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Neuroscience Seminar Dr. Deborah Toiber June 7 @ 1:30p
by Manitoba Neuroscience Network 04 Jun '18

04 Jun '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Susan Zettler Date: June 7, 2018 Time: 1:30 PM �C 2:30 PM Location: Samuel N. Cohen Auditorium, St. Boniface Hospital Albrechtsen Research Centre Deborah Toiber, PhD Senior Lecturer Department of Life Sciences Ben-Gurion University of the Negev Beer-Sheva, Israel Topic: NEUROPROTECTIVE FUNCTIONS FOR THE HISTONE DEACETYLASE SIRT6 Neurodegenerative diseases are caused by the loss of neuronal cells. For many years, researchers have been trying to find the causes and possible therapies for the diverse neurodegenerative pathologies. Yet, distinguishing between the causes and the consequences of neurodegeneration is difficult, as all the symptoms and markers get tangled in an array of phenotypes. The most accepted theory of aging is that the accumulation of unrepaired DNA damage is the main cause: As we age, we accumulate DNA lesions, until we reach a threshold of irreparable lesions. The histone deacetylase SIRT6 has been linked to the aging process. SIRT6 knockout mice exhibit an accelerated aging phenotype and die prematurely. SIRT6 promotes DNA repair, but its activity declines with age with a concomitant accumulation of DNA damage. We report that brain-specific SIRT6-deficient mice survive but present behavioral defects with major learning impairments by 4 months of age. Moreover, the brains of these mice show increased signs of DNA damage, cell death, and hyperphosphorylated Tau-a critical mark in several neurodegenerative diseases. Mechanistically, SIRT6 regulates Tau protein stability and phosphorylation through increased activation of the kinase GSK3��/��. Finally, SIRT6 mRNA and protein levels are reduced in patients with Alzheimer's disease. Taken together, our results suggest that SIRT6 is critical to maintain genomic stability in the brain and that its loss leads to toxic Tau stability and phosphorylation. Therefore, SIRT6 and its downstream signaling could be targeted in Alzheimer's disease and age-related neurodegeneration. For further information, please contact the CCARM Administration Office Tel: 235-3455 email: ccarm(a)sbrc.ca Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Tach�� Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326. 7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Abstract Submissions - DEADLINE TODAY
by networking＠manitobaneuroscience.ca 01 Jun '18

01 Jun '18

The abstract deadline is TODAY. Please make sure to submit your abstracts by 11:59pm. Registration deadline is in ONE WEEK on JUNE 8th. Abstracts can be submitted by clicking here <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/a bstract-submissions/> Click here to register <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/r egistration/> Inquiries relating to the MNN 2018 Scientific Meeting can be sent to mnn2018(a)manitobaneuroscience.ca <mailto:mnn2018@manitobaneuroscience.ca> We look forward to seeing you at the meeting! - The MNN Team ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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FW: Reminder: Dept. Physiology & Pathophysiology, Assistant Prof Candidate Lecture - Dr. Jeremy Chopek - May 31, 2018
by Manitoba Neuroscience Network 30 May '18

30 May '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Sharon McCartney, Spinal Cord Research Centre Gentle reminder of the following lecture tomorrow: Department of Physiology & Pathophysiology Division of Neuroscience and Spinal Cord Injury Assistant Professor Candidate Research Lecture Dr. Jeremy Chopek, PhD University College London Sobell Department of Motor Neuroscience and Movement Disorders TOPIC: “What goes down, must come up: understanding cellular communication between spinal cord and brainstem circuits during movement" Thursday, May 31, 2018| Noon-1:00 pm Physiology Seminar Room 431, Basic Medical Sciences Building All are welcome to attend Research Profile: Dr. Jeremy Chopek received his MSc (2009) in Kinesiology and PhD (2014) in the Department of Physiology & Pathophysiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Currently, he is a post-doctoral fellow at Dalhousie University (2014-), Department of Medical Neuroscience working with both Dr. Zhang and Dr. Brownstone at University College London. His work has began to characterize and understand microcircuit formation in both the medulla reticular formation, a centre vital for the initiation of movement and the lumbar spinal cord, the area in which movement is produced. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and 2P and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. Lecture notice attached For more information please contact Dr. Brent Fedirchuk, 204-789-3762 or Sharon McCartney, sharon(a)scrc.umanitoba.ca -- Spinal Cord Research Centre University of Manitoba Department of Physiology & Pathophysiology 409 - 745 Bannatyne Avenue Winnipeg, Manitoba Canada R3E 0J9 204-789-3770 Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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Two upcoming neuroscience talks...
by Manitoba Neuroscience Network 29 May '18

