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M N N S E M I N A R & V I S I T I N G S P E A K E R S E R I E S

D A T E:

Thursday November 15th, 2018

12:00 Noon

L O C A T I O N:

Theatre C Bannatyne Campus

**followed by a trainee lunch in SR415 Kleysen Bldg.

S P E A K E R Dr. Wei Lu Synapse and Neural Circuit Section

Porter Neuroscience Research Center

National Institute of Neurological Disorders and Stroke

National Institutes of Health

T O P I C: Making the brain’s own brake | Molecular mechanisms of inhibitory synapse development.

O b j e c t I v e s: Discuss the recent progress from my lab in understanding the molecular and cellular mechanisms for inhibitory synapse development

B I O S K E T C H:

Ph.D. (Neuroscience and Physiology). Laboratory of Edward Ziff, New York University School of Medicine, New York, 2006

M.S. (Molecular Biology/Entomology). Zhejiang University, China, 2000

B.S. (Biochemistry). Sichuan University, China, 1997

Recent publications: Steinkellner Thomas, Zell Vivien, Farino Zachary, Sonders Mark, Villeneuve Michael, Freyberg Robin, Przedborski Serge, Lu W, Freyberg Zachary, Hnasko Thomas (2018): Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons. The Journal of Clinical Investigation. 128 (2) Gu XL, Lu W (2018) Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons. Neuroscience Letters. 668, 147-153. Hutchison MA, Gu X, Adrover MF, Lee MR, Hnasko TS, Alvarez VA and Lu W (2018) Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior. Molecular Psychiatry. 23, 1213-1225. Yeh CY, Asrican B, Moss J, Quintanilla LJ, He T, Mao X, Casse F, Gebara E, Bao HC, Lu W, Toni N, Song J (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron. 99(3):493-510

For more information, contact the MNN office @ 204.235.3939

Tabrez Siddiqui Chair, MNN Seminar Series E: Tabrez.siddiqui@umanitoba.ca

Kelly Jorundson Coordinator, Membership & Operations Manitoba Neuroscience Network

Email: kjorund@sbrc.ca Tel: 204.235.3939 Fax: 204.237.4092

St. Boniface Hospital Albrechtsen Research Centre Room R4046 - 351 Taché Avenue, Winnipeg, MB R2H 2A6 CANADA

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