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MNN Seminar - Dr. Sari Hannila
by Winnipeg Chapter Society for Neuroscience 15 Feb '12

15 Feb '12

Everyone is invited.... Manitoba Neuroscience Network Seminar -Dr. Sari Hannila Date: Friday, Feb 24th, 2012 Time: 9:00 am Location: PX236/238 Psychiatry Bldg., Bannatyne Campus Dr. Sari Hannila Assistant Professor, Department of Human Anatomy & Cell Science Faculty of Medicine, University of Manitoba Topic: Downregulation of Smad2 by secretory leukocyte protease inhibitor enhances axonal regeneration in the CNS Dr. Hannila is originally from Sudbury, Ontario, and received her Bachelor of Science degree in Life Sciences from Queen's University in 1999. She then completed her PhD in the Department of Anatomy and Cell Biology at Queen's under the supervision of Dr. Michael Kawaja. Prior to joining the University of Manitoba in July, 2010, Dr. Hannila worked as a postdoctoral fellow in the laboratory of Dr. Marie T. Filbin at Hunter College in New York City. Her research focuses on the neurobiology of developing and regenerating axons in the central nervous system, with a particular interest in spinal cord injury. When the spinal cord is injured, regeneration of damaged axons is inhibited by CNS myelin and this leads to permanent paralysis. During her postdoctoral fellowship, Dr. Hannila discovered that a protein called secretory leukocyte protease inhibitor (SLPI) can reverse the inhibitory effects of myelin and enhance axonal growth. She is now building on these findings as an independent researcher at the University of Manitoba. She is currently testing SLPI in a rat model of spinal cord injury to determine if SLPI can promote axonal regeneration and improve functional recovery. If SLPI proves to be effective, she plans to conduct further studies in which SLPI will be administered in more complex, clinically-relevant models of spinal cord injury. In addition to its pro-regenerative effects, SLPI also has neuroprotective properties and to diversify her research program, Dr. Hannila plans to test SLPI in models of neurodegenerative diseases such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's, and Parkinson's disease. These studies will be complemented by ongoing experiments that will investigate the molecular mechanisms underlying SLPI's effects on axonal growth and neuronal survival, and this work will focus on SLPI's ability to regulate gene and protein expression. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Research Seminar - Dr. Sean Mulligan
by Winnipeg Chapter Society for Neuroscience 13 Feb '12

13 Feb '12

REMINDER: Hosted by: St. Boniface Research Centre. Division of Neurodegenerative Disorders Visiting Scientist - Dr. Sean Mulligan Friday, February 17, 2012 12:00 Noon Physiology Library 431 BMSB Bannatyne Campus Dr. Sean Mulligan Assistant Professor, Department of Physiology University of Saskatchewan Topic: Functional Optical Imaging in Free Nerve Endings: A Pain in the Dura. Research Interests: Pain sensitivity within the skull is restricted to the intracranial meninges, the system of membranes that envelops the brain. Afferent thinly myelinated Aδ-fibres and unmyelinated C-fibres that originate from the trigeminal ganglion densely innervate the meninges, in particular the cranial dura mater. It is widely recognized that activation or sensitization of these dural nociceptive afferents is responsible for the genesis of migraine headaches. However, any details of the pathophysiological mechanisms involved are largely speculative and remain to be discovered. Identification of the underlying mechanisms of activation of dural nociceptors may have important implications for understanding and mitigating the pathogenesis of migraine headaches. We have developed a novel en bloc dural-skull preparation that allows us for the first time to apply optical imaging techniques to directly study with high resolution the free nerve endings and terminals of the nociceptive fibres that terminate in the dura mater. The objective of our research is to gain insight into the neurophysiology of peripheral pain activation to better understand the pathophysiological processes that occur during migraine headache. It is our hope that this will lead to new peripheral drug targets and offer additional therapeutic treatments for this devastating illness. detection. Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Research Seminar - Dr. Sean Mulligan
by Winnipeg Chapter Society for Neuroscience 06 Feb '12

