- Neuro-All - University of Manitoba Mailing Lists

REMINDER: DND SPEAKER | DR. SHEENA JOSSELYN - TODAY NOON THEATRE C
by Winnipeg Chapter Society for Neuroscience 19 Oct '12

19 Oct '12

DND Visiting Speaker - Dr. Sheena Josselyn Date: Friday, October 19, 2012 Time: 12:00 noon Location: Theatre C, Banantyne Campus <http://www.sbrc.ca/wp-content/uploads/2012/05/josselyn.jpg> Dr. Sheena Josselyn <http://www.sickkids.ca/AboutSickKids/Directory/People/J/Sheena-Josselyn .html> Senior Scientist, Neurosciences & Mental Health Canada Research Chair <http://www.chairs.gc.ca/> , Molecular and Cellular Cognition Associate Professor, Department of Physiology University of Toronto Hospital for Sick Children, Toronto, ON TOPIC: Making and Breaking Memories A fundamental goal of neuroscience is to understand how memories are encoded and stored in the brain. Indeed, identifying the physical basis of memory within the brain (the memory trace) has been a long-standing challenge for scientists since Karl Lashley's "search for the engram" in the 1950's. Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased CREB are preferentially activated by fear memory expression, suggesting they are selectively recruited into the memory trace. Here we used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, suggesting that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace. Short bio: The research in Dr. Josselyn's lab is dedicated to understanding the neural basis of cognitive function and dysfunction. To unravel the molecular, cellular and circuit processes that underlie learning and memory, her lab uses a multidisciplinary approach include the use of genetically-engineered mice, viral vectors, cellular imaging, electrophysiology and detailed behavioral analysis. Her program of research focuses on two main elements 1) examining the brain regions and molecules responsible for normal memory formation and 2) using this knowledge to intervene in conditions in which memory is impaired (for instance in neurodegenerative diseases such as Alzheimer's disease). She has published extensively in the top scientific journals on these subjects and has shown that fear memories in mice can be "erased" and is currently examining novel treatments for the memory disorders that characterize Alzheimer's disease. For more information, please contact the DND Office at : t. 204.235.3939 e: dnd(a)sbrc.ca Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research Department of Pharmacology & Therapeutics University of Manitoba Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology

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NEW U of M Neuroscience Faculty positions available
by Winnipeg Chapter Society for Neuroscience 17 Oct '12

17 Oct '12

Dear Neuroscientists, Exciting times for neuroscience at the University of Manitoba continue with a new recruitment drive for 2 tenure-track faculty positions in the Traumatic Brain Injury Program at the Kleysen Institute for Advanced Medicine. Please see the attached advertisement and help bring the best candidate pool forward by encouraging qualified collaborators, acquaintances and past colleagues to apply. If you have any questions, let me know at canderson(a)sbrc.ca. Chris Anderson President, Winnipeg Chapter Society for Neuroscience

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Pharmacology/DND Seminar - Oct 12 @ noon
by Winnipeg Chapter Society for Neuroscience 10 Oct '12

10 Oct '12

Everyone invited... Pharmacology Seminar - Dr. Jim Davie view online: http://www.sbrc.ca/2012/10/pharmacology-seminar-dr-jim-davie/ Print PDF <http://www.printfriendly.com/print/v2?url=http://www.sbrc.ca/2012/10/ph armacology-seminar-dr-jim-davie/> Date: Friday, October 12, 2012 Time: 12:00 PM Location: Pharmacology Library A229 Chown Bldg. Bannatyne Campus** **Video-linked to R1002 SBRC, St. Boniface Campus <http://www.sbrc.ca/wp-content/uploads/2012/10/jim_davie.jpg> Jim Davie, Ph.D. Leader - Terry Fox Research Institute Prairie Node Scientific Director - Manitoba Health Research Council Scientist, Manitoba Institute of Child Health Senior Scientist, Manitoba Institute of Cell Biology Professor, Dept Biochemistry and Medical Genetics TOPIC: Histone modification dynamics and regulation of gene expression Jim Davie received his B.Sc. and Ph.D. degrees from the University of British Columbia. His post-doctoral training in the area of chromatin structure and function was done in the lab of Dr. Ken van Holde at Oregon State University. Dr. Davie is presently the Scientific Director of the Manitoba Health Research Council, Leader of the Terry Fox Research Institute Prairie Node, and Professor in the Department of Biochemistry and Medical Genetics at the University of Manitoba. He serves on several Editorial Boards of journals publishing in Biochemistry, Cell Biology and Molecular Biology and is Editor of the journal Biochemistry and Cell Biology. He has served as a Chair and panel member on CIHR and NCIC/CCSRI Peer Review Committees. His research interests include epigenetic regulation of gene expression in normal and disease (cancer) cells, nuclear matrix structure and function, sub-cellular trafficking of transcription factors and chromatin remodeling complexes, signal transduction pathways, chromatin structure and function, and biomarkers in the early detection of disease. He currently holds a Canada Research Chair in Chromatin Dynamics (Tier 1). Dr. Davie is the Past-President of the Canadian Society for Molecular Biosciences. /sent on behalf of Dr. Ben Albensi Seminar Coordinator, Department of Pharmacology & Therapeutics University of Manitoba e: balbensi(a)sbrc.ca Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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International Foundation for Research in Paraplegia: Application for Grants, Postdoctoral Fellowship and Schellenberg Prize
by Winnipeg Chapter Society for Neuroscience 02 Oct '12

