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S E M I N A R & V I S I T I N G S P E A K E R S E R I E S

D AT E

Friday, January 26, 2018

9:00am

L O C AT I O N

PX236/238 PsycHealth Building

S P E A K E R

Dr. Saeid Ghavami http://chrim.ca/researcher/saeid-ghavami/

Department of Human Anatomy & Cell Science, Max Rady College of Medicine Rady Faculty of Health Sciences University of Manitoba

T O P I C Mevalonate Cascade Inhibition and Glioblastoma Multiform: Role of Autophagy Modulation in Sensitizing the glioblastoma cells to Temozolomide.

Biosketch: Originally from Mashad, Khorasan, Iran, Dr. Ghavami has received his Bachelor of Chemistry degree from Shiraz University, Iran in 1989. He then completed his Master of Science and PhD degree in the Department of Clinical Biochemistry at Tarbiat Modarres University, Iran in 1996 and 2004 in Clinical Biochemsitry. Prior to joining to the Department of Human Anatomy and Cell Science, University of Manitoba in October 2013 as an Assistant Professor, Dr. Ghavami worked as a Post Doctoral Fellow in CancerCare Manitoba, Department of Physiology and Pathophysiology and St. Boniface Research Centre at the University of Manitoba for 9 years (2004-2013) and has built his research career on the effects of cellular stress in the regulation of cellular fate. Currently Dr. Ghavami is an Assistant Professor and Principal investigator and one of his major research focus is developing new therapeutic approaches in glioblastoma multiform, based on modification of apoptosis, autophagy, and unfolded protein response (UPR) pathway via cholesterol metabolism pathway.

Learning Objectives: At the end of this presentation the audience should be able to:

· Describe the cholesterol metabolism pathway and its effect on regulation of small Rho GTPase protein

· Describe the development of statin drug family and their pleotropic effects.

· Describe the general effects of statins in cancer

· Describe mechanism of regulation of autophagy pathway and autophagy flux

· Describe how cholesterol metabolism pathway regulate autophagy and cell death in glioblastoma cells

/sent on behalf of

Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour@umanitoba.ca

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network

Email: mailto:kjorund@sbrc.ca kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092

St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA

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