29 May '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Paul Fernyhough Everyone is invited to attend two upcoming neuroscience seminars.. Pharmacology & Therapeutics Seminar Series: Dr. Rachel Sare Date: Monday, June 18th, 2018 Time: 9:00 am Location: 071 Apotex **Please inform your students that a student lunch will be held at 12 Noon in 061 Apotex Centre** Rachel Sare Ph.D Ph.D in Human and Molecular Genetics Specialization in Neuroscience B.S. in Biochemistry and Cell Biology Topic: "Working To Understand Autism" *********** Pharmacology & Therapeutics Seminar Series: Dr. Abhishek Banerjee Date: Thursday, June 21st, 2018 Time: 12:00 pm Location: 071 Apotex **Please inform your students that a student lunch will follow at 1pm in room 061 Apotex Centre** Abhishek Banerjee Ph.D D.Phil (Oxford) Marie Curie Fellow and NARSAD Young Investigator, University of Zurich Topic: "Beyond E/I Balance: Inhibitory cell-types in Rett Syndrome Pathophysiology " For more information contact: Ran-Lee Rhinas 204-789-3553

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***ROOM CHANGE*** ON2134 Cancercare MNN Seminar Series: Eftekhar Eftekharpour | May 25th @ 9am
by Kelly Jorundson 25 May '18

25 May '18

L O C AT I O N ON2134 CancerCare S E M I N A R & V I S I T I N G S P E A K E R S E R I E S D AT E Friday, May 25th, 2018 9 am L O C AT I O N ON2134 CancerCare S P E A K E R Dr. Eftekhar Eftekharpour <http://umanitoba.ca/faculties/health_sciences/medicine/units/physiology/con…> Assistant Professor in the Department of Physiology and Pathophysiology; and the Regenerative Medicine Program, Rady Faculty of Health Sciences, University of Manitoba T O P I C "Die Another Way": An update on Regulated Cell Death Mechanisms: From basic science discoveries to potential new therapeutic approaches B I O Dr. Eftekhar Eftekharpour is an Assistant Professor in the Department of Physiology and Pathophysiology, and the Regenerative Medicine Program, in the Rady Faculty of Health Sciences, at the University of Manitoba. Eftekhar's research focuses on mechanisms of neuronal cell death in models of and neurotrauma and neurodegenerative diseases. By examining the contribution of oxidative stress in induction of cell death, his lab aims to develop novel neuroprotective approaches to inhibit functional deficits in these conditions. Eftekhar received his PhD degree in neurosciences from the University of Saskatchewan in 2001, and then undertook a postdoctoral fellowship in spinal cord injury and stem cell research at the University of Toronto and the Toronto Western Hospital. During his training, he was supported by a postdoctoral fellowship from The Christopher and Dana Reeve Foundation and has received several awards including a Synthes Award from the American Association of Neurological Surgeons. Eftekhar joined the University of Manitoba in 2010, and started his research lab in 2012 at the Spinal Cord Research Centre. His research has been published in top-tier journals including J. Neuroscience, GLIA and Free Radical in Biology and Medicine Journal. He is currently holding international research grants from The Paralyzed Veterans of America and the European Wings for Life Foundation. L E A R N I N G O B J E C T I V E S · To review the many forms of regulated cell death mechanisms: Autophagy, Apoptosis, Necroptosis, Ferroptosis. · Understanding the cellular Redox state, and its contribution to cell death and survival · To describe the importance of lysosomes in cell death and introduction of potential novel treatments for prevention of cell death. Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Abstract Submissions - DEADLINE EXTENDED
by networking＠manitobaneuroscience.ca 25 May '18

25 May '18

The abstract deadline has been extended to FRIDAY, June 1st. Registration deadline is JUNE 8th. Abstracts can be submitted by clicking here <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/a bstract-submissions/> Click here to register <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/r egistration/> Inquiries relating to the MNN 2018 Scientific Meeting can be sent to mnn2018(a)manitobaneuroscience.ca <mailto:mnn2018@manitobaneuroscience.ca> We look forward to seeing you at the meeting! - The MNN Team ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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Dept. Physiology & Pathophysiology, Assistant Prof Candidate Lecture - Dr. Jeremy Chopek - May 31, 2018
by Manitoba Neuroscience Network 24 May '18