06 Feb '12

Everyone is invited... Hosted by the Division of Neurodegenerative Disorders at St. Boniface Hospital Research Invited Speaker: Dr. Sean Mulligan Friday, February 17th, 2012 12:00 - 1:00 p.m. Physiology Conference Room 431 BMSB Bannatyne Campus Dr. Sean Mulligan Assistant Professor, Department of Physiology, University of Saskatchewan Topic: Functional Optical Imaging in Free Nerve Endings: A Pain in the Dura. Research Interests: Pain sensitivity within the skull is restricted to the intracranial meninges, the system of membranes that envelops the brain. Afferent thinly myelinated A -fibres and unmyelin-ated C-fibres that originate from the trigeminal ganglion densely innervate the meninges, in particular the cranial dura mater. It is widely recognized that activation or sensitization of these dural nociceptive afferents is responsible for the genesis of migraine headaches. However, any details of the pathophysiological mecha-nisms involved are largely speculative and remain to be discovered. Identification of the underlying mechanisms of activation of dural nociceptors may have important implications for understanding and mitigating the pathogenesis of migraine headaches. We have developed a novel en bloc dural-skull preparation that allows us for the first time to apply optical imaging techniques to directly study with high resolution the free nerve endings and terminals of the nociceptive fibres that terminate in the dura mater. The objective of our research is to gain insight into the neurophysiol-ogy of peripheral pain activation to better understand the patho-physiological processes that occur during migraine headache. It is our hope that this will lead to new peripheral drug targets and offer additional therapeutic treatments for this devastating illness. detection. Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 F: 204.237.4092 website: www.sfn-manitoba.ca

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"Edge of Science" Grand Rounds
by Winnipeg Chapter Society for Neuroscience 01 Feb '12

01 Feb '12

See attached.....Everyone is invited..... "Edge of Science" Grand Rounds Genetic Models of Human Disease Seminars Date: Monday, February 6, 2012 Time: 12:00 1:00 pm Location: Basic Medical Sciences Building Theatre (C) Dr Jasna Kriz Associate Professor Department of Psychiatry and Neuroscience Faculty of Medicine Laval University TOPIC: "Development of Model Systems for Live Imaging of Neuroinflammation and Brain Responses to Injuries and Neurodegeneration" Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 f: 204.237.4092 Email: wcsn(a)sbrc.ca Website: sfn-manitoba.ca

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CIHR Café Scientifiques, February 7, 2012, 7:00 pm
by Winnipeg Chapter Society for Neuroscience 27 Jan '12

27 Jan '12

The CIHR Café Scientifiques brings together experts with non-researchers in a relaxed atmosphere to talk about important health questions. The presenters at the next CIHR Cafe Scientifiques will be: Dr. Soheila Karimi, Assistant Professor, Physiology Principal Investigator, Regenerative Medicine Program and Spinal Cord Research Centre; Scientist, Manitoba Institute of Child Health; University of Manitoba Dr. Kristine Cowley, Research Associate Spinal Cord Research Centre University of Manitoba Dr. Larry Jordan, Professor & Principal Investigator Spinal Cord Research Centre University of Manitoba Topic: "Renewing Hope for Spinal Cord Injury" Tuesday, February 7, 2012, 7:00 pm McNally Robinson, Grant Park 1120 Grant Avenue, Winnipeg Poster attached All are welcome to attend! **Please RSVP: research_communications(a)umanitoba.ca or 204.474.9020 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 f: 204.237.4092 Email: wcsn(a)sbrc.ca Website: sfn-manitoba.ca

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Your input is important and appreciated
by Winnipeg Chapter Society for Neuroscience 26 Jan '12

26 Jan '12

Dear Neuroscientists, For the last 2 years, we have held an annual meeting of the Manitoba Neuroscience Network with the objective of forming a neuroscience community and getting better acquainted personally and scientifically. As we plan the 2012 conference, we can either maintain the basic meeting framework largely as it has been the first two years, or we can choose a more ambitious plan that will likely, if well attended, more strongly benefit the community-building process. Please click on the following link (http://www.surveymonkey.com/s/RK6LJ8M) to answer ONE question that will help organizers plan the 2012 MNN Conference. IF you have additional comments about the meeting, please email mnn(a)sbrc.ca <mailto:mnn@sbrc.ca> . Thank you. Chris Anderson President, Winnipeg Chapter Society for Neuroscience Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 f: 204.237.4092 Email: wcsn(a)sbrc.ca Website: sfn-manitoba.ca

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2012 Manitoba Neuroscience Annual Meeting
by Winnipeg Chapter Society for Neuroscience 24 Jan '12

24 Jan '12

Dear Manitoba Neuroscientists, We are now in the process of planning the 2012 Manitoba Neuroscience Annual Meeting. A date will be announced soon. I have planned the last 2 meeting programs myself and I am looking for fresh insight this year. I have received passing suggestions ranging from keeping the meeting format essentially the same, to changing to a trainee-centered event, to holding the meeting every 2 years for lack of new content, to having it planned as an overnight retreat to facilitate evening socialization. I want this to be the best event possible. I am therefore soliciting meeting format and location suggestions from potential participants. Please take a few moments to consider what you would like to see at the next MNN annual meeting. What would benefit us all from a community-building and collaboration standpoint? I am happy to take all suggestions but please get them to me as soon as you can. Thank you for your help. Sincerely, --------------------------------------------------------------------------------------- Chris M. Anderson, Ph.D. Associate Professor of Pharmacology and Therapeutics University of Manitoba Principal Investigator, Division of Neurodegenerative Disorders St. Boniface Hospital Research Center President, Winnipeg Chapter, Society for Neuroscience Director, Manitoba Neuroscience Network T: 204.235.3946 │ F: 204.237.4092 │ E: canderson(a)sbrc.ca

