- Neuro-All - University of Manitoba Mailing Lists

REMINDER: MNN Visiting Speaker - Dr. Katalin Toth - Fri. Feb. 9th Seminar *followed by trainee lunch
by Manitoba Neuroscience Network 07 Feb '18

07 Feb '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S SCIENTIFIC LECTURE (followed by neuroscience trainee lunch see below) D AT E Friday, February 9th, 2018 12:00 NOON* S P E A K E R Dr. Katalin Toth <https://cervo.ulaval.ca/en/katalin-toth> Professor - Dept of Psychiatry and Neuroscience CERVO Brain Research Centre, Université Laval L O C AT I O N 071 Apotex Bldg. T O P I C Information coding and calcium dynamics in hippocampal mossy fibre terminals *Trainee lunch to follow at 1pm in room SR415 KIAM Bldg. All trainees invited to attend (including students, postdocs, and research associates) A B S T R A C T Neurons encode and transmit information in the frequency and temporal precision of action potentials (APs) they discharge Presynaptic terminals are key elements involved in the translation of electrical signals to neurotransmitter release. The differential spatial assembly of a myriad of voltage-gated channels, calcium buffers and calcium sensors confers specific properties to presynaptic terminals.The dynamic modulation of neurotransmitter release is thought to support the neuronal code used to transfer information. We use electrophysiological measurements in acute hippocampal slices with rapid presynaptic two-photon calcium imaging and experimentally-constrained modelling to study the mechanism by which mossy finer terminals in the hippocampus translate granule cell firing to postsynaptic signals. Our aim is to elucidate how a mossy fiber boutons integrate incoming bursts of action potentials to propagate information to CA3 pyramidal neurones. Bio: Katalin Tóth earned her PhD in 1995 from the Eötvös Loránd University in Budapest, Hungary, under the supervision of Tamás F. Freund, after completing an undergraduate degree in Biology. She then spent the next 2 years as postdoctoral fellow in the laboratory of Richard Miles at the Pasteur Institute in Paris, France, and studied the properties of synaptic interactions between connected pairs of neurons. She moved to the National Institutes of Health in the USA where she worked with Chris J. McBain on the plastic properties of hippocampal networks. She established her laboratory in 2000 at Laval University where she is currently a Professor in the Department of Psychiatry and Neuroscience. Her research is focused on presynaptic release mechanisms and information processing at hippocampal mossy fibres. /sent on behalf of Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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2 upcoming international events on nutrition & dementia
by Kelly Jorundson 07 Feb '18

07 Feb '18

/sent on behalf of Ben Albensi Dear Dementia Research Community: For those of you interested in nutrition and dementia, there are two upcoming events that I would like to bring to your attention: The 2018 NIH Alzheimer's Research Summit <https://urldefense.proofpoint.com/v2/url?u=http-3A__bit.ly_2BQVye5&d=DwMFaQ…> is being held March 1-2 in Bethesda, Maryland. There are several interesting sessions, but one in particular, “Understanding the Impact of the Environment to Advance Disease Prevention” involves our professional interest area (PIA) Co-Chair, Prof Martha Clare Morris representing nutrition science. We encourage you to add to this discussion that will shape the research agenda in our field. The ILSA Europe Symposium - Nutrition for the Ageing Brain: Moving Towards Clinical Applications <https://urldefense.proofpoint.com/v2/url?u=http-3A__bit.ly_2EAZnH4&d=DwMFaQ…> is being held August 30-31 in Madrid, Spain. Translating knowledge about nutrition and diet to human clinical conditions remains an important challenge. This symposium will specifically focus on clinical aspects and novel strategies developed to determine whether diet and nutrients have efficacy in individuals affected by dementia and other neurodegenerative conditions. I encourage you to re-send this message to any email distribution lists you may have. For more information call one of my cell phones below. Thank you, With kind regards, Benedict C. Albensi, PhD, BCMAS, CRQM Communications Chair for Nutrition, Metabolism, & Dementia PIA Executive Committee ISTAART- Alzheimer’s Association, USA balbensi(a)sbrc.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker - Dr. Katalin Toth - Fri. Feb. 9th Seminar followed by trainee lunch
by Manitoba Neuroscience Network 02 Feb '18