24 May '18

cid:image001.jpg@01D158FE.B69B8D00 /sent on behalf of Dr. Brent Fedirchuk --------------------------------------------------------------------- Department of Physiology & Pathophysiology Division of Neuroscience and Spinal Cord Injury Assistant Professor Candidate Research Lecture Dr. Jeremy Chopek, PhD University College London Sobell Department of Motor Neuroscience and Movement Disorders TOPIC: What goes down, must come up: understanding cellular communication between spinal cord and brainstem circuits during movement" Thursday, May 31, 2018| Noon-1:00 pm Physiology Seminar Room 431, Basic Medical Sciences Building All are welcome to attend Research Profile: Dr. Jeremy Chopek received his MSc (2009) in Kinesiology and PhD (2014) in the Department of Physiology & Pathophysiology, University of Manitoba under the supervision of Dr. Phillip Gardiner, in the Spinal Cord Research Centre. His work examined how motor circuits were affected following spinal cord injury and exercise by examining alterations in motoneuron biophysical properties, stretch reflexes, gene expression and sensitivity to pharmacological agents. Currently, he is a post-doctoral fellow at Dalhousie University (2014-), Department of Medical Neuroscience working with both Dr. Zhang and Dr. Brownstone at University College London. His work has began to characterize and understand microcircuit formation in both the medulla reticular formation, a centre vital for the initiation of movement and the lumbar spinal cord, the area in which movement is produced. To achieve this, he uses a combination of transgenic mouse lines, optogenetic or photo-manipulation of single cell or whole cell populations, in-vitro electrophysiology, viral tracers and 2P and confocal microscopy. To date, he has subdivided the chx10 neuronal population in the brainstem into two distinct cell populations based on their morphology, biophysical properties, connectivity and projection patterns. In addition, he has also found a novel connectivity pattern of the spinal V3 interneuron population, which in addition to forming commissural connections also synapse locally with ipsilateral motoneurons. Please post the attached lecture notice. For more information please contact Dr. Brent Fedirchuk, 204-789-3762 or Sharon McCartney, <mailto:sharon@scrc.umanitoba.ca> sharon(a)scrc.umanitoba.ca -- Spinal Cord Research Centre University of Manitoba Department of Physiology & Pathophysiology 409 - 745 Bannatyne Avenue Winnipeg, Manitoba Canada R3E 0J9 204-789-3770 Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Email: kjorund(a)sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies. ****************************************** <http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710 <https://www.facebook.com/manitobaneuroscience/?fref=ts> cid:image007.png@01D29326.7E26D480 <https://www.instagram.com/manitobaneuroscience/> cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro> cid:image010.png@01D29326.7E26D480

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REMINDER - Abstract Deadline Approaching
by networking＠manitobaneuroscience.ca 22 May '18

22 May '18

The MNN 2018 Scientific Meeting is fast approaching, and so are the deadlines for abstract submission and registrations. The abstract deadline is FRIDAY, MAY 25 - only three days away! The registration deadline is JUNE 8. Abstracts can be submitted by clicking here <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/a bstract-submissions/> Click here to register <https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/r egistration/> Inquiries relating to the MNN 2018 Scientific Meeting can be sent to mnn2018(a)manitobaneuroscience.ca <mailto:mnn2018@manitobaneuroscience.ca> We look forward to seeing you at the meeting! - The MNN Team ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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2018 Nick Shepel Neuroscience Trainee Travel Award
by Kelly Jorundson 15 May '18