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Research Seminar: Dr. Sari Hannila
by Winnipeg Chapter Society for Neuroscience 12 Jan '12

12 Jan '12

Hosted by Department of Pharmacology & Therapeutics Dr. Sari S. Hannila Assistant Professor Department of Human Anatomy and Cell Science University of Manitoba TOPIC: "Downregulation of Smad2 by secretory leukocyte protease inhibitor enhances axonal regeneration in the CNS". Friday, January 20, 2012 12:00 - 13:00 Pharmacology Library Room A229 Chown Building Video-linked to St. Boniface Research Centre Room R1002 Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 f: 204.237.4092 Email: wcsn(a)sbrc.ca Website: sfn-manitoba.ca

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Research Seminar - Friday, Jan 13, 2011
by Winnipeg Chapter Society for Neuroscience 12 Jan '12

12 Jan '12

Pharmacology and Therapeutics Seminar - DR. PAUL FERNYHOUGH Date: Friday, January 13, 2012 Time: 12:00 PM Location: A229 Chown Building** http://myuminfo.umanitoba.ca/index.asp?sec=900&too=200&dat=1/13/2012&sta=0&… Dr. Paul Fernyhough Director of Division of Neurodegenerative Disorders Professor - Departments of Pharmacology and Therapeutics & Physiology University of Manitoba Topic: "MITOCHONDRIAL DYSFUNCTION IN NEURONS IN DIABETES" ** Videolinked to St. Boniface Research Centre R1002 Research Focus: Diabetic and Peripheral Neuropathies: Diabetic neuropathies are the Cinderella of neurological diseases. The WHO informs us that by 2025 there will be 300 million sufferers from diabetes worldwide - a figure approximately equal to the population of the USA. Currently close to 50% diabetic patients develop some form of peripheral nerve disease, which can lead to loss of protective sensation and limb amputation. The incidence is expected to rise 10-fold in the next 10 years in First Nations peoples of Canada. There is no treatment. My group is, therefore studying pathogenetic mechanisms and potential drug targets. Key approaches involve identification of the cellular transduction of damage signals (neurotrophic deficits, oxidative stress, glucose stress, mitochondrial dysfunction) and failure of cellular protective mechanisms. Techniques: cell culture, confocal microscopy, fluorescence imaging, neuronal plasmid transfection, general biochemistry and pharmacology. Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 T: 204.235.3939 f: 204.237.4092 Email: wcsn(a)sbrc.ca Website: sfn-manitoba.ca

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Brain Awareness Week - 2012
by Winnipeg Chapter Society for Neuroscience 06 Jan '12

06 Jan '12

Dear Manitoba Neuroscientists, Brain Awareness Week is coming March 12-18, 2012. This year our feature event will be a scientific visit and public presentation by Dr. Adrian Owen from the University of Western Ontario on March 15 and 16. Dr. Owen was recently recruited to Canada from Cambridge University as a Canada Excellence Research Chair (CERC) in Cognitive Neuroscience and Imaging. He is coming at the invitation of the Winnipeg Chapter Society for Neuroscience, the Faculty of Medicine and the President of the University of Manitoba. Dr. Owen's itinerary will include a minisymposium on cognitive neuroscience and brain imaging, to showcase work being done in Manitoba, as well as an open scientific seminar and an evening public lecture. I encourage all Manitoba neuroscientists to demonstrate the vibrancy of our research and clinical neuroscience communities by participating in the activities surrounding Dr. Owen's visit. If you would like to meet with Dr. Owen, participate as a speaker in the minisymposium (other than those already contacted), or if you have a specific idea for inclusion on his itinerary, please contact me at canderson(a)sbrc.ca. Thank you! Sincerely, Chris /sent on behalf of Chris M. Anderson, Ph.D. Associate Professor of Pharmacology and Therapeutics University of Manitoba Principal Investigator, Division of Neurodegenerative Disorders St. Boniface Hospital Research Center President, Winnipeg Chapter, Society for Neuroscience Director, Manitoba Neuroscience Network T: 204.235.3946 │ F: 204.237.4092 │ E: canderson(a)sbrc.ca

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