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**PLEASE SCROLL DOWN TO VIEW INFORMATION ON BOTH A PUBLIC LECTURE (FOLLOWED BY A RECEPTION) AS WELL AS A SCIENTIFIC LECTURE (FOLLOWED BY A TRAINEE LUNCH)

U N I V E R S I T Y O F M A N I T O B A ' S T H E V I C T O R H A V L I C E K M E M O R I A L L E C T U R E S H I P

PUBLIC LECTURE D A T E Monday, May 6th, 2019 8:00 pm (Followed by refreshments in the Atrium)

L O C A T I O N Samuel Cohen Auditorium, St. Boniface Hospital Research Centre

S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist

T O P I C Recent Advances in our Understanding of the Causes and Effects of Autism Spectrum Disorder

RESEARCH LECTURE

D AT E Tuesday, May 7, 2019 12:00 PM (noon)

LO C AT I O N Theatre B, BMSB, Bannatyne Campus

S P E A K E R Dr. David Amaral Distinguished Professor Department of Psychiatry & Behavioural Sciences and Center for Neuroscience, University of California, Davis CNPRC Core Scientist

T O P I C The Ups and Downs of Autism Spectrum Disorder: Tracking the trajectories of autism in the Autism Phenome Project

A B S T R A C T We are attempting to subdivide autism spectrum disorder into more homogeneous subtypes by recruiting a very large cohort of young children (2 - 3 1/2 years of age) into a comprehensive, multidisciplinary and longitudinal analysis of the features of autism. We have also enrolled age-matched typically developing children for comparison. To date, we have enrolled over 450 families into the Autism Phenome Project. In this talk, I will highlight some of the differences in brain development that we have discovered and the behavioral consequences of the different developmental trajectories. I will also provide an overview of data that demonstrates difference in cognitive development in subsets of children with autism. I will also summarize initial findings on the trajectories of autism severity from recent, unpublished analyses. Finally, I will briefly summarize data demonstrating brain changes in children at risk for autism as early as 6 months of age. The goal of these studies is to understand the biological etiologies of different forms of autism which will hopefully lead to more targeted and effective treatments of their debilitating features.

O B J E C T I V E S 1. Gain an understanding of the biological and behavioral heterogeneity of autism spectrum disorder. 2. Become knowledgable about the various developmental trajectories that can be followed by different children with autism spectrum disorder. 3. Understand how it is possible to carry out high quality neuroimaging in young children with neurodevelopmental disorders.

For more information, contact the MNN office @ 204.235.3939 Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui@umanitoba.camailto:Tabrez.siddiqui@umanitoba.ca

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA Email: kjorund@sbrc.camailto:kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092 . ****************************************** [cid:image003.jpg@01D159B3.9F0B9710]http://www.manitobaneuroscience.ca/ [cid:image007.png@01D29326.7E26D480]https://www.facebook.com/manitobaneuroscience/?fref=ts [cid:image009.jpg@01D29326.7E26D480] https://www.instagram.com/manitobaneuroscience/ [cid:image010.png@01D29326.7E26D480] https://twitter.com/manitobaneuro