15 May '18

/sent on behalf of Paul Fernyhough Nick Shepel Neuroscience Trainee Travel Award Application deadline: June 15, 2018 The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his laboratory partners and brought fire, humor, and a desire to always excel. His insistence to always try better has had a permanent effect on his lab mates and peers. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results. Purpose: The purpose of this fund shall be to recognize a young investigator (specifically in the neuroscience area) by providing an annual award(s) to support travel costs associated with the applicant's attendance at an upcoming national/international conference where the applicant is presenting a poster or oral presentation. This year, the value of the award may range from $300-600. Eligibility: At the time of application, students must be registered in the College of Medicine at the University of Manitoba. · Students must be registered as a full-time graduate student at a Manitoba university. · A student admitted under the "Provisional Status" may not receive the award during the provisional period. · Amount of award(s) may vary each year. · Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international) Submission Instructions: A complete application consists of the following: · Introductory letter describing meeting · Copy of abstract · Curriculum vitae · Current GPA, transcripts not needed · Proposed budget of travel costs · Submit your completed application materials to: Paul Fernyhough Director - Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Only original receipts will be accepted. Copies may be accepted only where proof of submission to another agency is provided. Request for reimbursement must be done within 2 weeks following travel otherwise eligibility may be voided. Kelly Jorundson Administrative Manager, Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Email: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> or kjorundson(a)sbgh.mb.ca <mailto:Kelly.jorundson@umanitoba.ca> Tel: 204.235.3939 Fax: 204.237.4092 St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA This email and any attachments may contain confidential, personal and/or privileged information intended for a specific individual and purpose. If you are not the intended recipient, you are hereby notified that any disclosure, copying, retaining, distribution, access, use or modification of the contents of this e-mailed information is strictly prohibited. If you receive this communication in error, please notify the sender immediately and delete or destroy the email message and any attachments or copies.

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DEADLINES for Travel Awards and MNN Scientific Meeting
by Manitoba Neuroscience Network 14 May '18

14 May '18

The Manitoba Neuroscience Network would like to make you aware of important upcoming deadlines: 1) TRAVEL AWARDS FOR NEUROSCIENCE PROJECTS NOW DUE MAY 20 The deadline for applications for Nancy Hettie Clark travel awards has been EXTENDED to MAY 20, 2018. Two travel awards of up to $700 each will be awarded to a PhD student and a postdoctoral fellow at the University of Manitoba. The eligible travel period is between May 1, 2018 and April 30, 2019. Eligible trainees are either PhD students or postdoctoral fellows. Student candidates must have a cumulative graduate grade point average of 3.5 or greater (University of Manitoba scale). Postdoctoral fellows must be within five years of receiving a doctoral degree. Candidates must demonstrate excellent research performance and potential in a neurosciences-related discipline, and must demonstrate they will disseminate research results that reflect a high-quality contribution by The University of Manitoba. A complete application package consists of the following: * Cover letter stating the following (1 page maximum): o Application category (PhD student or postdoctoral fellow) and your start date in that position o The conference title, location and dates o Type of presentation (e.g. poster or oral) o The importance of the meeting and significance for career development o Any information that would allow reviewers to assess the significance or impact of the conference (e.g. abstracts are peer-reviewed) o Clearly state your graduate GPA (students only) * Graduate level academic transcript (students only) * Listing of scholarly output (publications and presentations) * Support letter from the primary research advisor with (a) a merit assessment of the candidate and project, and (b) confirmation that there is a commitment to cover all eligible travel expenses less the award value * Copy of the submitted abstract Submit all materials to <mailto:info@manitobaneuroscience.ca> info(a)manitobaneuroscience.ca by MAY 20. The support letter may be appended or sent separately by the research advisor. 2) MANITOBA NEUROSCIENCE NETWORK SCIENTIFIC MEETING (ABSTRACTS DUE MAY 25; REGISTER BY JUNE 8) We remind you that the 2018 Scientific Meeting will be held JUNE 15. The meeting is co-chaired by Drs. Debbie Kelly, Jonathan Marotta and Mark Fry and will be held in the EITC Complex at the Fort Garry Campus of the University of Manitoba. There is a fabulous program planned, featuring a visit and talk by Dr. Lisa Saksida, Scientific Director of BrainsCAN Initiative at Western University. Abstracts and registrations are now being accepted. These links and the program can be found at: https://manitobaneuroscience.ca/events-and-news/annual-scientific-meeting/. The abstract deadline is MAY 25 and the registration deadline is JUNE 8. NEW this year - the student registration rate has bene reduced to only $20. Postdocs/Technicians are $40 and Faculty are $70. You may pay by credit card or by University of Manitoba FOP. If you pay by FOP, you will be registered for the meeting immediately but your payment will be pending. Once the FOP payment is processed, you will receive a receipt and confirmation by email. MNN Scientific Meeting inquiries should be sent to mnn2018(a)manitobaneuroscience.ca <mailto:mnn2018@manitobaneuroscience.ca> -The MNN Team ****************************************** <http://www.manitobaneuroscience.ca/> <https://www.facebook.com/manitobaneuroscience/?fref=ts> <https://www.instagram.com/manitobaneuroscience/> <https://twitter.com/manitobaneuro>

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