cid:image001.jpg@01D158FE.B69B8D00
/sent on behalf of Dr. Ben Albensi
Everyone is invited!
D A T E:
Monday, Feb 4, 2019
12:00 Noon
L O C A T I O N:
Theatre A Bannatyne Campus
**followed by a trainee lunch in 207 A&B Chown Bldg.
S P E A K E R:
Image result for dr george perryGeorge Perry
PhD Professor of Biology and Chemistry
Chief Scientist, Brain Health Consortium
Semmes Foundation Distinguished University Chair in Neurobiology
The University of Texas at San Antonio
T O P I C: Mitochondria At The Center Of Alzheimers Disease
Dr. Perrys studies are focused on the mechanism of formation and
physiological consequences of the cytopathology of Alzheimers disease. The
lab has shown that oxidative damage is the initial cytopathology in
Alzheimers disease. They are working to determine the sequence of events
leading to neuronal oxidative damage and the source of the increased oxygen
radicals.
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
[cid:image001.jpg@01D158FE.B69B8D00]
/sent on behalf of Mary Fry
All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information.
Special Cross-Disciplinary Seminar
hosted by Department of Biological Sciences
Date: Friday, Feb 1st, 2019
Time: 9:00am
Location: Room 207 Buller BLDG
Speaker:
John L. Wallace
Professor of Physiology & Pharmacology
University of Calgary
Topic: A gas from the Past: Adventures in Drug Discovery".
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca>
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
[cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/>
[cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>
[cid:image001.jpg@01D158FE.B69B8D00]
/sent on behalf of Mary Fry
All faculty, staff and students are welcome to attend. Faculty and students interested in meeting the speakers can contact Mark Fry (Mark.Fry(a)umanitoba.ca<mailto:Mark.Fry@umanitoba.ca>) or Kevin Scott (Kevin.Scott(a)umanitoba.ca<mailto:Kevin.Scott@umanitoba.ca>) for more information.
Special Cross-Disciplinary Seminar
hosted by Department of Biological Sciences
Date: Friday, Feb 1st, 2019
Time: 9:00am
Location: Room 207 JBRC
Speaker:
John L. Wallace
Professor of Physiology & Pharmacology
University of Calgary
Topic: A gas from the Past: Adventures in Drug Discovery".
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca<mailto:kjorund@sbrc.ca>
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
[cid:image003.jpg@01D159B3.9F0B9710]<http://www.manitobaneuroscience.ca/>
[cid:image007.png@01D29326.7E26D480]<https://www.facebook.com/manitobaneuroscience/?fref=ts> [cid:image009.jpg@01D29326.7E26D480] <https://www.instagram.com/manitobaneuroscience/> [cid:image010.png@01D29326.7E26D480] <https://twitter.com/manitobaneuro>
cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Friday, January 25th, 2019
9am
L O C A T I O N:
Px236/238 PsycHealth Bldg.
Bannatyne Campus
S P E A K E R
Dr. Saeid Ghavami
Assistant Professor
Human Anatomy & Cell Science
Rady Faculty of Health Sciences
T O P I C
Glioblastoma and Cholesterol Metabolism Pathway
Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of
Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ
treatment causes DNA damage and results in tumor cell apoptosis. TMZ also
induces autophagy and causes tumor cell resistance and thus fails to improve
the survival rate among patients. Statins are competitive inhibitors of the
rate determining enzyme of the mevalonate (MEV) cascade and best known for
their cholesterol (CH) lowering effect. Recently, it was reported that
long-term consumption of statins, prior to and in parallel with other cancer
therapeutic approaches, increased the survival rate of patients with various
forms of cancers. In this talk, I present our latest investigation about the
mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade
inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human
GBM cell lines and in primary human GBM cells in both cell monolayers and in
three-dimensional (3D) cell culture systems.
Learning Objectives:
1- The attendee will learn the concept of Cholesterol biosynthesis
pathway and its possible effect in glioblastoma new therapy strategies.
2- The participant will learn concept of autophagy pathway.
3- The participant will understand how autophagy is involved in
regulation of apoptosis.
4- The participant will learn the principal of glioblastoma 3D culture
model.
Short Biography:
Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz,
Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical
Biochemistry. His Postdoctoral training was focused on the application of
apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell
fate. His research program is focused on regulation of cellular phenotype
via targeting autophagy and unfolded protein response in the Department of
Human Anatomy and Cell Science, University of Manitoba, He has been the
recipient of a number of prestigious awards including CIHR/GSK/CLA
postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career
Development Award (top 10 in North America, 2009), ATS Science and
Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early
Career Research Award (2017). He has published more than 150 peer reviewed
article (google scholar: >12,800 citation, h-index 40) (scopous > 7800
citations, h-index 33).
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Friday, January 25th, 2019
9am
L O C A T I O N:
Px236/238 PsycHealth Bldg.
