Manitoba Neuroscience Network Seminar
Friday, May 31, 2013 | 9:00 am
Dr. Gordon Glazner
Associate Professor - Department of Pharmacology & Therapeutics,
University of Manitoba &
Principal Investigator, Division of Neurodegenerative Disorders, St.
Boniface Hospital Research
Topic: Investigating the role of NF-kB in diabetic neuropathy.
Location: PX236/238, Psychiatry Bldg. Bannatyne Campus
In people with diabetes, a major complication is neuropathy, in which
sensory nerve endings die back from the limbs. This leads to severe
pain, numbness, skin ulcerations and poor would healing, and often ends
in amputation of the limb. We and others have found that NF-kB, a
protein that regulates the production of other proteins, is decreased in
the sensory nerves of diabetic animals. We've also found that both the
hormones that stimulate NF-kB and a key antioxidant protein produced by
NF-kB action are decreased in sensory neurons. We propose now to use our
new knowledge to find if activation of this pathway can inhibit diabetic
neuropathy, and to find out if loss of this pathway in diabetes is the
root cause of neuropathy. This project is separated into five separate
aims. In Aim 1 we will deliver a NF-kB stimulating hormone, called CNTF,
to diabetic animals, and we will determine if this can reduce or reverse
formation of diabetic neuropathy. In Aim 2, we will see if inhibition of
this pathway, either by specific drugs or by genetic deficiency, can
increase the severity and risk for development of diabetic neuropathy in
rodents. In Aim 3, we will investigate whether diabetes inhibits more
members of the newly discovered pathway, and if we can rescue neurons by
reversing this loss. In Aim 4 we will discover whether increasing
anti-oxidant action can prevent formation of diabetic neuropathy. In aim
5, we will examine what it is about diabetes that causes inhibition of
this pathway. Our group has recently discovered a pathway that normally
keeps sensory nerves healthy is disrupted in diabetes. We believe that
this disruption is the underlying cause of neuropathy. The proposed work
will take these findings into whole animal "proof of concept" studies to
determine if manipulation of this pathway can be used therapeutically,
and will help to discover the underlying cause of diabetic neuropathy.
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Presented in co-operation with University of Manitoba Clinical
Neuroscience Rounds
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
The Society for Neuroscience has unveiled its Chapter Travel Awards for the 2013 Annual Scientific Meeting in San Diego. The Winnipeg Chapter will be selecting 2 nominees for these awards - one graduate student and one postdoctoral fellow.
The following are the eligibility criteria:
* Nominees must be first author of an abstract to be presented at the annual meeting with an abstract of the highest scientific merit
* The nominee and his or her advisor must be active members of SfN (provide membership ID numbers)
* The nominee must be a graduate student who has advanced to candidacy for a PhD or a postdoctoral fellow
* Only one applicant from a given laboratory may be considered by a chapter in any given calendar year
* Nominee may not be nominated for an award two years in a row
* Nominee is not a recipient of another SfN travel award in the same year
If you are interested in applying please forward the following information to Kelly Jorundson (wcsn(a)sbrc.ca <mailto:wcsn@sbrc.ca> ) by JUNE 5, 2013:
* Completed Graduate Student <http://www.sfn.org/Awards-and-Funding/Individual-Prizes-and-Fellowships/Tra…> or Postdoctoral Trainee <http://www.sfn.org/Awards-and-Funding/Individual-Prizes-and-Fellowships/Tra…> application
* Copy of the abstract submitted for the SfN annual meeting
* A one-page letter of recommendation from the nominee's mentor/advisor commenting on the nominee's contributions to neuroscience research
* Applicant's one-page CV, including education (graduate student nominees must include the date they advanced to PhD candidacy and PhD nominees must include the date they were awarded their postdoctoral degree), honors/awards, and publications (abstracts and manuscripts)
Thanks and good luck!
---------------------------------------------------------------------------------------
Chris M. Anderson, Ph.D.