02 Oct '12

Dear Madam, Dear Sir, Please find enclosed 3 annoucements from IRP - International Foundation for Research in Paraplegia, regarding: * IRP/IFP Research Grants in the field of "basic and clinical research on CNS regeneration neuroprotection and functional restoration" up to CHF 150'000.- for 2 years; * IRP/IFP Postdoctoral Fellowship in the field of "basic research in one or several aspects of CNS & spinal cord lesions and repair" up to CHF 80'000 for 1 year; * IRP/IFP Schellenberg Prize 2012 in the field of "spinal cord development, plasticity and regeneration following lesions" worth CHF 150'000.-. Deadline for applications is October 31st, 2012, with decisions to be made by the IRP/IFP Scientific Council in February 2013. We would be greatful if you could publish these annoucements through your usual channels and on your website. You'll find further useful information on www.irp.ch <http://www.irp.ch/> . We thank you in advance for your collaboration and remain at your disposal for any request. With best regards. IRP - Fondation internationale pour la recherche en paraplégie Joëlle Snella Assistante administrative Secrétariat IRP Rue François-Perréard 14 CH - 1225 Chêne-Bourg Tél. +41 22 349 03 03 Fax +41 22 349 44 05 jsnella(a)irp.ch www.irp.ch <http://www.irp.ch/> Retrouvez les photos du Bal du Printemps 2012 et les résultats de la loterie sur www.irp.ch <http://www.irp.ch/> ! Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Pharmacology Seminar Series
by Winnipeg Chapter Society for Neuroscience 28 Sep '12

28 Sep '12

Everyone Invited! pHARMACOLOGY Seminar Series Friday, October 5, 2012 12:00 - 13:00 Pharmacology Library, Room A229 Chown Building | Video-linked to St. Boniface Research Centre R1002 Marzena Kastyak-Ibrahim, PhD Department of Physics, University of Winnipeg Topic: "Imaging of white matter changes in AD mice by MR microscopy - a continuous challenge" Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Reminder: MNN Seminar | Dr. Grant Hatch | Friday Sept 28, 2012 9am
by Winnipeg Chapter Society for Neuroscience 26 Sep '12