Bannatyne Campus
S P E A K E R
Dr. Saeid Ghavami
Assistant Professor
Human Anatomy & Cell Science
Rady Faculty of Health Sciences
T O P I C
Glioblastoma and Cholesterol Metabolism Pathway
Abstract: Temozolomide (TMZ) is chemotherapeutic agent for treatment of
Grade IV Astrocytoma, otherwise known as Glioblastoma multiforme (GBM). TMZ
treatment causes DNA damage and results in tumor cell apoptosis. TMZ also
induces autophagy and causes tumor cell resistance and thus fails to improve
the survival rate among patients. Statins are competitive inhibitors of the
rate determining enzyme of the mevalonate (MEV) cascade and best known for
their cholesterol (CH) lowering effect. Recently, it was reported that
long-term consumption of statins, prior to and in parallel with other cancer
therapeutic approaches, increased the survival rate of patients with various
forms of cancers. In this talk, I present our latest investigation about the
mechanisms of the potentiation of TMZ-induced apoptosis by MEV cascade
inhibitor (cholesterol biosynthesis pathway) (simvastatin) (Simva) in human
GBM cell lines and in primary human GBM cells in both cell monolayers and in
three-dimensional (3D) cell culture systems.
Learning Objectives:
1- The attendee will learn the concept of Cholesterol biosynthesis
pathway and its possible effect in glioblastoma new therapy strategies.
2- The participant will learn concept of autophagy pathway.
3- The participant will understand how autophagy is involved in
regulation of apoptosis.
4- The participant will learn the principal of glioblastoma 3D culture
model.
Short Biography:
Saeid Ghavami got his BSc. in Chemistry in 1989 (Shiraz University, Shiraz,
Iran), MSc. and PhD (1995, 2004, TMU University, Tehran, Iran) in Clinical
Biochemistry. His Postdoctoral training was focused on the application of
apoptosis/autophagy/unfolded protein response (UPR) in regulation of cell
fate. His research program is focused on regulation of cellular phenotype
via targeting autophagy and unfolded protein response in the Department of
Human Anatomy and Cell Science, University of Manitoba, He has been the
recipient of a number of prestigious awards including CIHR/GSK/CLA
postdoctoral award (No #1 in Canada, 2007), Parker B Francis Career
Development Award (top 10 in North America, 2009), ATS Science and
Innovation Center Rising Star of Research Award (2017), CIHR/CCS/OICR Early
Career Research Award (2017). He has published more than 150 peer reviewed
article (google scholar: >12,800 citation, h-index 40) (scopous > 7800
citations, h-index 33).
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: <mailto:kjorund@sbrc.ca> kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Monday, January 14, 2019
12:00 Noon
(Followed by a trainee lunch in SR415 KIAM Bldg)
L O C A T I O N
Theatre C, Bannatyne Campus
S P E A K E R
D r. Keith Murai, Ph.D.
Director for the Centre for Research in Neuroscience
Professor, Neurology & Neurosurgery, Faculty and
Department of Medicine
Research Institute of the McGill University Health Centre
T O P I C
Astrocyte diversity and brain circuit microenvironments
Objectives:
1) Discuss the complexity and heterogeneity of astrocyte populations in the
CNS which may confer differential responses in the injured brain
2) Discuss the future potential of manipulating brain astrocytes for
treating brain injuries, increasing resiliency of neurons in brain diseases,
and promoting repair
Abstract:
Astrocytes are key partners for neurons in the healthy brain and contribute
to the physiology and homeostasis of neural circuits. The complex molecular,
functional, and structural properties of astrocytes enable these cells to
precisely regulate extracellular ionic balance, neurotransmission, brain
energetics, and cerebrovasculature. However, the mechanisms that enable
astrocytes to perform highly diverse and specialized functions in the brain
remain poorly understood. In this presentation, results will be provided
showing the remarkable anatomical and functional complexity of astrocytes
using advanced electron microscopy and molecular techniques. Furthermore,
new findings will be shown demonstrating how mature neurons signal to
neighbouring astrocytes to guide their molecular and physiological features
in multiple brain regions. This neuron to astrocyte communication is both
necessary and sufficient for astrocyte molecular diversification including
the expression of important molecules including glutamate transporters and
receptors, potassium channels, and water channels. Thus, ongoing
communication between neurons and astrocytes plays an fundamental role in
optimizing local neural circuit microenvironments to ensure optimal brain
health and function.