02 Feb '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S SCIENTIFIC LECTURE (followed by neuroscience trainee lunch see below) D AT E Friday, February 9th, 2018 12:00 NOON* S P E A K E R Dr. Katalin Toth <https://cervo.ulaval.ca/en/katalin-toth> Professor - Dept of Psychiatry and Neuroscience CERVO Brain Research Centre, Université Laval L O C AT I O N 071 Apotex Bldg. T O P I C Information coding and calcium dynamics in hippocampal mossy fibre terminals *Trainee lunch to follow at 1pm in room SR415 KIAM Bldg. (All neuroscience-related trainees invited to attend (including students, postdocs, and research associates) A B S T R A C T Neurons encode and transmit information in the frequency and temporal precision of action potentials (APs) they discharge Presynaptic terminals are key elements involved in the translation of electrical signals to neurotransmitter release. The differential spatial assembly of a myriad of voltage-gated channels, calcium buffers and calcium sensors confers specific properties to presynaptic terminals.The dynamic modulation of neurotransmitter release is thought to support the neuronal code used to transfer information. We use electrophysiological measurements in acute hippocampal slices with rapid presynaptic two-photon calcium imaging and experimentally-constrained modelling to study the mechanism by which mossy finer terminals in the hippocampus translate granule cell firing to postsynaptic signals. Our aim is to elucidate how a mossy fiber boutons integrate incoming bursts of action potentials to propagate information to CA3 pyramidal neurones. Bio: Katalin Tóth earned her PhD in 1995 from the Eötvös Loránd University in Budapest, Hungary, under the supervision of Tamás F. Freund, after completing an undergraduate degree in Biology. She then spent the next 2 years as postdoctoral fellow in the laboratory of Richard Miles at the Pasteur Institute in Paris, France, and studied the properties of synaptic interactions between connected pairs of neurons. She moved to the National Institutes of Health in the USA where she worked with Chris J. McBain on the plastic properties of hippocampal networks. She established her laboratory in 2000 at Laval University where she is currently a Professor in the Department of Psychiatry and Neuroscience. Her research is focused on presynaptic release mechanisms and information processing at hippocampal mossy fibres. /sent on behalf of Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Volunteers needed for Neurotalks career day
by outreach＠manitobaneuroscience.ca 23 Jan '18

23 Jan '18

/sent on behalf of Dr. Sari Hannila Hello everyone, Best wishes to all of you for a happy and productive 2018! You will be hearing about our upcoming outreach events for Brain Awareness Week over the next several weeks, but today I am writing to ask for your help with an event that will be happening slightly later in the year. Last year at the MNN meeting, I was approached by one of the leaders of Let's Talk Science - a student-run science outreach organization based at the U of M Fort Garry campus. Every year they host a science career day for high school students that focuses on a particular field. This year, they want to feature neuroscience and I'm excited to announced that we will be hosting "Neurotalks" at the U of M Bannatyne campus on Thursday, May 3rd! As part of this event, we will be hosting hands-on workshops for the students, and I am looking for volunteers to lead 4 different neuroscience-themed workshops that afternoon. The workshops can be led by individuals or by a group. Grad students and postdocs, you can lead these workshops if you wish! Just be sure to speak with your supervisor first - especially if you will be using your lab space, equipment, or materials. Here are the details and guidelines: 1. The workshops will be held from roughly 12-3 pm on May 3rd. The students will rotate through each workshop over the course of the afternoon, so you will repeat your activity four times. 2. Each workshop session should be approximately 30 minutes in length. 3. We anticipate that there will be 20-25 students in each group (max). 4. You are responsible for providing all of the materials required for your workshop. 5. Regarding the content, it can be anything you want! Just ensure that the content is appropriate for high school students. Workshops focusing on clinical subjects are most welcome! 6. A qualifier to the statement above: no live animals and no blood. If you want to use prepared tissues or cells, that's absolutely fine. I'm sure the students would enjoy recording from patch-clamped neurons! 7. Try to make the workshop as interactive and hands-on as possible. I'm sending this message now because if you are thinking of developing a workshop, you can pilot it during the Winnipeg Brain Bee in March. We would love to have some new activities for the Brain Bee this year! For those of you who have done workshops for Health Sciences Discovery Day, you are very welcome to modify those workshops for Neurotalks. Please send me the title and description of your workshop at your earliest convenience, along with a list of the members of your group (if applicable). There is no firm deadline, but if you would like to hold a pilot workshop during the Brain Bee, your plans should be in place by mid-February. Thank you all for your participation. Let's make this a memorable day for these students! Best wishes, Sari Sari S. Hannila, PhD Director of Outreach, Manitoba Neuroscience Network Sari S. Hannila, PhD Associate Professor, Department of Human Anatomy and Cell Science Associate Member, Spinal Cord Research Centre Max Rady College of Medicine, Rady Faculty of Health Sciences University of Manitoba ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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MNN Visiting Speaker - Dr. Katalin Toth - Fri. Feb. 9th @ 12noon 071 APOTEX
by Manitoba Neuroscience Network 19 Jan '18