26 Sep '12

Hosted by the Winnipeg Chapter Society for Neuroscience Everyone invited! Manitoba Neuroscience Network Seminar - Friday, Sept 28/12 9:00 am Dr. Grant Hatch Professor - Departments of Pharmacology and Therapeutics & Biochemistry and Medical Genetics Canada Research Chair in Molecular Cardiolipin Metabolism Director of the Lipid Lipoprotein and Atherosclerosis Research Group (LLARG) Director of the Centre for Research and Treatment of Atherosclerosis TOPIC: "Fatty acid transport across human brain microvessel endothelial cells: A unique role for arachidonic acid." Location: PX236/238 Psychiatry Bldg., Bannatyne Campus Short Biosketch: B.Sc. 4Yr U of Winnipeg; M.Sc. Biochemistry U of Saskatchewan; Ph.D. Biochemistry U Of Manitoba; Postdoctoral Fellow Biochemistry U of Alberta. Dr. Hatch was prairie born and prairie educated, having received his B.Sc. from the University of Winnipeg, his M.Sc. from the University of Saskatchewan, and his PhD from the University of Manitoba in 1989. He then went to the University of Alberta for a Post Doctoral Fellowship, which he completed in 1992. He then came to the University of Manitoba to assume the post of Assistant Professor. He rose through the ranks to become Professor in 2002. He became a Tier 1 Canada Research Chair in 2006. Hatch has won numerous career awards from the Manitoba Health Research Council, Heart and Stroke Foundation of Canada, Canadian Institutes of Health Research and the University of Manitoba, and he has published over 100 refereed articles, reviews and book chapters. Hatch relocated his laboratory to MICH in June 2011 and is looking forward to fruitful and productive collaborations with the MICH community. Studies on the regulation of phospholipid and lipid & lipoprotein metabolism with a focus on the childhood diseases Barth Syndrome & Persistant Pulmonary Hypertension of the Newborn. Dr. Hatch's laboratory is studying whether increasing the cells ability to remodel cardiolipin will aid in the treatment of Barth Syndrome, a rare genetic disease that weakens the heart. He and his colleagues are guided by the belief that their work may lead to new therapies to treat a range of diseases and disorders from Barth Syndrome to heart failure. A few years ago Hatch received a small grant from the Children's Hospital Foundation and subsequently a MICH grant to study Barth Syndrome. Based upon the foundation of these grants he published several papers on Barth Syndrome and was subsequently successful in obtaining several grants from the Barth Syndrome Foundation USA and most recently a five year grant from the Canadian Institutes of Health Research to continue with his studies. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Recall: Reminder: MNN Seminar | Dr. Grant Hatch | Friday Sept 28, 2012 9am
by Winnipeg Chapter Society for Neuroscience 26 Sep '12

26 Sep '12

Winnipeg Chapter Society for Neuroscience would like to recall the message, "Reminder: MNN Seminar | Dr. Grant Hatch | Friday Sept 28, 2012 9am".

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Reminder: MNN Seminar | Dr. Grant Hatch | Friday Sept 28, 2012 9am
by Winnipeg Chapter Society for Neuroscience 26 Sep '12

26 Sep '12

Hosted by the Winnipeg Chapter Society for Neuroscience Everyone invited! Manitoba Neuroscience Network Seminar Dr. Grant Hatch Professor - Departments of Pharmacology and Therapeutics & Biochemistry and Medical Genetics Canada Research Chair in Molecular Cardiolipin Metabolism Director of the Lipid Lipoprotein and Atherosclerosis Research Group (LLARG) Director of the Centre for Research and Treatment of Atherosclerosis TOPIC: "Fatty acid transport across human brain microvessel endothelial cells: A unique role for arachidonic acid." Location: PX236/238 Psychiatry Bldg., Bannatyne Campus Short Biosketch: B.Sc. 4Yr U of Winnipeg; M.Sc. Biochemistry U of Saskatchewan; Ph.D. Biochemistry U Of Manitoba; Postdoctoral Fellow Biochemistry U of Alberta. Dr. Hatch was prairie born and prairie educated, having received his B.Sc. from the University of Winnipeg, his M.Sc. from the University of Saskatchewan, and his PhD from the University of Manitoba in 1989. He then went to the University of Alberta for a Post Doctoral Fellowship, which he completed in 1992. He then came to the University of Manitoba to assume the post of Assistant Professor. He rose through the ranks to become Professor in 2002. He became a Tier 1 Canada Research Chair in 2006. Hatch has won numerous career awards from the Manitoba Health Research Council, Heart and Stroke Foundation of Canada, Canadian Institutes of Health Research and the University of Manitoba, and he has published over 100 refereed articles, reviews and book chapters. Hatch relocated his laboratory to MICH in June 2011 and is looking forward to fruitful and productive collaborations with the MICH community. Studies on the regulation of phospholipid and lipid & lipoprotein metabolism with a focus on the childhood diseases Barth Syndrome & Persistant Pulmonary Hypertension of the Newborn. Dr. Hatch's laboratory is studying whether increasing the cells ability to remodel cardiolipin will aid in the treatment of Barth Syndrome, a rare genetic disease that weakens the heart. He and his colleagues are guided by the belief that their work may lead to new therapies to treat a range of diseases and disorders from Barth Syndrome to heart failure. A few years ago Hatch received a small grant from the Children's Hospital Foundation and subsequently a MICH grant to study Barth Syndrome. Based upon the foundation of these grants he published several papers on Barth Syndrome and was subsequently successful in obtaining several grants from the Barth Syndrome Foundation USA and most recently a five year grant from the Canadian Institutes of Health Research to continue with his studies. For more information, contact the MNN Office at (T) 235.3939 or email: mnn(a)sbrc.ca Presented in co-operation with University of Manitoba Clinical Neuroscience Rounds Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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Med student summer research volunteer
by Winnipeg Chapter Society for Neuroscience 21 Sep '12

