Manitoba Neuroscience Network 2014/2015 Seminar & Visiting Speaker Series

Date: Friday, March 27th 2015

Time: 9:00 a.m.

Location: PX236/238 PsycHealth Bldg., Bannatyne Campus

Donald Miller, PhD

Professor, Neuroscience Research Program, Kleysen Institute for Advanced Medicine, Health Sciences Centre & University of Manitoba

Department of Pharmacology & Therapeutics, University of Manitoba

Topic: Medicating the brain: Potential routes for drug passage through the blood-brain barrier.

My research interests are in understanding the cellular factors that control blood-brain barrier (BBB) permeability under both normal and pathophysiological conditions. Utilizing both cell culture and

whole animal models, my laboratory examines various transport processes within the brain microvessel endothelial cells for moving drugs and solutes into and out of the brain. One area of research interest is

in drug efflux transporter localization and expression in the brain endothelial cells, and how modulation of transporter activity influences drug delivery to the brain.

My laboratory is also actively pursuing alternative routes for drug delivery across the BBB including transient modulation of BBB permeability and the use of magnetic nanoparticles for targeted delivery

to the brain.

Website: http://umanitoba.ca/faculties/health_sciences/medicine/units/pharmacology/fa...

For more information, contact the MNN Office at

(T) 235.3939 or email: mnn@sbrc.ca

Kelly Jorundson Administrative Manager Division of Neurodegenerative Disorders St. Boniface Hospital Research

& Department of Pharmacology & Therapeutics College of Medicine, Faculty of Health Sciences University of Manitoba

Room R4046 - 351 Taché Avenue Winnipeg, MB R2H 2A6 CANADA

Tel: 204.235.3939 | Fax: 204.237.4092 Email: kjorund@sbrc.ca OR Kelly.Jorundson@umanitoba.ca Website: www.sbrc.ca/dnd OR www.umanitoba.ca/medicine/units/pharmacology