19 Jan '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Friday, February 9th, 2018 12:00 NOON L O C AT I O N 071 Apotex Bldg. S P E A K E R Dr. Katalin Toth <https://cervo.ulaval.ca/en/katalin-toth> CERVO Brain Research Centre Université Laval Professor, Department of Psychiatry and Neuroscience T O P I C Information coding and calcium dynamics in hippocampal mossy fibre terminals Abstract: Neurons encode and transmit information in the frequency and temporal precision of action potentials (APs) they discharge Presynaptic terminals are key elements involved in the translation of electrical signals to neurotransmitter release. The differential spatial assembly of a myriad of voltage-gated channels, calcium buffers and calcium sensors confers specific properties to presynaptic terminals.The dynamic modulation of neurotransmitter release is thought to support the neuronal code used to transfer information. We use electrophysiological measurements in acute hippocampal slices with rapid presynaptic two-photon calcium imaging and experimentally-constrained modelling to study the mechanism by which mossy finer terminals in the hippocampus translate granule cell firing to postsynaptic signals. Our aim is to elucidate how a mossy fiber boutons integrate incoming bursts of action potentials to propagate information to CA3 pyramidal neurones. Bio: Katalin Tóth earned her PhD in 1995 from the Eötvös Loránd University in Budapest, Hungary, under the supervision of Tamás F. Freund, after completing an undergraduate degree in Biology. She then spent the next 2 years as postdoctoral fellow in the laboratory of Richard Miles at the Pasteur Institute in Paris, France, and studied the properties of synaptic interactions between connected pairs of neurons. She moved to the National Institutes of Health in the USA where she worked with Chris J. McBain on the plastic properties of hippocampal networks. She established her laboratory in 2000 at Laval University where she is currently a Professor in the Department of Psychiatry and Neuroscience. Her research is focused on presynaptic release mechanisms and information processing at hippocampal mossy fibres. /sent on behalf of Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN Seminar Saeid Ghavami - Jan 26th, 2018 9am
by Manitoba Neuroscience Network 19 Jan '18

