Everyone is invited....
Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, January 15th, 2016 | 3:00 p.m.
Timothy Kennedy
<https://www.mcgill.ca/neuro/research/researchers/kennedy>
Professor - Department of Neurology & Neurosurgery
co-Director - McGill Program in NeuroEngineering
Montreal Neurological Institute
McGill University
TOPIC: Making Connections: New Roles for Netrin-1 and DCC Regulating
Myelination, Synaptogenesis, and Plasticity
Location: Theatre C, Bannatyne Campus
Visit Dr. Kennedy's Website to learn about his research:
https://www.mcgill.ca/neuro/research/researchers/kennedy
For more information, please contact the MNN Office at 204.235.3939
The 2015/2016 MNN Seminar & Visiting Speaker Series is funded by:
* Winnipeg Chapter Society for Neuroscience - Manitoba
Neuroscience Network
* Division of Neurodegenerative Disorders, St. Boniface Hospital
Albrechtsen Research Centre
* Neuroscience Research Program, Health Sciences Centre &
University of Manitoba
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Everyone is invited to attend....
Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, December 11th, 2015 | 3:00 p.m.
Yu Tian Wang <http://www.neuroscience.ubc.ca/people/Wang>
Professor, Department of Medicine, Division of Neurology
Chair in Stroke Research
University of British Columbia
TOPIC: Peptide-based research tools and therapeutics in the
post-genome era
Location: Theatre C, Bannatyne Campus
Research Focus: I have a long-standing research interest in
understanding the molecular mechanisms responsible for regulating the
function and intracellular trafficking of neurotransmitter receptors
critical for brain functions such as learning, memory and cognition, and
investigating the manner by which these mechanisms may be altered in
central nervous disease processes. My goal is to be able to treat
central nervous disorders such as stroke, drug addiction, and
schizophrenia by designing new therapeutics that specifically target
these receptors and their pathways. With particular relevance to this
project, we have made a significant impact on stroke research. We
discovered that NMDA receptor NR2A and NR2B subunits have respective
roles in promoting cell survival and cell death (J. Neurosci. 27:2846,
2007). We have characterized the molecular steps downstream of the NR2B
death pathway, and also developed several specific inhibitors to disrupt
this pathway and demonstrated their therapeutic potentials in reducing
brain damage following stroke (Science 298:846, 2002; JBC 279:41267,
2004; Nature Med. 15:1399, 2009; J. Neurosci. 33:7997, 2013). To
translate these basic scientific discoveries into potential therapeutics
for brain dysfunctions, I founded, along with five other
scientists/clinicians, the NoNO Inc. in Toronto that has recently
completed a successful phase 2 clinical trial, demonstrating for the
first time a clinically effective neuroprotectant NA-1 (Tat-NR2B9c) in
reducing ischemic brain damage (Lancet Neurol 11:942, 2012). Our
research expertise spans functionally characterizing synaptic
plasticity, biochemically mapping protein-protein interaction sites, and
designing specific peptides for use in models of CNS disorders.
Kelly Jorundson
Winnipeg Chapter Society for Neuroscience
R4046 - 351 Tache Avenue
Winnipeg, MB R2H 2A6
Tel: 204.235.3939
Fax: 204.237.4092
Email: kjorund(a)sbrc.ca OR kjorund(a)yahoo.ca
Website: www.sfn-manitoba.ca
Please note lecture starts at 12noon.
Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, December 4th, 2015 | 12:00 Noon
Christoph J.W. Pröschel <https://www.urmc.rochester.edu/labs/proschel-lab/>
Associate Professor of Genetics
University of Rochester Medical Center,
Department for Biomedical Genetics,
Stem Cell and Regenerative Medicine Institute
Pathways of Human Disease Program
TOPIC: Glial cell therapy: the opportunity for restoring function by restoring tissue homeostasis.
Location: Theatre C, Bannatyne Campus
Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy
(Nat Med. 2005 Mar;11(3):277-83.).
The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases
(Parkinsons Disease, Multiple sclerosis).
We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells.
(PLoS One. 2011 Mar 2;6(3)).
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca
Everyone is invited...
Manitoba Neuroscience Network
2015/2016 Seminar & Visiting Speaker Series
Friday, December 4th, 2015 | 12:00 Noon
Christoph J.W. Pröschel <https://www.urmc.rochester.edu/labs/proschel-lab/>
Associate Professor of Genetics
University of Rochester Medical Center,
Department for Biomedical Genetics,
Stem Cell and Regenerative Medicine Institute
Pathways of Human Disease Program
TOPIC: Glial cell therapy: the opportunity for restoring function by restoring tissue homeostasis.
Location: Theatre C, Bannatyne Campus
Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy
(Nat Med. 2005 Mar;11(3):277-83.).
The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases
(Parkinsons Disease, Multiple sclerosis).
We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells.
(PLoS One. 2011 Mar 2;6(3)).
For more information, contact the MNN Office at
(T) 235.3939 or email: mnn(a)sbrc.ca