President, Winnipeg Chapter, Society for Neuroscience
T: 204.235.3946 │ F: 204.237.4092 │ E: chris.anderson(a)med.umanitoba.ca
Nick Shepel Student Travel Award
(view online: http://www.sbrc.ca/wp-content/uploads/2013/05/nick-shepel-award-2013.pdf)
Competition deadline: May 10th, 2013
The fund was established by the Division of Neurodegenerative Disorders, St. Boniface Hospital Research to honor Nick Shepel who was an outstanding researcher, friend and leader. Nick was a true inspiration to his lab partners and brought fire, humor, and a desire to always do better. His insistence to always try better will have a permanent effect on his lab mates. Nick led by example and taught that detailed preparation and execution of experiments ensured reliable results.
Purpose: The purpose of this fund shall be to recognize a young investigator (graduate student within the Faculty of Medicine - University of Manitoba) by providing an annual award (valued at up to $1,000) to support travel costs associated with the applicant's attendance at a national/international conference where the applicant is presenting a poster or oral presentation.
Eligibility: At the time of application, students must be registered in the Faculty of Medicine at the University of Manitoba.
1. "Registered" includes being accepted by the major department of study, admitted by the Faculty of Graduate Studies, or eligible to register in the Faculty of Graduate Studies.
2. A student admitted under the "Provisional Status" may not receive the award during the provisional period.
3. Only one award will be given per competition (valued at up to $1,000).
4. Students must be giving a poster or oral presentation at an upcoming scientific meeting (national/international)
Submission Instructions: A complete application consists of the following:
1. Introductory letter describing meeting
2. Copy of abstract
3. Curriculum vitae
4. Current GPA, transcripts not needed
5. Proposed budget of travel costs
6. Submit your completed application materials to: Dr. Paul Fernyhough Director - Division of Neurodegenerative Disorders St. Boniface Hospital Research R4046 - 351 Tache Avenue Winnipeg, MB R2H 2A6
How to apply for reimbursement: Reimbursement will be done in accordance with St. Boniface Hospital travel policies. Only original receipts will be accepted. Copies may be accepted only where proof of submission to another agency is provided.
For more information, contact:
Kelly Jorundson
Administrative Manager, Division of Neurodegenerative Disorders
St. Boniface Hospital Research
& Department of Pharmacology & Therapeutics
University of Manitoba
Room R4046 - 351 Taché Avenue
Winnipeg, MB R2H 2A6 CANADA
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology
2013 Nick Shepel Student Travel Award
Competition deadline: May 10th, 2013
The Nick Shepel Student Travel Award was established by the Division of
Neurodegenerative Disorders, St. Boniface Hospital Research to honor
Nick Shepel who was an outstanding researcher, friend and leader. Nick
was a true inspiration to his lab partners and brought fire, humor, and
a desire to always do better. His insistence to always try better will
have a permanent effect on his lab mates. Nick led by example and taught
that detailed preparation and execution of experiments ensured reliable
results.
Purpose: The purpose of this fund shall be to recognize a young
investigator (graduate student within the Faculty of Medicine -
University of Manitoba) by providing an annual award (valued at up to
$1,000) to support travel costs associated with the applicant's
attendance at a national/international conference where the applicant is
presenting a poster or oral presentation.
Eligibility: At the time of application, students must be registered in
the Faculty of Medicine at the University of Manitoba.
1. "Registered" includes being accepted by the major department of
study, admitted by the Faculty of Graduate Studies, or eligible to
register in the Faculty of Graduate Studies.
2. A student admitted under the "Provisional Status" may not
receive the award during the provisional period.
3. Only one award will be given per competition (valued at up to
$1,000).
4. Students must be giving a poster or oral presentation at an
upcoming scientific meeting (national/international)
Submission Instructions: A complete application consists of the
following:
1. Introductory letter describing meeting
2. Copy of abstract
3. Curriculum vitae
4. Current GPA, transcripts not needed
5. Proposed budget of travel costs
6. Submit your completed application materials to:
Dr. Paul Fernyhough
Director - Division of Neurodegenerative Disorders
St. Boniface Hospital Research
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
How to apply for reimbursement: Reimbursement will be done in
accordance with St. Boniface Hospital travel policies. Only original
receipts will be accepted. Copies may be accepted only where proof of
submission to another agency is provided.
For more information, contact:
Kelly Jorundson, Administrative Manager
Division of Neurodegenerative Disorders
R4046-351 Tache Ave., Winnipeg, MB R2H 2A6
E: kjorund(a)sbrc.ca <mailto:kjorund@sbrc.ca> T:204.235.3939 F:
204.237.4092
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca