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S E M I N A R & V I S I T I N G S P E A K E R S E R I E S
D A T E
Friday, February 23rd, 2018
9 am
L O C A T I O N
PX236/238 PsycHealth Building
S P E A K E R
Dr. Renee Douville https://www.uwinnipeg.ca/biology/people/faculty-staff/renee-douville.html Associate Professor & Chancellors Research Chair, Department of Biology, University of Winnipeg
Adjunct Professor, Department of Immunology, University of Manitoba
T O P I C Life is a Mixtape: Endogenous retrovirus-K blends neurological disease and immunity
A B S T R A C T
Endogenous Retroviruses (ERVs) are genetic elements of viral origin found within the human genome. Enhanced ERV expression has been associated with several inflammatory diseases; yet the mechanism behind their induction is poorly understood. ERVK is implicated in the neurological disease Amyotrophic Lateral Sclerosis (ALS). Our laboratory has shown that specific inflammatory signals can promote the re-activation of dormant ERVK elements within human astrocytes and neurons. Increased expression of ERVK relies on inflammatory transcription factors binding to the viral promoter. Inflammatory signals are also sufficient to promote viral polyprotein cleavage, leading to the formation of functional viral proteins, such as the integrase enzyme. ERVK integrase drives cellular DNA damage, as well as inhibits innate immunity, revealing mechanisms by which ERVK contributes to select disease processes. The findings generated from our research allows for identification of novel therapeutic targets to control pathogenic ERVK expression in inflammatory and neurodegenerative disease.
/sent on behalf of
Dr. Eftekhar Eftekharpour Coordinator, Seminar & Visiting Speaker Series Manitoba Neuroscience Network E: Eftekhar.Eftekharpour@umanitoba.ca
Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network
Email: kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092
St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA
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