Brief Bio:
Keith Murai is the Director of the Centre for Research in Neuroscience at
McGill University, Leader of the Brain Repair and Integrative Neuroscience
(BRaIN) Program at the Research Institute of the McGill University Health
Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill
University. He is a recipient of a Canada Research Chair position and is an
EJLB Scholar for Schizophrenia Research. His research has two main areas of
focus: (1) Understanding how neurons and glial cells cooperate to regulate
brain development and homeostasis and (2) Discovering mechanism that
regulate the plasticity of synapses that underlie memory formation,
neurodevelopmental disorders, and neurodegenerative diseases. His laboratory
uses advanced mouse genetic, imaging, electrophysiological, and optogenetic
techniques and has pioneered approaches for understanding glial cells in
brain function. He is an Associate (handling) Editor at Frontiers in
Cellular Neuroscience, Section Editor in Development and Plasticity at the
Journal of Experimental Neuroscience, and a Member of the editorial board at
Developmental Neurobiology. He has been an author on high impact research
studies published in journals such as the Journal of Neuroscience, PNAS,
Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell,
and Science.
/sent on behalf of
Tabrez Siddiqui
Chair, MNN Seminar Series
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480
cid:image001.jpg@01D158FE.B69B8D00
S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Monday, January 14, 2019
12:00 Noon
(Followed by a trainee lunch in SR415 KIAM Bldg)
L O C A T I O N
Theatre C, Bannatyne Campus
S P E A K E R
D r. Keith Murai, Ph.D.
Director for the Centre for Research in Neuroscience
Professor, Neurology & Neurosurgery, Faculty and
Department of Medicine
Research Institute of the McGill University Health Centre
T O P I C
Astrocyte diversity and brain circuit microenvironments
Objectives:
1) Discuss the complexity and heterogeneity of astrocyte populations in the
CNS which may confer differential responses in the injured brain
2) Discuss the future potential of manipulating brain astrocytes for
treating brain injuries, increasing resiliency of neurons in brain diseases,
and promoting repair
Abstract:
Astrocytes are key partners for neurons in the healthy brain and contribute
to the physiology and homeostasis of neural circuits. The complex molecular,
functional, and structural properties of astrocytes enable these cells to
precisely regulate extracellular ionic balance, neurotransmission, brain
energetics, and cerebrovasculature. However, the mechanisms that enable
astrocytes to perform highly diverse and specialized functions in the brain
remain poorly understood. In this presentation, results will be provided
showing the remarkable anatomical and functional complexity of astrocytes
using advanced electron microscopy and molecular techniques. Furthermore,
new findings will be shown demonstrating how mature neurons signal to
neighbouring astrocytes to guide their molecular and physiological features
in multiple brain regions. This neuron to astrocyte communication is both
necessary and sufficient for astrocyte molecular diversification including
the expression of important molecules including glutamate transporters and
receptors, potassium channels, and water channels. Thus, ongoing
communication between neurons and astrocytes plays an fundamental role in
optimizing local neural circuit microenvironments to ensure optimal brain
health and function.
Brief Bio:
Keith Murai is the Director of the Centre for Research in Neuroscience at
McGill University, Leader of the Brain Repair and Integrative Neuroscience
(BRaIN) Program at the Research Institute of the McGill University Health
Centre, and Professor in the Dept. of Neurology and Neurosurgery at McGill
University. He is a recipient of a Canada Research Chair position and is an
EJLB Scholar for Schizophrenia Research. His research has two main areas of
focus: (1) Understanding how neurons and glial cells cooperate to regulate
brain development and homeostasis and (2) Discovering mechanism that
regulate the plasticity of synapses that underlie memory formation,
neurodevelopmental disorders, and neurodegenerative diseases. His laboratory
uses advanced mouse genetic, imaging, electrophysiological, and optogenetic
techniques and has pioneered approaches for understanding glial cells in
brain function. He is an Associate (handling) Editor at Frontiers in
Cellular Neuroscience, Section Editor in Development and Plasticity at the
Journal of Experimental Neuroscience, and a Member of the editorial board at
Developmental Neurobiology. He has been an author on high impact research
studies published in journals such as the Journal of Neuroscience, PNAS,
Journal of Cell Biology, Nature Neuroscience, Current Biology, Neuron, Cell,
and Science.
/sent on behalf of
Tabrez Siddiqui
Chair, MNN Seminar Series
Kelly Jorundson
Coordinator, Membership & Operations
Manitoba Neuroscience Network
Room R4046 - 351 Taché Avenue,
Winnipeg, MB R2H 2A6 CANADA
Email: kjorund(a)sbrc.ca
Tel: 204.235.3939 Fax: 204.237.4092
.
******************************************
<http://www.manitobaneuroscience.ca/> cid:image003.jpg@01D159B3.9F0B9710
<https://www.facebook.com/manitobaneuroscience/?fref=ts>
cid:image007.png@01D29326.7E26D480
<https://www.instagram.com/manitobaneuroscience/>
cid:image009.jpg@01D29326.7E26D480 <https://twitter.com/manitobaneuro>
cid:image010.png@01D29326.7E26D480