21 Sep '12

The following medical student is available for volunteer neuroscience research experience in the Summer of 2013. Please contact the student directly if interested. Chris Anderson WCSN President Currently I am a Canadian second year medical student studying at the Royal College of Surgeons in Ireland. I am open to any volunteer opportunities in neurological research, and I have attached my CV and cover letter for your consideration. Thank you for your time, Shivaun Gannon ---------------------- shivaungannon(a)rcsi.ie

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DND Visiting Speaker - Dr. Sheena Josselyn - Please mark your calendars....
by Winnipeg Chapter Society for Neuroscience 21 Sep '12

21 Sep '12

Hosted by: Division of Neurodegenerative Disorders, St. Boniface Hospital Research Everyone Invited - DND Visiting Speaker - Dr. Sheena Josselyn view online: http://www.sbrc.ca/2012/09/dnd-visiting-speaker-dr-sheena-josselyn-2/ Date: Friday, October 19, 2012 Time: 12:00 noon Location: Theatre C, Banantyne Campus TOPIC: Making and Breaking Memories <http://www.sbrc.ca/wp-content/uploads/2012/05/josselyn.jpg> Dr. Sheena Josselyn <http://www.sickkids.ca/AboutSickKids/Directory/People/J/Sheena-Josselyn .html> Senior Scientist, Neurosciences & Mental Health Canada Research Chair <http://www.chairs.gc.ca/> , Molecular and Cellular Cognition Associate Professor, Department of Physiology University of Toronto Hospital for Sick Children, Toronto, ON A fundamental goal of neuroscience is to understand how memories are encoded and stored in the brain. Indeed, identifying the physical basis of memory within the brain (the memory trace) has been a long-standing challenge for scientists since Karl Lashley's "search for the engram" in the 1950's. Memories are thought to be encoded by sparsely distributed groups of neurons. However, identifying the precise neurons supporting a given memory (the memory trace) has been a long-standing challenge. We have shown previously that lateral amygdala (LA) neurons with increased CREB are preferentially activated by fear memory expression, suggesting they are selectively recruited into the memory trace. Here we used an inducible diphtheria-toxin strategy to specifically ablate these neurons. Selectively deleting neurons overexpressing CREB (but not a similar portion of random LA neurons) after learning blocked expression of that fear memory. The resulting memory loss was robust and persistent, suggesting that the memory was permanently erased. These results establish a causal link between a specific neuronal subpopulation and memory expression, thereby identifying critical neurons within the memory trace. Short bio: The research in Dr. Josselyn's lab is dedicated to understanding the neural basis of cognitive function and dysfunction. To unravel the molecular, cellular and circuit processes that underlie learning and memory, her lab uses a multidisciplinary approach include the use of genetically-engineered mice, viral vectors, cellular imaging, electrophysiology and detailed behavioral analysis. Her program of research focuses on two main elements 1) examining the brain regions and molecules responsible for normal memory formation and 2) using this knowledge to intervene in conditions in which memory is impaired (for instance in neurodegenerative diseases such as Alzheimer's disease). She has published extensively in the top scientific journals on these subjects and has shown that fear memories in mice can be "erased" and is currently examining novel treatments for the memory disorders that characterize Alzheimer's disease. For more information, please contact the DND Office at : t. 204.235.3939 e: dnd(a)sbrc.ca Kelly Jorundson Winnipeg Chapter Society for Neuroscience R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6 Tel: 204.235.3939 Fax: 204.237.4092 Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca

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