19 Jan '18

cid:image001.jpg@01D158FE.B69B8D00 S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Friday, January 26, 2018 9:00am L O C AT I O N PX236/238 PsycHealth Building S P E A K E R Dr. Saeid Ghavami <http://chrim.ca/researcher/saeid-ghavami/> Department of Human Anatomy & Cell Science, Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba T O P I C Mevalonate Cascade Inhibition and Glioblastoma Multiform: Role of Autophagy Modulation in Sensitizing the glioblastoma cells to Temozolomide. Biosketch: Originally from Mashad, Khorasan, Iran, Dr. Ghavami has received his Bachelor of Chemistry degree from Shiraz University, Iran in 1989. He then completed his Master of Science and PhD degree in the Department of Clinical Biochemistry at Tarbiat Modarres University, Iran in 1996 and 2004 in Clinical Biochemsitry. Prior to joining to the Department of Human Anatomy and Cell Science, University of Manitoba in October 2013 as an Assistant Professor, Dr. Ghavami worked as a Post Doctoral Fellow in CancerCare Manitoba, Department of Physiology and Pathophysiology and St. Boniface Research Centre at the University of Manitoba for 9 years (2004-2013) and has built his research career on the effects of cellular stress in the regulation of cellular fate. Currently Dr. Ghavami is an Assistant Professor and Principal investigator and one of his major research focus is developing new therapeutic approaches in glioblastoma multiform, based on modification of apoptosis, autophagy, and unfolded protein response (UPR) pathway via cholesterol metabolism pathway. Learning Objectives: At the end of this presentation the audience should be able to: · Describe the cholesterol metabolism pathway and its effect on regulation of small Rho GTPase protein · Describe the development of statin drug family and their pleotropic effects. · Describe the general effects of statins in cancer · Describe mechanism of regulation of autophagy pathway and autophagy flux · Describe how cholesterol metabolism pathway regulate autophagy and cell death in glioblastoma cells /sent on behalf of Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour(a)umanitoba.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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MNN 2018 Meeting Save The Date
by networking＠manitobaneuroscience.ca 15 Jan '18

15 Jan '18

Kae Normandeau Administrative Assistant Manitoba Neuroscience Network SR440 KIAM Building P: 204-318-2569 E: <mailto:kae.normandeau@umanitoba.ca> kae.normandeau(a)umanitoba.ca

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MNN Membership Renewal Notices
by info＠manitobaneuroscience.ca 04 Dec '17

04 Dec '17

You may have received an email asking you to renew your MNN membership for 2018. This was an error. Please disregard at this time. We are working on phase 2 of the website. It will soon be ready for membership renewals but it is not yet. We appreciate your patience and look forward to unveiling the full website at Manitobaneuroscience.ca <http://Manitobaneuroscience.ca> . Thank you. The MNN Team ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Dementia Journal Club by Dr Wang's lab - Nov 28 noon, Apotex Ctr 061 at HSC
by Manitoba Neuroscience Network 23 Nov '17

23 Nov '17

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Ben Albensi Everyone invited to attend! date Tuesday, November 28, 2017 Time 12:00 PM Location Univ. Manitoba HSC Campus (Apotex Ctr. 061) Dr Wang's lab will present the paper: Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis ABSTRACT The major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E4 (ApoE4), has been suggested to have detrimental effects on neurons, including direct toxicity via apoptosis. Thioredoxin-1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the regulation of apoptosis through the inhibition of apoptosis signalregulating kinase-1 (Ask-1). In this study, we have investigated the effects of ApoE on Trx1 in the brain. Our results showed that the protein levels of Trx1 were reduced in the hippocampus of ApoE4 targeted replacement (TR) mice compared to ApoE3 TR mice. The reduction was also seen in vitro after treatment of both human primary cortical neurons and neuroblastoma cells with human recombinant ApoE4 (rApoE4). Furthermore, ApoE4 caused a disruption of lysosomal integrity and a shift in the localization of Cathepsin D, an enzyme known to degrade Trx1. ApoE4 treatment induced in addition apoptosis through translocation of Death-domain associated protein-6 (Daxx) from the nucleus to the cytosol, suggesting an activation of the Ask-1 pathway. This toxicity was prevented by overexpression of Trx1 and other endogenous Ask-1 inhibitors. Our data suggests that down-regulation of Trx1 is involved in the toxicity caused by ApoE4. An activated ASK-1 pathway might indeed make cells more vulnerable to other insults such as amyloid-_, which could partially explain the mechanism behind the strongest genetic risk factor for AD.

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Relaunch Flyer
by Manitoba Neuroscience Network 23 Nov '17

23 Nov '17

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Sachin Katyal cid:image002.jpg@01D36371.A4A557F0

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