axon degeneration and regeneration. Dr. Fourniers group studies neuronal signalling in response to acute nerve cell injury and inflammation for the conception and validation of new therapeutic targets to promote neuroprotection and repair. /sent on behalf of Tabrez Siddiqui Chair Seminar Series Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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